• Title/Summary/Keyword: Challenges

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A Study on How Governance of Genetic Scissors CRISPR-Cas9 for Research on Embryos Can Encourage a Researcher to Have a Sense of Responsibility - Focus on the Bioethics and Safety Act Article 47 - (유전자가위 CRISPR-Cas9을 이용한 인간 배아 연구에 있어서 연구자의 책임의식 고양을 위한 거버넌스 -개정 생명윤리 및 안전에 관한 법률 제47조를 중심으로-)

  • Kim, Minsung
    • The Korean Society of Law and Medicine
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    • v.23 no.1
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    • pp.121-148
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    • 2022
  • CRISPR-Cas9 is one of the gene-editing technologies that infinite potential. It may provide human beings with many benefits or cause unanticipated challenges. The governance as standards setting or regulation of gene-editing technologies can contribute to keeping a balance between scientific value and ethical commitments. Guaranteeing public participation provides an additional opportunity to think about ethical and moral considerations: For whose benefit the internationally discussed governance of gene-editing technologies is directed at? There is a doubt regarding whether the governance justifies scientific researchers' gene-editing research. Suppose that governance promotes the advancement of CRISPR-Cas9, it should also encourage greater research responsibility. If not, there may be tragedies brought about by the misconduct of researchers. Thus, the essential matter on the governance for the research of CRISPR-Cas9 is the researchers' responsibility.

A study on EPB shield TBM face pressure prediction using machine learning algorithms (머신러닝 기법을 활용한 토압식 쉴드TBM 막장압 예측에 관한 연구)

  • Kwon, Kibeom;Choi, Hangseok;Oh, Ju-Young;Kim, Dongku
    • Journal of Korean Tunnelling and Underground Space Association
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    • v.24 no.2
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    • pp.217-230
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    • 2022
  • The adequate control of TBM face pressure is of vital importance to maintain face stability by preventing face collapse and surface settlement. An EPB shield TBM excavates the ground by applying face pressure with the excavated soil in the pressure chamber. One of the challenges during the EPB shield TBM operation is the control of face pressure due to difficulty in managing the excavated soil. In this study, the face pressure of an EPB shield TBM was predicted using the geological and operational data acquired from a domestic TBM tunnel site. Four machine learning algorithms: KNN (K-Nearest Neighbors), SVM (Support Vector Machine), RF (Random Forest), and XGB (eXtreme Gradient Boosting) were applied to predict the face pressure. The model comparison results showed that the RF model yielded the lowest RMSE (Root Mean Square Error) value of 7.35 kPa. Therefore, the RF model was selected as the optimal machine learning algorithm. In addition, the feature importance of the RF model was analyzed to evaluate appropriately the influence of each feature on the face pressure. The water pressure indicated the highest influence, and the importance of the geological conditions was higher in general than that of the operation features in the considered site.

Recent Advances in the Biotechnological Production of Natural Vanillin (생물공학에 기반한 천연 바닐린 생산에 관한 최근 연구)

  • Kim, Hyun-Song;Kim, Young-Ok;Lee, Jin-Ho
    • Journal of Life Science
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    • v.31 no.11
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    • pp.1046-1055
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    • 2021
  • Vanillin is the primary flavor and fragrance compound of natural vanilla and is extensively used in the food, beverage, perfumery, pharmaceutical industries, and other applications. Vanillin can be produced by chemical synthesis, extraction from vanilla plants, microbial bioconversion of natural precursors to vanillin, and direct fermentation using glucose. Currently, most commercially available vanillin is produced by extraction from cured vanilla pods and by chemical synthesis using guaiacol and glyoxylic acid as starting raw materials. Due to environmental issues, health complaints, preference for natural sources, and the limited supply and soaring price of natural vanilla, biotechnology-based vanillin production is regarded as a promising alternative. As many microorganisms that are able to metabolize several natural precursors, including ferulic acid, eugenol, isoeugenol, and lignin, and accumulate vanillin, have been screened and evaluated, myriad strategies and efforts have been employed for the development of commercially viable production technology. This review outlines the recent advances in the biotechnological production of natural vanillin with the use of these natural precursors. Moreover, it highlights the recent engineering approaches for the production of natural vanillin from renewable carbon sources based on the de novo biosynthetic pathway of vanillin from glucose, together with appropriate solution strategies to overcome the challenges posed to increase production titers.

A Study on Science and Technology Scholarly Societies' Understanding on Open Peer Review (과학기술 학회의 개방형동료심사에 관한 인식 연구 : 한국과학기술총연합회 산하 학회를 중심으로)

  • Jeong, Yong-il;Ro, Ji-Yoon;Cho, Sung-nam;Ahn, Sungsoo
    • The Journal of the Korea Contents Association
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    • v.22 no.10
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    • pp.59-73
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    • 2022
  • Open peer review intends to help review a manuscript in a transparent and accountable manner, opening up the identity of a reviewer and authors in a scholarly journal. Although some research about open peer review, for example, authors' understanding of open peer review, exists, research about editors' perspectives of a scholarly journal in Korean domestic science and technology fields has not been found. Editors' views may include whether an academic journal plans to adopt open peer review, when they might adopt it, or what the possible benefits, challenges, and issues in adopting open peer review would be. This paper presents a survey scheme, data, and analysis of Korean editors' perspectives on open peer review. Specifically, we designed the online survey questionnaire, collected the survey data from journal editors, and analyzed the survey results to explore editors' understanding of open peer review. We then compared our research with previous work, such as our Focused Group Interview and other similar domestic and foreign analysis. This study result is expected to help make an open peer review policy for public institutes to provide essential services for scholarly journals, including a scholarly peer review system. Academic society may also get some insights in adopting the open peer review method in the peer-review process.

Deriving AR Technologies and Contents to Establish a Safety Management System in Railway Infrastructure (철도 인프라 안전 관리 시스템 구축을 위한 AR 기술 및 콘텐츠 도출)

  • Jeon, Hae-In;Yu, Young-Su;Koo, Bon-Sang;Seo, Hyeong-Lyel;Kim, Ji-Hwan
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.42 no.3
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    • pp.427-438
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    • 2022
  • With the recent growing importance over safety management the need for advanced and technical approaches for on-site safety inspection methods has increased. Railway construction is subject to its own particular set of temporal and spatial challenges due to its unique facilities and equipment. This study aimed to investigate the field characteristics of railway infrastructure and improve the conventional field safety management methods by identifying the most appropriate features of AR technology. Group interviews and surveys were conducted with field safety experts to derive the major problems and inspection needs. Subsequently, various features of AR, such as BIM model projection, and remote conferencing, were investigated to determine their applicability to address safety issues. As a result, four problems in the current safety management process, such as 'lack of time due to the conventional inspection method and inspection of areas that are difficult to access', and three major inspection types, such as 'observance of work procedures, status of installation, adequate dimensional spacing', were identified to be improved when adopting AR based techniques. Furthermore, AR technology utilizing plans to solve safety inspection problems and effectively manage major inspection types were proposed, and a follow up survey was conducted with the same field safety experts to derive the priority of technology development.

Recent Advances on TENG-based Soft Robot Applications (정전 발전 기반 소프트 로봇 응용 최신 기술)

  • Zhengbing, Ding;Dukhyun, Choi
    • Composites Research
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    • v.35 no.6
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    • pp.378-393
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    • 2022
  • As an emerging power generation technology, triboelectric nanogenerators (TENGs) have received increasing attention due to their boundless promise in energy harvesting and self-powered sensing applications. The recent rise of soft robotics has sparked widespread enthusiasm for developing flexible and soft sensors and actuators. TENGs have been regarded as promising power sources for driving actuators and self-powered sensors, providing a unique approach for the development of soft robots with soft sensors and actuators. In this review, TENG-based soft robots with different morphologies and different functions are introduced. Among them, the design of biomimetic soft robots that imitate the structure, surface morphology, material properties, and sensing/generating mechanisms of nature has greatly benefited in improving the performance of TENGs. In addition, various bionic soft robots have been well improved compared to previous driving methods due to the simple structure, self-powering characteristics, and tunable output of TENGs. Furthermore, we provide a comprehensive review of various studies within specific areas of TENG-enabled soft robotics applications. We first explore various recently developed TENG-based soft robots and a comparative analysis of various device structures, surface morphologies, and nature-inspired materials, and the resulting improvements in TENG performance. Various ubiquitous sensing principles and generation mechanisms used in nature and their analogous artificial TENG designs are demonstrated. Finally, biomimetic applications of TENG enabled in tactile displays as well as in wearable devices, artificial electronic skin and other devices are discussed. System designs, challenges and prospects of TENGs-based sensing and actuation devices in the practical application of soft robotics are analyzed.

The Application of Genome Research to Development of Aquaculture (양식산업에 발전을 위한 유전체 분석 기술 적용)

  • Lee, Seung Jae;Kim, Jinmu;Choi, Eunkyung;Jo, Euna;Cho, Minjoo;Park, Hyun
    • Journal of Marine Life Science
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    • v.6 no.2
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    • pp.47-57
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    • 2021
  • In the fishery industry, global aquaculture production has stagnated due to overfishing of aquatic products, restrictions between countries, and climate change. The aquaculture suggests the possibility of a blue revolution that can be expanded in a new way. The aquaculture industry now accounts for more than half of the fishery products from the sea as a raw material for seafood for human consumption. Various latest biological research methods are being applied for the development of a sustainable aquaculture industry. Genomics has made significant progress in recent years. Since the genome sequence of Atlantic cod was sequenced in 2011, the genomes of more species have been sequenced. The genome information is providing a more robust and productive knowledge base for the aquaculture industry, including breeding and breeding of superior traits, improving disease resistance quality, and optimizing aquaculture feed and feed methods. This review looked at the status of genome analysis technology and the current status of genome research of aquaculture species. The development of genome research technology and massive genomic information is important in solving the challenges of the aquaculture industry and will help sustainable fisheries and aquaculture.

For Accuracy Improvement of High-tech Factory Construction Costs Predictions, Derivation of Correction Factors by Factory Capacity (하이테크 공장 건설 사업비 예측 정확도 향상을 위한 공장 생산량 기반 세부 공사별 보정계수 도출)

  • Choi, Seong Hoon;Kim, Jinchul;Oh, Jae Young;Kwon, Soonwook
    • The Journal of the Korea Contents Association
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    • v.21 no.11
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    • pp.203-212
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    • 2021
  • The high-tech industry, a highly knowledge-intensive industry based on advanced technologies such as electronics, new materials, and IT, is developing rapidly centering on the semiconductor, display, and battery fields. The market size of this industry is continuously increasing, and various challenges are coming forward due to various factors such as changes in the market, changes in demand, and the requirements of the clients. Many strategies are being implemented to advance the start-up time of factories, such as fast-track construction and basic line construction. Therefore, construction of high-tech factory is required to respond to various types of construction plans and early decision making, and an accurate and reliable method of calculating construction costs is needed. In this study the existing construction type was classified into the overall line configuration considering the total production of the factory, and a basic line configuration for quick production start-up. The correction ratio/value for each detailed construction required to calculate the construction cost of the basic line configuration type was derived. Finally, reliability and accuracy were verified by applying the correction ratio suggested in this study to a new high-tech factory construction project.

Expansion of the Scope of Electronic Commerce by Standardization: An Analysis a Secondhand Clothing Market (표준화를 통한 전자상거래의 영역 확장: 중고의류 시장 사례 분석)

  • Kim, Iljoo
    • The Journal of Society for e-Business Studies
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    • v.27 no.1
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    • pp.29-41
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    • 2022
  • Since the first sale of a banner advertisement in 1995, electronic commerce has become a new transaction channel for consumers. With more than 20 years of its history, electronic commerce has become an important consumption channel for everyone and inexperience is no more a reason that discourages the consumption through this channel. The great expansion of this channel is now a formidable thereat to traditional channels. However, products with high asset specificity and complexity are still having difficulty to be traded over the online channel where the experience of the products for a consumer is limited. Especially, variations of the same product's quality depending on how pre-owners used the product and high complexity to describe the quality of the products prevent used goods from being traded over e-channels. Added to that, the information asymmetry between sellers and buyers for used goods makes the establishment of market transaction difficult. Considering the challenges, the current case study discusses thredUP, a clothing resale platform company. In this paper, we study how the company could overcome those limitations in this toughest resale market through the use of AI for dynamic pricing and standarized product quality ratings. In addition, we also hope to provide readers with the opportunity to understand the secondhand industries and its market, and see where it is heading for in the future.

Arts Organization's Business Diversification Strategies: Case of Sanwoollim Theater Company (예술단체의 사업다각화 연구 - 산울림 소극장의 사례를 중심으로 -)

  • Song, JuYoung;Chang, WoongJo
    • Korean Association of Arts Management
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    • no.53
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    • pp.153-177
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    • 2020
  • Arts organizations commonly face a range of operational challenges, from a lack of skilled workers to limited financial resources and thus are dependent on subsidies from the government. Yet, to fully realize their mission arts organizations must both develop strategies to effectively utilize government support and seek a way forward that does not depend on public subsidies. Business diversification, a strategy from corporate management, entails the expansion of products and services, and entry into new industries, enabling companies to disperse risks and increase profits. We propose that business diversification can be effectively applied to arts organization to address the myriad operational difficulties they face. To understand how an arts organization might deploy business diversification we conducted a case study of an organization that is actively pursuing the strategy: Sanwoollim Theater. We interviewed staff members of Sanwoollim including the executive director, as well as selected audiences, to understand how the business diversification model was being applied at Sanwoollim. Our findings indicate that, in a complex arts and cultural space, business diversification is a fresh and flexible new strategy that can enable private cultural arts organizations to thrive sustainably. It is also evident that government support in the initial stages of the process encourages diversification and that successful private arts organizations will leverage government subsidies into a sustainable business plan.