• 대한기계학회논문집B
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• 제30권1호
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• pp.87-94
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• 2006

This paper presents the hydrodynamic design and performance analysis method for a miniaturized centrifugal blood pump using three-dimensional computational fluid dynamics (CFD) code. In order to obtain the hydraulically high efficient configuration of a miniaturized centrifugal blood pump for cardiopulmonary circulation, a well-established commercial CFD code was incorporated considering detailed flow dynamic phenomena in the blood pump system. A prototype of centrifugal blood pump developed by the present design and analysis method has been tested in the mock circulatory system. Predicted results by the CFD code agree very well with in vitro hydraulic performance data for a centrifugal blood pump over the entire operating conditions. Preliminary in vivo animal testing has also been conducted to demonstrate the hemodynamic feasibility for use of centrifugal blood pump as a mechanical circulatory support. A miniaturized centrifugal blood pump developed by the hydraulic design optimization and performance prediction method presented herein shows the possibility of a good candidate for intra and extracorporeal cardiopulmonary circulation pump in the near future.

• International Journal of Fluid Machinery and Systems
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• 제7권4호
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• pp.142-150
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• 2014

In the cardiopulmonary support system with an ECMO (extracorporeal membrane oxygenation), a higher pump head is demanded for a blood pump. In order to realize a blood pump with higher pump head, higher anti-hemolysis and thrombosis performances, a study on the development of unprecedented multistage blood pump was conducted. In consideration of the application of the blood pump for pediatric patients, a miniature two-stage centrifugal blood pump with the impeller's diameter of 40mm was designed and the performance was examined in experiments and computations. Some useful knowledge for a design of the blood pump with higher anti-hemolysis and thrombosis performances was obtained.

• International Journal of Fluid Machinery and Systems
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• 제3권2호
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• pp.102-112
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• 2010

Artificial heart pumps have attracted the attention of researchers around the world as an alternative to the organ used in cardiac transplantation. Conventional centrifugal pumps are no longer considered suitable for long-term application because of the possibility of occurrence of blood leakage and thrombus formation around the shaft seal. To overcome this problem posed by the shaft seal in conventional centrifugal pumps, the magnetically suspended centrifugal pump has been developed; this is a sealless rotor pump, which can provide contact-free rotation of the impeller without leading to material wear. In Europe, clinical trials of this pump have been successfully performed, and these pumps are commercially available. One of the aims of our study is to numerically examine the internal flow and the effect of leakage flow through the gap between the impeller and the pump casing on the performance of the pump. The results show that the pressure head increases compared with the pump without a gap for all flow rates because of the leakage of the fluid through the gap. It was observed that the leakage flow rate in the pump is sufficiently large; further, no stagnant fluid or dead flow regions were observed in the pump. Therefore, the present pump can efficiently enhance the washout effect.

• 한국산학기술학회:학술대회논문집
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• 한국산학기술학회 2003년도 춘계학술발표논문집
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• pp.256-259
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• 2003

Artificial heart is divided pulsation style and nonpulsation style greatly according to flowing of blood. nonpulsation pump is advantage of miniaturization avaliable because it is simple and non-volumic-pump than pulsation pump. Non pulsation pump is derided axial flow style and centrifugal style accordig to rotating style. An axial flow blood pump can be made smaller than a centrifugal blood pump because of its higher specific speed. A hemolysis is an important factor for the development of an axial flow blood pump. It is difficult to identify the areas where hemolysis nun. Evaluation of hemolysis both in in vitro and in vivo require a long time and are costly. Computational fluid dynamics(CFD) analysis enables the engineer to predict hemolysis on a computer. The aims of this study is Computational fluid dynamics in the whole axial flow pump and to verify the accuracy of prediction results of CFD analysis compare with in vitro experimental results.

• International Journal of Fluid Machinery and Systems
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• 제8권1호
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• pp.1-12
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• 2015

In cardiopulmonary support systems with a membrane oxygenation such as a percutaneous cardiopulmonary support (PCPS) or an extracorporeal membrane oxygenation (ECMO), blood pumps need to generate the pressure rise of approximately 200mmHg or higher, due to the high hydraulic resistances of the membrane oxygenation and of the cannula tubing. In order to realize the blood pump with higher pressure rise, higher anti-hemolysis and thrombosis performances, the development of novel centrifugal blood pump composed of two-stage has been conducted by the authors. In the present paper, effective attempts to decrease the wall shear stress and to suppress the stagnation are introduced for the prevention of hemolysis and thrombosis in blood pumps. The hemolysis test was also carried out and it was clarified that the decrease of wall shear stress is effective as a guideline of design of blood pumps for improving the anti-hemolysis performance.

• Journal of Mechanical Science and Technology
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• 제15권12호
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• pp.1869-1875
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• 2001

The paper presents computational and flow visualization results on a centrifugal blood pump. 4 impeller designs were tested at a rotational speed of 2000 rpm using blood analog as working fluid. All impellers have seven blades but of different geometry (Impellers A3, A4, B2 and R7). Flow visualization within the impeller passages was conducted using an image de-rotation system. A pair of large scale vortices was found within the blades of impeller R7 while a single vortex was found in most of the passages of backward facing impellers (Impellers A3, A4 and B2). To establish the effects of blade geometry on blood cells, CFD was used to simulate the blade to blade flow to provide an estimate of the maximum shear stress. The results showed that though most of the stresses within the blade passages are below a threshold level of 150 N/m$^2$for extensive erythrocyte damage to occur, there are some regions near to the leading edge of the pressure side where the shear stresses a abode threshold level.

• International Journal of Fluid Machinery and Systems
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• 제4권4호
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• pp.375-386
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• 2011

The turbo-type blood pump studied in this paper has an impeller that is magnetically suspended in a double volute casing. The impeller rotates with minimal fluctuations caused by fluid and magnetic forces. In order to improve stability of the rotating impeller and to facilitate long-term use, a careful investigation of the pressure fluctuations and of the fluid force acting on the impeller is necessary. For this purpose, two models of the pump with different volute cross-sectional area are designed and studied with computational fluid dynamics software. The results show that the fluid force varies with the flow rate and shape of the volute, that the fluctuations of fluid force decrease with increasing flow rate and that the vibratory movement of the impeller is more efficiently suppressed in a narrow volute.

• 한국유체기계학회 논문집
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• 제19권6호
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• pp.55-60
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• 2016

We present an experimental setup for measuring the mechanical performance of centrifugal blood pumps. Using a 3D printer to construct supporting parts and magnetic couplings, we developed the measurement setup that can be used for various types of blood pumps. The experimental setup is equipped with sensors to measure a variety of mechanical characteristics of blood pumps including pressure, flow rate, torque, temperature, and rotating speed. Our experimental measurements for two commercial blood pumps are consistent with data provided by manufacturers, which indicates that the our setup offers the accurate measurements of blood pump performance. Utilizing the experimental setup, we tested aqueous glycerin solutions mimicking the density and viscosity of blood, which enabled us to predict the difference in operations using water and blood.

• Journal of Advanced Marine Engineering and Technology
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• 제28권2호
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• pp.210-216
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• 2004

Flow visualization techniques were employed to qualitatively visualize the flow patterns through a 400％ scaled up centrifugal blood pump. The apparatus comprised of a scaled up centrifugal pump. high speed video camera. Argon Ion Laser Light Sheet and custom coded particle tracking software. Reynolds similarity laws are applied in order to reduce the rotational speed of the pump. The outlet (cutwater) region was identified as a site of high turbulence and thus a likely source of haemolysis. The region underneath the impeller was identified as a region of lower flow.

• 대한의용생체공학회:의공학회지
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• 제25권1호
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• pp.57-64
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• 2004

최근 심장질환에 의한 사망자 수는 놀랄 만큼 빠른 증가세를 보이고 있다. 인공심장은 혈액의 흐름에 따라 크게 박동류형과 무박동류형으로 나뉘며, 무박동류형 펌프는 비용적형으로 박동류형에 비해 소형화가 가능하다는 장점을 가지고 있다. 이러한 무박동류형 혈액펌프는 다시 구동방식에 따라 축류형과 원심형으로 구분되어지며, 그중 축류형 혈액펌프는 같은 무박동류형인 원심형 혈액펌프와 비교하였을 때 훨씬 간단한 구동장치와 제어장치를 가진다. 혈구가 파괴되어 헤모글로빈이 혈구 밖으로 빠져나가는 것을 용혈이라 하며 혈액이 응고하여 혈관을 막게되는 혈전현상은 이러한 용혈이 주된 원인이다. 따라서 혈액펌프가 구동함에 따라 발생하게 되는 용혈의 수치를 낮추는 것은 혈액펌프를 개발하는데 있어서 중요한 조건 중에 하나이다 이러한 용혈을 평가하기 위한 방법으로는 현재 in-vitro실험이 가장 널리 사용되어지고 있으나, 이러한 체외실험을 하기 위해선 상당한 비용과 장기간의 연구기간이 요구되어진다. 이러한 in-vitro실험의 단 전을 보완하기 위해 개발되어진 CFD해석법은, 엔지니어로 하여금 in-vitro실험을 실시하지 않고 용혈이 발생하는 지역과 용혈발생예측치를 추정할 수 있다. 본 연구의 목적은 in-vitro실험의 결과데이터와 CFD해석의 예측결과데이터의 여러 가지 비교를 통해 CFD해석의 정확성을 검증하고, 또한 이러한 정확성이 검증된 CFD해석법을 현재 개발되어지고 있는 축류형 혈액펌프의 개발단계에 적용하기 위함이다.