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http://dx.doi.org/10.5293/IJFMS.2015.8.1.001

Improvement of Two-Stage Centrifugal Blood Pump for Cardiopulmonary Support System and Evaluation of Anti-Hemolysis Performance  

Horiguchi, Hironori (Graduate School of Engineering Science, Osaka University)
Tsukiya, Tomonori (Department of Artificial Organs, National Cerebral and Cardiovascular Center)
Takemika, Toratarou (Graduate School of Engineering Science, Osaka University)
Nomoto, Takeshi (Graduate School of Engineering Science, Osaka University)
Tsujimoto, Yoshinobu (Graduate School of Engineering Science, Osaka University)
Publication Information
International Journal of Fluid Machinery and Systems / v.8, no.1, 2015 , pp. 1-12 More about this Journal
Abstract
In cardiopulmonary support systems with a membrane oxygenation such as a percutaneous cardiopulmonary support (PCPS) or an extracorporeal membrane oxygenation (ECMO), blood pumps need to generate the pressure rise of approximately 200mmHg or higher, due to the high hydraulic resistances of the membrane oxygenation and of the cannula tubing. In order to realize the blood pump with higher pressure rise, higher anti-hemolysis and thrombosis performances, the development of novel centrifugal blood pump composed of two-stage has been conducted by the authors. In the present paper, effective attempts to decrease the wall shear stress and to suppress the stagnation are introduced for the prevention of hemolysis and thrombosis in blood pumps. The hemolysis test was also carried out and it was clarified that the decrease of wall shear stress is effective as a guideline of design of blood pumps for improving the anti-hemolysis performance.
Keywords
Centrifugal Pump; Artificial Heart; Blood; Hemolysis; Thrombosis;
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Times Cited By KSCI : 1  (Citation Analysis)
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1 Horiguchi, H, Tsukiya, T., Nomoto, T., Takemika, T., and Tsujimoto, Y., 2014, "Study on the Development of Two-Stage Centrifugal Blood Pump for Cardiopulmonary Support System," International Journal of Fluid Machinery and Systems, Vol. 7, No. 4, pp.142-150. (DOI: 10.5293/IJFMS.2014.7.4.142)   DOI
2 ANSYS, Inc., 2006, "Modeling Flow Near the Wall", ANSYS CFX-Solver Modeling Guide, Release 11, pp.125-127.
3 ANSYS, Inc., 2006, "Modeling Flow Near the Wall", ANSYS CFX-Solver Theory Guide, Release 11, pp.110-111.
4 Takeda, H., 2005, "Basic Design on Pumps (in Japanese)," Dengyosha Technical Review, Vol. 29, No. 2, pp. 7-14. (http://www.dmw.co.jp/technical/pdf/no57.pdf)
5 Kameneva, M. V., Burgreen, G. W., Kono, K., Repko, B., Antaki, J. F., and Umezu, M., 2004, "Effects of Turbulent Stresses upon Mechanical Hemolysis: Experimental and Computational Analysis," ASAIO Journal, Vol. 50, No. 5, pp. 418-423.   DOI
6 Stepanoff, A. J., 1957, "Centrifugal and Axial Flow Pumps (Second Edition)," John Wiley & Sons Inc., pp. 172.
7 Heuser, G., Opitz, R., 1980, "A Couette Viscometer for Short Time Shearing of Blood," Biorheology, Vol. 17, pp. 17-24.   DOI
8 Giersiepen, M., Wurzinger, L. J., Opitz, R., and Reul, H., 1990, "Estimation of Shear Stress-Related Blood Damage in Heart Valve Prostheses - in Vitro Comparison of 25 Aortic Valves," The International Journal of Artificial Organs, Vol. 13, No. 5, pp. 300-306.