• 약학회지
• /
• 제43권5호
• /
• pp.674-681
• /
• 1999

This study was performed to investigate the effects of renal denervation and cromakalim, a K+ Channel opener, on central diuretic action of glibenclamide, an ATP-dependent K+ Channel blocker, in dog. Diuretic action of glibenclamide administered into the vein was weakened markedly by renal denervation and pretreatment of of cromakalim. Above results suggest that central diuretic action of glibenclamide is mediated by renal nerves and K+ Channel localized in kidney.

• Steel and Composite Structures
• /
• 제24권3호
• /
• pp.309-322
• /
• 2017

This paper conducted both numerical and theoretical studies to investigate the composite action of notched circular concrete-filled steel tubular (CFT) stub columns under axial compression and established a theoretical method to predict their ultimate bearing capacity. 3D finite element (FE) analysis was conducted to simulate the composite action and the results were in good agreement with experimental results on circular CFT stub columns with differently oriented notches in steel tubes. Parametric study was conducted to understand the effects of different parameters on the mechanical behavior of circular CFT stub columns and also the composite action between the steel tube and the core concrete. Based on the results, a theoretical formula was proposed to calculate the ultimate bearing capacity of notched CFT stub columns under compression with consideration of the composite action between the steel tube and the core concrete.

• 약학회지
• /
• 제43권5호
• /
• pp.665-673
• /
• 1999

This study was performed in order to investigate the effect of ketanserin, a specific antagonist of 5-HT2 receptor, on renal function in dogs. Ketanserin (50.0 and $150.0{\;}\mu\textrm{g}/kg$), when given intravenously, produced antidiuretic action accompanied with the decreased amounts of sodium and potassium excreted in urine (ENa, EK) and the increased reabsorption rates of sodium and potassium in renal tubules (RNa, RK). Ketanserin (50.0 and $50.0{\;}\mu\textrm{g}/kg$), when administered into a renal artery, elicited antidiuretic action in both experimental and control kidney, this time changes of renal function showed the same aspect as when given intravenously. Ketanserin (15.0 and $50.0{\;}\mu\textrm{g}/kg$) injected into the carotid artery exhibited also antidiuretic action and this antidiuretic action was not affected by renal denervation. Above results suggest that ketanserin elicits antidiuretic through central function, this central antidiuretic action is not mediated by renal nerves.

• 대한한방내과학회지
• /
• 제21권5호
• /
• pp.781-789
• /
• 2000

Objective : The purpose of these research was to investigate effects of water extract of Bistortae Rhizoma(BRE) on the hemostasia, anti-inflammatory action and central nervous system. Methods : we used mice and rats administered with the extract of the above herbs. Results : BRE decreased the permeability of evans blue into peritoneal cavity and cotton pellet granuloma formation. BRE did not decrease the acetic acid induced writhing syndrome and the histamine induced mouse paw edema. BRE inhibited the pentylenetetrazole and the strychnine induced convulsion. BRE shortened the bleeding time and plasma prtrombin time. BRE did not affect on the proliferation of Balb/c 3T3 cells. Conclusions : these results suggest that the effects of BRE are the hemostasia, anti-inflammatory action, and mild depressant activity of central nervous system.

• 생약학회지
• /
• 제19권3호
• /
• pp.208-215
• /
• 1988

To investigate the experimental effects of Chunwangboshimdan which have been widely used for aterial or auricular flutter, neurosis, insomnia and disease caused by cardiac malfunction, we have done the effects on the central nervous and cardiovascular system. The result as follow; It inhibited the convulsion induced by caffeine, the writhing syndrome induced by acetic acid and the spontaneous movement. Furthermore it prolonged the sleeping time induced by thiopental-Na in mice. It also showed the negative inotropic action on the isolated heart of frog, the vasodilative action as to peripheral bloods of rabbit ear and the hypotensive action in the anesthetized rabbit.

• The Korean Journal of Physiology
• /
• 제19권2호
• /
• pp.127-137
• /
• 1985

The present study was undertaken in order to investigate effect of ethanol extract of Rehmanniae radix(RREE) on electrophysiology of sinus node and papillary muscle. Rehmanniae radix is a herbal medicine which has been known to have diuretic, antipyretic, hemopoietic and cardiotonic effects. Action potentials were recorded by means of glass capillary microelectrode(technique) in rabbit sinoatrial nodal cells and papillary muscle cells which were superperfused with either tyrode solution or tyrode solutions containing different amount of RREE. The results obtained were as follows ; 1) In both central and peripheral nodal cells maximum diastolic potential (MDP) and amplitude of action potential (APA) were not affected by RREE. 2) Action potential duration as expressed $APD_{60}$(time to 60% repolarization) of central and peripheral pacemaker cells were significantly prolonged following perfusion with tyrode solution containing 0.1% RREE. 3) The rates of spontaneous firing from central pecemaker cell were decreased by RREE at concentration of 0.05% and 0. 1% while spontaneous rhythm of perinodal cell was decreased by 0.1% RREE. 4) The action potential duration of papillary muscle as expressed $APD_{60}$ were prolonged by 0.1% RREE.

• The Journal of Korean Physical Therapy
• /
• 제28권6호
• /
• pp.398-407
• /
• 2016

Purpose: The purpose of this study was to examine the changes in electroencephalogram (EEG) coherence and brain wave activity for first-person perspective action observation (1AO) and third-person perspective action observation (3AO) of healthy subjects. Methods: Thirty healthy subjects participated in this study. EEG was simultaneously recorded during the Relax period, the 1AO, and the 3AO, with event-related desynchronization (ERD) and coherence connectivity process calculations for brain wave (alpha, beta and mu) rhythms in relation to the baseline. Results: Participants showed increased coherence in beta wave activity in the frontal and central areas (p<0.05), during the 1AO using right-hand activity. Conversely, the coherence of the alpha wave decreased statistically significantly decreased in the frontocentral and parieto-occipital networks during the observation of the 1AO and the 3AO. The ERD values were larger than 40% for both central regions but were slightly higher for the C4 central region. The high relative power of the alpha wave during 1AO and 3AO was statistically significantly decreased in the frontal, central, parietal, and occipital regions. However, the relative power of the beta wave during 1AO and 3AO was statistically significantly increased in the parietal and occipital regions. Especially during 1AO, the relative power of the beta wave in the C3 area was statistically significantly increased (p<0.05). Conclusion: These findings suggest that 1AO and 3AO action observations are relevant to modifications of specific brain wave coherence and ERD values. EEG cortical activity during action observation may contribute to neural reorganization and to adaptive neuroplasticity in clinical intervention.

• Biomolecules & Therapeutics
• /
• 제10권1호
• /
• pp.50-58
• /
• 2002

lt had been reproted previously that (${\pm}$)6-chloro-7,8-dihydroxy-1-phenyl 2,3,4,5-tetra-hydro -lH-3benzazepine (SKF 81297), dopamine $D_1$ receptor agonist, produced diuresis by both Indirect action through central function and direct action being induced in kidney. This study was attempted in order to examine the diuresis mechanism of such SKF 81297 Diuretic action of SKF 81297 given into the vein or the carotid artery was not affected by renal denervation, whereas diuretic action of SKF 81297 administered into a renal artery was blocked completely by renal denervation, and then diuretic action of SKF 81297 injected into carotid artery was inhibited by SCH 23390, dopamine $D_1$ receptor antagonist, given into carotid artery. Above results suggest that indirect diuretic action of SKF 81297 elicites through central dopamine $D_1$ receptor and direct diuresis in kidney by influence of renal nerves.

• Biomolecules & Therapeutics
• /
• 제9권3호
• /
• pp.209-217
• /
• 2001

This study was attempted to investigate on renal effect of ($\pm$)6-chloro-7,8-dihydroxy-1-phenol 2,3,4,5-tetrahydro-lH-3 benzazepine (SKF 81297), dopamine $D_1$ receptor agonist, in dog. SKF 81297, when gluten intravenously, produced diuretic action along with the increases of renal plasma flow (RPF), glomerular filtration rate (GFR), amounts of N $a^{+}$ and $K^{+}$ excreted into urine ( $E_{Na}$ , $E_{K}$) and osmolar clearance ( $C_{osm}$). It also decreased the reabsorption rates of N $a^{+}$ and $K^{+}$ in renal tubule ( $R_{Na}$ , $R_{K}$) and free water clearance ( $C_{H2O}$), whereas ratios of $K^{+}$ agonist N $a^{+}$ in urine and filtration fraction (FF) was not changed. SKF 81297, when administered into a renal artery, elicited diuresis both in experimental kidney given the SKF 81297 and control kidney not given, while the effect was more remarkable in experimental kidney than those exhibited in control kidney. SKF 81297 given into carotid artery also exhibited diuresis, the potency at this time, compared to those induced by intravenous SKF 81297, was magnusgreat. Above results suggest that SKF 81297 produces diuresis by both indirect action through changes of central function and direct action being induced in kidney. Central diuretic action is mediated by improvement of renal hemodynamics, but direct action by inhibition of electrolytes reabsorption in renal tubule.enal tubule. tubule.

• Biomolecules & Therapeutics
• /
• 제2권3호
• /
• pp.229-235
• /
• 1994

In dogs, renal denervation did not affect the diuretic action accompanied with renal hemodynamic chanties and inhibition of electrolytes reabsorption rates in renal tubules by methoxyverapamil infused into the vein or into a renal artery, while renal denervation blocked the antidiuretic action due to the decreased free water and osmolar clearances along with the reduced sodium amounts excreted in urine by methoxyverpamil infused into the carotid artery. These experimental results suggest that methoxyverapamil may cause diuresis by direct action in kidney but the antidiuretic action through central function mediated by renal nerves.