Effects of Renal Denervation and SCH 23390, Dopamine Dl Receptor Antagonist, on Diuretic Action of SKF 81297, Dopamine Dl Receptor Agonist, in Dog

Dopamine Dl Recptor 효능제인 SKF 81297의 이뇨작용에 대한 신장 신경 제거 및 Dopamine Dl Receptor차단제인 SCH 23390의 영향

  • 고석태 (조선대학교 약학대학 약물학교실) ;
  • 정경희 (조선대학교 의과대학 약리학교실) ;
  • 임동윤 (조선대학교 의과대학 약리학교실)
  • Published : 2002.03.01


lt had been reproted previously that (${\pm}$)6-chloro-7,8-dihydroxy-1-phenyl 2,3,4,5-tetra-hydro -lH-3benzazepine (SKF 81297), dopamine $D_1$ receptor agonist, produced diuresis by both Indirect action through central function and direct action being induced in kidney. This study was attempted in order to examine the diuresis mechanism of such SKF 81297 Diuretic action of SKF 81297 given into the vein or the carotid artery was not affected by renal denervation, whereas diuretic action of SKF 81297 administered into a renal artery was blocked completely by renal denervation, and then diuretic action of SKF 81297 injected into carotid artery was inhibited by SCH 23390, dopamine $D_1$ receptor antagonist, given into carotid artery. Above results suggest that indirect diuretic action of SKF 81297 elicites through central dopamine $D_1$ receptor and direct diuresis in kidney by influence of renal nerves.



  1. Andersen, P. H., Gr nvald, F. C. and Jansen, J. A. (1985). A comparison between dopaminestimulatcd adenylcyclase and $H^3$-SCH 23390 binding in rat striatum. Life Sci, 37, 1971-1975 https://doi.org/10.1016/0024-3205(85)90028-1
  2. Andersen, P. H. and Jandsen, J. A. (1990). Dopamine receptor agonists: Selectivity and dopamine D, receptor efficacy. Eur. J. Pharmacol, 188, 335-341 https://doi.org/10.1016/0922-4106(90)90194-3
  3. Andersen, P. H., Nielsen, E. B., Gr$\phi$ envald, F. C. and Braestrup, C. (1986). Some atypical neuroleptics inhibit [$^3H$] SCH 23390 bing in vivo. Eur. J .Pharmacol., 120, 143-147 https://doi.org/10.1016/0014-2999(86)90656-4
  4. Arnt, J., Bogeso, K. P., Hyttel, J. and Meier, E. (1988a). Relative dopamine D, and $D_2$ receptor affinity and efficacy determine whether dopamine agonist induce hyperactivity or oral stereotypy in rats. Pharmacol. Toxicol., 62, 121-126
  5. Arnt, J., Hyttel, J. and Sanchez, C. (1992). Partial and full dopamine D, receptor agonists in mice and rats: relation bctween behavioural effects and stimulation of adenylate cydase activily in vitro. Eur. J. Pharmacol., 213, 259-26 https://doi.org/10.1016/0014-2999(92)90690-6
  6. Ashworth, R., Lote, C. J., Thewles, A. and Wood, J. A. (1989). Increased renal papillary solute concentration in response to atrial natriuretic factor (ANF) infusion in rats.J. Physiol., 417, 167-173
  7. Bello-Reuss, E., Pastoriza-Munoz, E. and Colinders, R. E. (1977). Acute unilateral renal denervation in rats with extracellular volume expansion. Am. J. Physiol., 232(1), F26-F32
  8. Borne, R. M. (1952). Hemodynamics and sodiurn excretion of denervated kidney in anethetized and unanethethized dog. Am. J. Physiol., 171, 14-158
  9. Elsa, B. R., Rumulo, E. C., Enrique, P. M., Robert, A. M. and Carl, W. G. (1975). Effects of acute unilateral renal denervation in the rat. J. Clin. Invest., 56, 208-212 https://doi.org/10.1172/JCI108069
  10. Goldberg, L. I, (1972). Cardiovascular and renal actions of dopamine: Potential clinical applications. Pannacot- Rev., 24, 1-29
  11. Green, R. (1990). Renal actions of atiral natriuretic factor. In: Atrial natriuretic factor edited by A. D. Struthers. Blackwell Scientic publications, Oxford 0X2 OEL, pp. 89-113
  12. Hardman, J. G., Limbird, L. E., Molinoff P. B., Ruddon, R. W. Gilman, A. G. (1996). Goodman & Gilman's The Phar-macological Basis of Therapeutics. 9th ed. McGraw Hill, International Edition, pp. 282-283
  13. Hytell, J. (1983). SCH 23390-The first selective dopamine $D_1$antagonisl. J. Parmacol, 91, 153-157 https://doi.org/10.1016/0014-2999(83)90381-3
  14. lorio, L. C., Barnett, A., Leitz, F. H., Houser, V. P., Korduba, C. A. (1983). SCH 23390, a potential benzazepine antipsy-chotic with unique interactions on doparninergic systems. J. Pharmacol. Exp. Ther., 226, 462-468
  15. Jtoh, Y., Beaulieu, M. and Kebabian, J. W. (1984). The chemical basis for the blockade of the D, dopamine receptor by SCH 23390. Eur. J. Pharmacol., 100, 119-124 https://doi.org/10.1016/0014-2999(84)90324-8
  16. Kebabian, J. W. and Calne, D. B. (1979). Multiple receptors for dopamine. Nature, 277, 93-96 https://doi.org/10.1038/277093a0
  17. 고석태. (1971). 닭의 신장 기능에 미치는 oxytocin의 영향. 약제학회지, 1, 34-36
  18. 고석태 · 정경희. (2001). Dopamine D, Receptor 효능제인 SKF 81297의 신장작용. 응용약물학회지 , 9, 209-217
  19. 고석태 ·강호연. (1984).개의 신내 혈류에 미치는 dopamine 의 영항. 약학회지, 28, 149-160
  20. 고석태 · 나한광 · 최인. (1996). 5-Hydoxytryptamine(5-HT)이 개의 신장 기능에 미치는 영향. 응용약물학회지, 1, 7-18
  21. 고석태 ·박화숙. (1990). Arachidonic acid가 개의 신장 기능 에 미치는 영향. 약학회지, 34, 252-261
  22. 고석태 ·유강준·황명성. (1998). Nitric oxide의 합성 억제제인 $N^G$-Nitro-L-Arginine 의 신장작용. 약학회지, 5, 519-526
  23. Nomura, G., Tababtake, T., Arai, S., Unv., D., Shimao, M. and Hattori, N. (1977). Effect of acute unilateral renal denervation on tubular reabsoiption in dog. Am. J. Physiol., 232, F16-F19
  24. Phillips, B. A. (1994). Quantitative Clinical Chemistry, Vol. 2, Methods, edited by peters and van Slyke, William & Wilkins
  25. Pitts, R. F. (1968). Physiology of the Kidney and Body Fluids, Chicago: Year Book Medical Pubulishers, Inc., p.150
  26. Romero, J. C,, Lahera, V, Salom, M. G. and Binondi, M. L. (1992). Role of the endo-thelium-dependent relaxing factor nitric oxide on renal function. J. Am, Soc, Nephron., 2, 1371-1387
  27. Seeman, P. (1981). Brain dopamine receptors. Pharmacol. Rev., 32, 229-313
  28. Sidhu, A., van Ocne, J. C., Dandrige, P,, Kaiser, C., Kebabian, J. W. (1986). [125-1] SCH 23390: The ligand of choice for idenlifying the $D_1$ dopamine receptor. Eur. Pharmacol., 128, 213-217 https://doi.org/10.1016/0014-2999(86)90768-5
  29. Slick, G. L., Agilera, A. J., Zambrack, E. J., DiBona, G. F. and Kaloyanides, G. F. (1975). Renal neuroadrenergic transmi-sion. Am. J. Physiol, 229, 60-68
  30. Smith, H. W., Finkelstein, N., Aliminosa, L., Crawford, B. and Graber, B. (1945). The renal clearances of substituted hippuric acid derivatives and other aromatic acids in dog and man. J. Clin. Invest., 21, 388-404
  31. Snedecor, G. W., and Cochran, W. G. (1980). Statistical Methods, 7th ed. lowa State Univ
  32. Stein, J. H., Congbalay, R. I., Karsh, D. U., Osgood, R. W. and Ferries, T. F. (1972). The effects of bradykinin on proxymal tubular sodium reabsorption in dog: Evidence for functional nephron heterogeneity. J. C1in. Invest., 51, 1709-1717 https://doi.org/10.1172/JCI106972
  33. Stein, J. H, Reineck, J. H., Osgood, R. W. and Ferries, T. F. Effect of acetylcholinc on proxymal tubular sodium reabsoiption in the dog. Am. J. Physiol., 220, 227-235
  34. Stoof, J. C. and Kebabian, J. W. (1984). Two dopamine receptors: Biochemistry, Physiology and pharmacology. Life Sci., 35, 2281-2296 https://doi.org/10.1016/0024-3205(84)90519-8
  35. Vidal, M. J., Romero, J. C. and Vanhoutte, P. M. (1998). Eneothelium-derived relaxing factor inhibits renin release. Eurr. J. Pharmacol., 149, 401-402