• 대한기계학회논문집
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• 제14권3호
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• pp.702-715
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• 1990

본 연구에서는 개수로 후래시 증발기 내부를 단순화된 형태로 가정하여 앞서 언급된 운전조건 및 유입되는 기포의 갯수유량(혹은 기공률)에 따라 증발기 내부의 속 도 및 온도분포를 수치적으로 계산해 보고자 한다. 이를 위해 유동을 정상상태의 난 류유동으로 가정하였으며, 구형의 기포에 대해 평균적인 운동 및 성장을 지배하는 방 정식을 세우고 상변화에 의한 증발량을 구하였다. 즉 입구에서 유입된 기포들이 성 장하면서 자유표면을 통해서 빠져나가는 운동 궤적을 추적함으로써 증발기 내부 유동 의 속도 및 온도분포를 구하고 이를 바탕으로 총 증발량 및 증발성능을 예측해 보고자 하는 것이다. 그리고 이렇게 계산된 결과들을 기존의 실험값과 비교하였다.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제13권5호
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• pp.2357-2380
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• 2019

In this paper, we investigate the impact of hardware impairments (HWIs) on the performance of a downlink massive MIMO system. We consider a single-cell system with maximum ratio transmission (MRT) as precoding scheme, and with all the HWIs characteristics such as phase noise, distortion noise, and amplified thermal noise. Based on the system model, we derive closed-form expressions for a typical user data rate under two scenarios: when a common local oscillator (CLO) is used at the base station and when separated oscillators (SLOs) are used. We also derive closed-form expressions for the downlink transmit power required for some desired per-user data rate under each scenario. Compared to the conventional system with ideal transceiver hardware, our results show that impairments of hardware make a finite upper limit on the user's downlink channel capacity; and as the number of base station antennas grows large, it is only the hardware impairments at the users that mainly limit the capacity. Our results also show that SLOs configuration provides higher data rate than CLO at the price of higher power consumption. An approach to minimize the effect of the hardware impairments on the system performance is also proposed in the paper. In our approach, we show that by reducing the cell size, the effect of accumulated phase noise during channel estimation time is minimized and hence the user capacity is increased, and the downlink transmit power is decreased.

• 한국수소및신에너지학회논문집
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• 제33권1호
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• pp.47-54
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• 2022

In this study, we performed numerical analysis for 1 kWe SOFC stack of internal manifold types according to the different manifold sizes to verify the influence of the flow uniformity into each cell. To simulate the flow phenomena in the stack, the continuity and momentum conservation equations including the standard k-𝜺 turbulent model for the steady-state conditions were applied. From the calculation results, we verified that the pressure drop from inlet pipes to outlet pipes decreased to a log scale as the manifold size increased in the internal manifold types. Also, we found that the flow uniformity increased on an exponential scale as the manifold size increased. In addition, the calculation results showed that the flow uniformity gradually improved as the fuel and oxygen utilization increased.

• BMB Reports
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• 제48권12호
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• pp.691-695
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• 2015

We report that phytosphingosine, a sphingolipid found in many organisms and implicated in cellular signaling, promotes megakaryocytic differentiation of myeloid leukemia cells. Specifically, phytosphingosine induced several hallmark changes associated with megakaryopoiesis from K562 and HEL cells including cell cycle arrest, cell size increase and polyploidization. We also confirmed that cell type specific markers of megakaryocytes, CD41a and CD42b are induced by phytosphingosine. Phospholipids with highly similar structures were unable to induce similar changes, indicating that the activity of phytosphingosine is highly specific. Although phytosphingosine is known to activate p38 mitogen-activated protein kinase (MAPK)-mediated apoptosis, the signaling mechanisms involved in megakaryopoiesis appear to be distinct. In sum, we present another model for dissecting molecular details of megakaryocytic differentiation which in large part remains obscure.

• Journal of Microbiology and Biotechnology
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• 제12권3호
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• pp.406-410
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• 2002

A new spin filter consisting of $50{\mu}m$ (nominal pore size) depth fitters rolled on a stainless steel grid was developed, using Saccharomyces cerevisiae as a model suspension cell to evaluate the spin filter performance. In a 1.8-1 fermentor with a rotation speed of 300 rpm and perfusion rate of 4 ml/min, a cell concentration of 49 g/l and ethanol concentration of 45 g/l from 100 g/l glucose could be obtained in a perfusion culture. The major mechanisms for cell separation used by the large-pore spin filter appeared to be centrifugal force and pivotal movement of the cells in the spin filter.

• Journal of Microbiology and Biotechnology
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• 제12권5호
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• pp.735-739
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• 2002

Large quantities of porcine hepatocyte aggregates with various degrees of aggregation (DA) could be obtained by controlling the suspension periods (0,9,24, and 48 h), and by entrapping the hepatocyte aggregates in model materials of encapsulation such as Ca-alginate and type-I collagen gels. The effects of DA on liver-specific functions of hepatocytes were evaluated in order to obtain optimum DA for the cell source of bioartificial liver (BAL) systems. Irregular rugged aggregates (size $75 \pm 28$ $\mu\textrm{m}$) farmed by 24 h of suspension culturing showed peak viability and hepatic functions such as ammonia removal and albumin secretion in the two types of entrapment systems, thus offering themselves as a stable cell source of a BAL system for hepatic functions and scale-up.

• 한국물환경학회지
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• 제23권6호
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• pp.807-813
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• 2007

Settling velocity is one of major parameters determining algal biomass in water quality modeling. In this study, the settling velocity of phytoplankton was measured in reservoir and stream sites of the Nakdong River, Korea. Settling velocities of various phytoplankton species were determined by measuring algal cell biomass settled in a sedimentation cylinder. Mean settling velocities were $0.22m\;day^{-1}$ in reservoir sites and $0.33m\;day^{-1}$ in stream sites, which were relatively higher compared with other default values suggested by water quality models (e.g. $0.1m\;day^{-1}$ in CE-QUAL-W2). The lower settling velocity in reservoirs than in stream implies the adaptation of phytoplakton to low turbulence in lentic environments. Cyanobacteria showed lower settling velocity ($0.2m\;day^{-1}$) than diatoms ($0.3m\;day^{-1}$), and this phenomenon may have resulted from buoyancy mechanisms of cyanobacteria. Cell volume did not show a significant correlation with settling velocity in this study, implying that conformation factors of colonies or other factors had large effects on settling velocity of algal cells as well as cell size. The result of this study may suggest proper coefficients of settling velocity of phytoplankton in the calibration of water quality model.

• 한국조사연구학회지:조사연구
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• 제5권1호
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• pp.1-26
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• 2004

The aim of this study lies in answering the question "How to form weighting cells to enhance sample representativeness in telephone, Internet and mobile surveys\ulcorner". For this, we explored 2% raw data of Year 2000 Population and Housing Census of Korea looking for meaningful patterns for ownership of telephones, the usage of Internet and/or mobile phones. We found that telephone coverage rates vary significantly by household size; 84.6% for one member households, contrasting 98.5% for two-or-more member households. Thus, telephone survey samples need to be weighted differently in sub-groups by household size for proportional representation of target population. Searching socio-demographic factors influencing the use of Internet by C5.0 tree models, we found that education levels and the occupation (or housing type, the automobile ownership) are two most important factors in addition to gender and age. Thus, surveyor might form weighting cells by such factors at the stage of post-stratification or set quotas, a priori, proportional to size of the cells by such factors. For mobile surveys, we approached similarly and found that education levels and the occupation (or the automobile ownership, marriage status) are two additional factors that may be used in forming weighing cells or in setting quotas for cells.

• 대한기계학회논문집
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• 제15권6호
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• pp.2073-2082
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• 1991

본 연구에서는 선회유동과 재순환영역이 있는 제한된 동축 분류유동(confined coaxial jet flow)을 갖는 연소기에 대하여 노즐을 통하여 분사된 연료액적의 증발 및 연소, 그리고 주위기체유동에 관한 제반현상을 정상상태 하에서 모사하고자 하는데 그 목적이 있으며 수치계산에 의한 이론적 해석방법으로 기상은 오일러 방식, 액상은 라 그란지 방식을 채택하였고 후술될 증발 및 연소모델을 적용하였다.

• Biomolecules & Therapeutics
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• 제24권3호
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• pp.260-267
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• 2016

Mesenchymal stem cells (MSCs) offer significant therapeutic promise for various regenerative therapies. However, MSC-based therapy for injury exhibits low efficacy due to the pathological environment in target tissues and the differences between in vitro and in vivo conditions. To address this issue, we developed adipose-derived MSC spheroids as a novel delivery method to preserve the stem cell microenvironment. MSC spheroids were generated by suspension culture for 3 days, and their sizes increased in a time-dependent manner. After re-attachment of MSC spheroids to the plastic dish, their adhesion capacity and morphology were not altered. MSC spheroids showed enhanced production of hypoxia-induced angiogenic cytokines such as vascular endothelial growth factor (VEGF), stromal cell derived factor (SDF), and hepatocyte growth factor (HGF). In addition, spheroid culture promoted the preservation of extracellular matrix (ECM) components, such as laminin and fibronectin, in a culture time- and spheroid size-dependent manner. Furthermore, phosphorylation of AKT, a cell survival signal, was significantly higher and the expression of pro-apoptotic molecules, poly (ADP ribose) polymerase-1 (PARP-1) and cleaved caspase-3, was markedly lower in the spheroids than in MSCs in monolayers. In the murine hindlimb ischemia model, transplanted MSC spheroids showed better proliferation than MSCs in monolayer. These findings suggest that MSC spheroids promote MSC bioactivities via secretion of angiogenic cytokines, preservation of ECM components, and regulation of apoptotic signals. Therefore, MSC spheroid-based cell therapy may serve as a simple and effective strategy for regenerative medicine.