• YAKHAK HOEJI
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• v.39 no.6
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• pp.689-694
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• 1995

Sphingolipids play important roles in cell regulation and signal transduction. Recently, a sphinogomyelin cycle has been described in which activation of neutral sphingomyelinase leads to the breakdown of sphingomyelin and the generation of ceramide. Ceramide, in turn, has emerged as a candidate intracellular mediator for the action of certain cell agonists and has multiple biologic actions. Ceramide is a potent suppressor of cell growth and an inducer of apoptosis. The present studies show that exposure of IM-9 cells to ceramide resulted in internucleosomal cleavage of DNA, yielding laddered patterns of oligonucleosomal fragments characteristic of apoptosis. DNA fragmentation induced by ceramide was also confirmed by diphenylamine assay. The effect of ceramide on cell cycle progression was also studied. The addition of ceramide increase G$_{1}$ phase distribution in cell cycle. Cell cycle-related cyclin D$_{1}$ gene expression was decreased in a time-dependent manner. These results suggest that apoptosis induced by ceramide is related to cell cycle associated with the alteration of cell cycle in IM-9 cells.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.60 no.11
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• pp.1993-1999
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• 2011

Today, the power utilities is setting on the slow load growth and the aging of power equipment, and then could spend the efforts on the stability of system performance. Asset management may be defined as the process of maximizing corporate profit by maximizing performance and minimizing cost over the entire life cycle of power equipment. Therefore, asset management is great way to fulfill the economic investment and the stability of system performance. This paper presents the application of effective asset managem ent from an economic perspective. A proposed method is considering the life cycle analysis using life cycle cost methodology for hydro-generator during the total life cycle. The life cycle cost methodology include a way to calculating maintenance and operating costs. The proposed method will be expected to play an important role in investment decision making considering economic evaluation.

• Nuclear Engineering and Technology
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• v.36 no.2
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• pp.175-183
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• 2004

For the analysis of a dry process fuel cycle, new modules were implemented into the fuel cycle analysis code DYMOND, which was developed by the Argonne National Laboratory. The modifications were made to the energy demand prediction model, a Canada deuterium uranium (CANDU) reactor, direct use of spent pressurized water reactor (PWR) fuel in CANDU reactors (DUPIC) fuel cycle model, the fuel cycle calculation module, and the input/output modules. The performance of the modified DYMOND code was assessed for the postulated once-through fuel cycle models including both the PWR and CANDU reactor. This paper presents modifications of the DYMOND code and the results of sample calculations for the PWR once-though and DUPIC fuel cycles.

• Transactions of the Korean hydrogen and new energy society
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• v.33 no.3
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• pp.261-265
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• 2022

In this paper, comparative studies between Linde, Claude and advanced cycle for the liquefaction of nitrogen have been completed. PRO/II with PROVISION release 2021. 1 from AVEVA company (Cambridge, UK) was used, and Peng-Robinson equation of the state model with Twu's alpha function was selected for the modeling of the condensation of nitrogen. When using Claude liquefaction, we can reduce the total compression power by 49.25% for the comparison of Linde cycle. And finally, we could conclude that 90.41% of total compression power was saved when using an advanced cycle being compared to Linde liquefaction cycle.

• Proceedings of the Korean Nuclear Society Conference
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• 2005.10a
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• pp.169-170
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• 2005

• Proceedings of the Korean Radioactive Waste Society Conference
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• 2017.10a
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• pp.25-26
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• 2017

• International Journal of Quality Innovation
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• v.9 no.3
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• pp.71-91
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• 2008

The definition of cycle time is the time from the wafer start to the wafer output. It usually takes one or two months to get the product since customer decides to produce it. The cycle time is a critical factor for customer satisfaction because it represents the response time to the market. Long cycle time reflects the ineffective investment for the capital. The cycle time is very important for foundry because long cycle time will cause customer unsatisfied and the order loss. Consequently, all of the foundries put lots of human source in the cycle time improvement. Usually, we make decisions based on the experience in the cycle time management. We have no mechanism or theory for cycle time management. We do work-in-process (WIP) management based on turn rate and standard WIP (STD WIP) set by experiences. But the experience didn't mean the optimal solution, when the situation changed, the cycle time or the standard WIP will also be changed. The experience will not always be applicable. If we only have the experience and no mechanism, management will not be work out. After interview several foundry fab managers, all of the fab can't reflect the situation. That is, all of them will have an impact period after product mix or utilization varied. In this study, we want to develop a formula for standard WIP and use statistical process control (SPC) concept to set WIP upper/lower limit level. When WIP exceed the limit level, it will trigger action plans to compensate WIP Profile. If WIP Profile balances, we don't need too much WIP. So WIP level could be reduced and cycle time also could be reduced.

• The Journal of Korean Academy of Prosthodontics
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• v.40 no.3
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• pp.236-245
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• 2002

The acrylic resin was first introduced as denture base materials in 1937 and it is commonly used for denture base fabrication nowadays. Three different curing cycles (Conventional curing cycle, short curing cycle and long curing cycle) and three commercially available heat-activated acrylic resins (Vertex RS, Lucitone 199 and ProBase Hot) were investigated to find the curing cycle and material that showed the minimum shrinkage of the resin during polymerization process. A brass master mold was fabricated and duplicated by additional silicone impression material. Stone molds were made by pouring of type III dental stone (SILKY-ROCK YELLOW, Whip-Mix, Louisville, Kentucky). It was embedded in the flask. Strain gauge and thermocouple were embedded in the specimen. Strain gauge and thermocouple were connected to signal conditioning amplifier and data was recorded by pre-programmed software. The parameters ESmax (Maximum expansion strain), Sb (Strain measured just before deflasking procedure), Sa (Strain measured just after deflasking procedure) and Sf (Strain measured at the end of the experiment) were measured. ${\Delta}$S was calculated from Sb and Sa (${\Delta}$S=Sb-Sa). In the experiment concerned about materials, the parameters 90-ESmax (Maximum expansion strain measured during early 90 minutes of curing procedure), 180-ESmax (Maximum expansion strain measured from 90 minutes to 180 minutes), Sb, Sa, ${\Delta}$S and Sf were measured and the following conclusions were made. 1. The ESmax value of conventional curing cycle showed the largest value and the 180-ESmax value of Lucitone 199 showed the smallest value. 90-ESmax values showed no significant difference (p<0.05). 2. ${\Delta}$S values of conventional curing cycle showed the positive values. ${\Delta}$S values of short curing cycle and long curing cycle showed the negative values. All three materials cured by conventional curing cycle showed the positive values. 3. The Sf values of long curing cycle and ProBase Hot (cured by conventional curing cycle) showed the smallest values.

• Journal of the Korean Society of Systems Engineering
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• v.11 no.2
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• pp.1-11
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• 2015

During the industrial plant system life cycle, required technologies are developed and assessed to analyze their performance, risks and costs. The assessment is called technology readiness assessment (TRA) and the measure of readiness is called technology readiness level (TRL). The TRL consists of 9 levels and through the TRL assessment, the technology to be developed and its components are assigned to their appropriate TRL. TRL assessment should be performed in each life cycle stages to monitor the technology readiness and analyze the potential risks and costs. However, even though the concept of TRL has been largely adopted by numerous organizations and industry, direct and clear assignment of target TRL for each life cycle stage has been overlooked. Direct mapping/assignment of target TRL for each life cycle has benefits as follow: (1) the technical risks condition of each life cycle stage can be better understood, (2) cost incurred if the technology development is failed can be analyzed in each life cycle stage, and (3) more effective decision making because the technology readiness achievement for each life cycle stages is agreed beforehand. In this paper, we propose a steel-making plant system life cycle and TRL assignment to each of the system life cycle stage. By directly assigning target TRL for each life cycle stages, we look forward to a more coordinated (in terms of exit criteria) and highly effective (in terms of technical risks identification and eventually prevent project failure) technology development and assessment processes.

• 전자공학회논문지 IE
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• v.46 no.3
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• pp.33-41
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• 2009

Because the stability of obstacle avoidance ability is important for the safe operation of mobile robots, this paper deals with the analysis of dynamic stability of Limit-cycle navigation method that was proposed by authors. Limit-cycle navigation method is fast and easy to implement for fast moving mobile robots using limit-cycle characteristics of the 2nd-order nonlinear function. It can be applied to robots in dynamically changing environment such as the robot soccer. By adjusting the radius of the motion circle and the direction of the obstacle avoidance, the mobile robot can avoid the collision with obstacles and move to the destination point. The stability of Limit-cycle navigation method is analyzed with a linear model. To demonstrate the effectiveness and applicability, it is applied to the robot soccer Simulations and real experiments ascertain the merits of the proposed method.