• Journal of Internet of Things and Convergence
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• v.6 no.4
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• pp.15-19
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• 2020

In this paper, we propose a optimal CW(Conention Window) synchronization scheme in IEEE 802.11 WLANs. IEEE 802.11 WLANs support DCF(Distributed Coordination Function) mode for the MAC(Medium Access Control) operation. In DCF, the CW increases exponentially according to the collisions and becomes minimum CW according to the success of data transmissions. However, since the base minimum CW value is hardware or standard specific, the number of active stations and network status are not considered to determine the CW value. Even though the researches on optimal CW have beend conducted, they do not consider the optimal CW synchronization among mobile stations which occur network performance degradation. Therefore, this paper calculates the optimal CW value and shares it with mobile stations in the network.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.04a
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• pp.212-212
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• 1994

본 연구소에서 분리하여 항암활성을 측정한바 있는 Sesquiterpene lactone계열의 KR-53170이 in vitro에 비해 in vivo에서 상대적으로 낮은 효력을 보이는데 착안 그 유도체들을 합성함으로써 in vivo stability 및 efficacy를 개선하고자 하였다. 합성된 물질의 in vivo activity는 human tumor cell중에서 A549(폐암), SK-OV-3(난소암1, SK-MEL-2(피부암), XF-498(중추신경계암), HCT-15(직장암)의 5개 암세포를 이용하여 ED$_{50}$($\mu\textrm{g}$/ml )를 측정하였으며 대조물질로는 KR-53170과 Cisplatin이 사용되었다. 그 결과 HR-53170의 terminal methyl ketone이 carboxylic acid로 변환된 CW-251001과 이것의 methyl ester인 CW-251002, ethyl ester인 CW-251003, 그리고 morpheline과 수용성으로 N-methylpiperazine, N-methyl-N'-aminopiperazine, 4-Piperidinopiperidine을 결합시켜서 합성한 CW-251011, CW-251012, CW-251013, CW-251014가 in vitro에서 어느 정도 활성을 유지하였다. 특히 이들중 CW-251001, CW-251012, CW-251013, CW-2s1014는 물에 대한 용해도가 상당히 개선되어 in vivo 활성검색을 위한 후보물질로 고려되었다. 하지만 이들중 CW-251001은 in vivo에서 낮은 농도에서는 활성이 거의 없었으며 놓은 농도에서는 독성을 나타내었다.

• Journal of Microbiology and Biotechnology
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• v.16 no.12
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• pp.1897-1903
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• 2006

In order to investigate the functions of the C-terminal region of chitinase ChiCW of Bacillus cereus 28-9, a C-terminal truncated enzyme, ChiCW$\Delta$FC, was expressed in Escherichia coli and purified to homogeneity for biochemical characterization. Compared with ChiCW, ChiCW$\Delta$FC exhibited higher chitinase activity at high temperature and pH, but expressed lower hydrolytic and binding activities toward insoluble substrates. In addition, kinetic properties indicated that ChiCW$\Delta$MC hydrolyzed oligomeric and polymeric substrates less efficiently than ChiCW. These results suggest that the C-terminal region of ChiCW plays important roles in substrate binding and hydrolysis of chitin. In addition, the biological meaning of C-terminal proteolytic modification of ChiCW is discussed.

• Journal of Microbiology and Biotechnology
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• v.19 no.10
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• pp.1169-1175
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• 2009

An antifungal chitinase, ChiCW, produced by Bacillus cereus 28-9 is effective against conidial germination of Botrytis elliptica, the causal agent of lily leaf blight. ChiCW as a modular enzyme consists of a signal peptide, a catalytic domain, a fibronectin type-III-like domain, and a chitin-binding domain. When two C-terminal domains of ChiCW were truncated, $ChiCW{\Delta}FC$ (lacking the chitin-binding domain and fibronectin type III-like domain) lost its antifungal activity. Since $ChiCW{\Delta}C$ (lacking the chitin-binding domain) could not be expressed in Escherichia coli as $ChiCW{\Delta}FC$ did, a different strategy based on protein engineering technology was designed to investigate the involvement of the chitin-binding domain of ChiCW ($ChBD_{ChiCW}$) in antifungal activity in this study. Because ChiA1 of Bacillus circulans WL-12 is a modular enzyme with a higher hydrolytic activity than ChiCW but not inhibitory to conidial germination of Bo. elliptica and the similar domain composition of ChiA1 and ChiCW, the C-terminal truncated derivatives of ChiA1 were generated and used to construct chimeric chitinases with $ChBD_{ChiCW}$. When the chitin-binding domain of ChiA1 was replaced with $ChBD_{ChiCW}$, the chimeric chitinase named ChiAAAW exhibited both high enzyme activity and antifungal activity. The results indicate that $ChBD_{ChiCW}$ may play an important role in the antifungal activity of ChiCW.

• YAKHAK HOEJI
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• v.48 no.6
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• pp.317-322
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• 2004

The use of nonsteroidal anti-inflammatory drugs (NSAIDs) is limited by their ability to induce gastrointestinal injury. It has been shown that nitric oxide (NO), similar to pro staglandins (PGs), appears to play an important role in gastric mucosal defence. We hypothesized that NSAIDs contained NO group would be less acutely toxic to the gastric mucosa, but would not interfere with their ability to suppress inflammatory process in rats. We have compared the ulcerogenic and anti-inflammatory effect of CW-501029 (NO-NSAIDs), CW-501027 (NSAIDs) and indomethacin. Both did not change mean blood pressure and heart rates, indicating that they had no side effect on cardiovascular system. We found that CW-501029 increased nitrite/nitrate levels without changing of blood pressure and heart rates. We suggest that it may help gastric mucosal blood flow, the which helps reducing the discomfort in astrointestinal system. Carrageenan-induced PGE2 increase was reduced in a similar tendency when compared CW-501027 or CW-501027 with control in back exudate of rats, but CW-501029 less reduced PGE2 than CW-502027 or indomethacin in gastric tissues. CW-501027 or CW-501029 reduced platelet aggregation. From these results we suggest that CW-501029 may improve the side effect by reduction of short-term gastric injury and less inhibition of PGs synthesis.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.33 no.5B
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• pp.318-325
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• 2008

HomePlug AV(HPAV) is the standard for distribution of Audio/video content as well as data within the home by using the power line. It uses a hybrid access mechanism that combines TDMA with CSMA/CA for MAC technology. The CSMA/CA protocol in HPAV has two main control blobs that can be used for access control: contention window(CW) size and deferral counter(DC). In this paper, we extensively investigate the impacts of CW and DC on performance through simulations, and propose an adaptive mechanism that adjusts the CW size to enhance the throughput in HPAV MAC. We find that the CW size is more influential on performance than the DC. Therefore, to make controlling the network easier, our proposal uses a default value of DC and adjusts the CW size. Our scheme simply increases or decreases the CW size if the network is too busy or too idle, respectively, We compare the performance of our proposal with those of the standard and other competitive schemes in terms of throughput and fairness. Our simulation and analysis results show that our adaptive CW mechanism performs very well under various scenarios.

• The Pure and Applied Mathematics
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• v.6 no.2
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• pp.103-111
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• 1999

We find some conditions under which G(f)-sequence of a CW-pair (X, A) is exact. And we also introduce a G(f)-sequence for a CW-triple (X, A, B) and examine when the sequence is exact.

• Proceedings of the Korean Information Science Society Conference
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• 2004.04a
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• pp.760-762
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• 2004

본 논문에서는 IEEE 802.11b WLAN 종단 간(end to end) 의 DATA 전송에 있어서 효율성 향상을 위한 방법을 충돌 횟수의 감소와 throughput 값의 증가를 나타낼 수 있는 방법을 통해서 제안한다. CW(contention window) 값이 충돌 발생할 시에 증가하는 것이 다음 프레임 전송 시 충돌 발생 확률을 줄이기 위한 것임에 착안하여 CW 값의 변화를 현재 방식에서 변화를 주어 전송 효율성 향상을 위한 알고리즘을 제안한다. 현재의 CW 값이 증가하는 방식은 유지하고 프레임 전송 성공 시 CW 값이 초기화되는 방식을 수정하고자 한다. 만일 CW 값이 크게 증가하였을 시에는 충돌이 많이 발생하고 있는 것으로 간주한다. 그래서 현재의 값 변화 방식인 CW 값이 최소값으로 초기화하는 것이 아니라 최소값 보다는 큰 CW 값을 유지하여 CW 값이 크게 변화되는 것을 막아 충돌 발생 확률을 줄일 수 있음을 확인한다. 본 논문에서는 3가지 방식의 알고리즘에 대하여 시뮬레이션 하였다. original 방식과 다른 알고리즘의 효율성을 시뮬레이션을 통해 비교하여 CW의 값이 전송 성능에 미치는 영향에 대한 결과를 보여준다.

• Microbiology and Biotechnology Letters
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• v.34 no.4
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• pp.352-356
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• 2006

CW-270031, an injectable carbapenem, is a novel synthesized pyrrolidinyl-thio carbapenems. It was evaluated for its in vitro antibacterial activities in comparison with those of imipenem and meropenem against standard strains and clinical isolated strains, CW-270031 was more active than imipenem against gram-negative (E. coli and Klebsiella oxytoca) clinical isolates, but it was slightly active than meropenem. Against Klebsiella aeruginosa CW-118 MIC were 0.048 $\mu$g/ml for CW-270031, 0.19 $\mu$g/ml for imipenem. Against clinical E. coli MIC range were 0.012$\sim$0.195 $\mu$g/ml for CW-270031, 0.097$\sim$0.39 $\mu$g/ml for imipenem. Against clinical Klebsiella oxytoca MIC$_{50}$ were 0.09 $\mu$g/ml for CW-270031, 0.39 $\mu$g/ml for imipenem. Against gram-positive standard strains and clinical CW-270031 was slightly more activity than meropenem, but CW-270033 was less active than imipenem against these tested isolates. The subcutaneous injection of CW-270031 in mice revealed that the half-life of CW-270031 in serum was about 13 min, long than that of meropenem (10.6 min). CW-270031. was stable to hydrolysis by dog renal dehydropeptidase I (DHP-l) enzyme, to an more stabilities shown by meropenem.

• Food Science of Animal Resources
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• v.41 no.5
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• pp.855-868
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• 2021

The present study was designed to investigate the effects of protein formula with different casein (C) to whey protein (W) ratios on dispersion stability, protein quality and body composition in rats. Modification of the casein to whey protein (CW) ratio affected the extent of protein aggregation, and heated CW-2:8 showed a significantly increased larger particle (>100 ㎛) size distribution. The largest protein aggregates were formed by whey protein self-aggregation. There were no significant differences in protein aggregation when the CW ratios changed from 10:0 to 5:5. Based on the protein quality assessment (CW-10:0, CW-8:2, CW-5:5, and CW-2:8) for four weeks, CW-10:0 showed a significantly higher feed intake (p<0.05), but the high proportion of whey protein in the diet (CW-5:5 and CW-2:8) increased the feed efficiency ratio, protein efficiency ratio, and net protein ratio compared to other groups. Similarly, CW-2:8 showed greater true digestibility compared to other groups. No significant differences in fat mass and lean mass analyzed by dual-energy x-ray absorptiometry were observed. A significant difference was found in the bone mineral density between the CW-10:0 and CW-2:8 groups (p<0.05), but no difference was observed among the other groups. Based on the results, CW-5:5 improved protein quality without causing protein instability problems in the dispersion.