• 한국방사선학회논문지
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• 제9권1호
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• pp.31-37
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• 2015

우리나라 국민의 연간 진단용 방사선 검사 건수는 매년 증가하고 있으며, 특히 의료 피폭의 절반이상을 차지하는 CT검사에 대한 각별한 주의가 요구된다. 본 연구에서는 현재 CT검사 중 가장 많은 부분을 차지하는 두부 CT에서 CT Number, Noise, Uniformity를 유지하면서 수정체 부분의 입사표면선량(ESD)을 줄이기 위해, 현재 사용하고 있는 Bismuth 차폐체와 Aluminum 6mm, Silicone 22mm를 비교 실험하였다. 실험 결과 IOML에 평행한 나선형 scan과 고식적 scan에서 차폐체를 사용하지 않을 때의 선량보다 각각 Bismuth 26.41%, 17.52%, Aluminum 18.24%, 9.39%, Silicone 19.47%, 14.39% 감소되었다. 물의 CT Number, Noise, Uniformity 항목에서 Bismuth 차폐체의 경우 팬텀영상 검사 기준을 초과하였으며, Aluminum, Silicone의 경우는 기준내에 포함되었다. 화질의 변화를 줄이면서 차폐의 효과를 보고자 할 때 가공성이 좋고 구입하기 쉬운 Silicone을 이용한 차폐체가 도움이 되리라 생각한다.

• 한국식생활문화학회지
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• 제32권5호
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• pp.453-464
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• 2017

Vegetable soup has been reported to have anti-inflammatory, anti-oxidative and anti-cancer effects. In this study, five kinds of vegetable soup were developed using a new manufacturing process and compositional changes in raw material, and anti-cancer and immuno-stimulatory activities were evaluated. Cytotoxicity tests based on MTT assay revealed that all vegetable soups had strong inhibitory effects against CT26 mouse colon cancer cells, with soups including Solomon's seal being most effective based on comparison of $IC_{50}$ values. Apoptosis in response to vegetable soup was occurred by 3-5 fold on cancer cells compared to normal cells. Mouse splenocytes increased by 266-541% in response to addition of vegetable soup in an in vitro proliferation experiment. In co-culture with splenocytes and CT26 cancer cells, splenocytes increased by more than 280% in every vegetable soup treatment, while cancer cells decreased by about 60% and cytokines such as $IFN- {\gamma}$ and IL-12 were secreted from splenocytes in high levels only in response to vegetable soup including Solomon's seal. In conclusion, all vegetable soups developed in this study had anti-cancer effects, and vegetable soup including Solomon's seal showed the strongest anti-cancer and immuno-stimulatory effects. These results suggest that functionality of vegetable soup could be increased by changes in manufacturing processes and raw materials composition.

• Journal of Ginseng Research
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• 제43권1호
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• pp.68-76
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• 2019

Background: In colorectal cancer (CRC), 40-60% of patients develop metastasis. The epithelial-mesenchymal transition (EMT) is a pivotal and intricate process that increases the metastatic potential of CRC. The aim of this study was to investigate the effect of Korean Red Ginseng extract (RGE) on colorectal metastasis through inhibition of EMT and the metastatic abilities of CRC cells. Methods: To investigate the effect of RGE on the metastatic phenotypes of CRC cells, CT26 and HT29 cells were evaluated by using an adhesion assay, a wound-healing assay, an invasion assay, zymography, and real-time reverse transcription-polymerase chain reaction. Western-blot analysis was conducted to elucidate the molecular mechanisms of RGE, which showed an inhibitory effect on the transforming growth factor-${\beta}1$ ($TGF-{\beta}1$)-induced EMT in HT29 cells. Additionally, the antimetastatic effect of RGE was evaluated in a mouse model of lung metastasis injected with CT26 cells. Results: RGE decreased the adhesion and migration ability of the CT26 cells and TGF-${\beta}1$-treated HT29 cells. The invasion ability was also reduced by RGE treatment through the inhibition of matrix metalloproteinase-9 expression and activity. Moreover, RGE suppressed the TGF-${\beta}1$-induced EMT via TGF-${\beta}1$/Smad-signaling-mediated Snail/E-cadherin expression in HT29 cells and lung tissue in CT26 tumor-bearing mice. Conclusion: Our results demonstrated that RGE inhibited colorectal lung metastasis through a reduction in metastatic phenotypes, such as migration, invasion, and the EMT of CRC cells.

• 한국의학물리학회지:의학물리
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• 제30권4호
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• pp.160-166
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• 2019

This study examined the clinical use of two newly installed computed tomography (CT) simulators in the Department of Radiation Oncology. The accreditation procedure was performed by the Korean Institute for Accreditation of Medical Imaging. An Xi R/F dosimeter was used to measure the CT dose index for each plug of the CT dose index phantom. Image qualities such as the Hounsfield unit (HU) value of water, noise level, homogeneity, existence of artifacts, spatial resolution, contrast, and slice thickness were evaluated by scanning a CT performance phantom. All test items were evaluated as to whether they were within the required tolerance level. CT calibration curves-the relationship between CT number and relative electron density-were obtained for dose calculations in the treatment planning system. The positional accuracy of the lasers was also evaluated. The volume CT dose indices for the head phantom were 22.26 mGy and 23.70 mGy, and those for body phantom were 12.30 mGy and 12.99 mGy for the first and second CT simulators, respectively. HU accuracy, noise, and homogeneity for the first CT simulator were -0.2 HU, 4.9 HU, and 0.69 HU, respectively, while those for second CT simulator were 1.9 HU, 4.9 HU, and 0.70 HU, respectively. Five air-filled holes with a diameter of 1.00 mm were used for assessment of spatial resolution and a low contrast object with a diameter of 6.4 mm was clearly discernible by both CT scanners. Both CT simulators exhibited comparable performance and are acceptable for clinical use.

• Fisheries and Aquatic Sciences
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• 제24권7호
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• pp.235-242
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• 2021

The present study investigated the critical thermal maxima (CT_max) of red-spotted grouper, Epinephelus akaara under different acclimation temperatures (T_acc). Fish were acclimated at 24℃, 28℃, and 32℃ water temperature for 2 weeks. Water temperature was increased at a rate of 1℃/h and CT_max level was measured following the critical thermal methodology (Paladino et al., 1980). The results showed that CT_max values of E. akaara were 35.61℃, 36.83℃, and 37.65℃ for fish acclimated at 24℃, 28℃, and 32℃, respectively. The acclimation response ratio (ARR) was 0.26. The CT_max values were significantly correlated with body size. Collectively, it is said that the CT_max value of red-spotted grouper can be affected by different adaptation temperature (24℃, 28℃, and 32℃) and the fish acclimated to a higher temperature has a higher CT_max level. Besides, the CT_max value of 35.61℃-37.65℃ indicating the upper thermal tolerance limit for E. akaara under different T_acc (24℃, 28℃, and 32℃). Understanding the thermal tolerance of E. akaara is of ecological importance in the conservation of this species.

• Journal of the Korean Data and Information Science Society
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• 제26권1호
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• pp.179-185
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• 2015

최근 고가의료장비의 도입으로 진단기술이 빠르게 발전하고 있으나 이에 따른 건강보험 재정의 부담이 크게 늘어 이에 대한 적절한 관리와 효율적 운영에 대한 정책이 필요하다. 이에 따라 본 연구에서는 의사결정나무분석 모형을 사용하여 CT 의료장비의 검사빈도에 영향을 미치는 요인을 파악하여 효율적 운영에 대한 방안을 제시한다.

• 대한영상의학회지
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• 제81권5호
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• pp.1227-1233
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• 2020

윤활막육종은 주로 사지, 특히 무릎 근처에 발생하는 악성 연부조직 종양으로, 가슴벽에 발생한 경우는 매우 드물다. 저자들은 26세 여성에서 앞가슴벽에 발생한 윤활막육종의 증례를 CT 및 MRI 소견을 중심으로 보고하고자 한다. CT에서 흉막하에 위치한, 경계가 좋으며 석회화를 동반한 작은 종괴로 관찰되어, 처음에는 양성 종양으로 생각하였다. 하지만 갑자기 심한 통증과 함께 종괴의 출혈과 혈흉이 동반되어 악성의 가능성을 고려하였다. MRI에서는 다엽성 종괴 내부에 액체액체층이 보였고, 이는 윤활막육종의 특징적인 영상 소견이다.

• Nuclear Medicine and Molecular Imaging
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• 제41권6호
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• pp.538-545
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• 2007

목적: 소세포폐암 환자에서 치료 전 $^{18}F$-FDG PET/CT에서 $^{18}F$-FDG의 섭취 정도(maxSUV)와 치료에 대한 반응, 그리고 재발과의 연관성에 대해 연구하고자 하였다. 대상 및 방법: 조직학적으로 소세포암으로 진단된 환자 26명을 대상으로 하였다. 모든 환자에서 병기설정 목적으로 $^{18}F$-FDG PET/CT를 시행하였으며, 항암 또는 방사선 치료에 대한 반응 평가를 위해 정기적으로 흉부 CT 검사를 시행하여 추적 관찰하였다. 모든 환자에서 $^{18}F$-FDG섭취 정도의 매개변수로 maxSUV 값을 사용하였다. 항암 또는 방사선 치료 중 또는 치료 후 흉부 CT를 기준으로 반응군과 비반응군으로 나누었다. 독립표본 T 검정을 이용하여 두 환자군간의 maxSUV 값을 비교하였다. 상관 분석을 이용해 FDG 섭취 정도와 재발, 그리고 $^{18}F$-FDG섭취 정도와 재발까지의 기간과의 관계를 평가하였다. ROC곡선을 이용하여 반응군과 비반응군 사이의 진단적 maxSUV 값을 추정하였다. 결과: 추적 관찰한 흉부 CT결과를 토대로 하여 총 26명의 환자 중 21명(81%)은 반응군으로 5명(19%)은 비반응군으로 분류하였다. 반응군과 비반응군의 폐병소에서 평균 maxSUV 값은 각각 $14.15{\pm}3.72$와 $9.17{\pm}2.15$였고, 반응군에서의 maxSU 값이 비반응군에서보다 통계학적으로 유의하게 낮았다(p<0.05). 반응군과 비반응군 사이의 진단적 maxSUV 값을 구하기 위한 ROC 곡선에서 maxSUV가 8.99일 때 100%의 민감도를 보였다. marSUV 값과 진단에서부터 재발까지의 기간은 음의 상관관계를 보였다(p<0.05, r=-0.757). 결론: 소세포폐암 환자에서 치료 전 $^{18}F$-FDG PET/CT 에서의 $^{18}F$-FDG의 섭취정도가 비반응군에서보다 반응군에서 통계적으로 유의하게 낮았다. 치료 전 $^{18}F$-FDG PET/CT에서 $^{18}F$-FDG의 섭취가 높은 환자에서 더 일찍 재발하였다.

• 대한방사성의약품학회지
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• 제5권2호
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• pp.101-112
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• 2019

Herein, 2-nitroimidazole-fluorophore conjugates were synthesized by linking 2-nitroimidazole and FITC or RITC via thiourea bonds. The prepared derivatives were stable for 2 h in Dulbecco's modified Eagle's medium (DMEM) at 37 ℃. The novel conjugates were studied for their in vitro uptake under hypoxic conditions using U87MG and CT-26 cell lines, showing significantly higher uptakes in hypoxic than normoxic cells. Immunohistochemical analysis confirmed hypoxia in U87MG and CT-26 xenografted tumor tissues. Moreover, the prepared conjugates were evaluated by in vivo experiments after intravenous injection in U87MG and CT-26 xenografted mice. Hypoxia was confirmed by immunohistochemistry of the prepared derivatives with co-injected pimonidazole. Confocal microscopy of the prepared derivatives showed strong fluorescence in hypoxic tumor tissues correlated with the pimonidazole distribution. This suggested that the 2-nitroimidazole-fluorophore conjugates are promising optical imaging probes for tumor hypoxia and are promising substitutes for pimonidazole immunohistochemistry, which requires a multi-step procedure of incubation involving antibody, second antibody, dye, hydrogen peroxide, and multiple washing steps.

• 대한약침학회지
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• 제10권1호통권22호
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• pp.5-16
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• 2007

Objectives : The aim of this study was to verify anti-cancer and anti-oxidant efficacies of Korean wild ginseng and cultivated wild ginseng of Korea and China. Methods : For the measurement of anti-oxidation, SOD-like activity was evaluated using xanthine oxidase reduction method under in vitro environment. Subcutaneous and abdominal cancer were induced using CT-26 human colon cancer cells for the measurement of growth inhibition of cancer cells and differences in survival rate. Results : 1. Measurement of anti-oxidant activity of ginseng, Chinese and Korean cultivated wild ginseng, and natural wild ginseng samples showed concentration dependent anti-oxidant activity in HX/XOD system. Anti-oxidant activity showed drastic increase at 1mg/ml in all samples. 2. For the evaluation of growth inhibition of cancer cells after hypodermic implantation of CT-26 cancer cells in the peritoneal cavity of mice, Chinese and Korean cultivated wild ginseng and natural wild ginseng groups showed significant inhibition of tumor growth from the 12th day compared to the control group. Similar inhibitory effects were also shown on the 15th and 18th days. But there was no significant difference between the experiment groups. 3. For the observation of increase in survival rate of the natural wild ginseng group, CT-26 cancer cells were implanted in the peritoneal cavity of mice.