• The Journal of Internal Korean Medicine
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• v.41 no.6
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• pp.959-966
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• 2020

Objectives: To examine the fundamental characteristics of interventional clinical trials registered in the CRIS (Clinical Research Information Service) database. Methods: We systematically analyzed the status of Korean medical interventions using the search function of the CRIS database. Results: From 2010 to January 2020, 267 Korean medicine-related clinical trials were registered with CRIS. The studies, which included many randomized trials (80.14%), focused primarily on demonstrating the effectiveness and safety of acupuncture and Korean herbal remedies. Most of these studies were government-sponsored and researcher-led clinical trials, but a few were company-sponsored trials. All trials were small and need improvement. Conclusion: This study reviews the current status of clinical trials in the field of Korean medicine and the basic data that can be used to create evidence-based Korean medicine.

• The Journal of Pediatrics of Korean Medicine
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• v.33 no.1
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• pp.17-33
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• 2019

Objectives The purpose of this study is to investigate the current status of registration of interventional studies focusing on children and adolescents in South Korea and the status of Korean medicine interventional studies through Clinical Research Information Service (CRIS). Methods CRIS was used to search interventional clinical researches which were registered from May, 2010 to October, 2018. Key words of 'child', 'children', 'adolescents', 'infant', 'toddler', 'elementary school student', 'middle and high school', 'middle school student', and 'high school student' were used. Results A total of 37 intervention clinical studies were selected. To identify the trends, years of registration in the CRIS, intervention types, disease categories, recruitment status, phase, institutions responsible for the research, consent, compensation and safety investigation were analyzed. Conclusions This study shows the current state of registration of interventional studies in children and adolescents in Korea. Since interventional studies in children and adolescents are essential for providing safe and effective treatment, further interventional studies, Korean medicine interventional studies and ethical considerations are needed.

• Journal of Society of Preventive Korean Medicine
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• v.24 no.2
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• pp.43-55
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• 2020

Objectives : The general and specific characteristics inherited in Korean traditional medicine research is to be identified and on the basis of this, the role of researchers, research institutes and government organizations is to be presented. Method : Analysis data targeted 399 cases of traditional medicine researches out of 696 cases, excluding overlapped 297 cases, that are relevanttokey-words, 'Oriental Medicine' and 'Herbal Prescription' registered in the National Institutes of Health Clinical Research Information Service(CRIS) as of 31 December, 2019. Including the regulation of the Ministry of Food and Drug Safety, research fund supporting, type of mediation, targeting disease and so forth, frequency analysis was carried out in order to confirm the general and specific characteristics of traditional medicine. Results : As a result of analyzing the data, researches of medicines(herbal medicines) and mediation(acupuncture, moxibustion) and were identified as the most and in the case of the targeting disease, it appeared in the order of targeting the research on musculoskeletal system and the healthy person.

• Safety and Health at Work
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• v.6 no.2
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• pp.156-156
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• 2015

• Journal of the Korean Mathematical Society
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• v.50 no.2
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• pp.445-464
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• 2013

We describe the one-dimensional and zero-dimensional cusps of the Satake compactification for the paramodular groups in degree two for arbitrary levels. We determine the crossings of the one-dimensional cusps. Applications to computing the dimensions of Siegel modular forms are given.

• Journal of the Korean Mathematical Society
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• v.57 no.2
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• pp.507-522
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• 2020

We complete the construction of the nonlift weight two cusp paramodular Hecke eigenforms for prime levels N < 600, which arise in conformance with the paramodular conjecture of Brumer and Kramer.

• Proceedings of the Technology Innovation Conference
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• 2003.06a
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• pp.90-107
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• 2003

참여정부의 출범과 한께 과학기술계에서는 동북아 과학기술 허브 구축방안 논의가 활발히 진행되고 있으나, 현재까지 이러한 논의는 법제도의 정비 및 과학기술특구 건설 등의 이슈에 한정되고 있는 실정이며, 더욱이 이를 뒷받침할 실증적 연구는 미미하다. 허브란 개념이 네트워크에서의 중심성(centrality)을 의미 하며, 현재 및 미래의 과학학기술협력 네트워크 발전에 정보통신기술이 중요한 역할을 수행함을 고려할 때, 우리나라의 초고속통신망 인프라를 십분 활용한 차세대 과학기술 정보인프라의 구축을 통한 동북아 사이버 연구네트워크상의 허브화(궁극적으로는 e-Science의 허브화를 지향)는 지역 클러스터 건설을 통한 물리적 허브화 못지 않게 중요하다 하겠다. 본 연구는 먼저 네트워크 분석기법을 동아시아의 과학기술협력 네트워크에 적용하여 주요 네트워크 지수를 실증적으로 진단하고, 특히 이를 유럽연합의 과학기술협력 네트워크의 패턴과 비교 분석하였다. 유럽 연합은 1984년부터 과학기술 협력 프로그램인 Framework Program을 시작하여 일찍부터 역내 과학기술협력 프로그램을 운영해 온 경험을 가지고 있고, 2000년부터는 자발적 협력과 네트워킹을 통해 유럽의 연구 개발 활동을 통합·조정하기 위해 새롭게 제안된 유럽 연구개발권 (European Research Area) 형성이 구체화되고 있어, 동북아 과학기술협력 네트워크를 건설하는데 좋은 벤치마킹 대상이라 할 수 있다. 이 보고서에서는 유럽 연구개발귄이라는 우산 아래서 유럽의 과학기술 활동이 조정 및 통합되는 과정을 살펴보고, 이를 위한 과학기술 정보인프라의 주요 기능을 컨텐트 (연구정보서비스와 메타데이터 표준), 시스템 (슈퍼 컴퓨팅, 광대역 네트워크, GRID), e-Science 응용연구 별로 살펴보았다. 끝으로 유럽의 경험을: 교훈삼아 동북아 e-Science 네트워크의 건설을 위한 정책적 시사점과 동북아 연구개발정보 Portal 및 APEC APGrid 연구망 등의 구체적인 정보인프라 구축방안을 도출하였다.

• Korean Journal of Agricultural and Forest Meteorology
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• v.22 no.4
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• pp.340-345
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• 2020

In this study, we developed the quality control and assurance method of measurement data of SPAR (Soil-Plant-Atmosphere-Research) system, a climate change research facility, for the first time. It was found that the precise processing of CO2 flux data among many observations were sig nificantly important to increase the accuracy of canopy photosynthesis measurements in the SPAR system. The collected raw CO2 flux data should first be removed error and missing data and then replaced with estimated data according to photosynthetic lig ht response curve model. Comparing the correlation between cumulative net assimilation and soybean biomass, the quality control and assurance of the raw CO2 flux data showed an improved effect on canopy photosynthesis evaluation by increasing the coefficient of determination (R2) and lowering the root mean square error (RMSE). These data processing methods are expected to be usefully applied to the development of crop growth model using SPAR system.

• The Journal of Pediatrics of Korean Medicine
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• v.36 no.3
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• pp.1-18
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• 2022

Objectives The purpose of this study was to investigate the current status of interventional clinical trial registration for children with precocious puberty and to secure basic data for the design of clinical trials for traditional Korean medicine treatment of precocious puberty. Methods The following resources were used to search for data: Clinicaltrial.gov, World Health Organization International Clinical Trials Registry Platform (WHO ICTRP), and Clinical Research Information Service (CRIS), using the search terms, 'Precocious puberty', 'child'. All clinical trials which were registered as of June 2022 were used. Results For the intervention and clinical trial design, gonadotropin releasing hormone (GnRH) analog was reported in 41.7% of trials, and single group assignment was performed in 66.7% of the studies. Prior consent had not been reported in 50% of the studies. Tanner stage and GnRH stimulation tests were reported by multiple trials as inclusion criteria, and prior treatment experiences for trial drugs were reported as exclusion criteria. The peak serum concentration of luteinizing hormone following GnRH stimulation test was used as a primary outcome in 45.8% of clinical trials, and other growth-related indicators such as growth rate, height, and predicted adult height were also reported. Conclusions In consideration of the design, eligibility criteria, and outcome measurement of the existing clinical trials identified in this study, it should be referred to in the design of clinical trials for traditional Korean medicine treatment of precocious puberty.

• Journal of the Korean Mathematical Society
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• v.53 no.3
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• pp.645-689
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• 2016

This article gives upper bounds on the number of Fourier-Jacobi coefficients that determine a paramodular cusp form in degree two. The level N of the paramodular group is completely general throughout. Additionally, spaces of Jacobi cusp forms are spanned by using the theory of theta blocks due to Gritsenko, Skoruppa and Zagier. We combine these two techniques to rigorously compute spaces of paramodular cusp forms and to verify the Paramodular Conjecture of Brumer and Kramer in many cases of low level. The proofs rely on a detailed description of the zero dimensional cusps for the subgroup of integral elements in each paramodular group.