• Korean Journal of Veterinary Research
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• v.35 no.3
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• pp.481-488
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• 1995

In oriental folk medicine, Artemisia messes-schmidiana var viridis(Compositae) has been used for jaundice, hepatitis, diuretic and liver cirrhosis etc. 1-naphthylisothiocyanate(ANIT) has been used for more than 20 years as a model compound to study mechanisms of intrahepatic cholestasis in laboratory animals as rat and mouse. Various biochemical and morphological changes including biliary epithelial and parenchymal cell necrosis occur in the liver of animals treated with ANIT. The purposes of present study are to examine pharmacological effects of Artemisia messes-schmidiana var viridis water extract(AMWE) on alterations of secretion volume and total bile acids level in bile juice, and that of serum AST, ALT, ALP, bilirubin, and glucose levels in rat. AMWE stimulated bile secretion and recovered ANIT-induced cholestasis. Bile acid concentrations increased to more than 60% compared with normal by ANIT, which were returned toward normal value with AMWE treatment. Serum AST and ALT activities were increased by ANIT and yet which were significantly decreased with AMWE treatment. In addition, this effect was apparent in AMWE pretreatment group. Serum glucose levels were increased with AMWE and ANIT, while were decreased compared with control in AMWE posttreatment group. Increased serum total bilirubin contents and ALP activities by ANIT were significantly decreased with AMWE posttreatment. In conclusion, AMWE exerted bile acid-independent choleresis effect and then improved to normal conditions ANIT-induced cholestatic syndromes. Also, AMWE have protective and regenerative effect of hepatocytes in rat.

• Weed & Turfgrass Science
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• v.3 no.3
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• pp.206-214
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• 2014

Numerous cases have been reported of naturalization by exotic ornamental plants. To obtain basic data about how those plants affect the ecosystems of Korea, we compiled a list of 78 species categorized as ornamentals from 309 naturalized species in Korea and analyzed their life forms, origin, and their current global status of naturalization and regulation. Plants belonging to Compositae comprised the largest group, with 23 species. In all, 75 species were considered herbaceous, and perennial species out-numbered annuals and biennials. Most species originated from Europe and North America. Except for Houttuynia cordata, the other 77 species were naturalized in other countries as well. Furthermore, 34 species, including Aster pilosus and Solidago altissima, have been subject to legal restrictions or classified as alert species in Korea or other countries. Therefore, monitoring may be required to prevent spread of those species, especially for species which have not been managed under domestic law up to now.

• Korean Journal of Pharmacognosy
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• v.36 no.3 s.142
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• pp.201-204
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• 2005

The rhizome extract of Atractylodes japonica Koidzumi(Compositae) exhibited a particular inhibition on the proliferation of cultured human tumor cell lines, in vitro. Thus, the intensive phytichemical investigation of the MeOH extract of Atractylodes japonica have been conducted by the way of activity-guided purification. The repeated column chromatographic separation of the n-hexane soluble part of extract resulted in the isolation of four sesquiterpenes (1-4) and a polyacetylene component (5). Chemical structures of them were identified as atractylon (1), atractylenolide Ⅰ(2), atractylenolide Ⅲ(3), eudesma-4(15),7(11)-dien-8-one (4) and 1,3-diacetyl-atractylodiol (5) by spectroscopic means. Among the isolates, compound 2-4 were shown to give moderate inhibitory effect in a dose dependent manner on the proliferation of cultured human tumor cell lines such as A549 (non small cell lung), SK-OV-3 (ovary), SK-MEL-2 (melanoma), XF498 (central nerve system) and HCT 15(colon), respectively.

• YAKHAK HOEJI
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• v.50 no.6
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• pp.429-435
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• 2006

The antidepressant effects of Cirsium japonicum compositae was investigated using open field test and forced swimming test. Total extract of Cirsium japonicum (CJ) was orally administered at dose of 20, 100, 300, 500 mg/kg bodyweight. Supplementation of CJ increased dose-dependently movement, rearing frequency and total turn angle in the center area of open field in mice. Treatment of Cirsium japonicum's extract (300 mg/kg, CJ) decreased immobile duration and increased mobile and strong mobile duration significantly; and it is comparable to that of imipramine and fluoxetine. These results indicate that CJ has antidepressant effect. Treatment of CJ did not induced any impairment in motor coordination and myorelaxation. These results indicate that the constituents or its complex of Cirsium japonicum could be a candidate of new antidepressant drug.

• Korean Journal of Plant Resources
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• v.14 no.3
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• pp.277-285
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• 2001

This study was conducted to know about the distribution of naturalized plants growing in Jeiu Island. A field survey and flora lists of relevant literatures were also investigated. The results obtained from this study were as follows: Definition of naturalized plants was determined in this study as “non-native species in Korea which have been introduced anthropologically or naturally and can reproduce and survive in wild habitats by themselves.” It was suggested that the number of naturalized plants in Jeju Island were 31 families, 111 genera, 188 taxa including 178 species, 10 varieties. Family Compositae and Gramineae covered 23% and 14% of naturalized plants, respectively. The number of naturalized plants in Jeju Island were 188 taxa ; 97 taxa in the whole south Korea,39 taxa in the southern part of Korea,15 taxa in the central part of Korea, and 37 taxa only in Jeju.

• Korean Journal of Plant Resources
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• v.22 no.2
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• pp.123-127
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• 2009

This study was carried out to investigate the classification and the growing characteristics of biennial weed species in a newly formed transplanting lawn grass land. Measuring size in the experimental plot was $1{\times}1m$ in the 9 different locations, and experimental design was randomized complete plot with 3 replications. The results obtained are summarized as follows. 1) Weed species in a newly formed lawn field are consisted of 29.4% of Cruciferae, 29.4% of Compositae, 23.5% of Caryophyllaceae, 11.8% of Gramineae, and 5.9% of Labiatae family 2) Emerging percentage of weed species are consisted of 47.1% on October, 41.2% on November, 5.9% on both September and December, respectively. 3) Distribution rate about flowering time of weed species was in order of 58.5% on May, 23.5% on April, 11.8% on March, and 5.9% on June. 4) Weed species were grouped according to the plant height. It was observed that below 20cm, 20-40cm, 40-60cm and above 60cm of plant height were 23.5%, 47.1%, 17.6% and 11.8%, respectively.

• Korean Journal of Pharmacognosy
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• v.52 no.4
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• pp.242-250
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• 2021

Artemisia frigida Willd (AW, Fringed sagewort), which is widespread in Mongolia, is a well-known medicinal plant as a member of the Compositae family. This study aims to explore the gastroprotective effect of water extract of AW on 150 mM HCl/60% ethanol-induced acute gastritis in 5 week old male ICR mice. Total polyphenols, total flavonoid contents, and anti-oxidant activity in vitro in AW were evaluated. First, the gross area of gastric mucosal damage was measured. Then western blot analysis was conducted to determine the possible mechanisms of action underlying the effects of AW. AW administration decreased gastric mucosal damage. Moreover, the group with AW treatment effectively inhibited nicotinamide adenine dinucleotide phosphate (NADPH) oxidase expression associated with oxidative stress. AW treatment enhanced an anti-oxidant effect through the increase of anti-oxidant proteins. Besides, the increased expressions of inflammatory cytokines induced by nuclear factor-kappa B (NF-κB) activation are alleviated through AW treatment. Taken together, AW exerted a gastroprotective effect against gastric mucosal damage. These results indicate that AW could have the potential used as a natural therapeutic drug for the treatment of acute gastritis.

• Korean Journal of Agricultural Science
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• v.46 no.1
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• pp.163-172
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• 2019

Ixeris dentata is a perennial plant belongs to Compositae family and it has been considered as a potential therapeutic agent in many biological activities like detoxification, elimination of blood stasis, anti-inflammatory, and analgesia. The I. dentata used in this experiment was collected in four areas of Yangpyeong, Dangjin, Chuncheon and Goesan, then transplanted to the farm of Department of Herbal Crop Research in National Institute of Horticultural and Herbal Science. The growth characteristics of I. dentata were investigated after harvesting. The aboveground biomass of plants collected from Chuncheon area was exhibited best, and the biomass of root in YangPyeong was showed best as 3.65 g/plant in dry weight. Based on the HPLC analysis, the leaf of I. dentata collected from Dangjin area was highest in carotenoids contents ($1,213{\mu}g/g$ dry weight), and the leaf of Chuncheon area was exhibited maximal phenolic compounds ($1,918{\mu}g/g$ dry weight). The results of this study could provide fundamental formation for selection of standard varieties of I. dentata and development of functional material by analysis of the growth characteristics and the contents of carotenoids and phenolic compounds.

• Journal of Climate Change Research
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• v.6 no.3
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• pp.243-248
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• 2015

This study was conducted to predict the changes of potential distribution for invasive alien plant, Conyza bonariensis in Korea. C. bonariensis was found in southern Korea (Jeju, south coast, southwest coast). The habitats of C. bonariensis were roadside, bare ground, farm area, and pasture, where the interference by human was severe. Due to the seed characteristics of Compositae, C. bonariensis take long scattering distance and it will easily spread by movement of wind, vehicles and people. C. canadensis in same Conyza genus has already spread on a national scale and it is difficult to manage. We used maximum entropy modeling (MaxEnt) for analyzing the environmental influences on C. bonariensis distribution and projecting on two different RCP scenarios, RCP 4.5 and RCP 8.5. The results of our study indicated annual mean temperature, elevation and temperature seasonality had higher contribution for C. bonariensis potential distribution. Area under curve (AUC) values of the model was 0.9. Under future climate scenario, the constructed model predicted that potential distribution of C. bonariensis will be increased by 338% on RCP 4.5 and 769% on RCP 8.5 in 2100s.

• Biomedical Science Letters
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• v.24 no.4
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• pp.357-364
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• 2018

Manganese (Mn) is used as main materials in various chemical processes of industry, but it suggested that Mn brings about its toxicant by fume or dust through respiratory system and skin barrier. Mn toxicant induces the loss of mental health and life quality by cerebrovascular and skin diseases. Nevertheless, it lefts much unknown on the mechanism and the effectively therapeutic methods about Mn toxicant. Therefore, this study was evaluated the cytotoxicity induced by manganese dioxide ($MnO_2$) in cultured NIH3T3 fibroblasts, and also, the correlation between $MnO_2$-induced cytotoxicity and oxidative stress was examined. While, the effect of Eclipta prostrata L. (EP) extract belong to Compositae was assessed against $MnO_2$-induced cytotoxicity in the view of antioxidative effect for searching the natural resources mitigating or preventing the $MnO_2$-induced cytotoxicity. In this study, $MnO_2$-induced cytotoxicity was revealed as mid-toxic by Borenfreud and Puerner's toxic criteria, and catalase (CAT), an antioxidant prevented $MnO_2$-induced cytotoxicity by the remarkable increase of cell viability in these cultures. While, in the protective effect of EP extract on $MnO_2$-induced cytotoxicity, EP extract effectively prevented the cytotoxicity induced by $MnO_2$ via antioxidative effects such as xanthine oxidase (XO) inhibitory ability and DPPH-radical scavenging ability. From the above results, EP extract showed the effective prevention against $MnO_2$-induced cytotoxicity correlated with oxidative stress by antioxidative effects. Conclusively, this study may be useful to research or development the alternatively therapeutic agent from natural resources like EP extract for the treatment of diseases resulted in oxidative stress.