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The Antidepressant Effects of Cirsium japonicum in ICR Mice  

Park, Hyung-Keun (Uimyung Research Institute for Neuroscience, Sahmyook University)
Yoon, Seo-Young (Uimyung Research Institute for Neuroscience, Sahmyook University)
Choi, Jong-Hyun (Uimyung Research Institute for Neuroscience, Sahmyook University)
Ko, Hong-Sook (Uimyung Research Institute for Neuroscience, Sahmyook University)
Suh, Yeon-Won (Department of Makeup & Coordination, Daewon Science College)
Lee, Yong-Soo (College of Pharmacy and Duksung Women's University)
Kim, Gun-Hee (Plant Resources Research Institute, Duksung Women's University)
Chung, Mi-Sook (Plant Resources Research Institute, Duksung Women's University)
Cheong, Jae-Hoon (Uimyung Research Institute for Neuroscience, Sahmyook University)
Publication Information
YAKHAK HOEJI / v.50, no.6, 2006 , pp. 429-435 More about this Journal
Abstract
The antidepressant effects of Cirsium japonicum compositae was investigated using open field test and forced swimming test. Total extract of Cirsium japonicum (CJ) was orally administered at dose of 20, 100, 300, 500 mg/kg bodyweight. Supplementation of CJ increased dose-dependently movement, rearing frequency and total turn angle in the center area of open field in mice. Treatment of Cirsium japonicum's extract (300 mg/kg, CJ) decreased immobile duration and increased mobile and strong mobile duration significantly; and it is comparable to that of imipramine and fluoxetine. These results indicate that CJ has antidepressant effect. Treatment of CJ did not induced any impairment in motor coordination and myorelaxation. These results indicate that the constituents or its complex of Cirsium japonicum could be a candidate of new antidepressant drug.
Keywords
Cirsium japonicum; antidepressants; forced swimming test;
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