• The Korean Journal of Physiology and Pharmacology
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• v.9 no.2
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• pp.131-135
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• 2005

Potassium channels in human skin fibroblast have been studied as a possible site of Alzheimer disease pathogenesis. Fibroblasts in Alzheimer disease show alterations in signal transduction pathway such as changes in $Ca^{2+}$ homeostasis and/or $Ca^{2+}-activated$ kinases, phosphatidylinositol cascade, protein kinase C activity, cAMP levels and absence of specific $K^+$ channel. However, little is known so far about electrophysiological and pharmacological characteristics of large-conductance $Ca^{2+}$-activated $K^+$ ($BK_{Ca}$) channel in human fibroblast (CRL-1474). In the present study, we found Iberiotoxin- and TEA-sensitive outward rectifying oscillatory current with whole-cell recordings. Single channel analysis showed large conductance $K^{+}$ channels (106 pS of chord conductance at +40 mV in physiological $K^+$ gradient). The 106 pS channels were activated by membrane potential and $[Ca^{2+}]_i$, consistent with the known properties of $BK_{Ca}$ channels. $BK_{Ca}$ channels in CRL-1474 were positively regulated by adenylate cyclase activator ($10{\mu}M$ forskolin), 8-Br-cyclic AMP ($300{\mu}M$) or 8-Br-cyclic GMP ($300{\mu}M$). These results suggest that human skin fibroblasts (CR-1474) have typical $BK_{Ca}$ channel and this channel could be modulated by c-AMP and c-GMP. The electrophysiological characteristics of fibroblasts might be used as the diagnostic clues for Alzheimer disease.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.28 no.11
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• pp.920-923
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• 2017

In this paper, we design the internal parameters of the SIMO channel sounder suitable for the measurement of the high-speed travel environment channel, and measure the characteristics of the wide-band channel by applying the proposed measurement method to the Yeoju Smart Highway piloted at 5.89 GHz C-ITS. Based on the design of the receiving array structure suitable for the real environment, the linear slope compensation method for the Doppler phase shift is applied to provide a reliable result on the Doppler effect due to the incoming angle information and the surrounding environment in the multipath environment.

• Journal of information and communication convergence engineering
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• v.7 no.3
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• pp.383-391
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• 2009

In this paper, blind equalization using a modified Fuzzy C-Means algorithm with Gaussian Weights (MFCM_GW) is attempted to the heavy noise-corrupted channels. The proposed algorithm can deal with both of linear and nonlinear channels, because it searches for the optimal channel output states of a channel instead of estimating the channel parameters in a direct manner. In contrast to the common Euclidean distance in Fuzzy C-Means (FCM), the use of the Bayesian likelihood fitness function and the Gaussian weighted partition matrix is exploited in its search procedure. The selected channel states by MFCM_GW are always close to the optimal set of a channel even the additive white Gaussian noise (AWGN) is heavily corrupted in it. Simulation studies demonstrate that the performance of the proposed method is relatively superior to existing genetic algorithm (GA) and conventional FCM based methods in terms of accuracy and speed.

• JSTS:Journal of Semiconductor Technology and Science
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• v.15 no.6
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• pp.653-657
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• 2015

A new paired gate-source voltage RF capacitance-voltage (C-V) method of extracting the effective channel length and parasitic capacitance using the intersection between two closely spaced linear regression lines of the gate capacitance versus gate length measured from S-parameters is proposed to remove errors from conventional C-V methods. Physically verified results are obtained at the gate-source voltage range where the slope of the gate capacitance versus gate-source voltage is maximized in the inversion region. The accuracy of this method is demonstrated by finding extracted value corresponding to the metallurgical channel length.

• Steel and Composite Structures
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• v.33 no.6
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• pp.877-889
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• 2019

The developments of double skin composite (DSC) walls with novel enhanced C-channel connectors (DSCW-EC) were reported. Followed axial compression tests on prototype walls were carried to evaluate structural performances of this novel DSC composite structures. The testing program consists of five specimens and focused on the layout of the novel enhanced C-channel (EC) connectors, which include the web direction of C-channels, steel-faceplate thickness, vertical and horizontal spacing of C-channels. Crushing in concrete core and buckling of steel faceplate were two main observed failed modes from the compression tests. However, elastic or plastic buckling of the steel faceplate varies with designed parameters in different specimens. The influences of those investigated parameters on axial compressive behaviors of DSCW-ECs were analyzed and discussed. Recommendations on the layout of novel EC connectors were then given based on these test results and discussions. This paper also developed analytical models for predictions on ultimate compressive resistance of DSCW-ECs. Validation against the reported test results show that the developed theoretical models predict well the ultimate compressive resistance of DSCW-ECs.

• Proceedings of the KSRS Conference
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• 2003.11a
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• pp.1255-1257
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• 2003

This study proposes a single-channel satellite remote sensing algorithm for retrieving aerosol optical thickness over global ocean using FY-1C/1D data. An efficient lookup table (LUT)method is adopted in this algorithm to generate apparent reflectance in channel 1 and channel 2 of FY-1C/1D over ocean. The algorithm scale the apparent reflectance in cloud-free conditions to aerosol optical thickness using a state-of-art radiative transfer model 6S with input of the relative spectral response of channel 1 and 2 of FY-1C/1D. Monthly mean composite maps of the aerosol optical thickness have been obtained from FY-1C/1D global area coverage data between 2001 and 2003. Aerosol optical thickness maps can show the major aerosol source which are located off the west coast of northern and southern Africa, Arabian Sea and India Ocean. These result is very similar to other satellite sensors such as AVHRR and MODIS in the location area of heavy aerosol optical thickness over global ocean. The algorithm have been used to FY-1D operational performance and it is the first operational aerosol remote sensing product in China.

• The Transactions of the Korean Institute of Electrical Engineers C
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• v.51 no.11
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• pp.517-525
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• 2002

The channel region of seep-sub-micrometer MOSFET is non-uniformly doped with pocket implant. Therefore, the advanced threshold voltage model is needed to account for the Short-Channel Effect and Reverse-Short-Channel Effect due to the non-uniform doping concentration in the channel region. In this paper, A scalable analytical model for the MOSFET threshold voltage is developed. The developed model is verified with MEDICI and TSUPREM simulator.

• The Bulletin of The Korean Astronomical Society
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• v.37 no.2
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• pp.107.1-107.1
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• 2012

We present the results of far-ultraviolet (FUV) observations of comet C/2001 Q4 (NEAT) obtained with Far-ultraviolet Imaging Spectrograph (FIMS) on board the Korean microsatellite STSAT-1, which operated at an altitude of 700 km in a sun-synchronous orbit. FIMS is a dual-channel imaging spectrograph (S channel 900-1150 ${\AA}$, L channel 1350-1750 ${\AA}$, ${\lambda}/{\Delta}{\lambda}$ ~ 550) with large image fields of view (S: $4^{\circ}.0{\times}4^{\prime}.6$, L: $7^{\circ}.5{\times}4^{\prime}.3$, angular resolution 5'-10') optimized for the observation of diffuse emission of astrophysical radiation. Comet C/2001 Q4 (NEAT) was observed with a scanning survey mode when it was located around the perihelion between 8 and 15 May 2004. Several important emission lines were detected including S I (1425, 1474 ${\AA}$), C I (1561, 1657 ${\AA}$) and several emission lines of CO $A^1{\Pi}-X^1{\Sigma}^+$ system in the L channel. Production rates of the notable molecules, such as C I, S I and CO, were estimated from the photon fluxes of these spectral lines and compared with previous observations. We compare the flux and the production rates in the radius of $3{\times}10^5$ km with $20{\times}10^5$ km from the central coma. We obtained L-channel image which have map size $5^{\circ}{\times}5^{\circ}$ The image was constructed for the wavelength band of L-channel (1350 - 1710 ${\AA}$. We also present the radial profiles of S I, C I, CO obtained from the spectral images of the central coma. The radial profiles of $2{\times}10^6$ km region are compared with the Haser model.

• Journal of the Korean institute of surface engineering
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• v.49 no.2
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• pp.152-158
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• 2016

We investigated the effect of capacitively coupled Ar plasma treatment on contact resistance ($R_c$) and channel sheet resistance ($R_{sh}$) of graphene field effect transistors (FETs), by varying their channel length in the wide range from 200 nm to $50{\mu}m$ which formed the transfer length method (TLM) patterns. When the Ar plasma treatment was performed on the long channel ($10{\sim}50{\mu}m$) graphene FETs for 20 s, $R_c$ decreased from 2.4 to $1.15k{\Omega}{\cdot}{\mu}m$. It is understood that this improvement in $R_c$ is attributed to the formation of $sp^3$ bonds and dangling bonds by the plasma. However, when the channel length of the FETs decreased down to 200 nm, the drain current ($I_d$) decreased upon the plasma treatment because of the significant increase of channel $R_{sh}$ which was attributed to the atomic structural disorder induced by the plasma across the transfer length at the edge of the channel region. This study suggests a practical guideline to reduce $R_c$ using various plasma treatments for the $R_c$ sensitive graphene and other 2D material devices, where $R_c$ is traded off with $R_{sh}$.

• Structural Engineering and Mechanics
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• v.70 no.4
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• pp.499-511
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• 2019

In this study, the axial compressive behavior of novel quadruple C-channel built-up cold-formed steel columns with different slenderness ratio was investigated, using the experimental and numerical analysis. The axial compressive capacity and failure modes of the columns were obtained and analyzed. The finite element models considering the geometry, material and contact nonlinearity were developed to simulate and analyze the structural behavior of the columns further. There was a great correlation between the numerical analyses and test results, which indicated that the finite element model was reasonable and accurate. Then influence of, slenderness ratio, flange width-to-thickness ratio and screw spacing on the mechanical behavior of the columns were studied, respectively. The tests and numerical results show that due to small slenderness ratio, the failure modes of the specimens are generally local buckling and distortional buckling. The axial compressive strength and stiffness of the quadruple C-channel built-up cold-formed steel columns decrease with the increase of maximum slenderness ratio. When the screw spacing is ranging from 150mm to 450mm, the axial compressive strength and stiffness of the quadruple C-channel built-up cold-formed steel columns change little. The axial compressive capacity of quadruple C-channel built-up cold-formed steel columns increases with the decrease of flange width-thickness ratio. A modified effective length factor is proposed to quantify the axial compressive capacity of the quadruple C-channel built-up cold-formed steel columns with U-shaped track in the ends.