• Toxicological Research
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• v.30 no.4
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• pp.291-296
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• 2014

Saururus chinensis has been reported to contain compounds such as lignans, alkaloids, diterpenes, flavonoids, tannins, steroids, and lipids. Fermentation is commonly used to break down certain undesirable compounds, to induce effective microbial conversion, and to improve the potential nutraceutical values. Previous studies have reported that the fermentation process could modify naturally occurring constituents, including isoflavons, saponins, phytosterols, and phenols, and could enhance biological activities, specifically antioxidant and antimicrobial properties. The probiotic strains used for fermentation exert beneficial effects and are safe. In this study, the antioxidative effects of the Bacillus subtilis fermentation of Saururus chinensis were investigated in a rat model with Triton WR-1339-induced hyperlipidemia by comparing the measured antioxidative biological parameters of fermented Saururus chinensis extract to those of nonfermented Saururus chinensis extract. Fermentation played a more excellent role than nonfermentation in ultimately protecting the body from oxidative stress in the liver of the experimental rats with Triton WR-1339-induced hyperlipidemia.

• BMB Reports
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• v.52 no.8
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• pp.475-481
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• 2019

The evolution of genome editing technology based on CRISPR (clustered regularly interspaced short palindromic repeats) system has led to a paradigm shift in biological research. CRISPR/Cas9-guide RNA complexes enable rapid and efficient genome editing in mammalian cells. This system induces double-stranded DNA breaks (DSBs) at target sites and most DNA breakages induce mutations as small insertions or deletions (indels) by non-homologous end joining (NHEJ) repair pathway. However, for more precise correction as knock-in or replacement of DNA base pairs, using the homology-directed repair (HDR) pathway is essential. Until now, many trials have greatly enhanced knock-in or substitution efficiency by increasing HDR efficiency, or newly developed methods such as Base Editors (BEs). However, accuracy remains unsatisfactory. In this review, we summarize studies to overcome the limitations of HDR using the CRISPR system and discuss future direction.

• Cross-Cultural Studies
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• v.23
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• pp.127-165
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• 2011

This paper focuses on the specificities and semantic meaning of Mikhail Bulgakov's metadrama White Guard and The Flight. The standard conception of metadrama is to purposefully break the dramatic illusion and make bare a playwright's self-consciousness of the theatrical art itself. With the use of the metadrama Bulgakov expressed the essentials of ugly reality, which he couldn't accept as a valuable truth. In this respect, Bulgakov's metadrama becomes at once a window, from which he views the external world in the theatrical vision, and a mirror, in which his political and existential stance as a playwright is reflected. In White Guard Bulgakov described the already theatricalized reality through several instances of 'play-within-play'. In The Flight, composed of eight pieces of dream, a life turned out to be a less solid and less firm reality than dream. Continuously demolishing the cognitive wall between reality and illusion, Bulgakov leads spectators to have a reflective view on the reality. Allowing more powerful demonstrativeness for a play-within-play than for a play-within-play, Bulgakov elevates a metadramatic technique to the level of thematic structure.

• Asia Pacific Journal of Corpus Research
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• v.2 no.2
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• pp.31-41
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• 2021

This paper makes a quantitative analysis of the diachronic evolution of ancient Chinese vocabulary by constructing and counting a large-scale rough annotated corpus. The texts from Si Ku Quan Shu (a collection of Chinese ancient books) are automatically segmented to obtain ancient Chinese vocabulary with time information, which is used to the statistics on word frequency, standardized type/token ratio and proportion of monosyllabic words and dissyllabic words. Through data analysis, this study has the following four findings. Firstly, the high-frequency words in ancient Chinese are stable to a certain extent. Secondly, there is no obvious dissyllabic trend in ancient Chinese vocabulary. Moreover, the Northern and Southern Dynasties (420-589 AD) and Yuan Dynasty (1271-1368 AD) are probably the two periods with the most abundant vocabulary in ancient Chinese. Finally, the unique words with high frequency in each dynasty are mainly official titles with real power. These findings break away from qualitative methods used in traditional researches on Chinese language history and instead uses quantitative methods to draw macroscopic conclusions from large-scale corpus.

• Proceedings of the Korea Information Processing Society Conference
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• 2020.05a
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• pp.44-46
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• 2020

Aggregating data with an optimal delay, which is a critical problem in Wireless Sensor Networks applications, is proven as NP-hard. In this paper, we focus on optimizing the aggregation delay by presenting an idea for channel and timeslot co-scheduling data aggregation in MWSNs. The proposed scheme, which names Break and Join, maximizes the number of sensor nodes to be scheduled in a working period, so that the overall number of working periods and data collection delay are reduced.

• Korea Trade Review
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• v.46 no.2
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• pp.229-243
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• 2021

This study aims to establish a research model to see how cultural differences affect negotiation outcomes. People from different countries tend to communicate in slightly different ways. So Recognizing the cultural differences in global businesses is an important preparation process and strategy. If such preparations are not made before doing business with companies in other cultures, many conflicts could arise in the negotiation process and even the negotiations could break down. Therefore, it is important to recognize cultural differences and establish appropriate strategies in international negotiations, and it is necessary to take a look at the factors that affect them one by one. For the purpose of this study, Cultural differences based on Edward Hall's context theory and Personal characteristics were set as moderator variables. and The EU countries(low context cultures) and the Korea(high context cultures) were sampled to study the effects of Negotiation strategy(Problem-Solving Approach).

• Transactions of the Korean hydrogen and new energy society
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• v.6 no.2
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• pp.85-90
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• 1995

Activation behavior, hydriding rate and disintegration were tested for hydrogen storage alloy particles fixed in an adhesive after treating with inorganic solution. Commertial adhesive as a binder was used. Chemical-treated particles showed the best characteristics for activation and a little effect of prevention the break down of the powders themselves after several repeated operations. Furthermore activation characteristics were found to show a similar trend to chemical-treated powders even in the fixed one with an adhesive, except for a slight decrease in reaction velocity.

• ETRI Journal
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• v.31 no.5
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• pp.554-564
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• 2009

In information security and network management, attacks based on vulnerabilities have grown in importance. Malicious attackers break into hosts using a variety of techniques. The most common method is to exploit known vulnerabilities. Although patches have long been available for vulnerabilities, system administrators have generally been reluctant to patch their hosts immediately because they perceive the patches to be annoying and complex. To solve these problems, we propose a security vulnerability evaluation and patch framework called PKG-VUL, which evaluates the software installed on hosts to decide whether the hosts are vulnerable and then applies patches to vulnerable hosts. All these operations are accomplished by the widely used simple network management protocol (SNMP). Therefore, system administrators can easily manage their vulnerable hosts through PKG-VUL included in the SNMP-based network management systems as a module. The evaluation results demonstrate the applicability of PKG-VUL and its performance in terms of devised criteria.

• Bulletin of the Korean Chemical Society
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• v.35 no.5
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• pp.1329-1332
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• 2014

The kinetic studies on the reactions of O,O-diethyl Z-S-aryl phosphorothioates with X-pyridines have been carried out in dimethyl sulfoxide. The free energy correlations with X in the nucleophiles are biphasic concave upwards with a break point at X = H, while those for substituent Z variations in the leaving groups are linear. The negative sign of ${\rho}_{XZ}$ implies that the reaction proceeds through a concerted mechanism for both the strongly and weakly basic pyridines. The biphasic concave upward free energy relationships with X are rationalized by a change in the nucleophilic attacking direction from frontside with the strongly basic pyridines to backside with the weakly basic pyridines.

• Bulletin of the Korean Chemical Society
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• v.34 no.6
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• pp.1829-1834
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• 2013

The nucleophilic substitution reactions of Y-aryl ethyl isothiocyanophosphates with substituted X-anilines and deuterated X-anilines were investigated kinetically in acetonitrile at $75.0^{\circ}C$. The free energy relationships with X in the nucleophiles exhibited biphasic concave downwards with a break point at X = H. A stepwise mechanism with rate-limiting bond formation for strongly basic anilines and with rate-limiting bond breaking for weakly basic anilines is proposed based on the negative and positive ${\rho}_{XY}$ values, respectively. The deuterium kinetic isotope effects (DKIEs; $k_H/k_D$) changed gradually from primary normal with strongly basic anilines, via primary normal and secondary inverse with aniline, to secondary inverse with weakly basic anilines. The primary normal and secondary inverse DKIEs were rationalized by frontside attack involving hydrogen bonded, four-center-type TSf and backside attack involving in-line-type TSb, respectively.