• Korean Journal of Organic Agriculture
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• v.20 no.3
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• pp.399-409
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• 2012

Effects of pretreatment and extraction conditions on total polyphenol yield from licorice root were investigated using statistical method. For pretreatment, heat treatment at $121^{\circ}C$ for 10 min was applied. Licorice root content in solvent (10, 20, and 30%) ethanol concentration (20, 40, and 60%) and reaction time (1, 2, and 3 h) were used as variables for extraction conditions. Two experiments, with heat treated and no treated licorice, were prepared with same experimental design. Box behnken design was employed and produced a total of 15 trials. Total polyphenol yield from licorice root was not affected by heat treatment. Among variables, licorice content in solvent showed most significant effect regardless of other variables (p<0.05). Finally, optimum conditions for the extraction of total polyphenol from licorice root was detected as following: 10% of licorice in solvent, 52% ethanol as solvent, 2 h of reaction time and non-heat treatment and the extraction yield from optimized condition was 17.6 mg/g licorice root.

• Korean Journal of Chemical Engineering
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• v.35 no.11
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• pp.2241-2255
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• 2018

RSM methodology was applied to present mathematical models for the fabrication of polyvinylidene fluoride (PVDF) dual-layer hollow fibers in membrane distillation process. The design of experiments was used to investigate three main parameters in terms of polymer concentration in both outer and inner layers and the flow rate of dope solutions by the Box-Behnken method. According to obtained results, the optimization was done to present the proper membrane with desirable properties. The characteristics of the optimized membrane (named HF-O) suggested by the Box-Behnken (at the predicted point) showed that the proposed models are strongly valid. Then, a morphology study was done to modify the fiber by a combination of three types of a structure such as macro-void, sponge-like and sharp finger-like. It also improved the hydrophobicity of outer surface from 87 to $113^{\circ}$ and the mean pore size of the inner surface from 108.12 to 560.14 nm. The DCMD flux of modified fiber (named HF-M) enhanced 62% more than HF-O when it was fabricated by considering both of RSM and morphology study results. Finally, HF-M was conducted for long-term desalination process up to 100 hr and showed stable flux and wetting resistance during the test. These stepwise approaches are proposed to easily predict the main properties of PVDF dual-layer hollow fibers by valid models and to effectively modify its structure.

• Journal of the Korean Society for Precision Engineering
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• v.25 no.8
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• pp.72-79
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• 2008

To meet demand of big capacity and high speed rotation for washing machine, more stress from bending and twisting are complexly loaded onto the shaft supporting the horizontal drum, causing problems in fracture strength and fatigue life. Shafting system is mainly divided into flange and shaft. Shaft and flange connected by inserting shaft serration into flange on the process of die casting. When the system is operating, the gap is formed between serration and flange. But, Serration has various design factors and the optimal values can't be easily determined. Using a design of experiment (DOE) based on the FEM (Finite Element Method), this study was performed investigating the interaction effect between the various design factors as well as the main effect of the each design factor under bending, twist and vibration and proposed optimum design using box-behnken method among response surface derived from regression equation of simulation-based DOE.

• 한국전산유체공학회:학술대회논문집
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• 2007.10a
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• pp.92-99
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• 2007

In this paper, optimization of the vaned centrifugal compressor was carried out at a given mass flow rate condition. Firstly, impeller optimization was conducted using response surface method (RSM) which is one of optimization methods. After the optimization of the impeller was completed, diffuser optimization was performed with the optimized impeller. In these processes, Navier-Stokes solver was used to calculate the flow inside the centrifugal compressor. And the optimization is performed with Box-Behnken design method which is efficient for fitting second-order response surfaces to reduce the number of calculations required. As a result, compared with the reference model, the efficiency and the pressure ratio of the optimized impeller and diffuser are found to be increased. The performance at off-design conditions is presented.

• International Journal of Fluid Machinery and Systems
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• v.9 no.2
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• pp.143-149
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• 2016

In this study, a method for the multi-objective optimization of an impeller for a centrifugal compressor using fluid-structure interaction (FSI) and response surface method (RSM) was proposed. Numerical simulation was conducted using ANSYS CFX and Mechanical with various configurations of impeller geometry. Each design parameter was divided into 3 levels. A total of 15 design points were planned using Box-Behnken design, which is one of the design of experiment (DOE) techniques. Response surfaces based on the results of the DOE were used to find the optimal shape of the impeller. Two objective functions, isentropic efficiency and equivalent stress were selected. Each objective function is an important factor of aerodynamic performance and structural safety. The entire process of optimization was conducted using the ANSYS Design Xplorer (DX). The trade-off between the two objectives was analyzed in the light of Pareto-optimal solutions. Through the optimization, the structural safety and aerodynamic performance of the centrifugal compressor were increased.

• Transactions of Materials Processing
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• v.30 no.1
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• pp.27-34
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• 2021

In this study, response surface method (RSM) was used in modeling and multi-objective optimization of the parameters of AA5052-H32 in incremental sheet forming (ISF). The goals of optimization were the maximum forming angle, minimum thickness reduction, and minimum surface roughness, with varying values in response to changes in production process parameters, such as tool diameter, tool spindle speed, step depth, and tool feed rate. A Box-Behnken experimental design (BBD) was used to develop an RSM model for modeling the variations in the forming angle, thickness reduction, and surface roughness in response to variations in process parameters. Subsequently, the RSM model was used as the fitness function for multi-objective optimization of the ISF process based on experimental design. The results showed that RSM can be effectively used to control the forming angle, thickness reduction, and surface roughness.

• Korean Chemical Engineering Research
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• v.59 no.3
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• pp.455-466
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• 2021

Micro and nanoparticles of Finasteride were prepared by gas-antisolvent method. The influence of process parameters such as pressure (100, 130 and 160 bar), temperature (308, 318 and 328 K) and solute concentrations (10, 25 and 40 mg/ml) on mean particle size was studied by Box-Behnken design. As ANOVA results indicated, the highest influence in production of smaller particles was attributed to the pressure. Optimum condition leading to the smallest particle size was as follows: initial solute concentration, 10 mg/ml; temperature, 308 K and pressure, 160 bar. The particles were evaluated with FTIR, SEM, DLS, XRD as well as DSC. The analyses revealed a size decrease in the precipitated Finasteride particles (232.4 nm, on mean) via gas-antisolvent method, as compared to the original particles (55.6 ㎛).

• Journal of the Society of Cosmetic Scientists of Korea
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• v.48 no.3
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• pp.255-264
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• 2022

The active ingredients of Napttegi Kong(GML, Glycine max landrace), a type of native rare soybeans, were identified, and an ultrasonic extraction method was introduced as an eco-friendly extraction method. Through the component analysis of the Napttegi Kong extract, the epicatechin, which was not found in conventional soybeans, was identified. For effective extraction using ultrasonic, the main extraction conditions were optimized using the response surface analysis method. Through the Box-Behnken design process, 15 experiments were conducted with the extraction temperature, the ratio of extraction solvent/solution, and extraction time as key independent variables. A quadratic regression equation for the two dependent variables, epicatechin content and total isoflavone content, was derived, and the coefficients of determination were found to be high as R² = 0.9939 and R² = 0.9844, respectively, confirming that the correlation showed high significance. The extraction conditions satisfying the maximum expectations of these two dependent variables were predicted. to be 40.4℃ of extraction temperature, 19.3 times of extraction solvent/solution, and 91 sec of extraction time. The expected value and the actual experimental value of the epikatechin content and the total isoflavone content were similar, so it was confirmed that this experimental method is a highly reliable optimization model.

• Journal of Korean Society of Environmental Engineers
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• v.30 no.6
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• pp.642-652
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• 2008

The aim of our research was to apply experimental design methodology in the optimization condition of Photo-Fenton oxidation of the residual livestock wastewater after the coagulation process. The reactions of Photo-Fenton oxidation were mathematically described as a function of parameters amount of Fe(II)($x_1$), $H_2O_2(x_2)$ and pH($x_3$) being modeled by the use of the Box-Behnken method, which was used for fitting 2nd order response surface models and was alternative to central composite designs. The application of RSM using the Box-Behnken method yielded the following regression equation, which is an empirical relationship between the removal(%) of livestock wastewater and test variables in coded unit: Y = 79.3 + 15.61x$_1$ - 7.31x$_2$ - 4.26x$_3$ - 18x$_1{^2}$ - 10x$_2{^2}$ - 11.9x$_3{^2}$ + 2.49x$_1$x$_2$ - 4.4x$_2$x$_3$ - 1.65x$_1$x$_3$. The model predicted also agreed with the experimentally observed result(R$^2$ = 0.96) The results show that the response of treatment removal(%) in Photo-Fenton oxidation of livestock wastewater were significantly affected by the synergistic effect of linear terms(Fe(II)($x_1$), $H_2O_2(x_2)$, pH(x$_3$)), whereas Fe(II) $\times$ Fe(II)(x$_1{^2}$), $H_2O_2$ $\times$ $H_2O_2$(x$_2{^2}$) and pH $\times$ pH(x$_3{^2}$) on the quadratic terms were significantly affected by the antagonistic effect. $H_2O_2$ $\times$ pH(x$_2$x$_3$) had also a antagonistic effect in the cross-product term. The estimated ridge of the expected maximum response and optimal conditions for Y using canonical analysis were 84 $\pm$ 0.95% and (Fe(II)(X$_1$) = 0.0146 mM, $H_2O_2$(X$_2$) = 0.0867 mM and pH(X$_3$) = 4.704, respectively. The optimal ratio of Fe/H$_2O_2$ was also 0.17 at the pH 4.7.

• Membrane and Water Treatment
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• v.10 no.6
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• pp.417-429
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• 2019

Poly Sulfone nanofibers were electrospun to fabricate membranes of different characteristics. To fabricate the fiber mats, polymer concentration, flowrate, and current density were determined as the most influencing factors affecting the overall performance of the membranes and studied through Response Surface Methodology. The Box-Behnken Design method (three factors at three levels) was used to design, analyze, and optimize the parameters to achieve the best possible performance of the electrospun membranes in forward osmosis process. Also, internal concentration polarization that characterizes the efficiency of the forward osmosis membranes was determined to better assess the overall performance of the fabricated electrospun membranes. Water flux to reverse salt flux was considered as the main response to assess the performance of the membranes. As confirmed experimentally, best membrane performance with the minimal structural parameter value could be achieved when predicted optimal values were used to fabricate the membranes through electrospinning process.