• Title/Summary/Keyword: Biological information

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The effects of sodium fluoride on oral normal cell cultured in vitro (체외에서 배양된 구강 내 정상세포에 불화나트륨이 미치는 영향)

  • Choi, Byul-Bora;Kim, Da-Hye;Kim, Ji-Young;Park, Sang-Rye
    • Journal of Korean society of Dental Hygiene
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    • v.16 no.3
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    • pp.471-477
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    • 2016
  • Objectives: Fluoride is widely used in the prevention and control of dental caries. The purpose of this study is to examine the biological effects of Sodium fluoride on the proliferation of oral normal cell in vitro(MDPC-23, HaCaT, HGF-1 cells). Methods: The proliferation of normal cells and the cyto-skeletal change of normal cells were assessed by WST-1 assay and F-actin stain assay. The statistical significances of the resulting data were analyzed using SPSS(Window 12.0). Results: The sodium fluoride(0-12 mM) treatment decreased the cell viability in a dose and time dependent manner: HaCaT(6 h): $100{\pm}0$, $98{\pm}0.39$, $82{\pm}2.68$, $75{\pm}0.83$, $69{\pm}1$, $67{\pm}1.42%$(p<0.005); HaCaT(24 h): $100{\pm}0$, $98{\pm}1.85$, $54{\pm}0.64$, $43{\pm}0.4$, $38{\pm}0.32$, $36{\pm}0.13%$(p<0.006), MDPC-23(6 h): $100{\pm}0$, $93{\pm}1.48$, $85{\pm}0.28$, $82{\pm}1.58$, $79{\pm}1.48$, $76{\pm}1.93%$(p<0.009); MDPC-23(24 h): $100{\pm}0$, $91{\pm}1.26$, $58{\pm}0.65$, $49{\pm}1$, $44{\pm}0.74$, $2{\pm}0.05%$(p<0.005), HGF-1(6 h): $100{\pm}0$, $97{\pm}2.93$, $89{\pm}5$, $71{\pm}5.42$, $58{\pm}4.82$, $43{\pm}3.47%$(p<0.009); HGF-1(24 h): $100{\pm}0$, $97{\pm}2.05$, $73{\pm}1.73$, $22{\pm}1.61$, $14{\pm}1.73$, $7{\pm}0.85%$(p<0.005). Thus, changes in cell morphology and disruption of filamentous(F)-actin organization were observed in higher concentration. Conclusions: These results suggest that higher concentrations of fluoride lead to a reduce the number of cells and morphology change of normal cell.

The Differential Effects of Acupuncture on Postures of Healthy Subjects (정상인의 자세에 따른 자침 효과의 차이)

  • Kim, Ji-Eun;Park, Kyung-Mo
    • Journal of Biomedical Engineering Research
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    • v.28 no.1
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    • pp.46-54
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    • 2007
  • Objective: The first aim of this study is to determine the effects of acupuncture on the autonomic nervous system (ANS) via Heart Rate (HR) and Pupil Size (PS), and to compare the effects of acupuncture on the subjects' ANS when they are in a sitting position with the effects when they are in a supine position. Methods: Ten healthy male subjects were randomized to receive either verum acupuncture stimulation in a sitting position (SitV), verum acupuncture stimulation in a supine position (SupV), sham acupuncture stimulation in a sitting position (SitS), and sham acupuncture stimulation in a supine position (SupS). Acupuncture stimulation was applied to Neguan point (PC6) on the forearm. The subject's electrocardiogram (ECG) and pupil size were recorded continuously from 5 min before stimulation to 12 min after stimulation. Results: Verum and sham acupuncture stimulation were found to have reduced heart rate (p<0.01) and to have increased pupil size (p<0.01) in all the subjects. But when the reduction in HR and the increment in PS after verum acupuncture stimulation (both sitting and supine position) were compared with those after sham acupuncture stimulation, it was found that the reduction in HR (74.48 and 73.47 bpm, p<0.063) and the increment of PS (7.32 and, 6.10 mm, p<0.001) after verum acupuncture stimulation were greater than those after sham acupuncture stimulation, and that the corresponding values were statistically significant. In addition, at the baseline, it was found that the subjects had a larger PS and a faster HR in a sitting position than when they did so in a supine position. And then the reduction and increment ratio in the subject's HR and PS when they underwent acupuncture stimulation in a sitting position was significantly different from the reduction and increment in their HR and PS when they underwent the procedure in a supine position-i.e., the reduction ratio in HR was greater when they underwent the procedure in a sitting position, and such reduction ratio was statistically significant (p<0.05). As for the increment in PS, it was greater when the subjects underwent the procedure in a supine position, and such increment was significant (p<0.05). Conclusion: Manual acupuncture stimulation on Neguan point (PC6) has more significant influence on the autonomic nervous system rather than sham acupuncture (tactile stimulation). And the position-induced different states of ANS have different influence on the acupuncture effect.

Prediction of Implicit Protein - Protein Interaction Using Optimal Associative Feature Rule (최적 연관 속성 규칙을 이용한 비명시적 단백질 상호작용의 예측)

  • Eom, Jae-Hong;Zhang, Byoung-Tak
    • Journal of KIISE:Software and Applications
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    • v.33 no.4
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    • pp.365-377
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    • 2006
  • Proteins are known to perform a biological function by interacting with other proteins or compounds. Since protein interaction is intrinsic to most cellular processes, prediction of protein interaction is an important issue in post-genomic biology where abundant interaction data have been produced by many research groups. In this paper, we present an associative feature mining method to predict implicit protein-protein interactions of Saccharomyces cerevisiae from public protein interaction data. We discretized continuous-valued features by maximal interdependence-based discretization approach. We also employed feature dimension reduction filter (FDRF) method which is based on the information theory to select optimal informative features, to boost prediction accuracy and overall mining speed, and to overcome the dimensionality problem of conventional data mining approaches. We used association rule discovery algorithm for associative feature and rule mining to predict protein interaction. Using the discovered associative feature we predicted implicit protein interactions which have not been observed in training data. According to the experimental results, the proposed method accomplished about 96.5% prediction accuracy with reduced computation time which is about 29.4% faster than conventional method with no feature filter in association rule mining.

Identification of SNPs in Highly Variable Lysozyme Gene in Korean Native Chicken Populations (한국 재래닭의 고변이 Lysozyme 유전자의 SNP 확인)

  • Hoque, M.R.;Kang, B.S.;Lim, H.K.;Choi, K.D.;Lee, J.H.
    • Korean Journal of Agricultural Science
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    • v.37 no.3
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    • pp.399-404
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    • 2010
  • Single nucleotide polymorphisms (SNPs) in chicken lysozyme (LYZ) gene were investigated in this study. The identification of SNPs in both exon and intron in LYZ gene has led to understanding of evolution for the domestic chicken populations. A total of 24 samples from two Korean native commercial chicken populations (CCPs) were used for the initial identification of SNPs by mixing three DNA samples for sequencing experiments. By comparing with red jungle fowl (RJF), two commercial chicken populations have 18 common polymorphisms. Between two commercial chicken populations, 15 polymorphisms were identified. Of the 33 polymorphisms identified, two indels (21 and 4 bp) were found. Whereas, only one polymorphism in exon 2 at the bp position 1426 was a non-synonymous substitution (p.Ala49Val), indicating the amino acid changes. The identified non-synonymous substitution (p.Ala49Val) is located close to the catalytic sites of the enzyme, which might affect its activity. In our investigation, the polymorphisms in LYZ gene can provide broad ideas for the variation of Korean native chicken populations from the ancestor of chicken breeds as well as the some biological functions of the LYZ gene.

Study precision attitude control of marine biological robot which utilizes a plurality of sensors (다중 센서를 이용한 해양 생체 로봇의 정밀 자세 제어 연구)

  • Kim, Min;Son, Kyung-Min;Park, Won-hyun;Kim, Gwan-Hyung;Byun, Ki-sik
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2015.05a
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    • pp.548-549
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    • 2015
  • 무인 잠수정은 자율 무인잠수정(이하 'AUV' 또는 '자율무인잠수정'을 혼용)과 원격조정잠수정(이하 'ROV'로 지칭)으로 분류를 할 수 있다. ROV는 테더 게이블로 인한 작업 범위의 한계와 운동성능 효율이 떨어지는 단점을 지니고 있어, 테더 케이블이 필요 없는 AUV에 대한 필요성이 증대되고 있다. 추측 항법 시스템인 관성 항법 시스템(inertial navigation system, 이하 'INS'로 지칭)은 외부 도움없이 관성측정 장치(inertial measurement unit, 이하 'IMU'로 지칭)를 활용하여 구성된 시스템을 말한다. IMU는 자이로 스코프(gyroscope), 가속도계(accelerometer), 지자기(magnetic)센서로 구성된 측정 장치로 3개의 센서를 사용하여 상호 보정을 통한 기동 체의 위치, 속도 및 자세 정보를 제공한다. 복합항법시스템은 추측항법시스템이 가지는 누적오차와 측위 항법시스템이 가지는 외부환경에 대한 단점을 상호 보완하는 방법으로 연구가 진행 중이다. 하지만 심해서 또는 해양의 특성에 따라 측위 시스템이 사용되지 못하기 때문에 추측 항법시스템의 다양한 관성 센서를 활용한 상로 보완과 신호처리 방법을 통한 연구 개발이 진행 중이다. 다양한 센서 정보를 통합하는 목적으로 칼만 필터와 같은 최적 필터기법이 보편적으로 사용되고 있다. 칼만 필터는 확률 선형 시스템에 대하여 공정잡음 및 측정 잡음이 가우시안 확률 분포를 따를 때 최적의 추정자가 된다. 또한 가우시안 조건을 만족하지 않는 경우에도 선형 추정자 중에 추정 오차의 분산이 가장 작은 추정자이다. 칼만 필터가 최상의 성능을 발휘 하려면 공정잡음과 측정 잡음의 실제 값을 정확히 알아내는 것이 중요하다. 잡음 수준에 대한 정보가 부정확 할 경우 칼만 필터는 발산 할 수 있기 때문에 시스템에서 잡음 수준의 공산은 칼만 필터의 최적 이득을 결정하는 중요한 요소로 추정치에 큰 영향을 준다. 따라서 칼만 필터를 추측항법시스템에 적용 시킬 경우 실제 모텔의 잡음 공분산을 정확히 추정할 수 있는 기법이 요구된다. 추측항법시스템은 다양한 센서를 활용하기 때문에 움직이는 기동 표적에 적용시 잡음공분상이 변하기 때문에 항법시스템이 저하 될 수 있다. 본 연구에서는 다양한 센서를 융합하여 해양 생체 로봇의 정밀 자세 제어가 가능한 시스템을 제안하고자 한다.

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Full-Length Enriched cDNA Library Construction from Tissues Related to Energy Metabolism in Pigs

  • Lee, Kyung-Tai;Byun, Mi-Jeong;Lim, Dajeong;Kang, Kyung-Soo;Kim, Nam-Soon;Oh, Jung-Hwa;Chung, Chung-Soo;Park, Hae-Suk;Shin, Younhee;Kim, Tae-Hun
    • Molecules and Cells
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    • v.28 no.6
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    • pp.529-536
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    • 2009
  • Genome sequencing of the pig is being accelerated because of its importance as an evolutionary and biomedical model animal as well as a major livestock animal. However, information on expressed porcine genes is insufficient to allow annotation and use of the genomic information. A series of expressed sequence tags of 5' ends of five full-length enriched cDNA libraries (SUSFLECKs) were functionally characterized. SUSFLECKs were constructed from porcine abdominal fat, induced fat cells, loin muscle, liver, and pituitary gland, and were composed of non-normalized and normalized libraries. A total of 55,658 ESTs that were sequenced once from the 5′ ends of clones were produced and assembled into 17,684 unique sequences with 7,736 contigs and 9,948 singletons. In Gene Ontology analysis, two significant biological process leaf nodes were found: gluconeogenesis and translation elongation. In functional domain analysis based on the Pfam database, the beta transducin repeat domain of WD40 protein was the most frequently occurring domain. Twelve genes, including SLC25A6, EEF1G, EEF1A1, COX1, ACTA1, SLA, and ANXA2, were significantly more abundant in fat tissues than in loin muscle, liver, and pituitary gland in the SUSFLECKs. These characteristics of SUSFLECKs determined by EST analysis can provide important insight to discover the functional pathways in gene networks and to expand our understanding of energy metabolism in the pig.

On-Line music score recognition by DPmatching (DP매칭에 의한 On-Line 악보인식)

  • 구상훈;이병선;김수경;이은주
    • Proceedings of the Korea Society of Information Technology Applications Conference
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    • 2002.11a
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    • pp.502-511
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    • 2002
  • 컴퓨터의 기술적 발전은 사회 여러 분야에 막대한 영향을 끼쳤다. 그중 악보 인식분야에도 커다란 영향을 주었다 그러나, On-line 상에서 그린 악보를 실시간으로 정형화된 악보형태로 변환하는 처리에 대한 연구가 미흡하여 이에 대한 연구가 필요하다. 본 논문에서는 실시간으로 악보를 인식하고, 사용자의 편의를 도모하기 위해 DP(Dynamic Programming) 매칭법을 이용한 On-Line 악보인식에 관한 방법을 제안하였다. 본 연구에서는 실시간으로 입력되는 악상기호를 인식하기 위해, 가장 유효한 정보인 악상 기호내의 방향, x, y 좌표를 이용하여 벡터형태로 추출한 후 음표와 비음표(쉼표, 기타기호)의 두개의 그룹으로 나누어진 표준패턴과의 DP매칭을 통해 인식한다. 먼저 tablet을 통해 실시간으로 악상 기호를 입력할 때 생기는 x, y좌표를 이용하여, 펜의 움직임에 대한 16방향 부호화를 수행한다. 음표와 비음표를 구분하기 위한 시간을 줄이고자 16방향 부호화를 적용하치 않고 사사분면부호화를 적용한다. 음표를 약식으로 그릴 경우 음표 머리에 해당하는 부분의 좌표는 삼사분면에 분포하고, 폐곡선의 음표일 경우에는 좌표가 사사분면에 고르게 나타난다. 폐곡선을 제외한 음표의 머리는 폐곡선과 같은 조건이면서 입력받은 y좌표값들 중에서 최소값과 최대값을 구한 다음 2로 나눈 값을 지나는 y좌표의 개수가 임의의 임계값 이상이면 음표로 판단한다. 위 조건을 만족하지 않을 경우 비음표로 취급한다. 음표와 비음표를 결정한 다음, 입력패턴과 표준패턴과의 DP매칭을 통하여 벌점을 구한다. 그리고 경로탐색을 통해 벌점에 대한 각각의 합계를 구해 최소값을 악상기호로 인식 하였다. 실험결과, 표준패턴을 음표와 비음표의 두개의 그룹으로 나누어 인식함으로써 DP 매칭의 처리 속도를 개선시켰고, 국소적인 변형이 있는 패턴과 특징의 수가 다른 패턴의 경우에도 좋은 인식률을 얻었다.r interferon alfa concentrated solution can be established according to the monograph of EP suggesting the revision of Minimum requirements for biological productss of e-procurement, e-placement, e-payment are also investigated.. monocytogenes, E. coli 및 S. enteritidis에 대한 키토산의 최소저해농도는 각각 0.1461 mg/mL, 0.2419 mg/mL, 0.0980 mg/mL 및 0.0490 mg/mL로 측정되었다. 또한 2%(v/v) 초산 자체의 최소저해농도를 측정한 결과, B. cereus, L. mosocytogenes, E. eoli에 대해서는 control과 비교시 유의적인 항균효과는 나타나지 않았다. 반면에 S. enteritidis의 경우는 배양시간 4시간까지는 항균활성을 나타내었지만, 8시간 이후부터는 S. enteritidis의 성장이 control 보다 높아져 배양시간 20시간에서는 control 보다 약 2배 이상 균주의 성장을 촉진시켰다.차에 따른 개별화 학습을 가능하게 할 뿐만 아니라 능동적인 참여를 유도하여 학습효율을 높일 수 있을 것으로 기대된다.향은 패션마케팅의 정의와 적용범위를 축소시킬 수 있는 위험을 내재한 것으로 보여진다. 그런가 하면, 많이 다루어진 주제라 할지라도 개념이나 용어가 통일되지 않고 사용되며 검증되어 통용되는 측정도구의 부재로 인하여 연구결과의 축적이 미비한 상태이다. 따라서, 이에 대한 재고와 새로운 방향 모색이 필요하다고 사료된다.로 사료되며, 임신관련 cytokine에 대한 다양한 연구가 요구되고 있다.₂/Hf(Variable)/Si 계에서 HfO₂ 박막이 Si 기판위에 직접 증착되면, 순수 HfO₂ 박막의

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Design of Low Power 4th order ΣΔ Modulator with Single Reconfigurable Amplifier (재구성가능 연산증폭기를 사용한 저전력 4차 델타-시그마 변조기 설계)

  • Sung, Jae-Hyeon;Lee, Dong-Hyun;Yoon, Kwang Sub
    • Journal of the Institute of Electronics and Information Engineers
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    • v.54 no.5
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    • pp.24-32
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    • 2017
  • In this paper, a low power 4th order delta-sigma modulator was designed with a high resolution of 12 bits or more for the biological signal processing. Using time-interleaving technique, 4th order delta-sigma modulator was designed with one operational amplifier. So power consumption can be reduced to 1/4 than a conventional structure. To operate stably in the big difference between the two capacitor for kT/C noise and chip size, the variable-stage amplifier was designed. In the first phase and second phase, the operational amplifier is operating in a 2-stage. In the third and fourth phase, the operational amplifier is operating in a 1-stage. This was significantly improved the stability of the modulator because the phase margin exists within 60~90deg. The proposed delta-sigma modulator is designed in a standard $0.18{\mu}m$ CMOS n-well 1 poly 6 Metal technology and dissipates the power of $354{\mu}W$ with supply voltage of 1.8V. The ENOB of 11.8bit and SNDR of 72.8dB at 250Hz input frequency and 256kHz sampling frequency. From measurement results FOM1 is calculated to 49.6pJ/step and FOM2 is calculated to 154.5dB.

Human Identification using EMG Signal based Artificial Neural Network (EMG 신호 기반 Artificial Neural Network을 이용한 사용자 인식)

  • Kim, Sang-Ho;Ryu, Jae-Hwan;Lee, Byeong-Hyeon;Kim, Deok-Hwan
    • Journal of the Institute of Electronics and Information Engineers
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    • v.53 no.4
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    • pp.142-148
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    • 2016
  • Recently, human identification using various biological signals has been studied and human identification based on the gait has been actively studied. In this paper, we propose a human identification based on the EMG(Electromyography) signal of the thigh muscles that are used when walking. Various features such as RMS, MAV, VAR, WAMP, ZC, SSC, IEMG, MMAV1, MMAV2, MAVSLP, SSI, WL are extracted from EMG signal data and ANN(Artificial Neural Network) classifier is used for human identification. When we evaluated the recognition ratio per channel and features to select approptiate channels and features for human identification. The experimental results show that the rectus femoris, semitendinous, vastus lateralis are appropriate muscles for human identification and MAV, ZC, IEMG, MMAV1, MAVSLP are adaptable features for human identification. Experimental results also show that the average recognition ratio of method of using all channels and features is 99.7% and that of using selected 3 channels and 5 features is 96%. Therefore, we confirm that the EMG signal can be applied to gait based human identification and EMG signal based human identification using small number of adaptive muscles and features shows good performance.

Analysis of River Disturbance using a GIS (I) (GIS기법을 이용한 하천 교란 실태의 분석(I))

  • Park, Eun-Ji;Kim, Kye-Hyun;Lee, On-Kil
    • Journal of Korea Spatial Information System Society
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    • v.10 no.2
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    • pp.81-93
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    • 2008
  • Current re-arrangement of river and waterway has been made uniformly ignoring characteristics of individual rivers thereby aggravating artificial river restructuring. Subsequently this severely affects the rivers' physical, chemical, and biological phenomenon. On the contrary, quantitative techniques to evaluate the aftermath of artificial river disturbance such as uprising of river bed, intrusion of foreign fisheries, and changes of ecological habitats are not available. To establish such quantitative techniques, analysis of river changes to evaluate the major causes of the river disturbance and its impacts is essential. Therefore, this study mainly focused on proposing a method which can be applied for the development of techniques to investigate river disturbance according to the major factors for the domestic rivers using airphotos and GIS techniques. For the analysis, the study area on the downstream of the river was selected and airphotos of the area were converted into GIS format to generate 'shape' files to secure waterways, river banks, and auxiliary data required for analyzing river disturbance. Trend analysis of the waterway sinuosity and changes of the flow path leaded to detailed verification of the river disturbance for specific location or time period, and this enabled to relatively accurate numbers representing sinuosity of the waterway and relevant changes. As the major results from the analysis, the relocation of waterways and the level of river sinuosity were quantified and used to verify the impacts on the stability of the waterways especially in the downstream of the dam. The results from this study enabled effective establishing proper measures against waterways' unstability, and emphasized subsequent researches for identifying better alternatives against river disturbances.

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