• Proceedings of the Korean Society of Medical Physics Conference
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• 2002.09a
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• pp.219-221
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• 2002

In this work, single event spectra were measured in order to gain the microdosimetric parameters of some heavy ion radiotherapy fields at HIMAC. Microdosimetry is now a well-established technique for the investigation of complex mixed radiation field. Changes in frequency mean lineal energy y$\_$F/ as a function of thickness of A150 phantom were obtained. The absorbed dose was obtained by using y$\_$F/. A direct relation between this single event probability distribution and relative biological effectiveness (RBE) was assumed in order to estimate RBE using the response function.

• Genomics & Informatics
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• v.5 no.1
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• pp.24-29
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• 2007

Computational virtual screening has become an essential platform of drug discovery for the efficient identification of active candidates. Moleculardocking, a key technology of receptor-centric virtual screening, is commonly used to predict the binding affinities of chemical compounds on target receptors. Despite the advancement and extensive application of these methods, substantial improvement is still required to increase their accuracy and time-efficiency. Here, we evaluate several advanced structure-based virtual screening approaches for elucidating the rank-order activity of chemical libraries, and the quantitative structureactivity relationship (QSAR). Our results show that the ensemble-average free energy estimation, including implicit solvation energy terms, significantly improves the hit enrichment of the virtual screening. We also demonstrate that the assignment of quantum mechanical-polarized (QM-polarized) partial charges to docked ligands contributes to the reproduction of the crystal pose of ligands in the docking and scoring procedure.

• Plant Biotechnology Reports
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• v.5 no.4
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• pp.317-322
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• 2011

We determined the nuclear DNA content (genome size) of over 35 accessions each of bamboo and rattan species from Southeast Asia. The 2C DNA per nucleus was quantified by flow cytometry. The fluorescence of nuclei isolated from the leaves and stained with propidium iodide was measured. The genome size of the bamboo species examined was between 2.5 and 5.9 pg DNA per 2C nucleus. The genome size of the rattan species examined ranged from 1.8 to 10.5 pg DNA per 2C nucleus. This information will be useful for scientists working in diverse areas of plant biology such as biotechnology, biodiversity, genome analysis, plant breeding, physiology and molecular biology. Such data may be utilized to attempt to correlate the genome size with the ploidy status of bamboo species in cases where ploidy status has been reported.

• Journal of Ecology and Environment
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• v.32 no.2
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• pp.109-113
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• 2009

Tree-ring width analysis has been used to assess the effects of air pollution on tree growth around industrial complexes. Our study was conducted to elucidate the effect of air pollutants on annual ring growth in black pines (Pinus thunbergii) of age 41$\sim$48 years around Ulsan Metropolitan City. The growth data were analyzed by multiple regression and the results are as follows: 1. The annual ring increment of black pines increased with tree age until age 40 years and then decreased gradually after age 40 years. 2. The increment of annual ring width of black pines was affected more by precipitation and evapotranspiration than air temperature. An annual ring decline appeared in the years 1968$\sim$1983, when annual ring indices below zero were observed. Decreased annual ring growth during this period may have been due to air pollution. 3. The heavy metal with the strongest effect on annual ring growth of black pines in the experimental stand was lead (Pb). The concentration of lead in the stand was estimated as over 6 ppm. 4. The technique of tree-ring width analysis may be useful for estimation of the extent of pollution in forest areas near industrial complexes.

• Journal of environmental and Sanitary engineering
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• v.18 no.2
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• pp.16-26
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• 2003

Analysis of benthic macroinvertebrate community and biological estimation of water quality was conducted at the national park of Mt. Jiri and its nearby area in Gurye, Sancheong and Hadong-gun from June to November, 2002. Total taxa of benthic macroinvertebrates were 124 species, 45 families, 15 orders, 5 classes in 3 phyla. Aquatic insects were 33 species in ephemeroptera, 28 species in Trichoptera, 21 species in plecoptera, 13 species in Diptera, 8 species in odonata, 5 species in hemiptera and 5 species in coleoptera, respectively. Non-insects were 5 species in Mollusca, 2 species in Hirudinea, 1 species in oligochaeta and 1 species in crustacea, respectively. Ephemeroptera, trichoptera and plecoptera as indicators in clean water were very abundant. Occurrence species at each survey area was 68 species at Mt. 1025-goji, 59 species at Mt. Eungseok-bong, 57 species at Mt. Wangdeung-jae, 50 species at Mt. Cheonwang-bong and 39 species at Mt. 645-goji, respectively. Mean species diversity indices at Mt. Cheonwang-bong, Mt. 1025-goji, Mt. Wangdeung-jae, Mt. Eungseok-bong and Mt. 645-goji were 3.33, 3.03, 3.41, 3.02 and 2.91, respectively, According to the saprobic system based on the species diversity indices of benthic macroinvertebrates, most survey areas except some sites are determined as Limnosaprobic area.

• Journal of Korean Society of Water and Wastewater
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• v.21 no.3
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• pp.295-303
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• 2007

Nitrogen compounds in municipal wastewater can be divided into biodegradable and nonbiodegradable fractions with biodegradability. Biodegradable nitrogen compounds can be removed through biological nitrification and denitrification processes, and nonbiodegradable nitrogen compounds affect the effluent quality of biological nutrient removal processes. The amount of nitrifiable nitrogen compounds, which are the sum of ammonia and biodegradable organic nitrogen, has been estimated by respirometry. Respirometry shows good estimation of the concentration of nitrifiable nitrogen when a synthetic sample of ammonium chloride is dosed. The estimated concentration of nitrifiable nitrogen compounds in municipal wastewater is close to ammonia concentration in municipal wastewater, but it is lower than that for the synthetic sample. If nitrogen assimilated into cell synthesis of nitrifiers and heterotrophs is considered, the total amounts of nitrifiable nitrogen compounds, which are nitrified and assimilated, could be more accurately estimated. The concentration of nitrifiable nitrogen compounds, which are biodegradable, is about 31 mg N/l, and this is 119% of ammonia and 94% of total nitrogen. Ammonia, nitrate, biodegradable organic nitrogen, and nonbiodegradable nitrogen are about 79%, 1%, 15%, and 5% of the total nitrogen in municipal wastewater, respectively.

• Journal of Biomedical Engineering Research
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• v.32 no.3
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• pp.264-269
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• 2011

To increase therapeutic efficiency and biological safety, it is important to precision control of acoustic output for therapeutic ultrasound equipment. In this paper, the electro-acoustic radiation conductance, one of electroacoustic characteristics of therapeutic ultrasound equipment, was measured by the radiation force balance method according to IEC 61161 standards and the acoustic output was estimated using the electro-acoustic radiation conductance. The estimation of acoustic output was conducted to continuous wave mode and pulse wave mode of duty cycle between 20% and 80%. The differences between prediction values and measurement results are within 5% of measurement uncertainty, which is a reasonably good agreement. The results show that acoustic output controlled by electro-acoustic radiation conductance was found to be an effective method.

• Journal of Biomedical Engineering Research
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• v.31 no.4
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• pp.285-291
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• 2010

Recently, advance on various modalities of diagnosing, prostate volume estimation became possible not only by the existing two-dimension medical images data but also by the three-dimensional medical images data. In this study, magnetic resonance image (MRI), computer tomography (CT) and ultrasound (US) were employed to evaluate prostate phantom volume measurements for estimation, comparison and analysis. For the prostate phantoms aimed at estimating the volume, total of 17 models were developed by using devils-tongue jelly and changing each of the 5ml of capacity from 20ml to 100ml. For the volume estimation through 2D US, the calculation of the diameter with C9-5Mhz transducer was conducted by ellipsoid formula. For the volume estimation through 3D US, the Qlab software (Philips Medical) was used to calculate the volume data estimated by 3D9-3Mhz transducer. Moreover, the images by 16 channels CT and 1.5 Tesla MRI were added by the method of continuous cross-section addition and each of imaginary prostate model's volume was yielded. In the statistical analysis for comparing the availability of volume estimation, the correlation coefficient (r) was more than 0.9 for all indicating that there were highly correlated, and there were not statistically significant difference between each of the correlation coefficient (p=0.001). Therefore, the estimation of prostate phantom volume using three-dimensional modalities of diagnosing was quite closed to the actual estimation.

• Journal of Korean Society on Water Environment
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• v.23 no.4
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• pp.474-481
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• 2007

With population growth, industrialization, and urbanization within the watershed, the hydrologic response changed dramatically, resulting in increases in peak flow with lesser time to peak and total runoff with shortened time of concentration. Infiltration is directly affected by initial soil moisture condition, which is a key element to determine runoff. Influence of the initial soil moisture condition on hydrograph analysis should be evaluated to assess land use change impacts on runoff and non-point source pollution characteristics. The Long-Term Hydrologic Impact Assessment (L-THIA) model has been widely used for the estimation of the direct runoff worldwide. The L-THIA model was applied to the Little Eagle Creek (LEC) watershed and Its estimated direct runoff values were compared with the BFLOW filtered direct runoff values by other researchers. The $R^2$ value Was 0.68 and the Nash-Sutcliffe coefficient value was 0.64. Also, the L-THIA estimates were compared with those separated using optimized $BFI_{max}$ value for the Eckhardt filter. The $R^2$ value and the Nash-Sutcliffe coefficient value were 0.66 and 0.63, respectively. Although these higher statistics could indicate that the L-THIA model is good in estimating the direct runoff reasonably well, the Antecedent Moisture Condition (AMC) was not adjusted in that study, which might be responsible for mismatches in peak flow between the L-THIA estimated and the measured peak values. In this study, the L-THIA model was run with AMC adjustment for direct runoff estimation. The $R^2$ value was 0.80 and the Nash-Sutcliffe coefficient value was 0.78 for the comparison of L-THIA simulated direct runoff with the filtered direct runoff. However there was 42.44% differences in the L-THIA estimated direct runoff and filtered direct runoff. This can be explained in that about 80% of the simulation period is classified as 'AMC I' condition, which caused lower CN values and lower direct runoff estimation. Thus, the coefficients of the equation to adjust CN II to CN I and CN III depending on AMC condition were modified to minimize adjustments impacts on runoff estimation. The $R^2$ and the Nash-Sutcliffe coefficient values increase, 0.80 and 0.80 respectively. The difference in the estimated and filtered direct runoff decreased from 42.44% to 7.99%. The results obtained in this study indicate the AMC needs to be considered for accurate direct runoff estimation using the L-THIA model. Also, more researches are needed for realistic adjustment of the AMC in the L-THIA model.

• Journal of Biomedical Engineering Research
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• v.22 no.3
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• pp.293-301
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• 2001

A patient-specific musculoskeletal model, whose parameters can be identified noninvasively, was developed for the automatic generation of patient-specific stimulation pattern in FES. The musculotendon system was modeled as a torque-generator and all the passive systems of the musculotendon working at the same joint were included in the skeletal model. Through this, it became possible that the whole model to be identified by using the experimental joint torque or the joint angle trajectories. The model parameters were grouped as recruitment of muscle fibers, passive skeletal system, static and dynamic musculotendon systems, which were identified later in sequence. The parameters in each group were successfully estimated and the maximum normalized RMS errors in all the estimation process was 8%. The model predictions with estimated parameter values were in a good agreement with the experimental results for the sinusoidal, triangular and sawlike stimulation, where the normalized RMS error was less than 17%, Above results show that the suggested musculoskeletal model and its parameter estimation method is reliable.