• 생물정신의학
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• 제8권1호
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• pp.47-52
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• 2001

It is known that the personality is the crucial factor in the treatment outcome of depression. The authors tried to identify the results of such studies and various components which determine the treatment outcome of depression. Nearly 60 papers published between the year 1990 and 2000 about the treatment of depression and personality were reviewed. Among them about 30 papers were selected to compare the research methods, results and discussions. The arguments and critics of the papers were discussed. In the many debates, the authors admitted the fact that premorbid personality trait influences the treatment outcome of depression negatively regardless of treatment method. Subtyping of depression is feasible along the presence of good or bad predictors of treatment outcome for depression. Differentiation of depression and personality seems to have no problem, however test of personality state before the development of psychiatric disorder such as depression is not amenable. For example, cluster A personality trait is often misunderstood as depression in clinical setting. In some cases cognitive behavioral therapy is effective in the treatment of depression accompanying personality disorder. The authors insist that the analysis of personality in the dimensional aspect rather than in the categorical aspect gives more information in the research of personality influencing the treatment outcome of depression. In addition, the reason why we understand the relationship between depression and personality were discussed.

• 대한약침학회지
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• 제18권3호
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• pp.11-18
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• 2015

Objectives: Systems biology is a novel subject in the field of life science that aims at a systems' level understanding of biological systems. Because of the significant progress in high-throughput technologies and molecular biology, systems biology occupies an important place in research during the post-genome era. Methods: The characteristics of systems biology and its applicability to traditional medicine research have been discussed from three points of view: data and databases, network analysis and inference, and modeling and systems prediction. Results: The existing databases are mostly associated with medicinal herbs and their activities, but new databases reflecting clinical situations and platforms to extract, visualize and analyze data easily need to be constructed. Network pharmacology is a key element of systems biology, so addressing the multi-component, multi-target aspect of pharmacology is important. Studies of network pharmacology highlight the drug target network and network target. Mathematical modeling and simulation are just in their infancy, but mathematical modeling of dynamic biological processes is a central aspect of systems biology. Computational simulations allow structured systems and their functional properties to be understood and the effects of herbal medicines in clinical situations to be predicted. Conclusion: Systems biology based on a holistic approach is a pivotal research methodology for understanding the mechanisms of traditional medicine. If systems biology is to be incorporated into traditional medicine, computational technologies and holistic insights need to be integrated.

• 대기
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• 제31권3호
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• pp.295-309
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• 2021

Diurnal variations of air temperature and relative humidity in the Urban Canopy Layer (UCL) of the Seoul metropolitan area are examined using the Weather Research and Forecasting model coupled with the Seoul National University Urban Canopy Model. The canopy layer air temperature is higher than 2-m air temperature and exhibits a more rapid rise and an earlier peak in the daytime. These result from the multiple reflections of shortwave radiation and longwave radiation trapping due to the urban geometry. Because of the absence of vegetation in the UCL and the higher canopy layer air temperature, the canopy layer relative humidity is lower than 2-m relative humidity. Additional simulations with building height changes are conducted to examine the sensitivities of the canopy layer meteorological variables to the urban canyon aspect ratio. As the aspect ratio increases, net sensible heat flux entering the UCL increases (decreases) in the daytime (nighttime). However, the increase in the volume of the UCL reduces the magnitude of change rate of the canopy layer air temperature. As a result, the canopy layer air temperature generally decreases in the daytime and increases in the nighttime as the aspect ratio increases. The changes in the canopy layer relative humidity due to the aspect ratio change are largely determined by the canopy layer air temperature. As the aspect ratio increases, the canopy layer relative humidity is generally increased in the daytime and decreased in the nighttime, contrary to the canopy layer air temperature.

• 융합보안논문지
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• 제12권2호
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• pp.99-106
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• 2012

2010년 3월 11일 대한민국 동해를 건너 위치한 일본에서 강진과 해일로 인하여 후쿠시마원전이 중단되고 폭발하여 방사능물질이 누출되었다. 한 국가에서 발생한 사고지만 누출된 방사능 물질은 해류와 기류를 타고 전 세계에 확산되었다. 국내에도 사고 이후 방사능비가 내린다는 공포심에 혼란이 있었고, 사고 발생 1년이 지나도 방사능오염에 대한 문제는 해결되지 않고 있다. 즉 이웃나라의 원전사고는 국내에도 큰 위협이 되는데 일본 뿐 만 아니라 서해 건너 중국해변에도 원자력발전소가 위치하고 있다. 이웃나라의 원전사고 위협이외 군사적 대치를 하고 있는 북한은 세계3위의 생화학무기 보유국이며 2010년 11월에는 연평도 포격도발을 하는 등 언제든 남한에 생화학물질을 살포 할 수 있는 상황이다. 본 연구는 이러한 위협에 대응하는 전략으로 기상조절기술인 인공강우기술을 접목해 보았다. 원전사고시 방사능물질과 북한의 생화학무기는 기상조건에 따라 농도가 달라 질 수 있으므로 인공강우기술만으로 완벽하게 위협을 제거할 수 없지만, 심리적 측면과 피해저감을 위한 방법으로 시도해 볼 가치가 있다. 국민안전확보를 위한 국가의 안보측면으로서 인공강우기술을 사용하기 위해서는 ADD와 같은 연구기관에서 상시적이고 적극적으로 기술연구개발을 해야 할 것이다.

• 정신신체의학
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• 제3권1호
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• pp.91-97
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• 1995

Pain is a complex symptom consisting of a sensation underlying potenial disease and associated emotional state. Acute pain is a reflex biological response to injury, in contrast, chronic pain consists of pain of a mininum of 6 months duration and associates with physical, emotional past experience, economic resources of the patient, family and society. Moreover, chronic pain is characterized by physiological affective and behavioral responses that are quite different than those of acute pain. The different type of stimuli exciting pain receptor are mechanical, thermal and chemical stimli and chronic pain are concerned with three of all stimli. The major three components of pain central(Analgesia) system in the brain and spinal cord are 'periaqueductal gray area of the mesencephalon', 'the raphe magnus nucleus' and 'pain inhibitory complex located in the dorsal horns of the spinal cord'. But unfortunately, the central biochemical mechanisms of chronic pain are not clearly defined. To proper management of chronic pain, comprehensive urderstanding as a psychosomatic aspect and multidisciplinary therapeuti-team approach must be emphasized.

• International Journal of Industrial Entomology and Biomaterials
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• 제4권2호
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• pp.117-120
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• 2002

Scelionid eggParasitoids Play an important role in biological control of some economically important pentatomids. Stink bug (Canthecona furcellatta Wolff,) is an important predator of Tasar silkworm larvae (Antheraea mylitta D.) and causes 30-40 percent loss in tasar silk industry. Psix striaticeps (Scelionid: Hymenoptera) has been found to be an important egg parasitoid. The parasitization potential of f striaticeps is mere than 60 percent and the sex ratio is female oriented. Studies indicate that the maintenance of existing scelionid population by avoiding harmful practices and the augmentation of scelionids either directly releasing them in the field or by indirectly making the field environment more favorable for them is an important aspect to control the pentatomid population in sericulture. Female bias sex ratio is advantageous to increase the parasitoid population in the field. 24-hour-old egg of stink bug and one-day old parasitoid is suitable for producing maximum progeny. 1 : 30 of parasitoid: host ratio is needed to regulate the estimated population in silkworm rearing field.

• 한국재료학회:학술대회논문집
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• 한국재료학회 2009년도 춘계학술발표대회
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• pp.47.1-47.1
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• 2009

Nanostructured biomaterials have increased those potential for utilizing in many medical applications. In this study, benefit of nanotechnology for the response with biological targets will be described in terms of size, effective surface area and surface energy (physical aspect). Also, correlations between physical and biological interactions (greater protein adsorption on nano surface roughness) will be discussed for understanding biocompatibility of nanostructured biomaterials including carbon nanotube composites and nanostructured titanium surfaces. In the application parts, various major tissue cells, such as bone, cartilage, vascular and bladder cell responses will be discussed with suggested nanomaterials. Lastly, immune responses with macrophage (adhesion and several major cytokines) on nanostructured biomaterials will be described for evasive immune response.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1997년도 추계학술대회
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• pp.369-372
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• 1997

Socket pressure distributions with gait analyses of a transfemoral and a transtibial prostheses were measured in order to assess an optimal socket fitting and unction. Ankle joint was aligned by the neutral and the dorsi/plantar flexed positions. Compared to dorsi and plantar flexed positions of ankle joint, cadence and walking speed increased with the neutral ankle joint alignment. Other gait parameters were close to the normative data with the neutral ankle joint alignment. For the transfemoral amputee, dorsiflexed alignment of the ankle joint created high pressure on the lateral aspect of the socket, on the other hand, plantarflexed alignment resulted in increased pressure on the medial aspect of the socket. For the transtibial amputee, dorsiflexed alignment of the ankle resulted in high pressure on the antero-lateral aspect of the socket during mid-stance, but plantarflexion of the ankle joint showed slight increases in pressure at the same location in the socket. The present study clearly demonstrated that malalignment of a prosthesis results in localized increasing pressure within the socket. Proper alignment of the prosthesis is required in order to acquire an appropriate socket-limb interface as well as the proper gait.

• 대한의용생체공학회:의공학회지
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• 제30권6호
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• pp.453-460
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• 2009

In this review paper, concepts in optofluidics are applied to an advanced manufacturing technology based on self-assembled microparts. The "optical" aspect of optofluidics will be described in the context of photolithography, and the "fluidic" aspect will be discussed in the context of self-assembly. First, optofluidic maskless lithography will be introduced as a dynamic fabrication method to generate microparticles in microfluidic channels. Next, the history and application of optofluidic lithography will be presented.

• Journal of Microbiology and Biotechnology
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• 제26권9호
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• pp.1505-1516
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• 2016

The detection of food pathogens is an important aspect of food safety. A range of detection systems and new analytical materials have been developed to achieve fast, sensitive, and accurate monitoring of target pathogens. In this review, we summarize the characteristics of selected nanomaterials and their applications in food, and place focus on the monitoring of biological and chemical contaminants in food. The unique optical and electrical properties of nanomaterials, such as gold nanoparticles, nanorods, quantum dots, carbon nanotubes, graphenes, nanopores, and polydiacetylene nanovesicles, are closely associated with their dimensions, which are comparable in scale to those of targeted biomolecules. Furthermore, their optical and electrical properties are highly dependent on local environments, which make them promising materials for sensor development. The specificity and selectivity of analytical nanomaterials for target contaminants can be achieved by combining them with various biological entities, such as antibodies, oligonucleotides, aptamers, membrane proteins, and biological ligands. Examples of nanomaterial-based analytical systems are presented together with their limitations and associated developmental issues.