• Polymer(Korea)
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• v.31 no.4
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• pp.329-334
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• 2007

Osmotic pellet system, which is one of the oral drug delivery systems, has been developed to improve manufacturing process, reduce product cost and other problems of osmotic tablet systems. Osmotic pellet is consisted of water swellable seed layer, drug layer, and membrane layer. Among them, the membrane layer plays an important role in a control of the drug release. In this work, we examined the effect of ratio for Eudragit RL and RS on the drug release behavior. Osmotic pellet with nifedipine as a model drug was easily obtained in a good yield by fluidized bed coater. Osmotic pellet showed round morphology with a range of size $1300{\sim}1500\;{\mu}m$. In the experiment of nifedipine release, the release amount increased with the increase of the ratio of Eudragit. This is due to the fact that Eudragit RL contains more hydrophilic quaternary ammonium group than Eudragit RS. Additionally, the release amount was retarded with increasing the membrane thickness. There are no differences in the release amount measured at the different pH 1.2, 6.5, 6.8, and 7.2. In conclusion, it was found that the drug release from osmotic pellets depended on the composition ratio and coating thickness of membrane layer.

• Journal of the Korean Society of Food Science and Nutrition
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• v.37 no.10
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• pp.1231-1237
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• 2008

This study was conducted to investigate the functional biological effects of hot water and ethanol extracts from Taraxacum mongolicum (TM). Then, the hot water and ethanol extracts of TM were measured for total flavonoids content, total phenolics content, electron donating ability, nitrite-scavenging ability, SOD-like activity, tyrosinase inhibitory effect, and elastase inhibitory effect. Total flavonoids contents of hot water and ethanol extracts from TM were 7.80$\pm$0.97 mg/g and 9.12$\pm$0.51 mg/g, respectively, and total phenolics contents were estimated as 54.20$\pm$1.95 mg/g for water extract and 79.43$\pm$4.44 mg/g for ethanol extract. The $RC_{50}$ values for electron donating ability of hot water and ethanol extracts were 943.98 $\mu$g/mL and 309.41 $\mu$g/mL. SOD-like activity and nitrite-scavenging ability were dependent on concentration of hot water and ethanol extracts, and the activity of ethanol extract was higher than that of hot water extract. However, hot water and ethanol extracts from TM showed no inhibitory activities on the elastase and tyrosinase inhibitory activities. Based on the above results, the ethanol extract of TM seems to be the most pertinent for use as functional food and cosmetic.

• Journal of Bio-Environment Control
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• v.17 no.1
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• pp.26-31
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• 2008

This experiment were conducted to investigate the response of growth and yield of potato after transplanting of plug seedlings 'Superior' and 'Dejima' produced at different plug cell size (105, 162, and 288) and photoperiod (8/16, 12/12, and 16/8, day/night) for 20 days in controlled plant growth system. Growth and relative growth rate of plug seedling 'Superior' was affected by plug cell size and photoperiod at 7weeks after transplanting. Tuber weight of 'Superior' was increased as cell size and photoperiod increased. That of 'Dejima' was highest in 105 cell and different with photoperiod. At 90 days after transplanting, tuber weight ($258.9{\sim}471.9\;g/plant) of 'Superior' was high in 105 and 162 cell size and 16/8 hr photoperiod. That ($278.2{\sim}428.0\;g/plant$) of 'Dejima' was high in 105 cell size, but was not different with photoperiod. The number of tuber per plant was $2.6{\sim}6.9$ of 'Superior' and $2.2{\sim}3.6$ 'Dejima'. Tuber number per plant was not significantly different with cell size and photoperiod. The large tuber over 80 g was $32.0{\sim}50.9%$ of 'Superior' and $41.0{\sim}56.7%$ of 'Dejima'. The large tuber in 'Superior' and 'Dejima' lowered as the cell size decreased. The large tuber of 'Superior' increased as photoperiod increased, but that of 'Dejima' was not differed. As the results, the optimal plug cell size and photoperiod of potato seedling is considered to be below 162 cell and over 12 hr of photoperiod.

• Food Science and Preservation
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• v.13 no.4
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• pp.483-489
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• 2006

Considering the development of fusion ingredients rom red ginseng and Cheonggukjang (soybean-fermented food), their commercial powders were evaluated in their Hunter's colors, volatile compounds, and sensory properties depending on manufacturing companies and mixing ratio of both powdered products. Hunters L, a and b values of red ginseng powders were $75.56\sim85.50,\;1.90\sim6.30,\;and\;23.29\sim35.08$, respectively, while those of Cheonggukjang powders were $64.96\sim71.69,\;4.64\sim8.30,\;and\;30.45\sim36.50$, respectively. Volatile compounds were mainly composed of hexanal, $\beta-pinene$, methyl benzene, 3,5-methyl propyl nonane, 2-propanone, decane, and 2,8-dimethyl undecane in red ginseng samples, and of 2,3-butanedione, decane, 2,2,7,7-tetramethyl octane, and 3-methyl butanal in Cheonggukjang samples. Total volatiles of the mixed samples decreased as ginseng decreased and Cheonggukjang increased. The mixed sample of both red ginseng and cheonggukjang in same amounts was the highest in its sensory acceptability, which was composed in the order of 2-propanone, 2-butanone, pentane, hexanal and 3-methyl butanal. The above results indicate that red ginseng and Cheonggukjang showed a potential as fusion ingredient for preparing new functional produce through further processing.

• Journal of the Korean Crystal Growth and Crystal Technology
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• v.17 no.4
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• pp.151-155
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• 2007

Quasi-phase-matched (QPM) second harmonic generation (SHG) waveguide devices for a green light generation were fabricated by a periodically patterned electrode on the +Z crystal surface and homogeneous LiCl solution using a 5 mol% MgO doped congruent z-cut lithium niobate crystals. Using selective chemical etching, we confirmed the periodic (${\sim}6.8{\mu}m$) domain inverted structure and measured SHG properties of fabricated periodically poled MgO : $LiNbO_3$ ridge-type waveguides.

• Proceedings of the Korean Society for Agricultural Machinery Conference
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• 2017.04a
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• pp.145-145
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• 2017

농작업 자세 중에서 중량물을 반복적으로 들고 내리는 자세는 요통과 같은 근골격계 질환의 유발행위로 분류된다. 이는 인간공학적 유해요인 평가도구에 의해 위험도 별로 정량화 할 수 있다. 이러한 평가방법은 농작업 자세를 개선하여 근골격계 질환을 예방할 수 있다는 측면에서 매우 중요하다. 그러나 기존의 작업자세 부하 평가방법들은 동적 자세를 평가하는데 있어 어려움이 있을 뿐 만 아니라 평가 과정에서 관찰자의 주관성이 개입 될 수 있다는 한계점을 갖고 있다. 이에 본 연구에서는 중량물을 들고 내리는 동적 자세에서 발생하는 부하를 Energy expenditure를 이용하여 평가할 수 있는 시스템을 개발하는 것이다. Energy expenditure는 체중, 성별 등과 같은 작업자 관련 변수와 중량물의 무게, 들어 올리는 높이, 빈도수 등과 같은 작업환경 관련 변수를 이용하여 최대 산소소비량을 예측하는 방법이다. 본 연구에서 제안하는 작업자 및 작업환경 관련 변수를 자동 측정하는 시스템은 초음파 거리측정 센서와 깔창 형태의 센서를 이용하여 구성하였다. 이를 통해 남성(6명), 여성(6명)을 대상으로 20kg의 중량물을 들고 내리는 동작에서 발생하는 Energy expenditure 값을 산출하였고, 산소소비량 측정 장비를 통해 획득된 최대 산소소비량($VO_2$)과 비교하여 검증하였다. 여성을 대상으로 한 Energy expenditure 값과 최대 산소소비량 간 상관관계는 0.984로 나타났으며, 남성의 경우에는 0.998로 높은 상관관계를 보였다. 이와 같은 에너지 대사율 평가시스템은 연속적이고 반복적인 실제 농작업 자세 부하를 동적인 상태에서 평가할 수 있을 뿐 만 아니라 산소소비량 측정기와 같은 추가적인 장비가 필요하지 않아 현장 적용성이 뛰어 날 것으로 기대된다.

• Journal of Biosystems Engineering
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• v.31 no.2 s.115
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• pp.121-127
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• 2006

An Altari radish pre-processing system, which feasible to process automatically such operations as leaf and root tail cutting and root peeling, for kimchi production was accomplished based on the foregone serial studies. In this study, the performances of the developed prototype machine, considered as a commercializing level, were analyzed and evaluated. The prototype machine attached Tiny PLC automatic control system was performed the sequent function as the rate of successful peeling was more than 98% for the Altari radish less than 70 mm diameter of a radish. The operating efficiency of this was 9 see/each, 128 kg/h, and it means as much as $5{\sim}6$ times that of a woman labor's. The sanitation and taste of the mechanized-processed Altari radish kimchi was almost same as that of the handmade. And they were suitable for manufactory of kimchi as the both short term ripening and storing kimchi. Developed machinery with one peeling device and two peeling devices that compared with hand processing, it was analyzed that the break-even yearly working days were 28 days and 19 days, and the break-even yearly processing amount were 28,700 kg, 32,400 kg, respectively.

• Journal of Pharmaceutical Investigation
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• v.37 no.4
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• pp.229-235
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• 2007

Multi-layered granules were prepared by a fluidized-bed coater and uniformed granules were obtained with a size range between $950{\sim}1000{\mu}m$ in diameter. The granule system was composed of three layers, i.e. seed layer with sugar sphere bead and a water-swellable polymer, middle layer with a drug, solubilizer and polymer, and the top layer of porous membrane with a polymeric binder. The aim of this work is to find out the dependence of a drug dissolution rate on the amount of a water-soluble binder and a solubilizer in the granule system. The results showed that the higher amount of hydrophilic binder in the porous membrane, gave the bigger pore size and porosity and made faster dissolution rate and also the higher amount of solubilizer in drug layer enhanced the dissolution rate of drug.

• Journal of the Korean Society of Food Science and Nutrition
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• v.38 no.1
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• pp.32-38
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• 2009

In this study, we investigated the anti-obesity activity of the herbal extract mixture (HEM). The inhibitory effect of HEM on triglyceride accumulation of 3T3-L1 preadipocyte was examined by Oil-Red O staining. HEM inhibited the triglyceride accumulation of 3T3-L1 preadipocyte cell and reduced glycerol-3-phosphate dehydrogenase (GPDH) activity. We further investigated the effect of HEM in prevention of obesity in male ICR mouse for 5 weeks. Experimental groups were divided into high fat diet group (HFD), HFD supplemented with 100 mg/kg HEM group (HEM1) and HFD supplemented with 200 mg/kg HEM group (HEM2). Body weight and food efficiency ration of HEM1 and HEM2 was decreased by 52% and 50% and by 45% and 50%, respectively. The amount of adipocyte in body weight was decreased. Blood triglyceride and total cholesterol of HEM1 was significantly decreased. These results indicate that HEM may be useful in preventing obesity.

• Journal of Biomedical Engineering Research
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• v.37 no.2
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• pp.68-74
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• 2016

In this study, we investigated the rotational characteristics which were comprised of directionality and linearity of target registration error (TRE) as a study in advance to enhance the accuracy of contour-based registration in neuronavigation. For the experiment, two rigid head phantoms that have different faces with specially designed target frame fixed inside of the phantoms were used. Three-dimensional coordinates of facial surface point cloud and target point of the phantoms were acquired using computed tomography (CT) and 3D scanner. Iterative closest point (ICP) method was used for registration of two different point cloud and the directionality and linearity of TRE in overall head were calculated by using 3D position of targets after registration. As a result, it was represented that TRE had consistent direction in overall head region and was increased in linear fashion as distance from facial surface, but did not show high linearity. These results indicated that it is possible for decrease TRE by controlling orientation of facial surface point cloud acquired from scanner, and the prediction of TRE from surface registration error can decrease the registration accuracy in lesion. In the further studies, we have to develop the contour-based registration method for improvement of accuracy by considering rotational characteristics of TRE.