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http://dx.doi.org/10.3746/jkfn.2009.38.1.032

The Effects of Herbal Extract Mixture on Anti-Obesity  

Chin, Hwi-Seung (R&D Center, Jung San Bio Technology)
Pack, Keum-Ju (R&D Center, Jung San Bio Technology)
Pack, Seung-Hee (R&D Center, Jung San Bio Technology)
Kim, Jae-Ki (R&D Center, Jung San Bio Technology)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.38, no.1, 2009 , pp. 32-38 More about this Journal
Abstract
In this study, we investigated the anti-obesity activity of the herbal extract mixture (HEM). The inhibitory effect of HEM on triglyceride accumulation of 3T3-L1 preadipocyte was examined by Oil-Red O staining. HEM inhibited the triglyceride accumulation of 3T3-L1 preadipocyte cell and reduced glycerol-3-phosphate dehydrogenase (GPDH) activity. We further investigated the effect of HEM in prevention of obesity in male ICR mouse for 5 weeks. Experimental groups were divided into high fat diet group (HFD), HFD supplemented with 100 mg/kg HEM group (HEM1) and HFD supplemented with 200 mg/kg HEM group (HEM2). Body weight and food efficiency ration of HEM1 and HEM2 was decreased by 52% and 50% and by 45% and 50%, respectively. The amount of adipocyte in body weight was decreased. Blood triglyceride and total cholesterol of HEM1 was significantly decreased. These results indicate that HEM may be useful in preventing obesity.
Keywords
anti-obesity; 3T3-L1; GPDH; body weight; food efficiency ration;
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