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The Effect of Drug Release from Osmotic Pellet Related to the Various Ratio of $Eudragit^{(R)}$ RL and RS  

Youn, Ju-Yong (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University)
Ku, Jeong (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University)
Lee, Soo-Young (Fusion Bio Research Center, Korea Research Institute of Chemical Technology)
Kim, Byung-Soo (Fusion Bio Research Center, Korea Research Institute of Chemical Technology)
Kim, Moon-Suk (Fusion Bio Research Center, Korea Research Institute of Chemical Technology)
Lee, Bong (Department of Polymer Engineering, Pukyung National University)
Khang, Gil-Son (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University)
Lee, Hai-Bang (Fusion Bio Research Center, Korea Research Institute of Chemical Technology)
Publication Information
Polymer(Korea) / v.31, no.4, 2007 , pp. 329-334 More about this Journal
Abstract
Osmotic pellet system, which is one of the oral drug delivery systems, has been developed to improve manufacturing process, reduce product cost and other problems of osmotic tablet systems. Osmotic pellet is consisted of water swellable seed layer, drug layer, and membrane layer. Among them, the membrane layer plays an important role in a control of the drug release. In this work, we examined the effect of ratio for Eudragit RL and RS on the drug release behavior. Osmotic pellet with nifedipine as a model drug was easily obtained in a good yield by fluidized bed coater. Osmotic pellet showed round morphology with a range of size $1300{\sim}1500\;{\mu}m$. In the experiment of nifedipine release, the release amount increased with the increase of the ratio of Eudragit. This is due to the fact that Eudragit RL contains more hydrophilic quaternary ammonium group than Eudragit RS. Additionally, the release amount was retarded with increasing the membrane thickness. There are no differences in the release amount measured at the different pH 1.2, 6.5, 6.8, and 7.2. In conclusion, it was found that the drug release from osmotic pellets depended on the composition ratio and coating thickness of membrane layer.
Keywords
osmotic pellet; fluidized bed coater; Eudragit RL; Eudragit RS; drug release;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 5  (Related Records In Web of Science)
Times Cited By SCOPUS : 3
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