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http://dx.doi.org/10.4333/KPS.2007.37.4.229

Controlled Release of Nifedipine in Multi-layered Granule System  

Lee, Soo-Young (Fusion Bio Research Center, Korea Research Institute of Chemical Technology)
Youn, Ju-Yong (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University)
Kim, Byung-Soo (Fusion Bio Research Center, Korea Research Institute of Chemical Technology)
Kim, Moon-Suk (Fusion Bio Research Center, Korea Research Institute of Chemical Technology)
Lee, Bong (Department of Polymer Engineering, Pukyong National University)
Khang, Gil-Son (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University)
Lee, Hai-Bang (Fusion Bio Research Center, Korea Research Institute of Chemical Technology)
Publication Information
Journal of Pharmaceutical Investigation / v.37, no.4, 2007 , pp. 229-235 More about this Journal
Abstract
Multi-layered granules were prepared by a fluidized-bed coater and uniformed granules were obtained with a size range between $950{\sim}1000{\mu}m$ in diameter. The granule system was composed of three layers, i.e. seed layer with sugar sphere bead and a water-swellable polymer, middle layer with a drug, solubilizer and polymer, and the top layer of porous membrane with a polymeric binder. The aim of this work is to find out the dependence of a drug dissolution rate on the amount of a water-soluble binder and a solubilizer in the granule system. The results showed that the higher amount of hydrophilic binder in the porous membrane, gave the bigger pore size and porosity and made faster dissolution rate and also the higher amount of solubilizer in drug layer enhanced the dissolution rate of drug.
Keywords
Multi-layered granule; Nifedipine; Fluidized-bed coater; Porous membrane; Solubilizer; Binder;
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Times Cited By KSCI : 2  (Citation Analysis)
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