• 인터넷정보학회논문지
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• 제21권3호
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• pp.71-81
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• 2020

디지털바이오헬스케어 산업은 문재인 정부의 3대 중점육성산업의 하나이다. 본 연구의 목적은 디지털바이오헬스케어산업의 연관 산업에 대한 파급효과와 투자효과를 비교분석하는 것이다. 디지털바이오헬스케어산업의 연관산업에 대한 파급효과를 분석하는 것은 산업 및 기술개발 정책의 수립에 매우 중요하다. 연구방법은 첫째, 표준산업분류 상의 33개 산업을 재분류하여 35개 산업대분류표로 재작성하였다. 둘째, 산업연관표의 분석틀을 활용하여 각종 유발계수와 파급효과계수들을 재작성하였다. 셋째, 디지털바이오헬스케어산업의 생산, 투자, 부가가치, 일자리부문에서 연관산업에 대한 파급효과를 비교하였다. 넷째, 투자효과측면에서 자체산업과 연관 산업과의 효과를 비교하였다. 이 연구의 결과가 산업정책 및 기술개발정책 수립에 용이하게 활용되기를 기대한다.

• 기술경영경제학회:학술대회논문집
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• 기술경영경제학회 2002년도 제21회 하계학술발표회 논문집
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• pp.157-179
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• 2002

Many advanced scholars and policy makers say that biotechnology is and will be the most important technology in 21th century. And biotechnology has a lots of character which are new and high tech industry, costing too much on early R&D stage and so on. One of them is that it can't be developed all seater by one single firm. So effective and efficient way to solve this generic problem is using the infrastructure which is given by government for flourishing the bio industry, especially, Knowledge infrastructure. The purpose of this study is to understand and give the information about which knowledge infrastructure affects biotechnology firms to obtain competitive advantage in technological improvement. To develop this object, I made 5 variables about infrastructure in biotechnology such as high-skilled researchers infrastructure, R&D policy infrastructure, industrialization infrastructure that supports the biotechnology industry, networking infrastructure between firms, universities, research centers, and finally bio-safety infrastructure. According to this study, to obtain technological competitive advantage for Korean bio firms, all main actors those are government, industry, university, research center they try to develop bio sector at the same time. After this cooperated effort, Korean bio firms and industry can get a international competitiveness in the global society which no one conquer the market.

• 수산해양기술연구
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• 제51권2호
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• pp.221-226
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• 2015

During the study periods, total 143 individuals of Lateolabrax japonicus were collected. Body length (BL) range was 2.0-11.8 cm. Empty stomach occurred in 8.4%. The most abundant prey was copepods. Among copepods, Tigriopus japonicus was the most abundant prey appeared 32.1 in %F. Next important prey was shrimps and mysids. The results of analysis in ontogenetic changes, main prey of two small size classes (2.0-3.9 cm, 4.0-5.9 cm) were copepods. Thereafter, copepods percentage was decreased, but shrimps, mysids, fishes percentage was increased by increasing body length from 8.0 cm< size class.

• 한국식품저장유통학회지
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• 제14권4호
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• pp.419-424
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• 2007

하우스 포도 중 대표적인 것으로는 거봉, 델라웨어, 캠벨, 청포도를 열거할 수 있는데, 이에 대한 생물학적 활성 효과 중 항산화와 항암 활성에 대한 보고는 많으나 면역활성에 대한 활성의 연구는 미흡한 실정이다. 이에 우리는 4종의 포도의 메탄올 추출물로 항산화, 항암, 그리고 면역활성을 분석하였다. 전자공유능을 측정하기 위한 DPPH를 이용한 실험 결과 포도 4종에서 모두 항산화 활성을 나타내었으며, 환원력을 알아보기 위한 FRAP 실험 또한 활성을 나타내었다. 산화스트레스에 의한 세포사멸 억제 효과는 약간 있는 것으로 나타났다. 반면에 포도 추출물에 의한 cell proliferation 활성은 증가하는 것으로 나타났다. Nitric oxide (NO) 생성 억제 실험에서는 LPS에 의해 유도된 NO의 활성을 감소시키지는 않으나 포도 추출물 자제가 Raw 264.7 세포에서 NO의 활성을 유도하는 것으로 나타났다. Wound healing assay를 이용하여 항암효과를 알아본 결과 포도추출물 4종에서 세포의 운동성을 억제하는 효과를 가지는 것으로 나타났다. Mouse primary spleen cell 에서의 cytokine IL-4, IL-13의 활성을 알아본 결과 Con A로 유도된 IL-4와 IL-13의 발현 양을 현저히 줄이는 것으로 나타났다. 이로 미루어 보아, 포도 4종에 대한 생물학적 활성 결과 항산화, 항암활성은 물론 항천식 활성이 있는 것으로 확인되어 면역조절 활성이 포도의 기능성에 중요한 역할을 할 것으로 판단된다.

• Animal Bioscience
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• 제34권4호
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• pp.642-651
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• 2021

Objective: This study aimed to determine the effects of different roughages in total mixed ration (TMR) inoculated with or without coculture of Lactobacillus acidophilus (L. acidophilus) and Bacillus subtilis (B. subtilis) on in vitro rumen fermentation and microbial population. Methods: Three TMRs formulations composed of different forages were used and each TMR was grouped into two treatments: non-fermented TMR and fermented TMR (F-TMR) (inoculated with coculture of L. acidophilus and B. subtilis). After fermentation, the fermentation, chemical and microbial profile of the TMRs were determined. The treatments were used for in vitro rumen fermentation to determine total gas production, pH, ammonianitrogen (NH3-N), and volatile fatty acids (VFA). Microbial populations were determined by quantitative real-time polymerase chain reaction (PCR). All data were analyzed as a 3×2 factorial arrangement design using the MIXED procedure of Statistical Analysis Systems. Results: Changes in the fermentation (pH, lactate, acetate, propionate, and NH3-N) and chemical composition (moisture, crude protein, crude fiber, and ash) were observed. For in vitro rumen fermentation, lower rumen pH, higher acetate, propionate, and total VFA content were observed in the F-TMR group after 24 h incubation (p<0.05). F-TMR group had higher acetate concentration compared with the non-fermented group. Total VFA was highest (p<0.05) in F-TMR containing combined forage of domestic and imported source (F-CF) and F-TMR containing Italian ryegrass silage and corn silage (F-IRS-CS) than that of TMR diet containing oat, timothy, and alfalfa hay. The microbial population was not affected by the different TMR diets. Conclusion: The use of Italian ryegrass silage and corn silage, as well as the inoculation of coculture of L. acidophilus and B. subtilis, in the TMR caused changes in the pH, lactate and acetate concentrations, and chemical composition of experimental diets. In addition, F-TMR composed with Italian ryegrass silage and corn silage altered ruminal pH and VFA concentrations during in vitro rumen fermentation experiment.

• 한국축산식품학회지
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• 제41권1호
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• pp.45-58
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• 2021

This study investigated the dietary effect of total mixed ration (TMR) based on high roughage content on the growth performance, carcass characteristics, and meat quality of Hanwoo steers. Twenty-four Hanwoo steers (average body weight, 195.3±4.7 kg; age, 8.5 mon) were randomly allocated to three experimental groups according to forage and concentrate ratio (DM basis): 25:75 (control), 50:50 (T50), and 70:30 (T70). Productivity in the fattening period and final body weight were significantly higher in the control. Average daily gain and feed conversion ratio were the same among treatments. Serum parameters, cholesterol, blood urea nitrogen, and total protein were higher in the control. Carcass weight was comparable in the control and T50 but feeding more roughage was significantly correlated with a higher intramuscular fat. Shear strength and drip loss were higher while n-6/n-3 was lower in T70 compared to the other groups. However, meat color was not significantly different among treatments. In terms of free amino acid contents, glutamic acid and glycine were higher in the control than T50 and T70. Overall, feeding Hanwoo steers with high forage content TMR had the lowest n-6/n-3 ratio of fatty acid content but highest intramuscular fat, shear strength, and drip loss. High forage content TMR is the best feed for Hanwoo steers that gives more benefits for human health and consumption but also provides the best meat grade and quality, which is important in the beef market in Korea.

• 대한기계학회논문집 C: 기술과 교육
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• 제5권1호
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• pp.23-52
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• 2017

바이오융합 및 의료기기 산업은 의학과 전기, 전자, 기계, 재료 등 공학이 융합되는 다학제간 응용기술 산업분야이다. 바이오 융합 및 의료기기를 이용해 인간의 삶의 질 향상을 목표로 하고 있으며 제품에 대한 인지도와 브랜드 파워가 매우 중요한 산업이다. 그러나, 자본/기술 의존형 산업으로 제품의 개발부터 생산까지 소요되어지는 기간이 길고 개별 제품의 시장 규모가 작고 수명주기가 짧다고 할 수 있다. 따라서 연구개발에 대한 지속적인 투자가 요구되어지는 산업으로 국가적인 차원에서 바이오벤처 기업들을 위해 기술적 지원, 제도적 뒷받침, 인력 양성 등의 산업생태계 전반을 활성화하고자 하는 노력이 필요하다.

• 생약학회지
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• 제36권1호통권140호
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• pp.50-55
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• 2005

Reactive oxygen species (ROS) are continuously produced at a high rate as a by-product obtained in the aerobic metabolism. A major portion of living organisms has defense system as superoxide dismutase or catalase against damage produced by ROS. Several lines of evidence provided that ROS appears to cause to develop aging and various diseases. Spatholobus suberectus Dunn has been known as a Korean folk medicine for promoting blood circulation and relieving blood stasis as anemia. In this study, we have investigated the antioxidant activities of Spatholobus suberectus Dunn in order to find the antioxidant substances from natural products. For various antioxidant experiment, the major antioxidant component was isolated from EtOAc extract of Spatholobus suberectus Dunn. This compound was identified as (-)-epicatechin by chemical and physical analysis.

• 생약학회지
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• 제35권3호통권138호
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• pp.184-188
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• 2004

This study was carried out to evaluate glutathione S-transferase (GST) activity and hyaluronidase inhibitory effect of medicinal plants. The EtOH extracts of 20 species plants were tested. As the result, Acorus gramineus and Pueraria lobata exhibited GST activity. On the continuous experiment, the n-BuOH fraction of Acorus gramineus and the $H_2O$ fraction of Pueraria lobata showed the elevation of GST activity. On the experiment of hyaluronidase inhibitory effect, Acorus gramineus exhibited a potent inhibitory activity. These results suggest that the extract of Acorus gramineus can be applicable for the development of a new anti-inflammatory agent.

• Asian-Australasian Journal of Animal Sciences
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• 제27권11호
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• pp.1562-1570
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• 2014

The effects of Lactobacillus mucosae (L. mucosae), a potential direct fed microbial previously isolated from the rumen of Korean native goat, on the rumen fermentation profile of brewers grain were evaluated. Fermentation was conducted in serum bottles each containing 1% dry matter (DM) of the test substrate and either no L. mucosae (control), 1% 24 h broth culture of L. mucosae (T1), or 1% inoculation with the cell-free culture supernatant (T2). Each serum bottle was filled anaerobically with 100 mL of buffered rumen fluid and sealed prior to incubation for 0, 6, 12, 24, and 48 h from which fermentation parameters were monitored and the microbial diversity was evaluated. The results revealed that T1 had higher total gas production (65.00 mL) than the control (61.33 mL) and T2 (62.00 mL) (p<0.05) at 48 h. Consequently, T1 had significantly lower pH values (p<0.05) than the other groups at 48 h. Ammonia nitrogen ($NH_3$-N), individual and total volatile fatty acids (VFA) concentration and acetate:propionate ratio were higher in T1 and T2 than the control, but T1 and T2 were comparable for these parameters. Total methane ($CH_4$) production and carbon dioxide ($CO_2$) were highest in T1. The percent DM and organic matter digestibilities were comparable between all groups at all times of incubation. The total bacterial population was significantly higher in T1 (p<0.05) at 24 h, but then decreased to levels comparable to the control and T2 at 48 h. The denaturing gradient gel electrophoresis profile of the total bacterial 16s rRNA showed higher similarity between T1 and T2 at 24 h and between the control and T1 at 48 h. Overall, these results suggest that addition of L. mucosae and cell-free supernatant during the in vitro fermentation of dried brewers grain increases the VFA production, but has no effect on digestibility. The addition of L. mucosae can also increase the total bacterial population, but has no significant effect on the total microbial diversity. However, inoculation of the bacterium may increase $CH_4$ and $CO_2$ in vitro.