• Proceedings of the Korean Society for Bioinformatics Conference
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• 2004.11a
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• pp.50-56
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• 2004

Bifurcation analysis of cell cycle regulation in the budding yeast is performed basedon the mathematical model by Chen et al [Molecular biology of cell, 11:369-391, 2000]. On the bifurcation diagram, locations of both stable and unstable solutions of the nonlinear differential equations are presented by taking the mass of cell as a controlparameter. Based on the bifurcation diagram, dynamic mechanism underlying the 'start' transition, initiation of a new round of cell cycle, and the 'finish' transition, completion of cell cycle and returning back to the initial state, is discussed: the 'start' transition is a transition from a stable fixed solution for a small mass and to an oscillatory state for a large mass, and the 'finish' transition is a switching back to the stable fixed solution from the oscillatory state. To understand the role of the genes during the cell cycle regulation, bifurcation diagrams for the mutants are compared with that of the wild type.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.56 no.1
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• pp.174-182
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• 2007

In this paper, we study the influence of infection ratio on gradual reduction of drug dose for the five state HIV infection model that explicitly includes the population of the virus. We first compute all equilibrium points of the model and investigate the stabilities of them. As a result, a bifurcation diagram is obtained which shows a change in the equilibrium points, or in their stability properties, as the drug effect $\eta$ is varied from 0 to 1(alternatively, drug dose is changed from 1 to 0). Based on the bifurcation diagram, we show that the gradual reduction of drug dose can be applied for the treatment of AIDS patients. Moreover, we analyze the influence of the variation of infection ratio on the gradual reduction treatment. Computer simulation results are also presented to validate the proposed results.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.56 no.10
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• pp.1836-1843
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• 2007

In this paper, we study the NvBAT treatment for AIDS patients that is combined with PI rather than RTI, while the Previous results have been focused on the NvBAT in conjuction with RTI. To this end, we obtain a bifurcation diagram which shows a change in the equilibrium points, and in their stability properties as the PI drug effect is varied. Based on the bifurcation diagram, we show that the NvBAT can be combined with drug PI for the treatment of AIDS patients. Various computer simulation results are included, which show the superiority of the NvBAT with PI over that with RTI. Accordition to simulation result, the NvBAT combined with PI is able to keep virus load level lower than that combined with RTI, which is crucial to avoid the emergence of drug-resistant mutants. Moreover, it is shown that, for some AIDS patients, NvBAT with RTI cannot make patients into long term non-progressor, while NvBAT with PI can.

• Journal of Mechanical Science and Technology
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• v.17 no.12
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• pp.1994-2003
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• 2003

The vibration of a flexible cantilever tube with nonlinear constraints when it is subjected to flow internally with fluids is examined by experimental and theoretical analysis. These kinds of studies have been performed to find the existence of chaotic motion. In this paper, the important parameters of the system leading to such a chaotic motion such as Young's modulus and the coefficient of viscoelastic damping are discussed. The parameters are investigated by means of system identification so that comparisons are made between numerical analysis using the design parameters and the experimental results. The chaotic region led by several period-doubling bifurcations beyond the Hopf bifurcation is also re-established with phase portraits, bifurcation diagram and Lyapunov exponent so that one can define optimal parameters for system design.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2003.05a
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• pp.495-500
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• 2003

The vibration of a flexible cantilever tube with nonlinear constraints when it is subjected to flow internally with fluids is examined by experiment and theoretical analysis. These kind of studies have often been performed that finds the existence of chaotic motion. In this paper, the important parameters of the system leading to such a chaotic motion such as Young's modulus and coefficient of viscoelasticity in tube material are discussed. The parameters are investigated by means of a system identification so that comparisons are made between numerical analysis using the parameters of a handbook and the experimental results. The chaotic region led by several period-doubling bifurcations beyond the Hopf bifurcation is also re-established with phase portraits and bifurcation diagram so that one can define optimal parameters for system design.

• Proceedings of the KSME Conference
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• 2004.11a
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• pp.595-600
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• 2004

This paper deals with a cause analysis of a squeal noise in a brake system. It has been proved that the squeal noise is influenced by the angular misalignment of a disk, disk run-out, with the previously experimental study. In this study, a cause of the noise is examined by using FE analysis program(SAMCEF) and numerical analyses with a derived analytical equation of the disk based on the experimental results. The FE analyses and numerical results show that the squeal noise is due to the disk run-out as the experimental results and the frequency component of the noise equals to that of a disk's bending mode arising from the Hopf bifurcation.

• Proceedings of the Korean Society for Bioinformatics Conference
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• 2005.09a
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• pp.278-283
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• 2005

Cell cycle is regulated cooperatively by several genes. The dynamic regulatory mechanism of protein interaction network of cell cycle will be presented taking the budding yeast as a sample system. Based on the mathematical model developed by Chen et at. (MBC, 11,369), at first, the dynamic role of the feedback loops is investigated. Secondly, using a bifurcation diagram, dynamic analysis of the cell cycle regulation is illustrated. The bifurcation diagram is a kind of ‘dynamic road map’ with stable and unstable solutions. On the map, a stable solution denotes a ‘road’ attracting the state and an unstable solution ‘a repelling road’ The ‘START’ transition, the initiation of the cell cycle, occurs at the point where the dynamic road changes from a fixed point to an oscillatory solution. The 'FINISH' transition, the completion of a cell cycle, is returning back to the initial state. The bifurcation analysis for the mutants could be used uncovering the role of proteins in the cell cycle regulation network.

• Journal of Power Electronics
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• v.19 no.3
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• pp.655-664
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• 2019

In order to analyze the nonlinear phenomena of the bifurcation and chaos caused by the switching of nonlinear switching devices in inductively coupled power transfer (ICPT) systems, a Jacobian matrix model, based on discrete mapping numerical modeling, is established to judge the system stability of the periodic closed orbit and to study the nonlinear behavior of Hopf bifurcation in a system under full resonance. The general flow of the parameter design, based on the stability principle for ICPT systems, is proposed to avoid the chaos and bifurcation phenomena caused by unreasonable parameter selection. Firstly, based on the state equation of SS-type compensation, a three-dimensional bifurcation diagram with the coupling coefficient as the bifurcation parameter is established with a numerical simulation to observe the nonlinear phenomena in the system. Then Filippov's method based on a Jacobian matrix model is adopted to deduce the boundary of stable operation and to judge the type of the bifurcation in the system. Then the general flow of the parameter design based on the stability principle for ICPT systems is proposed through the above analysis to realize stable operation under the conditions of weak coupling. Finally, an experimental platform is built to confirm the correctness of the numerical simulation and modeling.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 1998.03a
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• pp.21-27
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• 1998

An analysis for the prediction of wrinkling formation in curved sheets during metal froming is presented. We construct "Wrinkling Limit diagram"(WLD) which represent the combinations of the critical principal stresses for wrinkling formation in curved sheet elements subjected to biaxial plane stress. Here the scheme of plastic bifurcation theory for thin shells based on the Donnell-Mushtari-Vlasov shell theory is used. In this study, the effects of the material variables (yield stress, plastic hardening coefficient, plastic anisotropic parameter, and so on) and sheet geometry on the critical conditions for wrinkling is carried out numerically.merically.

• 정보저장시스템학회:학술대회논문집
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• 2005.10a
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• pp.177-178
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• 2005

The load/unload behavior of the hard disk drive slider is studied in terms of the air bearing static characteristics. The numerical continuation methods are applied to calculate suspension force - equilibrium position curve. The critical preloads of the femto size slider are analyzed. The hi-stability conditions are depicted on the skew angle - preload diagram. The perturbation method is used to check the stability of the solution branches.