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NvBAT Treatment for AIDS Patients: The Superiority of PI Over RTI  

Jo, Nam-Hoon (숭실대 공대 전기공학부)
Publication Information
The Transactions of The Korean Institute of Electrical Engineers / v.56, no.10, 2007 , pp. 1836-1843 More about this Journal
Abstract
In this paper, we study the NvBAT treatment for AIDS patients that is combined with PI rather than RTI, while the Previous results have been focused on the NvBAT in conjuction with RTI. To this end, we obtain a bifurcation diagram which shows a change in the equilibrium points, and in their stability properties as the PI drug effect is varied. Based on the bifurcation diagram, we show that the NvBAT can be combined with drug PI for the treatment of AIDS patients. Various computer simulation results are included, which show the superiority of the NvBAT with PI over that with RTI. Accordition to simulation result, the NvBAT combined with PI is able to keep virus load level lower than that combined with RTI, which is crucial to avoid the emergence of drug-resistant mutants. Moreover, it is shown that, for some AIDS patients, NvBAT with RTI cannot make patients into long term non-progressor, while NvBAT with PI can.
Keywords
AIDS; Non-Progressor; PI; Bifurcation Diagram; Lyapunov Stability;
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Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By SCOPUS : 0
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