• ALGAE
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• 제31권1호
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• pp.73-84
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• 2016

Marine organisms are frequently used to be harmful and have lower side effects than synthetic drugs. The cognitive improving efficacy of gamma aminobutyric acid-enriched fermented Saccharina japonica (FSJ) on the memory deficient rats, which were induced by trimethyltin chloride (TMT), was investigated by assessing the Morris water maze test and by performing choline acetyltransferase (ChAT), cAMP response element binding protein (CREB), and brain derived neurotrophic factor (BDNF) immunohistochemistry. The neurite outgrowth of Neuro2a cells was assessed in order to examine the underlying mechanisms of the memory enhancing effects of FSJ. Treatment with FSJ tended to shorten the latency to find the platform in the acquisition test of the Morris water maze at the second and fourth day compared to the control group. In the probe trial, the FSJ treated group increased time spent in the target quadrant, compared to that of the control group. Consistent with the behavioral data, these treatments recovered the loss of ChAT, CREB, and BDNF immunepositive neurons in the hippocampus produced by TMT. Treatment with FSJ markedly stimulated neurite outgrowth of the Neuro2a cells as compared to that of the controls. These findings demonstrate that FSJ may be useful for improving the cognitive function via regulation of neurotrophic marker enzyme activity.

• Biomolecules & Therapeutics
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• 제22권5호
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• pp.406-413
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• 2014

to valproic acid (VPA) during pregnancy produces ASD-like core behavioral phenotypes as well as hyperactivity in offspring both in human and experimental animals, which makes it a plausible model to study ASD-related neurobiological processes. In this study, we examined the effects of two of currently available attention defecit hyperactivity disorder (ADHD) medications, methylphenidate (MPH) and atomoxetine (ATX) targeting dopamine and norepinephrine transporters (DAT and NET), respectively, on hyperactive behavior of prenatally VPA-exposed rat offspring. In the prefrontal cortex of VPA exposed rat offspring, both mRNA and protein expression of DAT was increased as compared with control. VPA function as a histone deacetylase inhibitor (HDACi) and chromatin immunoprecipitation experiments demonstrated that the acetylation of histone bound to DAT gene promoter was increased in VPA-exposed rat offspring suggesting epigenetic mechanism of DAT regulation. Similarly, the expression of NET was increased, possibly via increased histone acetylation in prefrontal cortex of VPA-exposed rat offspring. When we treated the VPA-exposed rat offspring with ATX, a NET selective inhibitor, hyperactivity was reversed to control level. In contrast, MPH that inhibits both DAT and NET, did not produce inhibitory effects against hyperactivity. The results suggest that NET abnormalities may underlie the hyperactive phenotype in VPA animal model of ASD. Profiling the pharmacological responsiveness as well as investigating underlying mechanism in multiple models of ASD and ADHD may provide more insights into the neurobiological correlates regulating the behavioral abnormalities.

• 생명과학회지
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• 제19권11호
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• pp.1651-1657
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• 2009

본 연구는 흰쥐의 흉추 9번을 타박 손상시키고 1주간의 휴식 후 스트레스를 유발하지 않는 저강도 트레드밀운동을 7주동안 수행하여, 가자미근 위축지연 변화를 western blotting과 H&E 염색 그리고 면역형광염색법으로 관찰하였으며, BBB-검사를 이용하여 기능적 회복을 관찰하였다. 형태학적 변화의 결과 척수손상 후 트레드밀 운동에 의해 하지부위 가자미 근과 근섬유의 횡단면 크기가 증가하였으며, 근섬유 세포에서 IGF-I 단백질 발현이 증가하였다. 또한 생화학적인 결과 척수손상 후 트레드밀 운동에 의해 하지부위 골격근 IGF-I 단백질 발현이 증가하였으며, 행동학적 검사를 통해 트레드밀 운동그룹이 비 운동그룹보다 기능적 회복이 개선된 것을 확인하였다. 이러한 결과는 근 비대에 직접적으로 관여하는 IGF-I 단백질 발현량이 운동에 의해 증가하여 가자미근크기 증가와 같은 근 위축 지연을 확인하였으며, 이러한 변화를 통해 기능적 회복에 긍정적인 결과를 보여주었다. 따라서 운동은 척수손상 환자에게 효과적인 기능재활 치료방법이 될 수 있으며, 장애를 최소화하여 자발적인 일상생활을 도모할 수 있을 것이라 생각된다.

• 인지과학
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• 제32권3호
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• pp.141-167
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• 2021

진정성은 철학에서 위선이나 기만적인 삶의 반대 개념이다. 진정성에 기초해 인간이 삶에서 경험하는 다양한 긍정적 요인들이 해외에서는 연구되어 온 반면, 진정성 측정을 시도한 국내 연구들은 대부분 한국 문화의 특징들을 고려하지 않았거나 특정 분야의 사용 목적으로만 개발되었다. 본 연구에서는 한국 문화의 특수성에 기반하여 연구자들이 보편적으로 사용할 수 있는 진정성 척도를 개발했다. 이를 위해, 기존의 진정성 척도를 구성하는 문항들과 사회적 관계를 중요시하는 한국 사회의 문화적 가치를 반영하는 문항들을 통합했다. 그 결과, 탐색적 요인분석과 확인적 요인분석을 통해 진정성은 자기 인식, 행동 진정성, 관계 진정성의 세 가지 요인으로 구성된다는 사실을 확인하였다. 또한 삶의 만족도, 마음챙김, 자아존중감, HEXACO, 사회적 바람직성, 자기조절초점, 정서다양성과의 상관관계를 분석하여, 준거타당도를 검증하였다. 이러한 결과는 새로운 진정성 척도가 신뢰롭고 타당한 도구라는 것을 의미하였고, 일상에서의 진정성에 대한 경험적 개인차 연구에 중요한 도구가 될 것으로 기대된다.

• International Journal of Computer Science & Network Security
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• 제22권12호
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• pp.63-70
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• 2022

The essence of the definition of "tolerance" is analyzed. Motivational, knowledge and behavioral criteria for tolerance of future teachers are highlighted. Indicators of the motivational criterion are the formation of value orientations, motivational orientation, and the development of empathy. Originality and productivity of thoughts and judgments, tact of dialogue, pedagogical ethics and tact are confirmed as indicators of the knowledge criterion. The behavioral criterion includes social activity as a life position, emotional and volitional endurance, and self-control of one's own position. The formation of tolerance is influenced by a number of factors: the social environment, the information society, existing stereotypes and ideas in society, the system of education and relationships between people, and the system of values. The main factors that contribute to the education of tolerance in future teachers are highlighted. Analyzing the structure of tolerance, it is necessary to distinguish the following functions of tolerance: - motivational (determines the composition and strength of motivation for social activity and behavior, promotes the development of life experience, because it allows the individual to accept other points of view and vision of the solution; - informational (understanding the situation, the personality of another person); - regulatory (tolerance has a close connection with the strong - willed qualities of a person: endurance, selfcontrol, self-regulation, which were formed in the process of Education); - adaptive (allows the individual to develop in the process of joint activity a positive, emotional, stable attitude to the activity itself, which the individual carries out, to the object and subject of joint relations). The implementation of pedagogical functions in the information society: educational, organizational, predictive, informational, communicative, controlling, etc. provides grounds to consider pedagogical tolerance as an integrative personal quality of a representative of any profession in the field of "person-person". The positions that should become conditions for the formation of tolerance of the future teacher in the information society are listed.

• 감성과학
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• 제23권3호
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• pp.103-120
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• 2020

본 논문에서는 인지적 정서조절의 방법으로 활용되는 자기거리두기의 개념과 측정, 효과에 대해 소개하였다. 자기거리두기(self-distancing)는 자신에게 몰입하는 상태의 반대 개념으로, 자신의 경험을 다룰 때 한 발짝 물러나서 이를 다소 관조적으로 바라보는 행위를 일컫는다. 자신의 경험을 다룰 때 마음속에서 자신과 얼마나 거리를 두는지에 따라 인지적 정서적으로 지각되는 정도가 다르고 이는 사건을 이해하는 정도는 물론 이로 인한 정서의 양상에까지 영향을 준다. 그 간의 많은 연구들에 따르면, 자기거리두기를 많이 하는 것이 개인의 정서에 도움이 된다는 결과들이 지배적인데, 본 논문에서는 이러한 결과들을 정리하여 자기거리두기가 무엇을 의미하고 어떤 효과가 있는지를 정리해 보았다. 먼저 본 연구에서는 이러한 자기거리두기 개념의 이해를 돕기 위해 관찰자 관점, 자기반성, 이성적 태도 등의 개념을 통해 자기거리두기가 어떤 특징이 있고 어떤 방향에서 바라보고 접근하게 되는지를 제시하였고, 이와 함께 자기거리두기를 어떻게 측정할 수 있는지 또한 짚어보았다. 그리고 이를 바탕으로 자기거리두기로부터 얻을 수 있는 효과를 정서적, 인지적, 생리적, 행동적, 발달적 측면에서 세분화하여 소개하였다. 한편, 이 개념으로부터 기대되는 긍정적인 효과들이 반복적으로 검증됨에도 불구하고 일관되지 않은 결과들도 함께 발견되고 있어 이를 함께 언급하였다. 아울러 자기거리두기가 앞으로 연구되는 과정에서 다루어져야 하는 부분들에 대한 고찰이 함께 이루어졌다. 마지막으로 이연구가 가진 학술적·실용적 의미들을 짚어보았다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제27권3호
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• pp.216-225
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• 2016

Objectives: The purposes of this study are to evaluate the effect of a school-based social skills training program on the emotional regulation of children and adolescents and to assess the plan for effective school-based mental health services. Methods: The Child and Adolescent Mental health promotion team of Bugok National Hospital conducted school-based social skills training (N=90, 7 sessions) for elementary and middle school students. Evaluations were conducted before and after the application of the program using a prosocial behavior questionnaire, a cohesiveness questionnaire, the Korean version of the 20-item Toronto Alexithymia Scale, a self-esteem scale, and the Novaco anger scale, in order to identify any changes. Results: The social skills training program increased the prosocial behavior and cohesiveness of the children and adolescents and decreased their alexithymic tendency and degree of anger, but did not significantly change their self-esteem. Conclusion: The social skills training program positively influences the emotional and behavioral levels of children and adolescents. The emotional regulation program based on a social skills training program is expected to have positive results in school-based mental health services. Future investigations are needed to validate the long term effects of this program.

• 보건교육건강증진학회지
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• 제16권2호
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• pp.19-40
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• 1999

In order to ascertain the attitudes of residents to their health and the National Health Promotion Law, surveyors interviewed 1,220 subjects, 1% of men and women in Kyungsan city, who were twenty-year-old or more. The major findings are as follows: Men and women were 48.2% and 51.8%, respectively. The recognition rate of enacting and enforcing this law is 59.2% of men and 51.3% of women. With regard to the behavioral attitude to the health in the distinction of sex and age, current smokers are 31.2% of the interviewees, 61.6% of the men and 3.3% of the women. Current drinkers are 35.1%, 59.5% of the men and 12.3% of the women, but on the other hand there is little significance in the distinction of age. The acknowledgement proportion of enacting and enforcing this law is 59.2% of male and 51.3% of female. In terms of the recognition rate of the contents according to the general characteristics of interviewees, it appears that the indication of a warning expression on a packing paper of cigarette case and a liquor bottle is 92.4% and also the designation of a smoking free area in public facilities is 94.8%. Prohibition of cigarette-sale to the teenagers who are under 19, is 96.0%. Considering these facts, the recognition rate is high. On the contrary, 48.8% is accounted for encouraging a medical check-up before marriage which is in a low position. As a result of multiple behavior as a independent educational level, marital significant variables. In case of having undergone a periodic medical examination the recognition rate was high whereas frequent exercise led to the low recognition rate. Concerning the details of the undertaking in accordance with each factor of general characteristics, the greater part of them have been appraised successfully whether it is recognized or not. On the other side, no effect got answered about the result of the undertaking subjects to general and peculiar behavior attitude towards health was in effect or not. A great majority approved of more reinforcement of legal regulation about smoking and drinking regardless of whether they perceived the details of the law of promotion of National Health Promotion Law or not. Additionally there was significant difference in reinforcing legal regulation of smoking and drinking in compliance with the attitude of the substance of this law. With regard to education, public relations and evaluation about national health through public health centers by our government, the younger and the higher in education they are, the more deficient they feel. First of all, those who were aware of the enforcement of this law as well as plenty of scarcity answered that better service of disease prevention had to be expanded than ever. In consideration of the above-stated results, the education to public health and the business of public relations should be reinforced and a practical campaign for health life should also spread out for the purpose of encouraging to practise healthy life-style.

• 한국직업건강간호학회지
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• 제7권1호
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• pp.33-46
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• 1998

Introduction : In Korea, national attention to the workplace health promotion programs (HPP) for employees began in early 1990s. Governmental supports for the HPP and education programs have given to the employees. The purpose of this study is to find the performance degree of employees' health promoting lifestyle(HPL). Subjects and Methods : For this study, 615 employees who attended governmental educations were selected as research samples. The tool for measuring HPL used in this study was developed for Korean by In-Sook Park in 1995. It is composed of 4-point scaled 60 items and divided into 11 subcategories. The data were collected by self reporting questionnaires from June to December in 1997. Those data were analyzed percentile, mean, standard deviation, ANOVA, t-test with SAS program. Major findings are as follows; 1. The total mean score of the employees' HPL performance was 2.66. The average scores of 'harmonious relationships' category were the highest as 3.11, whereas the one of 'professional health maintenance' were the lowest as 2.02. The remains were 'sanitary life'(2.90), 'emotional support(2.85), 'regular diet'(2.84), 'self achievement'(2.78), 'healthy diet'(2.56), 'rest and sleep'(2.56), 'exercise and activity'(2.54), 'diet control'(2.53), 'self-control'(2.52). 2. The factors affecting HLP were category of industries and sex, age, marital status, education level, major, educational experience of health promotion, among personal characteristics. The employees of service industries, female, older age, married, nurse, educated for health promotion, graduated from junior college performed HLP more than the others. 3. The participation rates of employees for HPP were 12.4%, because of limited time and facilities and equipments. Recommendations; 1. The regulation for performing the health promotion programs in the industries is essential for activating industrial health promoting movement. 2. More governmental supports for educations and services for health promotion programs in the industries are needed. 3. For behavioral changes of the employees, the contents of educations have to consist of exercise and activity, rest and sleep, diet and smoking habits. 4. The evaluating studies for ready made health promotion programs in the industries are expected.

• 한국생활과학회지
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• 제10권1호
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• pp.101-111
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• 2001

The purpose of this study was to investigate using and evaluative criteria for purchasing of sleepwear in winter. Subjects were 523 males and females aged from twenties to fifties, living in Chongju and Taejon. For data analysis, frequency, descriptive analysis, t-test, and F-test were used. The results are as follows. First, the ownership of sleepwear was sweat suits with zippered top, pajamas, T-shirts/pants, underwear, and nightgown in order. The mean of using sweat suits was used the highest, and subjects used more home wear than sleepwear in winter. Second, the using or sleepwear had a significant difference in cold-sensitiveness and body types. Cold-sensitive group used sweat suit and T-shirts/pants more than cold-insensitive group. Also, groups who are thin wore sweat suit the most while groups who are corpulent, used underwear the most when they slept. Third, subjects, who are married women and use bed, used nightgown, but pajamas were used by groups who are older, married, and professional. Sweat suits and T-shirts/pants were used the most by single aged twenties. Forth, consumers considered the wearing comfort when they purchased sleepwear for winter, and they evaluated washing/management, fabric, design/style, economic, service, brand, and others' response in order, for judging the quality of sleepwear. Also, the evaluative criteria had a significant difference in demographic variables such as sex, occupation, and marital state. These results implied that sleepwear would be needed for winter in terms of behavioral temperature regulation. Especially, cold-sensitive and thin group would wear knitted and two-piece sleepwear for thermal comfort when they sleep in winter. Also, Using and evaluative criteria of sleepwear would be different in demographic characteristics. For winter, sleepwear should be develop based on physiologic as well as demographic variables.