• Journal of Pharmacopuncture
• /
• v.9 no.3 s.21
• /
• pp.139-145
• /
• 2006

Objectives : The purpose of this case in so report the patient with Reflex sympathetic dystrophy, who is improved by Bee venom. Method : We treated the patient with Bee venom who was suffering from Reflex sympathetic dystrophy, using Digital Infrared Thermographic Imaging and Verbal Numerical Rating Scale(VNRS) to evaluate the therapeutic effects. We compared the temperature of the patient body before and after treatment. Result and Conclusion : We found that Bee venom had excellent outcome to relieve pain, atrophy and ankle joint ROM, and that Bee venom also had clinical effect on hypothermia on the Digital Infrared Thermographic Imaging.

• Journal of Pharmacopuncture
• /
• v.11 no.2
• /
• pp.125-130
• /
• 2008

Objective The purpose of this study was to report the efficiency of Bee Venom Pharmacopunture Therapy by managering of Benign Prostatic Hyperplasia patients. Method Two patients were treated with Bee Venom Pharmacopunture and another Korean Medicine therapy for six weeks and compared with I-PSS(International Prostate Symptom Score) before and after. Results After treated with Bee Venom Pharmacopunture Therapy, 'I-PSS' values decreased significantly all the patients. Conclusions Bee Venom Pharmacopunture Therapy was shown fairly effective to Benign Prostatic Hyperplasia.

• Journal of Pharmacopuncture
• /
• v.19 no.1
• /
• pp.45-50
• /
• 2016

Objectives: The purpose of this study was to investigate the antifungal effect of bee venom (BV) and sweet bee venom (SBV) against Candida albicans (C. albicans) clinical isolates. Methods: In this study, BV and SBV were examined for antifungal activities against the Korean Collection for Type Cultures (KCTC) strain and 10 clinical isolates of C. albicans. The disk diffusion method was used to measure the antifungal activity and minimum inhibitory concentration (MIC) assays were performed by using a broth microdilution method. Also, a killing curve assay was conducted to investigate the kinetics of the anti-fungal action. Results: BV and SBV showed antifungal activity against 10 clinical isolates of C. albicans that were cultured from blood and the vagina by using disk diffusion method. The MIC values obtained for clinical isolates by using the broth microdilution method varied from $62.5{\mu}g/mL$ to $125{\mu}g/mL$ for BV and from $15.63{\mu}g/mL$ to $62.5{\mu}g/mL$ for SBV. In the killing-curve assay, SBV behaved as amphotericin B, which was used as positive control, did. The antifungal efficacy of SBV was much higher than that of BV. Conclusion: BV and SBV showed antifungal activity against C. albicans clinical strains that were isolated from blood and the vagina. Especially, SBV might be a candidate for a new antifungal agent against C. albicans clinical isolates.

• Journal of Acupuncture Research
• /
• v.20 no.2
• /
• pp.68-76
• /
• 2003

Objective : In the pain control, Bee Venom Acupuncture therapy is highly effective but cause allergic side-effects frequently. This study was performed to compare Bee Venom(BV) with BV Partner(BVP) in decreasing side-effects of BV. Methods : BV partner(BVP) which dilutes the Morus bombycis Koiduzumi Herbal Acupuncture was developed to decrease the side effects of the Bee Venom. We used D.I.T.I. to verify the effectiveness of BVP in decreasing side-effect of BV. We injected BV to Group I (n=18) at 4 points of body [Fengmen(風門 : B12), Feishu(肺兪 : B13), Fufen(附分 : B41), Pohu(魄戶 : B42)], and BVP to group II (N=18) at the same points. We observed the chages of temperature at beginning, 5 minutes, 1 hour, 1 day, 2days and 7days after injection. Results : The following results were obtained; 1. The difference of temperature had been continued until 2days in BV group, but 1day in BVP group. 2. The difference of temperature was significantly greater than time at 1hour in BV and at 5 minutes in BVP. 3. Other side-effects(the local pain, redness, angioedema and pruritus) were less appeared in BVP than BV group, too.

• Journal of Acupuncture Research
• /
• v.25 no.1
• /
• pp.97-106
• /
• 2008

Objectives : This study was designed to evaluate the effects of Bee Venom Pharmacopuncture therapy in patients with lumbar spinal stenosis. Methods : We investigated 16 patients with lumbar spinal stenosis. We divided patients into two groups : Bee Venom Pharmacopuncture was performed with acupuncture therapy for one group, and the other group received acupuncture therapy only. To evaluate the effectiveness of the treatment applied to the two groups, we used the Visual Analog Scale(VAS) and the Oswestry Low-back Pain Disability Index(ODI). We compared the VAS and ODI scores of the two groups statistically. Results : The Bee Venom Pharmacopuncture group received more effective relief than the acupunctureonly group as measured by decreasedpain and disability reported on the VAS and ODI by patients with lumbar spinal stenosis. Conclusions: Bee Venom Pharmacopuncture therapy can be used in addition to acupuncture therapy for highly effective treatment of patients with lumbar spinal stenosis. Further clinical studies are needed to verify these findings.

• Journal of Korean Medicine Rehabilitation
• /
• v.27 no.4
• /
• pp.155-161
• /
• 2017

The purpose of this study is to research and report the effect of Bee Venom pharmacopuncture therapy at facet joint for the two patients who was diagnosed as herniated intervertebral disc (HIVD) of lumbar spine. Two patients were hospitalized and treated with Complex Korean Medical treatment such as acupuncture, herbal medicine and Essential bee venom (EBV) pharmacopuncture in Dongsuwon hospital of oriental medicine. We measured their pain and function of daily life by numerical rating scale (NRS), straight leg rasing test (SLRT), Roland-morris disability questionnaire (RMDQ). As the result, we found the improvement of gait disturbance, functional disorder, and pain. This study suggested that Bee Venom pharmacopuncture therapy at facet joint is considered to conservative treatment for HIVD of lumbar spine. But further clinical studies are needed to clarify the effect of Bee Venom pharmacopuncture therapy at facet joint for the two patients with HIVD of lumbar spine.

• Journal of Acupuncture Research
• /
• v.19 no.6
• /
• pp.67-79
• /
• 2002

Objective : This study was designed to find out the effects of Korean bee-venom therapy on neck pain due to soft tissue damage. Methods : This study was carried out for 34 patients who had neither structral defectiveness of cervical spine nor neural injury but simple soft tissue damage among poeple who visited Hye-dang Oriental Hospital from March 4, 2002 to September 30, 2002. Group A of 17 patients was taken Korean bee-venom therapy Group B of 17 patients was taken common acupuncture therapy. Results : We have found out the good effects of Korean bee-venom therapy on the patients due to soft tissue damage. Conclusions : The Korean bee-venom therapy is useful on the patients of neck pain due to soft tissue damage.

• Toxicological Research
• /
• v.19 no.1
• /
• pp.51-66
• /
• 2003

This study was performed to evaluate single and repeated-dose toxicities of Bee Venom Extracts (F1, F3) in Spraque-Dawley. F1 was injected subcutaneously to rat at dose levels of 0, 0.0002, 0.002, 0.02 mg/kg/day for single-dose toxicity study and repeated-dose toxicity study. F3 was injected subcutaneously to rat at dose level of 0, 0.003, 0.03, 0.3 mg/kg/day for single-dose toxicity study and repeated-dose toxicity study. In both studies, there were no dose related changes in mortality, clinical sign, body weight change, food and water consumption, opthalmoscopy, organ weights, urine analysis, biochemical examination, and hematological findings of all animals treated with Bee Venom (F1, F3). Gross and histopathological findings revealed no evidence of specific toxicity related to Bee Venom (F1, F3). These results suggest that the subcutaneous NOEL (No Observed Effect Level) of Bee Venom (F1, F3) may be over F1 -0.02 mg/kg, F3-0.3 mg/kg.

• Journal of Acupuncture Research
• /
• v.20 no.1
• /
• pp.228-235
• /
• 2003

Objective : Psoriasis is a common skin disease and the difficulty of its medical management is well known. This study was designed to investigate the effect of bee venom aqua-acupuncture on psoriasis. Methods : Bee venom aqua-acupuncture was performed two times a week. The following points were selected: LI-11(曲池), LI-15, K-9(築賓) on both sides of body. For herbal medicine, YanHyulJiHwangTang-gami was given. We checked involvement in plaque, erythematous popules and invasiveness according to psoriasis area severity index(PASI). Results :After 9 weeks of treatment, the patient showed that itching symptoms was disappeared and score of PASI changed from 26.2 to 0. Conclusions : These results suggest that bee venom aqua-acupuncture and herbal medicine has good effect on psoriasis. But further studies are required to concretely prove the effectiveness of bee venom aqua-acupuncture for treating psoriasis.

• Journal of Haehwa Medicine
• /
• v.13 no.2
• /
• pp.267-276
• /
• 2004

Objective : The purpose of this study is to compare the effect of Bee-Venom Therapy and common acupuncture therapy for the lateral epicondylitis. Methods : This study has been carried out for 24 cases of ankle sprain patients who have visited Dr. An Keun Hyeong's Oriental Clinic from april 1, 2004 to august 30, 2004. We have treated 12 cases of them by Bee-Venom therapy(group I) and the other 12 cases by common acupuncture therapy(group II). And we have compared those two group. Results : 1. There were statistical significance on the pain and grip strength with bee-venom therapy group. 2. There were statistical significance on the pain and grip strength with common acupuncture therapy group. 3. Bee-venom therapy group was more statistical significance than common acupuncture therapy group on the pain. 4. There were no statistical significance between bee-venom therapy group and common acupuncture therapy group on the grip strength.