Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Single and Four-Week Subcutaneous Toxicity Studies of a Bee Venom Extracts (F1, F3) In Rats

봉독 추출물(Fl, F3)의 랫드에 대한 단회 및 4주 반복 피하 투여 독성시험

  • 박기수 (서울대학교 수의과대학 공중보건학교실) ;
  • 조성대 (서울대학교 수의과대학 공중보건학교실) ;
  • 안남식 (서울대학교 수의과대학 공중보건학교실) ;
  • 정지원 (서울대학교 수의과대학 공중보건학교실) ;
  • 양세란 (서울대학교 수의과대학 공중보건학교실) ;
  • 박준석 (서울대학교 수의과대학 공중보건학교실) ;
  • 홍인선 (서울대학교 수의과대학 공중보건학교실) ;
  • 서민수 (서울대학교 수의과대학 공중보건학교실) ;
  • 조은혜 (서울대학교 수의과대학 공중보건학교실)
  • Published : 2003.03.01
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Abstract

This study was performed to evaluate single and repeated-dose toxicities of Bee Venom Extracts (F1, F3) in Spraque-Dawley. F1 was injected subcutaneously to rat at dose levels of 0, 0.0002, 0.002, 0.02 mg/kg/day for single-dose toxicity study and repeated-dose toxicity study. F3 was injected subcutaneously to rat at dose level of 0, 0.003, 0.03, 0.3 mg/kg/day for single-dose toxicity study and repeated-dose toxicity study. In both studies, there were no dose related changes in mortality, clinical sign, body weight change, food and water consumption, opthalmoscopy, organ weights, urine analysis, biochemical examination, and hematological findings of all animals treated with Bee Venom (F1, F3). Gross and histopathological findings revealed no evidence of specific toxicity related to Bee Venom (F1, F3). These results suggest that the subcutaneous NOEL (No Observed Effect Level) of Bee Venom (F1, F3) may be over F1 -0.02 mg/kg, F3-0.3 mg/kg.

Keywords

References

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