• Toxicological Research
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• v.13 no.4
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• pp.401-408
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• 1997

Adult male ICR mice were exposed to methylmercuric chloride (CH$_3$HgCI) through drinking water for 80 days. The distribution of mercury in the kidney, liver, spleen and cerebellum of the mouse was examined according to a autometallographic silver-enhancement technique based on a physical development process which renders mercury deposit visible. Grains of mercury traces were located in the proximal convoluted tubules. Lesser staining of the grains was seen in the collecting tubules of medulla. The glomerular basement membrane was void. In the liver, mercury accumulations were present primarily in the hepatocytes around portal area containing interlobular bile duct, artery and portal vein. Also grains of mercury traces were accumulated in the white pulp of the spleen and Purkinje cell layer of the cerebellum.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1996.11a
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• pp.27-31
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• 1996

암환자의 생명을 가장 위협하는 암세포의 전이는 숙주와 암세포의 상호작용을 포함하는 여러단계의 연쇄적인 과정이다. 전이의 발생은 하나의 세포나 집단의 암세포가 첫번째 암발생 부위에서 분리되어 국소적으로 침투하고 순환기계에 들어가 다른곳에 흡착 후 다른 장기의 interstitium과 parcnchyma에 입출(extravasate)하게 되며 2차적 colony로서 자라나 stroma나 basement membrine과 같은 생물학적 울타리를 파괴한다. 전이의 각단계에서 암세포는 면역세포의 공격을 피하여야만 한다. 세포의 이동은 태아의 생성(embryonic events), 성장세포의 재조함(remodeling), 상처 치유(wound healing), 맥관형성 (angiogenesis), 면역 방어 (immune defence)의 경우에 아주 중요한 역활을 한다. 정상적인 경우에 세포의 이동은 잘 통제가 되지만 암세포의 이동은 비정상적으로 통제가 되거나 자체내에서 통제가 된다. 암세포는 숙주에서 생산되는 scatter factors, growth factor, extracellular matrix components, 그리고 암세포에서 발생되는 autocrine utility factors를 포함한 여러가지 인자에 의해 영향을 받는다.

• Korean Journal of Pharmacognosy
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• v.29 no.3
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• pp.149-154
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• 1998

Binding of urokinase-type plasminogen activator to its cellular receptor accelerate production of plasmin from plasminogen on the cell surface. Plasmin can digest extracellular matrix components and basement membranes through activating certain proMMPs, which is related to the invasiveness to the cells. Plasmin also acts the regulation of blood coagulation and relates closely to cardiovascular diseases such as stroke and coronary occlusion. Therefore, its inhibitors may be useful as antimetastatic agents and to the treatment of cardiovascular diseases. To search for plasmin inhibitors from plant resources, we screened plasmin inhibitory activities with 76 methanol extract of plant species. Among them, three plant samples showed strong inhibitory activities (>70%) and thirteen plant samples showed more than 50% inhibitory activities of plasmin. Their inhibitory activities were not directly related with uPA inhibitory activites and cell viability.

• Korean Journal of Veterinary Research
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• v.24 no.1
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• pp.64-68
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• 1984

Undifferentiated leiomyosarcomas were encountered in two dogs, and an ultrastructural study was carried out. The results of this study were summarized as follows; 1. The nuclei of mosts tumor cells showed bilobate appearance. 2. Most cells of the tumors had not a distinct basement membrane. 3. Most cells of the tumors had a degenerative rough endoplasmic reticulum. 4. Intercellular matrix contained some amounts of collagen. 5. Attachment areas between tumor cells were not apparent, but a few tight junction were clearly seen. 6. Myofibrils were present in bipolor end area.

• Proceedings of the Korea Institute of Fire Science and Engineering Conference
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• 2008.04a
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• pp.163-167
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• 2008

Fire-fighters are struggling against heat and dense smoke by fire when it occurs at the basement or the inner place of a building. An indoor fire-fighting robot with well heat-resistance, great searching cameras and good extinguishing ability has been developed. It never suffocate, coming into the fire district and extinguishes fire directly. In this study, several experiment was conducted to evaluate field working ability of the fire-fighting robot. As a result, a series of passing obstacles, finding fire place and fire suppression by the remote controlling with image information appeared satisfactory.

• Proceedings of the Korea Institute of Fire Science and Engineering Conference
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• 2012.04a
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• pp.302-305
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• 2012

지하 주차장에서 차량사고에 의해 차량화재가 발생하는 것을 고려하여 대규모 연소실험을 실시하였다. 연소 실험결과 실험체 Car1, Car2 의 최대 발열량은 5.4MW가 측정 되었으며, 최고온도는 Car1에서 $1206^{\circ}C$와 Car2에서 최고 온도 $1113^{\circ}C$가 측정 되었다.

• Proceedings of the Korean Society of Soil and Groundwater Environment Conference
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• 2003.04a
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• pp.287-291
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• 2003

To delineate the internal structures of alluvial aquifer, high resolution seismic and GPR methods were adopted in Buyeo Gunsu-Ri area. The result of seismic refraction survey shows the water table of the aquifer and the result of seismic reflection reveals the basement and somewhat dominant internal structures of alluvial aquifer. The internal heterogeneity due to variations in channel behavior can be delineated using GPR survey. GPR profiles for the point bar deposits near Buyeo county reveals two different stratigraphic units the lower inclined heterogeneous strata and the upper horizontally stratified strata. According to the increase of demand for water resource using artificial recharge in alluvium, it is believed that the information acquired by high resolution geophysical methods will have an important roles for the effective and sustainable development and usage of groundwater in alluvial aquifer.

• International Journal of Aeronautical and Space Sciences
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• v.2 no.2
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• pp.82-94
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• 2001

The purpose of this paper is to analyze the static and dynamic stability-of the unmanned airship under development ; the target airship's over-all length of hull is 50m and the maximum diameter is 12.5m. For the analysis, the dynamic model of an airship was defined and both the nonlinear and linear dynamic equations of motion were derived. Two different configuration models (KA002Y and KA003Y) of the airship were used for the target model of the static stability analysis and the dynamic stability analysis. From the result of analyses, though the airship is unstable in static stability, dynamic characteristics of the airship can provide the stable dynamic stability. All of the results, airship models and dynamic flight equations will be an important basement and basic information for the next step of developing the automatic flight control system(AFCS) and the stability augmentation system(SAS) for the unmanned airship as well as for the stratospheric airship in the future.

• Economic and Environmental Geology
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• v.32 no.1
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• pp.33-41
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• 1999

A new sedimentary basin is reported from the marine multi-channel seismic data which were acquired for the hydrocarbon exploration on the southwestern Korean continental shelf in 1970. Along the southeastern part of Line 1192, the about 60-km-long basin with the thickness of 0.55~1.1 s is observed on the near-trace gather. However, both new and previous 24-fold stack sections fail to show the basin image probably due to its rugged top beneath the shallow water. The boundary contact between the basement with the velocity of about 5200m/s and the basin filling with the velocities of 4300~4700 m/s is unclear. These velocites are calculated from the corresponding shot gathers. Compared with the Haenam Basin, a neighbouring onshore Cretaceous sedimentary basin, we interpret that the new basin includes the volcanics and volcaniclastic sequences deposited in the lacustrine environment. This nonmarine basin was possibly formed as the result of the tectonic movement during the Cretaceous, implying the wide occurrence of the Cretaceous basins over the southern Korean Peninsula as well as its southwestern continental shelf.

• Economic and Environmental Geology
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• v.22 no.3
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• pp.267-276
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• 1989

This paper presents results of interpretaton of gravity data by iterative nonlinear inversion methods. The gravity data are obtained by a theoretical formula for two-dimensional 2-layer structure. Depths to the basement of the structure are determined from the gravity data by four interative inversion methods. The four inversion methods used here are the Gradient, Gauss-Newton, Newton-Raphson, and Full Newton methods. Inversions are performed by using different initial guesses of depth for the over-determined, even-determined, and under-determined cases. This study shows that the depth can be determined well by all of the methods and most efficiently by the Newton-Raphson method.