Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Detection of Mercury in Kidney, Liver, Spleen and Cerebellum of the Mouse by Autometallography

오토메탈로그라피에 의한 마우스의 신장, 간장, 비장, 및 소뇌에 축적된 수은의 검출

  • 조현욱 (순천대학교 자연대 생물학과) ;
  • 김명훈 (광주보건전문대학 물리치료과) ;
  • 황규영 (순천대학교 자연대 생물학과) ;
  • 이성태 (순천대학교 자연대 생물학과)
  • Published : 1997.12.01
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Abstract

Adult male ICR mice were exposed to methylmercuric chloride (CH$_3$HgCI) through drinking water for 80 days. The distribution of mercury in the kidney, liver, spleen and cerebellum of the mouse was examined according to a autometallographic silver-enhancement technique based on a physical development process which renders mercury deposit visible. Grains of mercury traces were located in the proximal convoluted tubules. Lesser staining of the grains was seen in the collecting tubules of medulla. The glomerular basement membrane was void. In the liver, mercury accumulations were present primarily in the hepatocytes around portal area containing interlobular bile duct, artery and portal vein. Also grains of mercury traces were accumulated in the white pulp of the spleen and Purkinje cell layer of the cerebellum.

Keywords

References

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