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A Study on the Cytologic Features of Fine Needle Aspiration Cytology in the Thyroid Follicular Neoplasm and Nodular Goiter (갑상선의 여포상 종양과 결절성 갑상선 종대에 대한 세침 흡인 세포학적 연구)

  • Yoo, Jin-Ye;Cho, Hye-Jae;Ko, Il-Hyang
    • The Korean Journal of Cytopathology
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    • v.9 no.1
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    • pp.69-78
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    • 1998
  • There is a lot of difficulty in the diagnosis of follicular lesions of the thyroid by fine needle aspiration cytology(FNAC). The main purpose of this report is offering more guidance regarding the cytologic appearance to distinguish follicular neoplasm from nodular golfer and laying stress on the presence of mixed group. The histologic and cytologic findings of 23 follicular neoplasms and 13 nodular (adenomatous) getters were reviewed. Histologic specimens were classified into the microfollicular(MIF), mixed(MIX), and nodular getter(NG) groups. The comparison of histologic patterns with histologic diagnosis revealed that all the lesions with predominantly microfollicular, trabecular, or solid pattern were follicular carcinoma and all the lesions with predominantly macrofollicular pattern were nodular goiter. The distinguishing cytologic features for the MIF group were irregular cell arrangement in cell groups(100%, p=0.00001), absence of atrophic follicular cells(100%, p=0.0007), abundant microfollicles(100%, 0=0.002), pleomorphic nuclei(100%, p=0.002), not predominant syncytial smear pattern(100%, p=0.002), heterochromatin(100%, p=0.032), absence of macrofollicles(100%, p=0.038), scant colloid(100%, 0=0.04), clear back-ground(83%, p=0.00006), and uniform sized follicles(83%, p=0.014). And regular cell arrangement(honeycomb appearance) in cell groups(85%, p=0.0000), atrophic change of follicular cells(69%, p=0.0002), syncytial smear pattern(54%, p=0.000), monomorphic nuclei(85%, p=0.008), and hemorrhagic background(100%, p=0.027) were characteristic features of the NG group. Seventeen out of 36 cases(47%) were the MIX group composed of combined cytologic features of the MIF and NG groups. Therefore the frequent presence of the MIX group is considered to be main cause of the difficulty in the diagnosis of follicular lesions by FNAC. The mixed morphologic feature may support the hypothesis of a biologic 'continuum' between nodular goiter and follicular neoplasm of thyroid gland.

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Compensatory Hyperhidrosis after Thoracoscopic Sympathectomy in Essential Hyperhidrosis (본태성 다한증 환자의 수술 후 발생하는 보상성 다한증)

  • Seo, Eui Kyo;Cho, Yong Eun;Yoon, Do Heum;Kim, Young Soo
    • Journal of Korean Neurosurgical Society
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    • v.30 no.4
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    • pp.486-492
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    • 2001
  • Objective : Essential hyperhidrosis is a pathological condition of excessive sweating beyond that required to cool the body, though poorly understood, originating from a dysfunction of the sympathetic nervous system. Thoracoscopic sympathectomy is the most popular treatment for upper limb hyperhidrosis, because it is a safe, effective, minimally invasive, and time-saving method. However, the common complication is the compensatory hyperhidrosis in other areas of the body, notably on the back, chest, abdomen, and buttocks. Compensatory hyperhidrosis is severe enough for some people, especially those living in a warm climate or engaging in heavy physical activities, to regret ever having had operation. The pathophysiological mechanisms underlying compensatory hyperhidrosis are incompletely understood, even though it is thought to be a truly compensatory feature related to thermoregulation of the body. Materials and Methods : we studied the clinical features of total 233 patients who were diagnosed as essential hyperhidrosis and treated with thoracoscopic sympathectomy or sympathicotomy from March 1992 to July 2000. Results : The success rate of thoracoscopic sympathetic surgery(sympathectomy or sympathicotomy) was 98.7%. The global rate of compensatory hyperhidrosis was 77% ; 84% in group T2, 3 sympathectomy, 76% in group T2 sympathectomy, 43% in group T2, 3 sympathicotomy and 59% in group T2 sympathicotomy. The rate of embarrassing or disabling compensatory sweating was significantly higher in T2 sympathectomy and in T2, 3 sympathectomy than in T2 sympathicotomy and T2, 3 sympathicotomy with significancy in statistic analysis(p<0.01). The precipitating factors of compensatory hiperhidrosis, including heat(warm weather), anxiety, stress, and exertion were noted. The compensatory hyperhidrosis was the main cause of patient dissatisfaction after thoracoscopic sympathectomy. Conclusion : The degree of compensatory hyperhidrosis is closely related to the extent of thoracic sympathectomy.

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Assessment of Nucleus-DNA Damage in Red Pepper Cells Treated with γ-Radiation through Comet Assay (Comet 분석을 통한 방사선처리 고추세포의 핵 DNA 손상평가)

  • An, Jung-Hee;Back, Myung-Hwa;Kim, Jae-Sung;Jeong, Jeong-Hag;Kwon, Soon-Tae
    • Journal of Plant Biotechnology
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    • v.31 no.3
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    • pp.225-230
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    • 2004
  • We employed single cell gel electrophoresis method (comet assay) to analyze the degree of nucleus-DNA damage in the leaves of red pepper (Capsicum annuum L.) seedlings exposed to $^{60}$ CO v-radiation stress. Nucleus-DNA damage was measured as the ratio of tail length (T) to head length (H) in individual comet image isolated from pepper leaf cell. The T/H ratio of control-cells and treated-cells at 50 or 100 Gy were 1.28 and 3.54 or 3.39, respectively, suggesting that nuclei of pepper cells were severely damaged in the integrity of DNA strand by the treatment of enhanced v-radiation. The percentage of head-DNA in control-cells was 76.8%, whereas those of 50 and 100 Gy treated-cells were 55.9% and 59.9%, respectively. Pretreatment of low dose (4 to 20 Gy) radiation to seeds decreased DNA-damage in the leaves of seedlings treated with high dose radiation at 50 or 100 Gy. In this experiment, we developed a sensitive, reliable and rapid method for evaluating genotoxic effect in the nuclei of plant cells by employing comet assay.

A Study on the Evaluating Shrinkage Cracking Properties of Concrete by Size of Specimen of Plat-Ring Restrained Test Method (판상-링형 구속시험방법의 시험체 치수에 따른 콘크리트 수축균열 특성 평가에 관한 연구)

  • Choi, Hyeong-Gil;Nam, Jeong-Soo;Na, Chul-Sung;Back, Yong-Kwan;Kim, Gyu-Yong;Kim, Moo-Han
    • Proceedings of the Korea Concrete Institute Conference
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    • 2008.11a
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    • pp.581-584
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    • 2008
  • In this study, it is willing to present that fundamental data for proposing quantitatively shrinkage cracking evaluation method such as plat-ring type restrained test method. To examine suitable size of specimen of plat-ring type restrained test method, Evaluated concrete about restrained shrinkage crack properties of numerical analysis of 3D solid element using the MIDAS program, drying shrinkage deformation, restrained shrinkage stress, crack area and crack point with inside ring diameter of specimen in 100mm, 150mm, 200mm and high of Specimen in 30mm, 50mm after curing in condition of constant temperature and usual habit of temperature 20${\pm}$3$^{\circ}$C, humidity 60${\pm}$5%. As a result, it was available about suitable estimation with inside ring diameter of specimen in more than 150mm and high of Specimen in 50mm. Hereafter, it is considered that the study concerning environmental condition and mixing factor in plat-ring type restrained test method is need.

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Prediction of the Spinal Load during Static Loading Conditions using EMG model and Three Optimization models (정적 부하 작업에서 EMG 모델과 세가지 최적화 모델을 이용한 척추 부하 평가)

  • Song, Young Woong;Chung, Min Keun
    • Journal of Korean Society of Occupational and Environmental Hygiene
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    • v.15 no.1
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    • pp.61-70
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    • 2005
  • This study investigated the spinal loads(L5/S1 disc compression and shear forces) predicted from four biomechanical models: one EMG model and three optimization models. Three objective functions used in the optimization models were to miminize 1) the cubed muscle forces : MF3, 2) the cubed muscle stress : MS3, 3) maximum muscle intensity : MI. Twelve healthy male subjects participated in the isometric voluntary exertion tests to six directions : flexion/extension, left/right lateral bending, clockwise/ counterclockwise twist. EMG signals were measured from ten trunk muscles and spinal loads were assessed at 10, 20, 30, 40, 50, 60, 70, 80, 90%MVE(maximum voluntary exertion) in each direction. Three optimization models predicted lower L5/S1 disc compression forces than the EMG model, on average, by 31%(MF3), 27%(MS3), 8%(MI). Especially, in twist and extension, the differences were relatively large. Anterior-posterior shear forces predicted from optimization models were lower, on average, by 27%(MF3), 21%(MS3), 9%(MI) than by the EMG model, especially in flexion(MF3 : 45%, MS3 : 40%, MI : 35%). Lateral shear forces were predicted far less than anterior-posterior shear forces(total average = 124 N), and the optimization models predicted larger values than the EMG model on average. These results indicated that the optimization models could underestimate compression forces during twisting and extension, and anterior-posterior shear forces during flexion. Thus, future research should address the antagonistic coactivation, one major reason of the difference between optimization models and the EMG model, in the optimization models.

A Case Study on Local Erosion Characteristics Evaluation of the Inchon Coast (인천 해안지역 지반의 국지적 침식특성 평가)

  • Kwak, Ki-Seok;Lee, Ju-Hyung;Park, Jae-Hyeon;Chung, Moon-Kyung
    • Proceedings of the Korean Geotechical Society Conference
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    • 2006.03a
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    • pp.455-465
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    • 2006
  • In this study, the effect of scour was evaluated by regional and geotechnical characteristics and back data were accumulate for the design against scour through the local erosion characteristics evaluation of the Inchon coast. The erosion characteristics for the undisturbed soil samples collected near the main locations at the Incheon 2nd bridge, the Hwangyeong bridge, and a coast road in Songdo, are determined quantitatively through the scour rate tests. On the basic soil properties test, the bed around the Inchon coast chiefly consists of fined grained soils, and the soil samples were classified as silty clay(ML) or clay(CL) under the Unified Soil Classification System. On the scour rate test, the critical shear stress increases when the undrained shear strength increases as of the general trend of fine grained soils, and the average scour rate for the maximum velocity by 100 year flood is 173mm/hr at the Incheon 2nd bridge, 67mm/hr at the Hwangyeong bridge and 10mm/hr at a coast road in Songdo, respectively. Comparing to the scour rate of coarse grained soil, that of the bed around the Inchon coast is turned out to be very low. Therefore, the relative ability of the bed around the Inchon coast to resist erosion is assumed to be very high.

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Application of flat DMT and ANN for reliable estimation of undrained shear strength of Korean soft clay (국내 연약지반의 신뢰성있는 비배수 전단강도 추정을 위한 flat DMT와 인공신경망 이론의 적용)

  • Byeon, Wi-Yong;Kim, Young-Sang;Lee, Seung-Rae;Jeong, Eun-Taeg
    • Proceedings of the Korean Geotechical Society Conference
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    • 2004.03b
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    • pp.154-161
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    • 2004
  • The flat dilatometer test(DMT) is a geotechnical tool to estimate in-situ properties of various types of ground materials. The undrained shear strength is known to be the most reliable and useful parameter obtained by DMT. However, the existing relationships which were established for other local deposits depend on the regional geotechnical characteristics. In addition, the flat dilatometer test results have been interpreted using three intermediate indicesmaterial index($I_p$), horizontal stres index($K_p$), and dilatometer modulus($E_p$) and the undrained shear strength is estimated only by using the horizontal stress index($K_D$). In this paper, an artificial neural network was developed to evaluate the undrained shear strength by DMT and the ANN, based on the $p_0,\;p_1,\;p_2,\;{\sigma}'_v_0$, and porewater pressure. The ANN which adopts the back-propagation algorithm was trained based on the DMT data obtained from Korean soft clay. To investigate the feasibility of ANN model, the prediction results obtained from data which were not used to train the ANN and those obtained from existing relationships were compared.

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A Study of the Trends in Korean Nursing Research on Critical Care in the Last 10 Years (2008-2017) Using Integrated Review and Key Word Analysis (통합적 고찰과 키워드 분석을 이용한 최근 10년(2008-2017) 동안의 국내 중환자간호 연구 동향 분석)

  • Kang, Jiyeon;Kim, Soo Gyeong;Cho, Young Shin;Ko, Hyunyoung;Back, Ji Hyun;Lee, Su Jin
    • Journal of Korean Critical Care Nursing
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    • v.11 no.2
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    • pp.75-85
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    • 2018
  • Purpose : The purpose of this study was to examine the possible direction of critical care nursing research in the future by analyzing the trends of recent Korean studies. Method : Using a database search, we selected 263 articles on critical care nursing that were published in Korean journals between 2008 and 2017. Then, we conducted an integrative review of the contents of the selected articles and analyzed the English abstracts using the relevant packages and functions of the R program. Results : The number of studies concerning critical care nursing has increased over the 10-year period, and the specific topic of each study has diversified according to the time at which it was conducted. In terms of quality, the majority of the research was published in high-level academic journals. The key words regularly studied over the past decade were: knowledge, delirium, education, restraint, stress, and infection. Studies related to vancomycin-resistant enterococci infection, compliance, and standards have decreased, while studies related to death, communication, and safety have increased. Conclusion : Randomized controlled trials and protocol research for evidence-based critical care need to be conducted, as does research on family involvement. The key word analysis of unstructured text used in this study is a relatively new method; it is suggested that this method be applied to various critical care nursing research and develop it methodologically.

Design Requirements by Evaluating Comfort while Wearing Korean Naval Duty Uniforms for Summer and Winter (대한민국 동하절기 해군 함상복의 착용쾌적성 평가를 통한 디자인 요소 요구성능 분석)

  • Lee, Hyo-Hyun;Shin, Sora;Lee, Joo-Young
    • The Korean Journal of Community Living Science
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    • v.27 no.3
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    • pp.419-435
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    • 2016
  • The purpose of the present study was to suggest the design requirements for Korean naval duty uniforms by evaluating the physiological and psychological comfort while wearing the uniforms. Two sets of wear trials were conducted with summer uniforms(eight young males) and winter uniforms(seven other young males). The summer wear trial consisted of 10-min rest, 60-min exercise, and 10-min recovery at an air temperature($T_{air} $) of $33^{\circ}C$ and 62%RH, followed by 10-min recovery at a $T_{air} $ of $23^{\circ}C$ and 64%RH(total 90 min). The winter wear trial consisted of 20-min rest at $T_{air} $ $20^{\circ}C$ and 55%RH, 25-min rest, 30-min exercise, and 35-min recovery at a $T_{air} $ of 0oC and 43%RH(total 110 min). Rectal and seven skin temperatures, clothing microclimate, heart rate, oxygen consumption, total sweat rate, and subjective perceptions were measured during the wear trials. By evaluating the experimental results from the wear trials, we extracted the following psycho-physiological design requirements to improve the current Korean naval uniforms: (1) It is important to maintain the skin temperatures within their comfort range, which depends on the body region (higher than $30^{\circ}C$ in winter, but less than $35^{\circ}C$ in summer). (2) In summer, the feet should be protected from the high heat of the ship floor surface. (3) In summer, sweat from the back should be sufficiently absorbed and allowed to dry quickly.

Forging Process Design of Self-Piercing Rivet for Joining dissimilar Sheet Metals (이종재료 접합을 위한 Self-Piercing Rivet의 단조공정설계)

  • Kim, Dong-Bum;Lee, Mun-Yong;Park, Byung-Joon;Park, Jong-Kweon;Cho, Hae-Yong
    • Journal of Advanced Marine Engineering and Technology
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    • v.36 no.6
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    • pp.802-807
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    • 2012
  • Self-piercing rivet is sheet joining method. It is being used more to join aluminum alloy sheets. Self-piercing riveting is a large-deformation process that involves piercing. The self-piercing rivet, under the press from the punch, pierces the top sheet and forms a mechanical interlock with the bottom sheet. In this study, forging process was designed for manufacturing self-piercing rivet. The forging process has been simulated by using commercial FEM code DEFORM-2D. In simulation of forging process for manufacturing rivet, process sequence, formability, forging load, and distributions of stress and strain were investigated. The suitable forging process could be designed by comparisons of simulation results. The developed process consists of four stages: upsetting, first chamfering, back extrusion, and second chamfering. The simulated results for forging process were confirmed by experimental trials with the same conditions.