• Title/Summary/Keyword: BCC

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Protective Effects of BCC Against Oxidative Stress in Cardiomyocyte Cells

  • Bong-Geun Shin;Dae-Kwan Kim
    • Biomedical Science Letters
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    • v.30 no.1
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    • pp.10-16
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    • 2024
  • Oxidative stress caused by elevated reactive oxygen species (ROS) in the heart causes various heart diseases. Oxidative stress is known as a factor that causes diseases in various organs as well as the heart. Diseases such as heart failure, myocardial infarction, and cardiomyopathy caused by oxidative stress in the heart can be treated with medication or surgery. Recently, blood cells concentrate (BCC) is used in various treatment areas such as orthopedics, gynecology, and urology. BCC therapy is applied to treatment by concentrating platelets and white blood cells necessary for regeneration through simple centrifugation using autologous blood. As the platelets are activated, many growth factors are released from alpha granules of the platelets. Growth factors such as TGF-β1, PDGF, VEGF, and EGF derived from platelets are involved in various cell signaling pathway. Due to these growth factors, BCC can contribute to tissue regeneration and can treat various diseases. CD34+ cells contained in BCC may also play an important role in tissue regeneration. In this study, we investigated whether BCC has a regenerative effect on heart disease, and if so, what mechanism causes the effect. To observe this, cardiomyocyte cells were treated with H2O2 to induce oxidative stress. And the effect was confirmed in the presence or absence of BCC. As a result, in the presence of BCC, the oxidative stress of cardiomyocyte cells was reduced and cell damage was also reduced. These results suggest that BCC therapy can be a new treatment alternative for heart disease.

Reoccurred Multiple Basal Cell Carcinomas: A Case Report (전신에 새로이 발생한 다발성 기저세포암 1예)

  • Young Soo Yoon;Geon Hwi Kim;Kyung Hee Min
    • Korean Journal of Head & Neck Oncology
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    • v.39 no.1
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    • pp.23-26
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    • 2023
  • Basal cell carcinoma (BCC) is the most common skin cancer. Ultraviolet radiation exposure and genetic predisposition are known to be the most important etiological factors. Multiple BCC is often associated with genetic familial conditions such as BCC syndrome, basal cell nevus syndrome. We present a case of 54-year-old female who had multiple BCC that had reoccurred. She was completely cured after receiving radio-chemotherapy for leukemia 16 years ago. She had multiple lesions (scalp, left thigh, right popliteal fossa, and right buttock), and had underwent wide excisions of all lesions. All biopsies revealed BCC. Six years later, she had also multiple lesions; left forehead, frontal vertex scalp, parietal vertex scalp, right occipital scalp, and lower abdomen. We performed wide excision. Histopathological examination revealed BCC. She had no signs of any BCC associated syndrome. We report a rare case of nonsyndromic multiple BCC that reoccurred at the new site.

Effects of Preoperative Biopsies on Recurrence in Head and Neck Skin Cancer

  • Jung, Ji Eun;Rah, Dong Kyun;Kim, Yong Oock
    • Archives of Plastic Surgery
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    • v.39 no.5
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    • pp.518-521
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    • 2012
  • Background Skin cancer is the most common malignant tumor in humans. Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the two most common types of skin cancers. When skin cancer is clinically suspected, preoperative biopsies are recommended for a definite diagnosis. However, despite a concern over potential increased risk of metastasis associated with mechanical manipulation, there have been few investigations into whether a preoperative biopsy affected the recurrence of BCC and SCC. Methods Primary BCC or SCC patients who underwent standard surgical excision from 1991 to 2010 were reviewed and a retrospective analysis was performed. Ultimately, 45 BCC patients and 54 SCC patients, who did not meet the exclusion criteria, were analyzed. To identify whether a preoperative biopsy affected the recurrence of BCC and SCC, the recurrence rates of each with and without biopsy were compared. Results Preoperative biopsy had no statistically significant effect on recurrence (BCC, P=0.8680; SCC, P=0.7520). Also, there was no statistical significance between the interval from initial biopsy to first operation and recurrence (BCC, P=0.2329; SCC, P=0.7140). Even though there was no statistical significance, the mean interval from the biopsy to the operation among the BCC patients who underwent preoperative biopsy was 9.2 months in those who had recurrence and 2.0 months in those who had no recurrence. Conclusions There was no statistically significant relationship between preoperative biopsy and recurrence of BCC and SCC. However, there was a tendency toward recurrence in patients with a longer interval between the biopsy and the corrective operation in BCC.

Irradiation-induced BCC-phase formation and magnetism in a 316 austenitic stainless steel

  • Xu, Chaoliang;Liu, Xiangbing;Xue, Fei;Li, Yuanfei;Qian, Wangjie;Jia, Wenqing
    • Nuclear Engineering and Technology
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    • v.52 no.3
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    • pp.610-613
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    • 2020
  • Specimens of austenitic stainless steel were irradiated with 6 MeV Xe ions to two doses of 7 and 15 dpa at room temperature and 300 ℃ respectively. Then partial irradiated specimens were subsequently thermally annealed at 550 ℃. Irradiation-induced BCC-phase formation and magnetism were analyzed by grazing incidence X-ray diffraction (GIXRD) and vibrating sample magnetometer (VSM). It has been shown that irradiation damage level, irradiation temperature and annealing temperature have significant effect on BCC-phase formation. This BCC-phase changes the magnetic behavior of austenitic stainless steel. The stress relief and compositional changes in matrix are the driving forces for BCC-phase formation in austenitic stainless steel during ion irradiation.

A rare case of abdominal adenoid basal cell carcinoma in a patient with a history of radiation therapy

  • Kim, Ji Hun;Kim, Sun Eung;Cheon, Young Woo
    • Archives of Plastic Surgery
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    • v.47 no.1
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    • pp.78-82
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    • 2020
  • Basal cell carcinoma (BCC) is the most common skin cancer and its incidence is steadily increasing. Prior radiation therapy is one of the most important risk factors for BCC. Although the mechanism remains undefined, long-term studies have shown that people exposed to radiation have an increased risk of BCC. Despite the fact that BCC occurs most frequently in sun-exposed areas of the body, patients with a history of radiation therapy have an increased risk of BCC in areas previously exposed to radiation. Here, we report a case of adenoid BCC on the abdomen in a 67-year-old woman after radiation therapy post-hysterectomy.

Efficient Problem-Solving Idea Generation in the Design Phase VE of Construction Projects using Business Creativity Codes(BCC) (건설 설계VE의 효율적 문제해결 아이디어 도출을 위한 비즈니스 창의성 코드(BCC) 활용방안)

  • Kim, Huy-Qyou;Park, Young-Taek
    • Journal of the Korea Institute of Building Construction
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    • v.16 no.4
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    • pp.367-379
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    • 2016
  • Although the importance of creative thinking is rapidly increasing in the new century, the generation of creative ideas and its application in the construction industry have been considered relatively difficult. Thus there have been a few studies on the subject that how to apply creative thinking tools with empirical evidence in the construction industry. Value engineering(VE) has been widely applied in the design phase of construction projects due to the government regulation, Brainstorming has been the most prevalent idea generation techniques in the VE activities during the past several decades. Contrary to popular belief, the performance of brainstorming is not so good. It is known as the brainstorming myth. This paper proposes the business creativity codes(BCC) as an alternative idea generation tool in the design phase VE of construction projects. In order to examine the effectiveness of the BCC, 50 successful field cases awarded in the design VE competition of government agency are used. The result shows that the BCC can be used as an effective idea generation tool in the design phase VE construction projects.

A TMO Supporting Library and a BCC Scheduler for the Microscale Real-time OS, TMO-eCos) (초경량 실시간 운영체제 TMO-eCos를 위한 TMO 지원 라이브러리 및 BCC 스케줄러)

  • Ju, Hyun-Tae;Kim, Jung-Guk
    • Journal of KIISE:Computing Practices and Letters
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    • v.15 no.7
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    • pp.505-509
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    • 2009
  • It is the most important object of real-time computing to make real-time tasks keep their given time conditions. In this paper, we implemented BCC(Basic Concurrency Constraint) scheduler which is provided as an essential element of TMO(Time-triggered Message-triggered Object) model, and TMO Supporting Library that supports object-oriented design for TMO. BCC scheduler is a means to design timeliness-guaranteed computing, and it predicts the start of SpMs first, and then it makes the execution of SvMs deferred when it is predicted that any SpM begins to run currently. In this way, BCC is able to prevent collisions between SpM and SvM, and it gives higher priority to SpMs than SvMs.

Real-time BCC Volume Isosurface Ray Casting on the GPU (GPU를 이용한 실시간 BCC 볼륨 등가면 레이 캐스팅)

  • Kim, Minho;Lee, Young-Joon
    • Journal of the Korea Computer Graphics Society
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    • v.18 no.4
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    • pp.25-34
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    • 2012
  • This paper presents a real-time GPU (graphics processing unit) ray casting scheme for rendering isosurfaces of BCC (body-centered cubic) volume datasets. A quartic spline field is built using the 7-direction box-spline filter accompanied with a quasi-interpolation prefilter. To obtain an interactive rendering speed on the graphics hardware, the shader code was optimized to avoid lookup table and conditional branches and to minimize data fetch overhead. Compared to previous implementations, our work outperforms the comparable one by more than 20% and the rendering quality is superior than others.