Korean Journal of Head & Neck Oncology (대한두경부종양학회지)

The Korean Society for Head and Neck Oncology (대한두경부종양학회)
권호 표지
DOI QR코드

DOI QR Code

Reoccurred Multiple Basal Cell Carcinomas: A Case Report

전신에 새로이 발생한 다발성 기저세포암 1예

  • Young Soo Yoon (Department of Plastic and Reconstructive Surgery, Nowon Eulji Medical Center, Eulji University School of Medicine) ;
  • Geon Hwi Kim (Department of Plastic and Reconstructive Surgery, Nowon Eulji Medical Center, Eulji University School of Medicine) ;
  • Kyung Hee Min (Department of Plastic and Reconstructive Surgery, Nowon Eulji Medical Center, Eulji University School of Medicine)
  • 윤영수 (노원을지대학교병원 성형외과학교실) ;
  • 김건휘 (노원을지대학교병원 성형외과학교실) ;
  • 민경희 (노원을지대학교병원 성형외과학교실)
  • Received : 2022.09.22
  • Accepted : 2022.12.21
  • Published : 2023.05.30
Download PDF
⟨ Previous Next ⟩

Abstract

Basal cell carcinoma (BCC) is the most common skin cancer. Ultraviolet radiation exposure and genetic predisposition are known to be the most important etiological factors. Multiple BCC is often associated with genetic familial conditions such as BCC syndrome, basal cell nevus syndrome. We present a case of 54-year-old female who had multiple BCC that had reoccurred. She was completely cured after receiving radio-chemotherapy for leukemia 16 years ago. She had multiple lesions (scalp, left thigh, right popliteal fossa, and right buttock), and had underwent wide excisions of all lesions. All biopsies revealed BCC. Six years later, she had also multiple lesions; left forehead, frontal vertex scalp, parietal vertex scalp, right occipital scalp, and lower abdomen. We performed wide excision. Histopathological examination revealed BCC. She had no signs of any BCC associated syndrome. We report a rare case of nonsyndromic multiple BCC that reoccurred at the new site.

Keywords

References

  1. Kiiski V, Vries E, Flohil SC, Bijl MJ, Hofman A, Stricker BHC, et al. Risk Factors for Single and Multiple Basal Cell Carcinomas. Arch Dermatol. 2010;146:848-855. https://doi.org/10.1001/archdermatol.2010.155
  2. Bartos V. Development of Multiple-Lesion Basal Cell Carcinoma of the Skin: A Comprehensive Review. Med Bull Sisli Etfal Hosp 2019;53:323-328. https://doi.org/10.14744/SEMB.2019.08058
  3. Kim DH, Ko HS, Jun YJ. Nonsyndromic Multiple Basal Cell Carcinomas. Arch Craniofac Surg. 2017;18:191-196. https://doi.org/10.7181/acfs.2017.18.3.191
  4. Verkouteren JAC, Smedinga H, Steyerberg EW, Hofman A, Nijsten T. Predicting the Risk of a Second Basal Cell Carcinoma. J Invest Dermatol. 2015;135:2649-2656 https://doi.org/10.1038/jid.2015.244
  5. Ramachandran S, Lear JT, Ramsay H, Smith AG, Bowers B, Hutchinson PE, et al. Presentation with multiple cutaneous basal cell carcinomas: association of glutathione S-transferase and cytochrome P450 genotypes with clinical phenotype. Cancer Epidemiol Biomarkers Prev. 1999;8:61-67.
  6. Ramsay HM, Fryer A, Strange RC, Smith AG. Multiple basal cell carcinomas in a patient with acute myeloid leukaemia and chronic lymphocytic leukaemia. Clin Exp Dermatol. 1999;24:281-282. https://doi.org/10.1046/j.1365-2230.1999.00480.x
  7. Travis LB, Curtis RE, Hankey BF, Fraumeni JF Jr. Second cancers in patients with chronic lymphocytic leukemia. J Natl Cancer Inst. 1992;84:1422-1427. https://doi.org/10.1093/jnci/84.18.1422
  8. Ron E, Preston DL, Kishikawa M, Kobuke T, Iseki M, Tokuoka S, et al. Skin tumor risk among atomic-bomb survivors in Japan. Cancer Causes Control. 1998;9:393-401. https://doi.org/10.1023/A:1008867617415
  9. Ron E, Modan B, Preston D, Alfandary E, Stovall M, Boice JD Jr. Radiation-induced skin carcinomas of the head and neck. Radiat Res. 1991;125:318-325. https://doi.org/10.2307/3578117
  10. Watt TC, Inskip PD, Stratton K, Smith SA, Kry SF, Sigurdson AJ, et al. Radiation-related risk of basal cell carcinoma: a report from the Childhood Cancer Survivor Study. J Natl Cancer Inst. 2012;104:1240-1250.  https://doi.org/10.1093/jnci/djs298