• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.26 no.1
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• pp.1-18
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• 2013

Objective: Recently the demands for the effective and safe depigmentative and anti-aging agents of the skin have increased due to the medical, pharmaceutical and cosmetic reasons. The purpose of this study is to investigate the MKG(Methanol Extract of Kaempferia galanga) and their dermal bioactivity properties related to cosmeceuticals such as depigmentation. Methods: We assessed inhibitory effects of MKG on melanin production in B16/F10 melanoma cells, on mushroom tyrosinase activity, effects of MKG on the expression tyrosinase, TRP-1, TRP-2, GSK-$3{\beta}$, CREB, MITF in B16/F10 melanoma cells without cytotoxicity range. Cell viability was measured by MTT assay and tyrosinase activity was assessed using by DOPA staining, western-blot analysis. We measured inhibition of melanin synthesis and tyrosinase activity by down-regulation of melanogenic enzyme expressions in ${\alpha}$-MSH induced melanogenesis B16/F10 melanoma cells. Results: MKG inhibited tyrosinase-activity, total melanin contents and dendrite out-growth. MKG inhibited melanogenesis by down-regulation of tyorsinase, TRP-1, TRP-2, CREB, and MITF in B16/F10 cells. The treatment with MKG at the 12.5, $25{\mu}g/ml$ level significantly inhibited the melanin synthesis induced ${\alpha}$-MSH in B16/F10 melanoma cells compared with untreated control. Conclusion: These results suggest that MKG inhibit melanin biosynthesis which is involved in hyper-pigmentation. So MKG is considered to be used as a whitening components reducing cytotoxicity.

• Journal of Microbiology and Biotechnology
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• v.30 no.5
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• pp.749-752
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• 2020

In the search for novel, natural melanogenesis inhibitors, a new sesquiterpene, inularin, was isolated from the flowers of Inula britannica, and the structure was determined using spectroscopic and chemical methods. The antimelanogenic effects of inularin on B16F10 melanoma cells and zebrafish embryos were evaluated. Inularin dose-dependently reduced melanocyte-stimulating hormone-induced melanin production and L-DOPA oxidation in B16F10 cells. Zebrafish embryos were used to confirm the antimelanogenic activity. Inularin significantly decreased the pigmentation of embryos compared with untreated controls.

• Plant Resources
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• v.3 no.3
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• pp.223-225
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• 2000

A new forma, Cremastra appendiculta Makino f. albiflora B. Kil, f. nov. is described from Naejangsan, Jeollabuk-do, Korea. It is easily distinguished from C. appendiculata by having light white-green flower of outer perianth segment and white color of inner perianth segment of the flower.

• Korean Journal of Agricultural Science
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• v.11 no.1
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• pp.176-181
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• 1984

Linear free energy relation ship(LFER) on the insecticidal activity of O,O-diethylphenylphosphate (A) and 3,5-dimethylphenyl-O,O-diethylphosphate (B) derivatives were studied by EHT MO calculation method and regression analysis method. LFER between varying substituent constants and $pI_{50}$ constants of phosphates, (A) & (B) were calculated with applying Hammett, Okamoto-Brown, Taft and Swain-Lupton's DSP equations;percent resonance effect(R) and field effect(F) of (A) were %R=33.5 & %F=66.5 and also that of (B) were %R=2 & %F=98, respectively. On the basis of above findings, the insecticidal activities were similar for both (A) and (B), but (B) have larger field and inductive contribution than (A), due to the 3,5-dimethyl group of (B).

• Journal of the Chungcheong Mathematical Society
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• v.27 no.1
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• pp.113-121
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• 2014

In this paper, we define an extension $f^*:[a,\;b]{\rightarrow}\mathbb{R}$ of a function $f:[a,\;b]_{\mathbb{T}}{\rightarrow}\mathbb{R}$ for a time scale $\mathbb{T}$ and show that f is McShane delta integrable on $[a,\;b]_{\mathbb{T}}$ if and only if $f^*$ is McShane integrable on [a, b].

• Journal of the Chungcheong Mathematical Society
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• v.27 no.2
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• pp.327-333
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• 2014

In this paper, we define the extension $f^*:[a,b]{\rightarrow}\mathbb{R}$ of a function $f:[a,b]_{\mathbb{T}}{\rightarrow}\mathbb{R}$ for a time scale $\mathbb{T}$ and show that f is Riemann delta integrable on $[a,b]_{\mathbb{T}}$ if and only if $f^*$ is Riemann integrable on [a,b].

• Journal of the Chungcheong Mathematical Society
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• v.26 no.3
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• pp.625-630
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• 2013

In this paper, we define an extension $f^*:[a,b]{\rightarrow}\mathbb{R}$ of a function $f^*:[a,b]_{\mathbb{T}}{\rightarrow}\mathbb{R}$ for a time scale $\mathbb{T}$ and show that $f$ is Henstock delta integrable on $[a,b]_{\mathbb{T}}$ if and only if $f^*$ is Henstock integrable on $[a, b]$.

• Bulletin of the Korean Mathematical Society
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• v.53 no.5
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• pp.1373-1384
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• 2016

In this paper, we research the normality of sequences of meromorphic functions concerning the sequence of omitted functions. The main result is listed below. Let {$f_n(z)$} be a sequence of functions meromorphic in D, the multiplicities of whose poles and zeros are no less than k + 2, $k{\in}\mathbb{N}$. Let {$b_n(z)$} be a sequence of functions meromorphic in D, the multiplicities of whose poles are no less than k + 1, such that $b_n(z)\overset{\chi}{\Rightarrow}b(z)$, where $b(z({\neq}0)$ is meromorphic in D. If $f^{(k)}_n(z){\neq}b_n(z)$, then {$f_n(z)$} is normal in D. And we give some examples to indicate that there are essential differences between the normal family concerning the sequence of omitted functions and the normal family concerning the omitted function. Moreover, the conditions in our paper are best possible.

• Communications of the Korean Mathematical Society
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• v.33 no.3
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• pp.889-899
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• 2018

In this paper, we present some upper bounds for unitarily invariant norms inequalities. Among other inequalities, we show some upper bounds for the Hilbert-Schmidt norm. In particular, we prove $${\parallel}f(A)Xg(B){\pm}g(B)Xf(A){\parallel}_2{\leq}{\Large{\parallel}}{\frac{(I+{\mid}A{\mid})X(I+{\mid}B{\mid})+(I+{\mid}B{\mid})X(I+{\mid}A{\mid})}{^dA^dB}}{\Large{\parallel}}_2$$, where A, B, $X{\in}{\mathbb{M}}_n$ such that A, B are Hermitian with ${\sigma}(A){\cup}{\sigma}(B){\subset}{\mathbb{D}}$ and f, g are analytic on the complex unit disk ${\mathbb{D}}$, g(0) = f(0) = 1, Re(f) > 0 and Re(g) > 0.

• The Journal of Natural Sciences
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• v.10 no.1
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• pp.9-12
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• 1998

In this paper, we obtain that if $\psi : E \to F$ is a fibrewise fibration then postcomposition $\psi :C_B(Y, E) \to C_B(Y, F)$ is fibrewise fibration and if (X, A) is a closed fibrewise cofibration the the precomposition $\upsilon :C_B(X, E) \to C_B(A, E)$ is also a fibrewise fibration.