Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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The Antimelanogenic Effect of Inularin Isolated from Flowers of Inula britannica on B16F10 Melanoma Cells and Zebrafish Embryos

  • Jang, Dae Kil (Department of Food Science and Biotechnology, Dongguk University) ;
  • Jung, Seung-Hyun (Department of Applied Marine Bioresource Science, National Marine Biodiversity Institute of Korea) ;
  • Jeong, Ji Hye (Department of Applied Marine Bioresource Science, National Marine Biodiversity Institute of Korea) ;
  • Yoo, Hee Min (Center for Bioanalysis, Korea Research Institute of Standards and Science) ;
  • Lee, Ik Soo (Herbal Medicine Research Division, Korea Institute of Oriental Medicine) ;
  • Shin, Han-Seung (Department of Food Science and Biotechnology, Dongguk University)
  • Received : 2020.03.13
  • Accepted : 2020.04.01
  • Published : 2020.05.28
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Abstract

In the search for novel, natural melanogenesis inhibitors, a new sesquiterpene, inularin, was isolated from the flowers of Inula britannica, and the structure was determined using spectroscopic and chemical methods. The antimelanogenic effects of inularin on B16F10 melanoma cells and zebrafish embryos were evaluated. Inularin dose-dependently reduced melanocyte-stimulating hormone-induced melanin production and L-DOPA oxidation in B16F10 cells. Zebrafish embryos were used to confirm the antimelanogenic activity. Inularin significantly decreased the pigmentation of embryos compared with untreated controls.

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References

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