• Journal of Korea Society of Digital Industry and Information Management
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• v.8 no.2
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• pp.189-198
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• 2012

The demand of smart phone that recently came into spotlight as a new media is sharply increasing not only in Korean market but also in worldwide market but the academic study on this is still in the beginning stage. Hence, it would be a well-timed topic for discussion to make a systematic investigation and analysis. The technology acceptance model used in this study as a theoretical frame can set various external factors in introduction of new information technology as variables. This study made an assumption that such external factors would influence on perceived usefulness, easiness and amusement and such perceived awareness would make an impact on user's satisfaction and repurchase intention. This study proposed an empirical model in order to find out the recommendations and repurchase intention for new media, smart phone. This study model was validated to be very effective model that can explain more concretely and systematically for repurchase of smart phone. In conclusion, this paper illustrates a paradigm shift in smart environment to smart device manufacturers under fierce competition in the world market as well as various analysis results on consumer's use patterns according to such paradigm shift, which shall be utilized as useful information when establishing a marketing strategy for smart phone.

• Journal of Engineering Education Research
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• v.20 no.1
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• pp.18-27
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• 2017

This study aims to investigate industry needs for convergence education in the field of nano-technology, bio-technology, robot, and design. Firstly, the area of convergence technology in nano-tech, bio-tech, robot, and design fields was examined through the literature review and case study. The areas were validated by the experts review who consisted of four industry experts and four professors in the relevant fields. Second, a questionnaire was developed for investigating industry's needs on convergence education. The questionnaire consisted of three parts: 1) awareness of necessity for convergence education, 2) the needs for convergence new technology education from the perspective of industry, and 3) opinions on convergence education. The questionnaire was validated by three engineering education experts. Third, the survey was conducted in cooperation with the Sector Council of Industrial Resources. A total of 400 respondents responded to the questionnaires: 98 in the nano-technology field, 74 in the design field, 58 in the robotics field, and 170 in the bio-technology field. Fourth the industry needs for convergence education were analyzed and implications were suggested. The results of this study are expected to provide a guideline for developing convergence education programs in higher education.

• Journal of environmental and Sanitary engineering
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• v.17 no.3
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• pp.115-120
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• 2002

This study was performed on a questionnaire survey of 500 people about their awareness for indoor air pollution, and measured efficiency of air cleaner which can remove the CO and air-borne particulate of ETS(Environmental Tobacco Smoke) in air clean chamber. The room-size cleaner for measuring indoor air contaminants has been applied to evaluation of two different air cleaner such as the mechanic air cleaner with hepafilter(HPA) and the electrostatic air cleaner with metal plate. The measuring experiment was carried out in a chamber by sampling the air. The results obtained were as follows; As respondents are having their 90% of daytime indoors a day, and 38% of them can feel indoor air pollutions degrees directly by their sense of smell, For the installation of indoor pollution control equipment, 34% of all respondents installed air cleaner because of the problem of economical charge and almost respondents was not satisfied the trust of ability purified indoor air pollutants. In the experimental results, it was found that more than 95% of CD and air-borne particulate of ETS were removed within 20 minutes. The reaction kinetics of removal pollutants was verified as the pseudo-first order, Finally, it appeared that the room-sire air cleaner can be applied to new technology for removing indoor air contaminants.

• Toxicological Research
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• v.22 no.4
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• pp.423-429
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• 2006

Recent reports on the photocarcinogenicity and photogerotoxicity of many compounds led to an increasing awareness for the need of a standard approach to test for photogenotoxicity. The comet assay has been recently validated as a sensitive and specific test system for the quantification of DNA damage. Thus, the objectives of this study are to investigate the utility of photo-comet assay for detecting photo-mutagens, and to evaluate its ability to predict rodent photo-carcinogenicity. Photo-comet assays were performed using L5178Y $Tk^{+/-}$ mouse lymphoma cells on five test substances (8-methoxypsoralen, chlorpromazine, lomefloxacin, anthracene and retinoic acid) that demonstrated positive results in photocarcinogenicity tests. For the best discrimination between the test substance-mediated DNA damage and the undesirable DNA damage caused by direct UV absorption, a UV dose-response of the cells in the absence of the test substances was firstly fnalized. Out of 5 test substances, positive comet results were obtained for chlorpromazine, lomefloxacin, anthracene and retinoic acid while 8-methoxypsoralen found negative. An investigation into the predictive value of this photo-comet assay for determining the photocarcinogenicity showed that photo-comet assay has relatively high sensitivity. Therefore, the photo-comet assay with mammalian cells seems to be a good and sensitive predictor of the photocarcinogenic potential of new substances.

• Journal of Pharmaceutical Investigation
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• v.39 no.4
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• pp.243-248
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• 2009

The purpose of this study was to investigate the effects of morin, an antioxidant, on the bioavailability of doxorubicin (DOX) in rats. Thus, DOX was administered intravenously (10 mg/kg) or orally (50 mg/kg) with or without oral morin (0.5, 3 and 10 mg/kg). In the presence of morin, the total area under the plasma concentration-time curve (AUC) of DOX was significantly greater than that of the control. In the presence of 3 and 10 mg/kg of morin, the peak concentration $C_{MAX}$) was significantly higher than that of the control. Consequently, the absolute bioavailability (AB) of DOX in the presence of morin was 3.7-8.3%, which was significantly enhanced compared with those of the control group (2.7%). The relative bioavailability (RB) of DOX was 1.36 to 3.02 times higher than those of the control group. Compared to the intravenous control, the presence of morin increased the AUC of DOX, but was not significantly affected. The enhanced bioavailability of oral DOX by oral morin may be due to the inhibition of both P-glycoprotein (P-gp) and cytochrome P450 (CYP) 3A in the intestine and/or liver by morin. This result may suggest that the development of oral DOX combination with morin is feasible, which is more convenient than the i.v. dosage forms. The present study raised the awareness about the potential drug interactions by concomitant use of DOX with morin.

• Journal of Korean society of Dental Hygiene
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• v.13 no.2
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• pp.211-220
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• 2013

Objectives : This study intended to figure out illegal treatment by unlicensed person in dental area and factors, which were considered as user's position on the basis of the local community investigation of health conditions in chungbuk provinces in 2008. Methods : This study used chi-square test and complex sample design of multi-variate logistic regression analysis to question 12,443 peoples who have experience on illegal dental treatment. Results : Multi-variate logistic regression analysis results showed that factors having related to illegal dental treatment are sex, age, education standards, subjective awareness of oral health condition, drinking experience of lifetime, unmet need of dental treatment, chewing difficulty, use of dentures, experience of scaling and the use of interdental care instrument. Conclusions : As a result of this study, in order to root out illegal dental treatment, we need to expand the breadth of health insurance coverage so that it can reduce the burden of dental expenses. Moreover, we need to set out health service of public oral health to inform the importances of maintaining good oral health and the problems of illegal dental treatment by unlicensed person.

• Journal of Information Technology Applications and Management
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• v.19 no.4
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• pp.115-135
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• 2012

Currently, smart signage as a new kind of advertisement media has been widely used and has had a significant effect on consumers. In this study, we examine the impact on the attitude towards smart signage advertisement based on the Ducoffe's Web advertisement model. In particular, we investigate how the advertising factors (interaction, informativeness, irritation, and entertainment) as well as the contextual factors (localization, immediacy, and personalization) have effects on the value and attitude towards smart signage advertisement. Furthermore, we examine the moderating effect of individual defensive propensity on the relationship between affecting factors and the advertising value. By analyzing 192 samples from undergraduates, we found that four out of seven factors have significant effects on the value towards smart signage. More specifically, for advertising factors, informativeness and irritation have positive effects on the advertising value. For contextual factors, on the other hand, localization and entertainment have positive effects on the value towards smart signage. Besides, we discovered that the defensive propensity moderate the relationship between localization and the advertising value.

• Journal of rehabilitation welfare engineering & assistive technology
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• v.11 no.4
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• pp.299-306
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• 2017

The Korean medical device industry has increased dramatically due to various investments in the domestic medical device industry and the introduction of new technologies, but the domestic medical device usage rate in great hospital is still low. In this paper, improvement point for domestic medical device was suggested by domestic medical device usage rate and user and manager's perception survey in great hospitals in Korea. To do this, a survey on the types of medical devices and domestic medical device usage rates were conducted at four national university hospitals in Korea. From this results, the priority survey medical devices were selected. Improvements of Korean medical devices were suggested by failure mode analysis and user awareness surveys for the priority survey medical devices.

• Journal of the Korean Home Economics Association
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• v.43 no.11 s.213
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• pp.165-183
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• 2005

Total fertility rate in South Korea is the lowest in the world. A fertility rate below replacement fertility level will result in serious social problems in the long term. Therefore, it is worthwhile to study a general understanding about the low fertility rate phenomenon and to investigate the effectiveness of fertility policies in order to ameliorate the resulting social problems due to the low fertility rate. This research was a descriptive examination into the low fertility rate phenomenon and an investigation of the needs for fertility potties and their effectiveness. The study subjects were consisted of 769 unmarried people aged from 18 to 40 years old. Data were collected from June to August 2004 and were analyzed by frequencies, mean, and standard deviation. The following results were revealed. First, unmarried people in general had positive perspectives about getting marriaged, giving birth, and being a parent. In addition, the primary cause of low fertility rate was economical difficulties for raising a child. Third, unmarried people thought that the low fertility rate phenomenon resoled in both positive and negative changes in a society. Fourth, policies for economical supports for raising children, establishing social atmosphere for gender equality, and trustful public educational systems were the political alternatives that people really wanted for having a child in the future. Effective alternatives for policies and strategies to address the low fertility rate problems are suggested in the discussion section.

• BMB Reports
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• v.51 no.3
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• pp.143-150
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• 2018

The Hippo signaling pathway plays an essential role in adult tissue homeostasis and organ size control. Abnormal regulation of Hippo signaling can be a cause for multiple types of human cancers. Since the awareness of the importance of the Hippo signaling in a wide range of biological fields has been continually grown, it is also understood that a thorough and well-rounded comprehension of the precise dynamics could provide fundamental insights for therapeutic applications. Several components in the Hippo signaling pathway are known to be targeted for proteasomal degradation via ubiquitination by E3 ligases. ${\beta}-TrCP$ is a well-known E3 ligase of YAP/TAZ, which leads to the reduction of YAP/TAZ levels. The Hippo signaling pathway can also be inhibited by the E3 ligases (such as ITCH) which target LATS1/2 for degradation. Regulation via ubiquitination involves not only complex network of E3 ligases but also deubiquitinating enzymes (DUBs), which remove ubiquitin from its targets. Interestingly, non-degradative ubiquitin modifications are also known to play important roles in the regulation of Hippo signaling. Although there has been much advanced progress in the investigation of ubiquitin modifications acting as regulators of the Hippo signaling pathway, research done to date still remains inadequate due to the sheer complexity and diversity of the subject. Herein, we review and discuss recent developments that implicate ubiquitin-mediated regulatory mechanisms at multiple steps of the Hippo signaling pathway.