• BMB Reports
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• v.45 no.8
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• pp.427-432
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• 2012

Primary cilia, single hair-like appendage on the surface of the most mammalian cells, were once considered to be vestigial cellular organelles for a past century because of their tiny structure and unknown function. Although they lack ancestral motility function of cilia or flagella, they share common ground with multiciliated motile cilia and flagella on internal structure such as microtubule based nine outer doublets nucleated from the base of mother centrioles called basal body. Making cilia, ciliogenesis, in cells depends on the cell cycle stage due to reuse of centrioles for cell division forming mitotic spindle pole (M phase) and assembling cilia from basal body (starting G1 phase and maintaining most of interphase). Ciliary assembly required two conflicting processes such as assembly and disassembly and balance between these two processes determines the length of cilia. Both process required highly conserved transport system to supply needed substance to grow tip of cilia and bring ciliary turnover product back to the base of cilia using motor protein, kinesin and dynein, and transport protein complex, IFT particles. Disruption of ciliary structure or function causes multiple human disorder called ciliopathies affecting disease of diverse ciliated tissues ranging from eye, kidney, respiratory tract and brain. Recent explosion of research on the primary cilia and their involvement on animal development and disease attracts scientific interest on how extensively the function of cilia related to specific cell physiology and signaling pathway. In this review, I introduce general features of primary cilia and recent progress in understanding of the ciliary length control and signaling pathways transduced through primary cilia in vertebrates.

• Steel and Composite Structures
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• v.26 no.4
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• pp.463-471
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• 2018

The bolted end-plate beam-column connections have been widely used in steel structure and composite structure because of its excellent seismic performance. In this paper, the end-plate bolted connection is applied in the concrete structure, A new-type of fabricated beam-column connections with end-plates is presented, and steel plate hoop is used to replace stirrups in the node core area. To study the seismic behavior of the joint, seven specimens are tested by pseudo-static test. The experimental results show that the new type of assembly node has good ductility and energy dissipation capacity. Besides, under the restraint effect of the high-strength stirrup, the width of the web crack is effectively controlled. In addition, based on the analysis of the factors affecting the shear capacity of the node core area, the formula of shear capacity of the core area of the node is proposed, and the theoretical values of the formula are consistent with the experimental value.

• Structural Engineering and Mechanics
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• v.72 no.5
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• pp.557-568
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• 2019

Accurate modeling of contact interface in bolted joints is crucial in predicting the dynamic behavior for bolted assemblies under external load. This paper presents a contact pressure distribution based non-uniform virtual material method to describe the joint interface of assembly structure, which is connected by sparsely distributed multi-bolts. Firstly, the contact pressure distribution of bolted joints is obtained by the nonlinear static analysis in the finite element software ANSYS. The contact surface around bolt hole is divided into several sub-layers, and contact pressure in each sub-layer is thought to be evenly. Then, considering multi-asperity contact at the micro perspective, the relationship between contact pressure and interfacial virtual material parameters for each sub-layer is established by using the fractal contact theory. Finally, an experimental platform for the dynamic characteristics testing of a beam lap structure with double-bolted joint is constructed to validate the efficiency of proposed method. It is found that the theoretical results are in good agreement with experimental results by impact response in both time- and frequency-domain, and the relative errors of the first four natural frequencies are less than 1%. Furthermore, the presented model is used to examine the effect of rough contact surface on dynamic characteristics of bolted joint.

• Journal of Welding and Joining
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• v.22 no.6
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• pp.25-29
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• 2004

Some industrial steel structures are composed by components linked by several welding joints to constitute an assembly. The main interest of assembly simulation is to evaluate the global distortion of welded structure. The general method, thermo-elasto-plastic analysis, leads to excessive model size and computation time. In this study, a simplified method called "Local and Global approach" was developed to break down this limit and to provide a accurate solution for distortion. Local and global approach is composed of 3 steps; 1) Local simulation of each welding joint on a dedicated mesh (usually very fine due to high thermal gradients), taking into account for the non linearity of the material properties and the moving heat source. 2) Transfer to the global model of the effects of the welding joints by projection of the plastic strain tensors. 3) Elastic simulation to determine final distortions in global model. The welding deformation test for mock-up structure was performed to verify this approach. The predicted welding distortion by this approach had a good agreement with experiment results.

• Nuclear Engineering and Technology
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• v.33 no.1
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• pp.93-101
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• 2001

The spacer grid is one of the main structural components in the fuel assembly, which supports the fuel rods, guides cooling water, and protects the system from an external impact load, such as earthquakes. Therefore, the mechanical and structural properties of the spacer grids must be extensively examined while designing them. In this paper, a numerical method for predicting the buckling strength of spacer grids is presented. Numerical analyses on the buckling behavior of the spacer grids are performed for a various array of sizes of the grids considering that the spacer grid is an assembled structure with thin-walled plates and imposing proper boundary conditions by nonlinear dynamic finite element method using ABAQUS/Explicit. Buckling tests on several numbers of specimens of the spacer grid were also carried out in order to compare the results between the test and the simulation result. The drop test is accomplished by dropping a carriage on the specimen at a pre-determined position. From this test, the specimens are buckled only at the uppermost and the lowermost layer among the multi-cells, which is similar to the local buckling at the weakest point of the grid structure. The simulated results also similarly predicted the local buckling phenomena and were found to give good correspondence with the experimental values for the thin-walled grid structures.

• Structural Engineering and Mechanics
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• v.28 no.6
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• pp.677-694
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• 2008

A vibration power minimization model is developed, based on the mobility matrix method, for a vibration isolation system consisting of a vibrating source placed on an elastic support structure through multiple resilient mounts. This model is applied to investigate the design optimization of an X-Y motion stage-based vibration isolation system used in semiconductor wire-bonding equipment. By varying the stiffness coefficients of the resilient mounts while constraining the dynamic displacement amplitudes of the X-Y motion stage, the total power flow from the X-Y motion stage (the vibrating source) to the equipment table (the elastic support structure) is minimized at each frequency interval in the concerned frequency range for different stiffnesses of the equipment table. The results show that when the equipment table is relatively flexible, the optimal design based on the proposed vibration power inimization model gives significantly little power flow than that obtained using a conventional vibration force minimization model at some critical frequencies. When the equipment table is rigid enough, both models provide almost the same predictions on the total power flow.

• Proceedings of the KSR Conference
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• 2007.11a
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• pp.1036-1041
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• 2007

In this paper, we studied the optimized design of roof structure to be separable roof structure. Also, the design have to satisfy with the GM/RT 2100' missile protection tests to verify the safety of railway vehicle structure. The separable roof structure design could have easier assembly process than whole roof structure in case of the interior outfitting and so on. Optimized design have to have as good as whole roof structure about results from the structure analysis. We studied separable roof structure to be optimized along with GM/RT 2100. The separable roof structure showed that the results have the same level of structure analysis

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.8
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• pp.378-385
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• 2017

This study investigated the design of a snap fit, which is widely used for fastening plastic parts. We analyzed the assembly mechanism of a lock snapfit, measured the assembly force and separation force based on the design of experiments, and derived a regression equation through an analysis of variance. The response surface methodology was also used. Polybutylene terephthalate was used to fabricate specimens, and the assembly force and separation force were measured using a micro-tensile tester. The length, width, thickness, and interference were considered as factors. A second-order regression model was used to derive the regression equation. The assembly force decreased with increasing length and width, but it increased with increasing thickness and interference. The finite element method was used to analyze the assembly mechanics. The width decreased the assembly force by increasing the ductility. The influences of the factors for low assembly force and high release force were shown to be opposite to each other. It was necessary to design a structure that minimized the assembly force while maintaining an appropriate level of separation force.

• Management & Information Systems Review
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• v.33 no.4
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• pp.63-75
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• 2014

The paper investigates empirically the determinants of standardization activity at the industry level, focusing on market structure. The enactments or amendments of collective standards is used as the proxy variable for standardization activity. The independent variables, in addition to market structure, are technological opportunity, factor intensity, export ratio, and industry characteristics(assembly). We estimated the logistic regression model(so-called Logit), using the pooling data for 9 Korean industries, including foods, textiles, chemicals, nonmetallic minerals, metals, electronics and electrics, machinery, automobiles, and shipbuilding, over 2006-2009. The empirical finding shows that market structure has no any effects on the enactments or amendments of collective standards in Korea. This might infer that oligopolistic firms devote themselves to de facto standards determined by market rather than de jure standards such as collective standards and Korean Standards(KS). Besides market structure variable, whereas technological opportunity and assembly characteristics are likely to relate positively with the enactments or amendments of collective standards, capital intensity and export ratio have no any relationship with industrial standardization, respectively.

• Membrane Journal
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• v.25 no.4
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• pp.332-342
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• 2015

In this study, to solve the major problem of reverse osmosis (RO) membrane, surface of reverse osmosis membrane was modified by silane-epoxy multi layer. Octyltrimethoxysilane (OcTES) was polymerized to membrane surface via cross-linking by Sol-gel method. n = 8 alkylgroup of OcTES formed the branch structure by self assembly. And for improve fouling resistance of RO membrane, Ether group of ethylene glycol diglycidyl ether (EGDE) was given to improve hydrophilicity of RO membrane surface by ring-opening. To analyze structure of RO membrane surface with FE-TEM and AFM. Membrane surface of the ridge and valley structure and the bridge structure was confirmed due to the multi-layer surface modification of OcTES and EGDE. And through the increase of the roughness, the branch structure was formed well on membrane surface. Through the XPS analysis was identified chemical structure of membrane surface. And confirmed that the hydrophilic surface modification is given to the surface of the film through a Contact angle analysis. In optimization of EGDE surface modification condition, was suitable 0.5 wt% EGDE concentraion and $70^{\circ}C$ ring-opening temperature. In result of fouling resistance test and MFI is SUL-H10, $PA-OcTES_{1.0}$, $PA-OcTES_{1.0}-EGDE_{0.5}$ 68.7, 60.4, 5.4 ($10E-8hr/mL^2$), multi-layer surface modified membrane improved fouling resistance.