• BMB Reports
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• 제45권8호
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• pp.427-432
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• 2012

Primary cilia, single hair-like appendage on the surface of the most mammalian cells, were once considered to be vestigial cellular organelles for a past century because of their tiny structure and unknown function. Although they lack ancestral motility function of cilia or flagella, they share common ground with multiciliated motile cilia and flagella on internal structure such as microtubule based nine outer doublets nucleated from the base of mother centrioles called basal body. Making cilia, ciliogenesis, in cells depends on the cell cycle stage due to reuse of centrioles for cell division forming mitotic spindle pole (M phase) and assembling cilia from basal body (starting G1 phase and maintaining most of interphase). Ciliary assembly required two conflicting processes such as assembly and disassembly and balance between these two processes determines the length of cilia. Both process required highly conserved transport system to supply needed substance to grow tip of cilia and bring ciliary turnover product back to the base of cilia using motor protein, kinesin and dynein, and transport protein complex, IFT particles. Disruption of ciliary structure or function causes multiple human disorder called ciliopathies affecting disease of diverse ciliated tissues ranging from eye, kidney, respiratory tract and brain. Recent explosion of research on the primary cilia and their involvement on animal development and disease attracts scientific interest on how extensively the function of cilia related to specific cell physiology and signaling pathway. In this review, I introduce general features of primary cilia and recent progress in understanding of the ciliary length control and signaling pathways transduced through primary cilia in vertebrates.

• Steel and Composite Structures
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• 제26권4호
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• pp.463-471
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• 2018

The bolted end-plate beam-column connections have been widely used in steel structure and composite structure because of its excellent seismic performance. In this paper, the end-plate bolted connection is applied in the concrete structure, A new-type of fabricated beam-column connections with end-plates is presented, and steel plate hoop is used to replace stirrups in the node core area. To study the seismic behavior of the joint, seven specimens are tested by pseudo-static test. The experimental results show that the new type of assembly node has good ductility and energy dissipation capacity. Besides, under the restraint effect of the high-strength stirrup, the width of the web crack is effectively controlled. In addition, based on the analysis of the factors affecting the shear capacity of the node core area, the formula of shear capacity of the core area of the node is proposed, and the theoretical values of the formula are consistent with the experimental value.

• Structural Engineering and Mechanics
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• 제72권5호
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• pp.557-568
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• 2019

Accurate modeling of contact interface in bolted joints is crucial in predicting the dynamic behavior for bolted assemblies under external load. This paper presents a contact pressure distribution based non-uniform virtual material method to describe the joint interface of assembly structure, which is connected by sparsely distributed multi-bolts. Firstly, the contact pressure distribution of bolted joints is obtained by the nonlinear static analysis in the finite element software ANSYS. The contact surface around bolt hole is divided into several sub-layers, and contact pressure in each sub-layer is thought to be evenly. Then, considering multi-asperity contact at the micro perspective, the relationship between contact pressure and interfacial virtual material parameters for each sub-layer is established by using the fractal contact theory. Finally, an experimental platform for the dynamic characteristics testing of a beam lap structure with double-bolted joint is constructed to validate the efficiency of proposed method. It is found that the theoretical results are in good agreement with experimental results by impact response in both time- and frequency-domain, and the relative errors of the first four natural frequencies are less than 1%. Furthermore, the presented model is used to examine the effect of rough contact surface on dynamic characteristics of bolted joint.

• Journal of Welding and Joining
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• 제22권6호
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• pp.25-29
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• 2004

Some industrial steel structures are composed by components linked by several welding joints to constitute an assembly. The main interest of assembly simulation is to evaluate the global distortion of welded structure. The general method, thermo-elasto-plastic analysis, leads to excessive model size and computation time. In this study, a simplified method called "Local and Global approach" was developed to break down this limit and to provide a accurate solution for distortion. Local and global approach is composed of 3 steps; 1) Local simulation of each welding joint on a dedicated mesh (usually very fine due to high thermal gradients), taking into account for the non linearity of the material properties and the moving heat source. 2) Transfer to the global model of the effects of the welding joints by projection of the plastic strain tensors. 3) Elastic simulation to determine final distortions in global model. The welding deformation test for mock-up structure was performed to verify this approach. The predicted welding distortion by this approach had a good agreement with experiment results.

• Nuclear Engineering and Technology
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• 제33권1호
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• pp.93-101
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• 2001

The spacer grid is one of the main structural components in the fuel assembly, which supports the fuel rods, guides cooling water, and protects the system from an external impact load, such as earthquakes. Therefore, the mechanical and structural properties of the spacer grids must be extensively examined while designing them. In this paper, a numerical method for predicting the buckling strength of spacer grids is presented. Numerical analyses on the buckling behavior of the spacer grids are performed for a various array of sizes of the grids considering that the spacer grid is an assembled structure with thin-walled plates and imposing proper boundary conditions by nonlinear dynamic finite element method using ABAQUS/Explicit. Buckling tests on several numbers of specimens of the spacer grid were also carried out in order to compare the results between the test and the simulation result. The drop test is accomplished by dropping a carriage on the specimen at a pre-determined position. From this test, the specimens are buckled only at the uppermost and the lowermost layer among the multi-cells, which is similar to the local buckling at the weakest point of the grid structure. The simulated results also similarly predicted the local buckling phenomena and were found to give good correspondence with the experimental values for the thin-walled grid structures.

• Structural Engineering and Mechanics
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• 제28권6호
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• pp.677-694
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• 2008

A vibration power minimization model is developed, based on the mobility matrix method, for a vibration isolation system consisting of a vibrating source placed on an elastic support structure through multiple resilient mounts. This model is applied to investigate the design optimization of an X-Y motion stage-based vibration isolation system used in semiconductor wire-bonding equipment. By varying the stiffness coefficients of the resilient mounts while constraining the dynamic displacement amplitudes of the X-Y motion stage, the total power flow from the X-Y motion stage (the vibrating source) to the equipment table (the elastic support structure) is minimized at each frequency interval in the concerned frequency range for different stiffnesses of the equipment table. The results show that when the equipment table is relatively flexible, the optimal design based on the proposed vibration power inimization model gives significantly little power flow than that obtained using a conventional vibration force minimization model at some critical frequencies. When the equipment table is rigid enough, both models provide almost the same predictions on the total power flow.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2007년도 추계학술대회 논문집
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• pp.1036-1041
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• 2007

In this paper, we studied the optimized design of roof structure to be separable roof structure. Also, the design have to satisfy with the GM/RT 2100' missile protection tests to verify the safety of railway vehicle structure. The separable roof structure design could have easier assembly process than whole roof structure in case of the interior outfitting and so on. Optimized design have to have as good as whole roof structure about results from the structure analysis. We studied separable roof structure to be optimized along with GM/RT 2100. The separable roof structure showed that the results have the same level of structure analysis

• 한국산학기술학회논문지
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• 제18권8호
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• pp.378-385
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• 2017

본 연구는 플라스틱 부품의 체결에 널리 활용되고 있는 스냅핏의 설계에 관하여 연구하였다. 이탈방지 기능이 우수한 이탈방지 스냅핏은 형상과 체결 메카니즘이 복잡하여 기존의 이론식에 기반한 체결력과 이탈력을 해석적으로 구할 수가 없다. 따라서 본 연구에서는 이탈방지 스냅핏에 대하여 체결 메커니즘을 분석하고, 실험계획법에 기반하여 체결력 및 이탈력을 측정하고, 분산분석을 통하여 회귀식을 도출하였다. 실험계획은 중심합성계획을 사용하였다. Polybutylene terephthalate를 이용하여 시편을 제작하여 미소인장시험기를 이용하여 체결력과 이탈력을 측정하였다. 설계인자는 Length, Width, Thickness, Interference 등 4개를 선정하였으며, 2차 회귀모형을 이용하여 체결력과 이탈력에 대한 회귀식을 도출하였다. Length와 Width가 증가할수록 체결력은 낮아졌으며, Thickness와 Interference는 증가할수록 체결력이 증가하였다. 이탈력은 체결력과 반대의 결과를 나타내었다. 유한요소법을 이용하여 체결 역학에 대하여 분석하였다. Width는 체결단계에서 단면관성모멘트의 증가를 통한 보의 강성 증가 효과 보다는, 오히려 길이 증가에 따른 연성증대로 인하여 체결력을 감소시키는 것으로 나타났다. 낮은 체결력과 높은 이탈력을 위한 인자들의 영향도는 서로 상반되는 것으로 나타났다. 적정 수준의 이탈력을 유지하면서 체결력을 최소화하는 설계가 필요한 것으로 나타났다.

• 경영과정보연구
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• 제33권4호
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• pp.63-75
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• 2014

본 연구는 시장구조에 초점을 맞추어 산업의 표준화 활동 결정요인을 우리나라 제조업에 대해서 계량적으로 검증한다. 단체표준 제정 및 개정 여부를 산업 차원에서 표준화 활동의 대리변수로 삼았고, 그 결정요인으로 시장구조 이외에도 기술적 기회, 자본집약도, 수출비율, 산업특성(조립산업 여부) 등을 고려하였다. 분석대상은 식료, 섬유, 화학, 비금속광물, 금속, 전기전자, 기계, 자동차, 조선 등 9개 업종이며, 2006-2009년 기간 동안 혼용자료(pooling data)를 사용하였다. 추정방법으로는 로지스틱 회귀분석(logistic regression analysis)을 활용하였다. 연구결과, 시장집중도는 산업의 단체표준화 활동에 아무런 영향을 미치지 않는 것으로 분석되었다. 이는 독점적 시장일수록 소수의 대기업들이 공적 표준(de jure standards)인 단체표준보다는 '사실상의 표준(de facto standards)'에 더 관심을 가지고 있을 가능성을 보여준다. 시장구조 이외의 변수의 경우에는 기술적 기회와 조립산업 여부는 단체표준화 활동에 대해서 정(+)의 유의한 효과를 보인 반면, 자본집약도와 수출비율은 단체표준화와는 연관이 없는 것으로 분석되었다.

• 멤브레인
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• 제25권4호
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• pp.332-342
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• 2015

본 연구는 역삼투막의 막오염을 해결하기 위하여 실란-에폭시 층을 형성시킨 다층 표면개질법을 이용하여 역삼투막의 내오염성을 향상시키고자 하였다. Sol-gel법을 이용하여 Octyltrimethoxysilane (OcTES)을 막 표면에 가교를 통해 고분자화 하였으며 n = 8인 OcTES의 알킬기가 자발적인 self-assembly를 통하여 막 표면에 가지구조를 형성시켰다. 그 위에 ethylene glycol diglycidyl ether (EGDE)의 ether기를 ring-opening을 통해 막 표면에 친수성을 부여하여 역삼투막의 내오염성을 향상시키고자 하였다. FE-TEM, AFM을 이용하여 막의 단면 및 표면구조 분석을 하였고 막 표면의 ridge and valley 구조와 OcTES, EGDE의 다층 표면개질로 인한 bridge 구조를 확인하였으며, 거칠기의 증가를 통해 막 표면의 가지가 잘 형성되었음을 확인하였다. XPS를 통하여 막 표면의 화학구조에 대한 관찰과 표면개질이 잘 이루어졌음을 확인하였으며, contact angle 분석을 통해 표면개질막의 표면에 친수성이 부여되었음을 확인하였다. EGDE 표면개질 조건 최적화를 진행한 결과 EGDE 농도는 0.5 wt%, ring-opening 온도는 $70^{\circ}C$가 가장 적합하였고, 내오염성 실험 결과 및 막오염지수(MFI)는 SUL-H10, $PA-OcTES_{1.0}$, $PA-OcTES_{1.0}-EGDE_{0.5}$이 68.7, 60.4, 5.4 ($10E-8hr/mL^2$)로 나타나 다층 표면 개질막의 내오염성이 매우 향상되었음을 확인할 수 있었다.