• Genomics & Informatics
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• v.16 no.4
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• pp.23.1-23.5
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• 2018

Virus taxonomy was initially determined by clinical experiments based on phenotype. However, with the development of sequence analysis methods, genotype-based classification was also applied. With the development of genome sequence analysis technology, there is an increasing demand for virus taxonomy to be extended from in vivo and in vitro to in silico. In this study, we verified the consistency of the current International Committee on Taxonomy of Viruses taxonomy using an in silico approach, aiming to identify the specific sequence for each virus. We applied this approach to norovirus in Caliciviridae, which causes 90% of gastroenteritis cases worldwide. First, based on the dogma "protein structure determines its function," we hypothesized that the specific sequence can be identified by the specific structure. Firstly, we extracted the coding region (CDS). Secondly, the CDS protein sequences of each genus were annotated by the conserved domain database (CDD) search. Finally, the conserved domains of each genus in Caliciviridae are classified by RPS-BLAST with CDD. The analysis result is that Caliciviridae has sequences including RNA helicase in common. In case of Norovirus, Calicivirus coat protein C terminal and viral polyprotein N-terminal appears as a specific domain in Caliciviridae. It does not include in the other genera in Caliciviridae. If this method is utilized to detect specific conserved domains, it can be used as classification keywords based on protein functional structure. After determining the specific protein domains, the specific protein domain sequences would be converted to gene sequences. This sequences would be re-used one of viral bio-marks.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.20 no.11
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• pp.3491-3497
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• 1996

The work factor approach was applied to determine $G_ {IC}$ of fiber reinforced composites (AS4/3501) from a single unidirectional (0-deg) DCB specimen. Elastic work factors of DCB specimen for three different symmetrical staking sequences were derived from a simple bending theory and a finite element method. The results showed that elastic work factors calculated from both methods were comparable each other. In particular, the elastic work factor of DCB specimen with symmetrical stacking sequence is independent of stacking sequence. The $G_ {IC}$ determined from the work factor approach was compared with that determined by the compliance method. The results showed that the work factor approach and the compliance method produce comparable results of $G_ {IC}$. Thus, $G_ {IC}$ can be determined from a single DCB specimen using the work factor approach.

• Korean Journal of Computational Design and Engineering
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• v.3 no.4
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• pp.211-222
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• 1998

Parametric design is an important modeling paradigm in CAD/CAM applications, enabling efficient design modifications and variations. One of the major issues in parametric design is to develop a geometric constraint solver that can handle a large set of geometric configurations efficiently and robustly. In this appear, we propose a new approach to geometric constraint solving that employs a graph-based method to solve the ruler-and-compass constructible configurations and a numerical method to solve the ruler-and-compass non-constructible configurations, in a way that combines the advantages of both methods. The geometric constraint solving process consists of two phases: 1) planning phase and 2) execution phase. In the planning phase, a sequence of construction steps is generated by clustering the constrained geometric entities and reducing the constraint graph in sequence. in the execution phase, each construction step is evaluated to determine the geometric entities, using both approaches. By combining the advantages of the graph-based constructive approach with the universality of the numerical approach, the proposed approach can maximize the efficiency, robustness, and extensibility of geometric constraint solver.

• ETRI Journal
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• v.28 no.3
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• pp.367-370
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• 2006

This letter presents a multi-modal approach to tracking geographic objects such as buildings and road signs in a video sequence recorded from a moving vehicle. In the proposed approach, photogrammetric techniques are successfully combined with conventional tracking methods. More specifically, photogrammetry combined with positioning technologies is used to obtain 3-D coordinates of chosen geographic objects, providing a search area for conventional feature trackers. In addition, we present an adaptive window decision scheme based on the distance between chosen objects and a moving vehicle. Experimental results are provided to show the robustness of the proposed approach.

• Journal of the Korea Society of Computer and Information
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• v.23 no.5
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• pp.1-7
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• 2018

Reference string recognition is to extract individual reference strings from a reference section of an academic article, which consists of a sequence of reference lines. This task has been attacked by heuristic-based, clustering-based, classification-based approaches, exploiting lexical and layout characteristics of reference lines. Most classification-based methods have used sequence labeling to assign labels to either a sequence of tokens within reference lines, or a sequence of reference lines. Unlike the previous token-level sequence labeling approach, this study attempts to assign different labels to the beginning, intermediate and terminating tokens of a reference string. After that, post-processing is applied to identify reference strings by predicting their beginning and/or terminating tokens. Experimental evaluation using English and German reference string recognition datasets shows that the proposed method obtains above 94% in the macro-averaged F1.

• International Journal of Fuzzy Logic and Intelligent Systems
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• v.14 no.3
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• pp.209-215
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• 2014

Sequence tagging is the task of predicting frame-wise labels for a given input sequence and has important applications to diverse domains. Conventional methods such as maximum likelihood (ML) learning matches global features in empirical and model distributions, rather than local features, which directly translates into frame-wise prediction errors. Recent probabilistic sequence models such as conditional random fields (CRFs) have achieved great success in a variety of situations. In this paper, we introduce a novel discriminative CRF learning algorithm to minimize local feature mismatches. Unlike overall data fitting originating from global feature matching in ML learning, our approach reduces the total error over all frames in a sequence. We also provide an efficient gradient-based learning method via gradient forward-backward recursion, which requires the same computational complexity as ML learning. For several real-world sequence tagging problems, we empirically demonstrate that the proposed learning algorithm achieves significantly more accurate prediction performance than standard estimators.

• Proceedings of the Korean Geotechical Society Conference
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• 1999.10a
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• pp.473-480
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• 1999

This paper presents the results of a parametric study on the behavior of mechanically stabilized earth retaining wall. It has been recognized that the currently available design guidelines, which is base on the limit equilibrium approach, cannot properly account the interaction effect between the components, construction sequence, and foundation settlement which may impose a significant influence on the wall behavior. A parametric study using finite element analysis was performed to investigate the behavior of MSE wall under different construction conditions and the applicability of the current design approach. In the parametric analysis, the effects of the construction sequence, the surcharge, and the foundation stiffness were studied and a detailed finite element modeling for various components of the system were employed. The results, such as wall displacement and earth pressure distributions, reinforcement forces, vertical stress distribution were then thoroughly analyzed to investigate the effect of construction details on the wall behavior.

• Proceedings of the Korean Society for Quality Management Conference
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• 2007.04a
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• pp.491-497
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• 2007

The planning and scheduling is considered as an important function because it influence to the overall performance of production in manufacturing system for supporting global objectives. In this paper, propose the hybrid approach to solve the problem which considered alternative resources and sequences, a sequence-dependent setups and transportation times. The objective of this problem is minimize the makespan with AGV traveling time. A iterative two heuristic algorithm(PSO, SA) is proposed to obtain the sequence of operations and CPLEX package is used to obtain the optimal sub-lot sizes(OLS) when the sequence of operations and greedy-based AGV dispatching rules are fixed or given. we show that performance of iterative two heuristic algorithms and simple numerical experiment.

• BMB Reports
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• v.44 no.4
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• pp.250-255
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• 2011

In multicellular organisms, including humans, understanding expression specificity at the tissue level is essential for interpreting protein function, such as tissue differentiation. We developed a prediction approach via generated sequence features from overrepresented patterns in housekeeping (HK) and tissue-specific (TS) genes to classify TS expression in humans. Using TS domains and transcriptional factor binding sites (TFBSs), sequence characteristics were used as indices of expressed tissues in a Random Forest algorithm by scoring exclusive patterns considering the biological intuition; TFBSs regulate gene expression, and the domains reflect the functional specificity of a TS gene. Our proposed approach displayed better performance than previous attempts and was validated using computational and experimental methods.

• Proceedings of the Korean Society for Bioinformatics Conference
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• 2000.11a
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• pp.45-52
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• 2000

Genomic approach produces massive amount of data within a short time period, New high-throughput automatic sequencers can generate over a million nucleotide sequence information overnight. A typical DNA chip experiment produces tens of thousands expression information, not to mention the tens of megabyte image files, These data must be handled automatically by computer and stored in electronic database, Thus there is a need for systematic approach of data collection, processing, and analysis. DNA sequence information is translated into amino acid sequence and is analyzed for key motif related to its biological and/or biochemical function. Functional genomics will play a significant role in identifying novel drug targets and diagnostic markers for serious diseases. As an enabling technology for functional genomics, bioinformatics is in great need worldwide, In Korea, a new functional genomics project has been recently launched and it focuses on identi☞ing genes associated with cancers prevalent in Korea, namely gastric and hepatic cancers, This involves gene discovery by high throughput sequencing of cancer cDNA libraries, gene expression profiling by DNA microarray and proteomics, and SNP profiling in Korea patient population, Our bioinformatics team will support all these activities by collecting, processing and analyzing these data.