• Title/Summary/Keyword: Antitumor

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Studies on Immunopotentiating Activities of Antitumor Polysaccharide from Aerial Parts of Taraxacum platycarpum

  • Jeong, Jong-Yup;Chung, Yeoun-Bong;Lee, Chong-Chull;Park, Soo-Wan;Lee, Chung-Kyu
    • Archives of Pharmacal Research
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    • v.14 no.1
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    • pp.68-72
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    • 1991
  • The polysaccharide fraction from Taraxii Herba showed potent immunopotentiating activities with antitumor activities. The fraction having small amount of protein inhibited the growth of solid tumor and increased peritoneal exudate cells and immunoorgan weights in normal mice, and also increased hypersensitivities in tumor bearing mice.

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Synthesis of Mannich Bases of Antineoplaston A10 and their Antitumor Activity

  • Choi, Bo-Gil;Seo, Hee-Kyoung;Chung, Byung-Ho;Choi, Sang-Un;Lee, Chong-Ock
    • Archives of Pharmacal Research
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    • v.17 no.6
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    • pp.467-469
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    • 1994
  • Some Mannich bases of Antineoplaston A10 which is antitumor agent under chlinical investigation were synthesized and tested fro cytotoxicity. The tested compounds (2a, 2b, 2d) showed good activity comparable to that of carboplatin.

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Antitumor Activity of the Extract of Unripe Cotton Ball (목화의 미성숙다래 추출물의 항종양활성)

  • 박정일;김왕유;이용희;문경식;김준겸;김원기;이승기
    • YAKHAK HOEJI
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    • v.43 no.1
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    • pp.23-27
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    • 1999
  • We previously reported that the extract of unripe cotton ball of Gossypium indicum shows cytotoxic activity and induces an apoptosis in vitro. In present study, its antitumor activity was investigated in vivo. Butanol soluble extract of unripe cotton ball reduced the weight of solid tumor in sarcoma 180 transplanted mouse model. It showed stronger activity than that of Krestin.

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Preparation and Antitumor Activities of Poly(polyethylene glycol methacrylate-co-methacryloyloxymethyl-5-fluorouracil) Prodrug

  • Cho, Suk-Hyung;Kim, Kong-Soo
    • Macromolecular Research
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    • v.11 no.5
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    • pp.317-321
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    • 2003
  • In order to prepare a prodrug, poly(polyethylene glycol methacrylate-co-methacryloyloxymethyl-5-fluorouracil) (poly(PEGM-co-MAOFU)) prodrug particles were prepared by precipitation polymerization of MAOFU and PEGM in polyacrylic acid solution. The size of prodrug particles were 0.2-0.35 ${\mu}{\textrm}{m}$. The antitumor activity of prodrugs against sarcoma-l80 tumor cell in mice was demonstrated and the polymer particles themselves showed low toxicity and good biocompatibility when they were administrated into mice.

Screening of Korean medicinal plants for antitumor activity

  • Chang, Il-Moo;Woo, Won-Sick
    • Archives of Pharmacal Research
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    • v.3 no.2
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    • pp.75-78
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    • 1980
  • Potential antinumor activity of sixteen Korean medicinal plants was tested against leukemia SN 36, murine tomor model. Survival studies by measuring life span indicated that Morus alba (Moraceae), Verbascum phlomoides (Scrophulariaceae), Curcuma longa (Zingbieraceae), Torilis japonica (Umbelliferae), Bupleurum falcatum (Umbelliferae) and Codonopsis pilosula (Campanulaceae) exhibited significant antitumor activity with the dose-schedule employed in the experiment. Methanol (70%) extracts of Platycodon gradiflorum (Campanulaceae), Bupleurum longeradiatum (Umbelliferae) and Asiasarum sieboldii (Aristolochiaceae) showed rather potent toxicity.

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Synthesis and Antitumor Activity of Cannabigerol

  • Baek, Seung-Hwa;Han, Du-Seok;Yook, Chan-Nam;Kim, Young-Chae;Kwak, Jung-Suk
    • Archives of Pharmacal Research
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    • v.19 no.3
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    • pp.228-230
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    • 1996
  • Cannabigerol(3) was synthesized and evaluated for its inhibitory activity against mouse skin melanoma cells. Cannabigerol displayed significant antitumor activity [inhibitory concentration $(IC_{50})=31.31\mug/mL]$ in vitro assay.

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Studies on Antitumor and Immunopotentiation Activities of Polysaccharides from Trichosanthes Rhizome

  • Chung, Yeoun-Bong;Lee, Chong-Chull;Park, Soo-Wan;Lee, Chung-Kyu
    • Archives of Pharmacal Research
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    • v.13 no.3
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    • pp.285-288
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    • 1990
  • The polysaccharide fraction from the rhizome of Trichosanthes kirilowii (Cu-curbitaceae) showed marked antitumor and cytotoxic activity with immunopotentiating activity. It was evidenced by the increase in the number of circulating leucocytes and peritoneal exudate cells and the recovery of lowered antibody forming activity in mice. The polysaccharide was mainly composed of glucose, galactose, fructose, manmose and xylose and a small amount of protein.

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Synthesis and Quartemization of 6-(Substitutedamino)-Purines with Antitumor Activity Screening

  • El-Bayouki, Khairy-A.M.;Basyouni, Wahid-M.;El-Din, S.M.;Habeeb, A.G.
    • Archives of Pharmacal Research
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    • v.17 no.2
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    • pp.60-65
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    • 1994
  • Reaction of c-chloro-9-benzyl-8-(methylthio)purine 3 with primary amines afforoded, the comesponding 6-(substitutedamino)purines 4a-g. The latter products when methylated with methyl iodide yielded smoothly $N^3$-methyl purinium iodide salts 5a-f rather than the probable $N^1\;and\;N^7$-derivatives. 9-Benzyl-3-methyl-6-(methylmino)-8-(methylthio)purine 8 was obtained upon treating the purinium iodide 5a with alkali. Most of the synthesized compounds were screened for their antitumor activity.

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Antitumor Activity of 23, 24-dihydrocucurbitacin D Isolated from Bryonia alba L.

  • Sohn, Hyung-Ok;Lee, Young-Gu;Lim, Heung-Bin;Kwon, Nyoun-Soo;Goorgen V. Aprikian;Lee, Dong-Wook
    • Toxicological Research
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    • v.16 no.4
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    • pp.263-267
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    • 2000
  • The cytotoxic and antitumor activity of 23,24-dihydrocucurbitacin D (dhc D) isolated from Bryonia alba L. was examined. Our results showed that dhc D strongly inhibited the viability of the cultured cancer cells, A-549, COLO 205, SK-MEL-2, and L121O. It also exhibited effective antitumor activity in ICR mice, which had been intra peritoneally implanted with sarcoma 180 ascites tumor cells. The dhc D also strongly inhibited the viability of immortalized macrophages RAW 264.7, but not normal peritoneal macrophages. These results indicate that dhc D has antiproliferative effect on cancer cells and it may more sensitive on immortalized cells than normal cells.

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Antitumor Components from Naematoloma fasciculare

  • Ding, Yan;Bao, Hai Ying;Bau, Tolgor;Li, Yu;Kim, Young-Ho
    • Journal of Microbiology and Biotechnology
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    • v.19 no.10
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    • pp.1135-1138
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    • 2009
  • The bioassay-guided fractionation of MeOH extract from Naematoloma fasciculare afforded a petroleum ether fraction (NFPF) and four known compounds, which showed good antitumor activities to inhibit MCF-7 cell line proliferation in vitro and tumor growth in $H_{22}$ implanted mice in vivo. In addition, a number of unsaturated aliphatic acids were identified in NFPF by GC analysis. These results showed that NFPF inhibits tumor growth through the activity of unsaturated aliphatic acids together with two active compounds, ergosterol peroxide (1: 62.17 mg/g in NFPF) and ergosterol (2: 3.13 mg/g in NFPF), and indicate the potential utility of NFPF as an antitumor drug.