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http://dx.doi.org/10.4014/jmb.0901.022

Antitumor Components from Naematoloma fasciculare  

Ding, Yan (College of Traditional Chinese Medicinal Material, Jilin Agricultural University)
Bao, Hai Ying (College of Traditional Chinese Medicinal Material, Jilin Agricultural University)
Bau, Tolgor (Institute of Mycology, Jilin Agricultural University)
Li, Yu (Institute of Mycology, Jilin Agricultural University)
Kim, Young-Ho (College of Pharmacy, Chungnam National University)
Publication Information
Journal of Microbiology and Biotechnology / v.19, no.10, 2009 , pp. 1135-1138 More about this Journal
Abstract
The bioassay-guided fractionation of MeOH extract from Naematoloma fasciculare afforded a petroleum ether fraction (NFPF) and four known compounds, which showed good antitumor activities to inhibit MCF-7 cell line proliferation in vitro and tumor growth in $H_{22}$ implanted mice in vivo. In addition, a number of unsaturated aliphatic acids were identified in NFPF by GC analysis. These results showed that NFPF inhibits tumor growth through the activity of unsaturated aliphatic acids together with two active compounds, ergosterol peroxide (1: 62.17 mg/g in NFPF) and ergosterol (2: 3.13 mg/g in NFPF), and indicate the potential utility of NFPF as an antitumor drug.
Keywords
Naematoloma fasciculare; antitumor; MCF-7; $H_{22}$ mice; ergosterol peroxide; ergosterol; conjugated linoleic acid;
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1 Doi, K., T. Shibata, M. Nara, S. Tsuboyama, T. Sakurai, and K. Tsuboyama. 1986. Structures of naematolin and naematolin B, 1S,9S-ring-fused caryophyllane sesquiterpenoids. Chem. Lett. 5:653-656
2 Doi, K., T. Shibata, N. Yokoyama, H. Terasawa, O. Matsuda, and S. Kashino. 1990. Structure of naematolin C and naematolin G, novel 4,8,11,11-tetramethyltricyclo [5.4.0.02,3] undecane sesquiterpenoids. J. Chem. Soc. 10: 725-726
3 Ito, H., K. Kasama, S. Naruse, and K. Shimura. 1982. Antitumor effect of palmitoleic acid on Ehrlich ascites tumor. Cancer Lett. 17: 197-203   DOI   ScienceOn
4 Ito, Y., H. Kurita, and T. Yamaguchi. 1967. Naematolin, a new biologically active substance produced by Naematoloma fasciculare [Hyphaloma fasciculare]. Chem. Pharm. Bull. 15:2009-2010   DOI   PUBMED   ScienceOn
5 Kikkawa, H., Y. Azuhata, and D. Matsuura. 1995. Anti-tumor promoting effect of kampo formulation on rat urinary bladder carcinogenesis. VII. Effect of ergosterol and relative compounds on rat urinary bladder carcinogenesis. Wakan Iyakugaku Zasshi 12: 346-347
6 Kobayashi, M., M. M. Krishna, B. Haribabu, and V. A. Anjaneyulu. 1993. Marine sterol. XXV. Isolation of 23-demethylgorgost-7-ene-triol and (24S)-Ergostan-3$\beta$,5$\alpha$,6$\beta$,7$\beta$,15$\beta$-pentol from soft corals of the Andaman and Nicobar Coasts[J]. Chem. Pharm. Bull. 41: 87-89   DOI   ScienceOn
7 Kuo, Y. C., C. Y. Lin, W. J. Tsai, C. L. Wu, C. F. Chen, and M. S. Shiao. 1994. Growth inhibitors against tumor cells in Cordyceps sinensis other than cordycepin and polysaccharides. Cancer Invest. 12: 611-615   DOI   ScienceOn
8 Lee, C. O., E. C. Choi, and B. K. Kim. 1981. Studies on the antitumor components of Korean basidiomycetes. IV. Antitumor components of Naematoloma fasciculare (Fr.) Karst. Arch. Pharmacol Res. 4: 117-122   DOI   ScienceOn
9 Shiono, Y., R. Matsuzaka, H. Wakamatsu, K. Muneta, T. Murayama, and M. Ikeda. 2004. Fascicularones A and B from a mycelial culture of Naematoloma fasciculare. Phytochemistry 65: 491-496   DOI   ScienceOn
10 You, Y. J., Y. Kim, N. H. Nam, and B. Z. Ahn. 2003. Antitumor activity of unsaturated fatty acid esters of 4'-demethyldeoxypodophyllotoxin. Bioorg. Med. Chem. Lett. 13:2629-2632   DOI   ScienceOn
11 Ding, Y., H. Y. Bao, T. Bau, and Y. Li. 2006. Anti-tumor effect of Naematoloma fasciculare polysaccharide. Jun Wu Xue Bao 25: 611-615
12 Takaku, T., Y. Kimura, and H. Okuda. 2001. Isolation of an anti-tumor compound from Agaricus blazei Murill and its mechanism of action. J. Nutr. 131: 1409-1413   ScienceOn
13 Azahata, Y. and M. K. Yokota. 2000. Anti-tumor promoting effect of an active component of polyporus, ergosterol and related compounds on rat urinary bladder carcinogenesis in a short-term test with concanavalin A. Biol. Pharm. Bull. 23: 1298-1302   DOI   PUBMED   ScienceOn
14 Yoshida, J., S. Takamura, N.Yamaguchi, L. J. Ren, H. Chen, S. Koshimura, and S. Suzuki. 1989. Antitumor activity of an extract of Cordyceps sinensis (Berk.) Sacc. against murine tumor cell lines. Jpn. J. Exp. Med. 59: 157-161   PUBMED
15 Ikeda, M., Y. Sato, T. Sassa, and Y. Miura. 1978. Structures of fasciculols, new plant growth inhibitors from Naematoloma fasciculare. Tennen Yuki Kagobutsu Toronkai Koen Yoshishiu 21: 584-591
16 Tsuboyama, S., T. Sakurai, K. Tsuboyama, and K. Doi. 1986. Crystal structure and absolute configuration of a new cis-fused caryophyllene derivative. Naematolin 3-p-bromobenzoate. Bull. Chem. Soc. Jpn. 59: 1921-1924   DOI
17 Igarashi, M. and T. Miyazawa. 2000. Newly recognized cytotoxic effect of conjugated trienoic fatty acids on cultured human tumor cells. Cancer Lett. 148: 173-179   DOI   ScienceOn
18 Kwon, H. C., I. Y. Jung, and S. Y. Kim. 1999. Cytotoxic constituents of Bombycis corpus. Yakhak Hoechi 43: 169-172   ScienceOn
19 Maria, D., B. M. Giorgio, and V. Giovanni.,Koc$\grave{o}$r, Marian 1980. Fungal metabolites. IX. Triterpenes from Naematoloma sublateritium. J. Nat. Prod. 44: 351-354   DOI
20 Bok, J. W., L. Lermer, and J. Chilton. 1999. Antitumor sterols from the mycelia of Cordyceps sinensis. Phytochemistry 51:891-898   DOI   ScienceOn
21 Diak, J. 1975. The study of compounds biosynthesized by Naematoloma fasciculare (Huds ex Fr.) P. Karst. I. Analysis in vitro. Pol. J. Pharmacol. Pharm. 27: 235-241   ScienceOn
22 Azahata, Y. and K. Sugiyama. 1994. Anti-tumor promoting effect of Kampo formulations on rat urinary bladder carcinogenesis (VI). Effect of ergosterol on rat urinary bladder carcinogenesis in long-term assay. Wakan Iyakugaku Zasshi 11: 344-345
23 Kubo, I., A. Matsumoto, M. Kozuka, and W. F. Wood. 1985. Calmodulin inhibitors from the bitter mushroom Naematoloma fasciculare (Fr.) Karst. (Strophariaceae) and absolute configuration of fasciculols. Chem. Pharm. Bull. 33: 3821-3825   DOI   PUBMED   ScienceOn
24 Mao, Y., J. K. Liu, Z. X. Lu, Y. Zhao, S. F. Liu, L. L. Li, et al. 2005. Grifolin, a potential antitumor natural product from the mushroom Albatrellus confluens, inhibits tumor cell growth by inducing apoptosis in vitro. FEBS Lett. 579: 3437-3443   DOI   ScienceOn
25 Paterson, R. and M. Russell. 2006. Ganoderma - a therapeutic fungal biofactory. Phytochemistry 67: 1985-2001   DOI   PUBMED   ScienceOn
26 Bradley, M. O., N. L. Webb, F. H. Anthony, P. Devanesan, P. A. Witman, S. Hemamalini, et al. 2001. Tumor targeting by covalent conjugation of a natural fatty acid to paclitaxel. Clin. Cancer Res. 7: 3229-3238   ScienceOn
27 Kawagishi, H., R. Katsumi, T. Sazawa, T. Mizuno, T. Hagiwara, and T. Nakamura. 1988. Cytotoxic steroids from the mushroom Agaricus blazei. Phytochemistry 27: 2777-2779   DOI   ScienceOn
28 Kirsti, K., L. Kangas, and R. Hiltunen. 1989. Ergosterol peroxide, an active compound from Inonotus radiatus. Planta Med. 55: 389-390   DOI   ScienceOn
29 Nozoe, S., T. Akira, and O. Tomihisa. 1993. Chirality of the 3-hydroxy-3-methylglutaric acid moiety of fasciculic acid A, a calmodulin antagonist isolated from Naematoloma fasciculare[J]. Chem. Pharm. Bull. 41: 1738-1742   DOI   ScienceOn
30 Suzuki, K., H. Fujimoto, and M. Yamazaki. 1983. The toxic principles of Naematoloma fasciculare. Chem. Pharm. Bull. 31:2176-2178   DOI   PUBMED   ScienceOn
31 Takahashi, A., G. Kusano, and T. Ohta. 1989. Fasciculic acids A, B and C as calmodulin antagonists from the mushroom Naematoloma fasciculare. Chem. Pharm. Bull. 37: 3247-3250   DOI   PUBMED   ScienceOn
32 Herbich, J., K. Lohwag, and R. Rotter. 1966. Fatal poisoning with the green-leaf sulfur cap (Nematoloma fasciculare). Arch. Toxikol. 21: 310-320   DOI