Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Antitumor Components from Naematoloma fasciculare

  • Ding, Yan (College of Traditional Chinese Medicinal Material, Jilin Agricultural University) ;
  • Bao, Hai Ying (College of Traditional Chinese Medicinal Material, Jilin Agricultural University) ;
  • Bau, Tolgor (Institute of Mycology, Jilin Agricultural University) ;
  • Li, Yu (Institute of Mycology, Jilin Agricultural University) ;
  • Kim, Young-Ho (College of Pharmacy, Chungnam National University)
  • Published : 2009.10.31
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Abstract

The bioassay-guided fractionation of MeOH extract from Naematoloma fasciculare afforded a petroleum ether fraction (NFPF) and four known compounds, which showed good antitumor activities to inhibit MCF-7 cell line proliferation in vitro and tumor growth in $H_{22}$ implanted mice in vivo. In addition, a number of unsaturated aliphatic acids were identified in NFPF by GC analysis. These results showed that NFPF inhibits tumor growth through the activity of unsaturated aliphatic acids together with two active compounds, ergosterol peroxide (1: 62.17 mg/g in NFPF) and ergosterol (2: 3.13 mg/g in NFPF), and indicate the potential utility of NFPF as an antitumor drug.

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References

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