Synthesis of Mannich Bases of Antineoplaston A10 and their Antitumor Activity

  • Published : 1994.12.01

Abstract

Some Mannich bases of Antineoplaston A10 which is antitumor agent under chlinical investigation were synthesized and tested fro cytotoxicity. The tested compounds (2a, 2b, 2d) showed good activity comparable to that of carboplatin.

Keywords

References

  1. Physiol. Chem. Phys v.5 Biologically active peptides in human urine1. Isolation of a group of medium-sized peptides Burzynski,S.R.
  2. Fed. Proc. v.32 Effect of urinary peptides on DNA, RNA and protein synthesis in normal and neoplastic cells Burzynski,S.R.;Georgiades,J.
  3. Physiol. Chem. Phys. v.8 Antineoplastons: Biochemical defense against cancer Burzyski,S.R.
  4. Proc. 13th Intil. Cong. Chemother(Vienna) v.17 Purification, structure determination, synthesis and animal toxicity studies of antineoplaston A10 Burzynski,S.R.;Hendry,L.B.;Mohabbat,M.O.;Liau,M.C.;Khalid,M.;Burzynski,B.
  5. Drug Exp. Clin. Res. v.10 Toxicology studies of oral formulation of antineoplaston A10 in cancer patients Burzynski,S.R.;Mohabbat,M.O.;Burzynski,B.
  6. Drugs of the future v.11 Antineoplaston AS2-1 Burzynski,S.R.
  7. Drugs of the future v.11 Synthetic antineoplastons and analogs Burzynski,S.R.
  8. U.S. Patent 4,918,193 Methods for preparing 3-[N-Phenyl-acetylaminopiperidine]-2,6-dione Burzyski,S.R.
  9. U.S. Patent 5,089,508 Substituted piperidnediones, substituted phenylacetic acids, and substututed phenylacetyl-glutamines for treatment of AIDS Burzyski,S.R.
  10. Appl. Wo 9204,043 Urine peptides for the treatment of Parkinson's disease Burzyski,S.R.
  11. U.S. Patent 4,705,796 Use of 3-N-phenlacetylamino-2,6-piperidinedione for treatment of neuropsychiatric disorsers Hendry,L.B.;Diamond,A.H.;Diamond,B.I.;Ewing,D.E.
  12. Appl. WO 91 16,309;US Appl. 508,839 Preparation of 3-phenylacetaminopiperidind-2,6-diones as cytocytic agents Hendry,L.B.;Chu,C.K.;Mahesh,V.B.
  13. Chem, Pharm, Bull. v.37 no.11 Synthesis and antitumor properties of N¹-acyloxymethyl derivatives of bis(2,6-dioxopiperazines) Jun,C.C.;Han,L.S.;Cai,F.T.;Toshihito,K.;Toshoyuki,M.;Toshiharu,N.
  14. Archiv der Pharmazie Potentiellecytostatica durch aminomethylierung NH-acides hypnotika Werner,W.;Fritzsche.
  15. Pharmaceutical Industry v.19 no.5 Improved preparation of antitumor agent antineoplaston A10 Xu Wenfang.;Zhao Yulan.;Yuan Yumei.;Yu YongHui.;