Synthesis and Quartemization of 6-(Substitutedamino)-Purines with Antitumor Activity Screening

  • El-Bayouki, Khairy-A.M. (Natural Research Center) ;
  • Basyouni, Wahid-M. (Natural Research Center) ;
  • El-Din, S.M. (Natural Research Center) ;
  • Habeeb, A.G. (Natural Research Center)
  • Published : 1994.04.01

Abstract

Reaction of c-chloro-9-benzyl-8-(methylthio)purine 3 with primary amines afforoded, the comesponding 6-(substitutedamino)purines 4a-g. The latter products when methylated with methyl iodide yielded smoothly $N^3$-methyl purinium iodide salts 5a-f rather than the probable $N^1\;and\;N^7$-derivatives. 9-Benzyl-3-methyl-6-(methylmino)-8-(methylthio)purine 8 was obtained upon treating the purinium iodide 5a with alkali. Most of the synthesized compounds were screened for their antitumor activity.

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