Toxicological Research
- Volume 16 Issue 4
- /
- Pages.263-267
- /
- 2000
- /
- 1976-8257(pISSN)
- /
- 2234-2753(eISSN)
Antitumor Activity of 23, 24-dihydrocucurbitacin D Isolated from Bryonia alba L.
- Sohn, Hyung-Ok (Laboratory of Biochemistry, Korea Ginseng and Tobacco Research Institute) ;
- Lee, Young-Gu (Laboratory of Biochemistry, Korea Ginseng and Tobacco Research Institute) ;
- Lim, Heung-Bin (Department of Tobacco Science, Chungbuk National University) ;
- Kwon, Nyoun-Soo (Department of Biochemistry, College of Medicine, Chung-Ang University) ;
- Goorgen V. Aprikian (Institute of Biochemistry, Armenian National Academy of Sciences) ;
- Lee, Dong-Wook (Laboratory of Biochemistry, Korea Ginseng and Tobacco Research Institute)
- Published : 2000.12.01
Abstract
The cytotoxic and antitumor activity of 23,24-dihydrocucurbitacin D (dhc D) isolated from Bryonia alba L. was examined. Our results showed that dhc D strongly inhibited the viability of the cultured cancer cells, A-549, COLO 205, SK-MEL-2, and L121O. It also exhibited effective antitumor activity in ICR mice, which had been intra peritoneally implanted with sarcoma 180 ascites tumor cells. The dhc D also strongly inhibited the viability of immortalized macrophages RAW 264.7, but not normal peritoneal macrophages. These results indicate that dhc D has antiproliferative effect on cancer cells and it may more sensitive on immortalized cells than normal cells.
Keywords