• Title/Summary/Keyword: Anti-aging Effect

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Effect of Combined Use of various Anti-microbial Materials on Brewing of Low Salted Kochujang (저식염 고추장 양조시 항균물질 혼합첨가의 영향)

  • Park, Seon-Ju;Kim, Dong-Han
    • Applied Biological Chemistry
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    • v.50 no.4
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    • pp.287-294
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    • 2007
  • Effect of combined use of anti-microbial materials, such as ethanol, mustard and chitosan, on the quality of low salted kochujang was investigated during fermentation at $20^{\circ}C$ for 12 weeks. Viable cells of yeast increased remarkably during fermentation, but increasing ratio was significantly low in ethanol-mustard added kochujang. Activity of ${\beta}-amylase$ was high in anti-microbial material added kochujang, whereas ${\alpha}-amylase$ and protease activities were low in those groups. Water activity decreased during fermentation with being low in the control kochujang prepared with normal-salt without anti-microbial materials. Hunter L-, a- and b-values of kochujang increased during fermentation, and the degree of increase in total color difference $({\Delta}E)$ was low in ethanol added kochujang. Titratable acidity of kochujang was decreased in anti-microbial materials added group at late aging period, and oxidation-reduction potential was low in the control kochujang. Total sugar and reducing sugar contents of kochujang were high in ethanol-mustard added kochujang. Ethanol contents of kochujang increased at late aging period, with high values in ethanol-chitosan added kochujang. Amino nitrogen content increased during middle of fermentation, and ammonia nitrogen content of kochujang decreased in ethanol-mustard-chitosan added group during fermentation. After 12 weeks fermentation, sensory results showed that ethanol or ethanol-mustard added kochujang were the highest in color and flavor with the highest overall acceptability.

The Effect of Kimchi Intake on Production of Free Radicals and Anti-oxidative Enzyme Activities in the Liver of SAM (김치가 노화촉진 쥐 간의 유리기 생성 및 항산화효소 활성에 미치는 영향)

  • 김종현;권명자;이소영;류재두;문갑순;최홍식;송영옥
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.31 no.1
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    • pp.109-116
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    • 2002
  • This study was performed to investigate the effect of kimchi intake on antiaging characteristics in liver of senescence-accelerated mouse (SAM) in terms of free radical production and anti-oxidative enzyme activities. Two hundred twenty SAM were divided into four groups and fed kimchi diet for 12 months. Experimental groups were kimchi free AIN-76 diet (control) group, Korean cabbage kimchi diet (KCK) group, mustard leaf added (30%) Korean cabbage kimchi diet (MKCK) group, and mustard leaf kimchi diet (MLK) group. Amount of freez-dried kimchi added to the diet was 5% that is equivalent to 50 g of fresh kimchi. Concentrations of total free radical, OH radical, $H_2O$$_2$in the liver significantly increased as aged (p<0.05). But those free radical concentrations from kimchi diet groups were lower than those of control (p<0.05). Among kimchi groups, MKCK and MLK groues showed greater inhibiting effect than KCK. Antioxidant enzyme activities of Cu, Zn-SOD, Mn-SOD, GSH-px, catalase and GSH/GSSG in kimchi groups were significantly increased (P

Anti-aging Effects of Cedrol and Collagen-derived Peptide (세드롤과 콜라겐 유래 펩타이드의 피부노화 개선효과)

  • Ryu, Jong Seong;Cho, Hwan Il;Won, Ji Hee;Jeon, Mi Na;Kwon, Oh Sun;Won, Bo Mi;Lim, Jun Man;Lee, Sang Hwa
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.41 no.3
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    • pp.229-235
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    • 2015
  • Skin aging is the phenomena finally expressed on the skin surface and related to the changes in the microstructure of the skin texture. Which is resulted in wrinkle formation and uneven tone of skin and so on. In this study, the synergy effect of Cedrol and a collagen-derived peptide in type III collagen synthesis was evaluated by in vitro test. The physiological skin state of 22 female volunteers was measured after using the cosmetics for 4 weeks. Results showed that Cedrol and a collagen-derived peptide had the excellent synergy effect in type III collagen synthesis. The cosmetics improved skin microrelief, star configurations, skin gloss, skin tone, hydration and elasticity except skin lightening. In conclusion, this study proved that Cedrol and collagen-derived peptide had the synergy effect of type III collagen synthesis in the cell level and cosmetics with those was improved skin aging in human volunteer test.

Protective effect of Thymus quinquecostatus extracts UVB-induced matrix metalloproteinase-1 via suppressing MAPKs phosphorylation in human keratinocyte (사람의 각질세포에서 UVB 유도에 따른 MMP-1의 발현 조절과 MAPKs 인산화에 타임 추출물이 미치는 효과)

  • Jung, Hana;Jeong, Hyun Ju;Shin, Kyounghee;Kim, Yung Sun;Moon, Jae Heon;Lee, Tae Hoon
    • Journal of Applied Biological Chemistry
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    • v.61 no.4
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    • pp.417-421
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    • 2018
  • Ultraviolet rays are electromagnetic waves with a shorter wavelength than visible light, and ultraviolet rays that pass through the ozone layer are the main cause of skin aging. Chronic exposure of skin tissue to ultraviolet light activates the Mitogen-activated Protein Kinases (MAPKs) signaling pathways in human keratinocytes, resulting in increased production of matrix metalloproteinases (MMPs). In this study, we investigated the herbal extracts from Jeju Island on the anti-aging effect in human keratinocytes (HaCaTs) by ultraviolet stimulation. We examined that herb extract from Jeju Island were decreased in anti-aging activity on measuring the level of MMP-1 gene and protein expression in ultraviolet-induced keratinocytes. As a result, it was confirmed that Thymus quinquecostatus extract (TQE) significantly reduced the expression of MMP-1 in a dose-dependent manner by UV irradiated HaCaTs. According to our data, TQE significantly attenuated UV-induced phosphorylation of the MAPKs signaling elements ERK1/2, JNK1/2 and p38 proteins. These results suggest that the MAPKs pathway may contribute to the inhibitory effect of TQE on UV-induced MMP-1 production in human keratinocytes. Our results suggest that TQE may be a protective agent against skin aging by preventing UV-induced MMP-1 production.

Fertility effect of chronically administered CBNU-1 on male rats

  • Park, Jeong-Sook;Han, Kun;Kim, Gee-Young
    • Proceedings of the PSK Conference
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    • 2003.04a
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    • pp.269.3-270
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    • 2003
  • CBNU-1 has been used as a folk medicine in India for general physical strengthening, anti-aging, blood sugar stabilization, urinary tract rejuvenation, enhanced brain functioning potency, kidney rejuvenation, immune system strengthening, arthritis, hypertension and many other application for numerous conditions. The present study was conducted to evaluate the possibility of CBNU-1 as fertility agent. (omitted)

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Effects of Egg Shell Membrane Hydrolysates on Anti-Inflammatory, Anti-Wrinkle, Anti-Microbial Activity and Moisture-Protection

  • Yoo, Jinhee;Park, Kimoon;Yoo, Youngji;Kim, Jongkeun;Yang, Heejin;Shin, Youngjae
    • Food Science of Animal Resources
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    • v.34 no.1
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    • pp.26-32
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    • 2014
  • This study was conducted to examine the effects of eggshell membrane hydrolysates (ESMH) on the anti-inflammatory, anti-wrinkle, anti-microbial activity, and moisture-protection for cosmetic use. Whole ESMH (before fractionation), and fraction I (>10 kDa), fraction II (3-10 kDa), and fraction III (<3 kDa) of the hydrolysates were assessed in this experiment. As lipopolysaccharide (LPS) and IFN-${\gamma}$ caused the inflammation on Raw264.7 cell, whole ESMH and fraction I showed to be effective in inhibiting the induction of cell inflammation depending on the concentration, and also showed outstanding effect to suppress the skin inflammation. Fraction I inhibited collagenase and elastase activities to a greater extent than the other fractions, while all fractions had antibiotic effects at concentrations of 10 mg/disc and 20 mg/disc. In addition, it showed the moisture protection effects of skin on the holding amount and losing amount of moisture in upper-inner arm of the human body with a relatively low loss rate in skin, which confirmed that the hydrolyzed fractions of ESM helps to form the superior protective layer of moisture. It was concluded that ESMH fractions with different molecular weights, especially the 10 kDa fraction, have anti-lipopolysaccharide, anti-IFN-${\gamma}$-induced inflammation, anti-collagenase and elastase activities, and thus can be used as a cosmetic agent to protect skin.

Effects of Catechin-rich Green Tea Extract on the MMP-1 Activity of HaCaT Keratinocyte Cells and on UVB-induced Skin Damage in Hairless Mice (각질형성세포에서 MMP-1 활성 및 자외선 유도 무모쥐 피부손상에 대한 카테킨 고함유 녹차추출물의 영향)

  • Yang, Won Kyung;Park, Yang Chun;Kim, Bok Kyu;Choi, Jeong June;Ryu, Geon Seek;Kim, Seung Hyung
    • Korean Journal of Medicinal Crop Science
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    • v.27 no.2
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    • pp.143-150
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    • 2019
  • Background: Skin is an organ that protects the human body from various environmental stimuli that can induce immune system activation. Skin aging can be largely divided into two categories: physiological aging, which is caused by the a decreased physiological function of the skin and structural changes with aging, and photoaging, which is caused by the chemical stress induced by external stimuli such as ultraviolet (UV) radiation. Methods and Results: The objective of this study was to investigate the anti-wrinkle and UV protective effect of catechin-rich green tea extract (CGTE) in activated keratinocyte (HaCaT cells) and UV-induced skin damage in hairless mice. The results showed that CGTE inhibits the tumor necrosis factor-alpha interferon-gamma ($TNF-{\alpha}+IFN-{\gamma}$)-induced expression of matrix metalloproteinase (MMP)-1 in HaCaT cells. In addition, the CGTE treatment significantly reduced wrinkle formation, epidermal thickness, collagen deposition, and transepidermal water loss in dorsal skin irradiated with UVB. However, the ${\beta}$-glucosidase activity was significantly increased. The CGTE treatment inhibits mRNA expression and enzyme activity of MMP-2 and MMP-9 in the dorsal skin irradiated with UVB. Conclusions: It is expected that CGTE can be effectively used as a functional food and cosmetic ingredient to improve skin moisture retention and reduce wrinkle formation.

Effects of Ultrasound on Skin Elasticity and Elasticity of Deeper Skin in Healthy Women (초음파 사용이 건강한 여성의 피부 탄력과 피부 깊은 탄력 개선에 미치는 영향)

  • Min-Joo Ko;Gi-Soo Kim;Eun-Mi Jang;Jae-Seop Oh
    • Journal of The Korean Society of Integrative Medicine
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    • v.11 no.1
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    • pp.79-86
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    • 2023
  • Purpose : Aging is reflected on the face of women due to the depletion of collagen and hydration in the facial skin overtime. This study investigated the effect of multiple SONO® ultrasound for a 4-week period on the skin health by measuring the skin elasticity and deeper skin elasticity in the tested women subjects. Methods : Twenty healthy women were recruited for this experiment. All the participants applied multiple ultrasound device (SONO®) during this experiment. The SONO® device was set to ANTI-AGING function and five power steps such as 1, 3, 10 and 17 MHz were used during this experiment, and directly contacted with the facial skin. Specifically, the probe was contacted with the entire face except for the nose and eyes for 10 min on each side of the face every day and repeated for 4 weeks. The skin elasticity and the elasticity of deeper skin were measured at three times (0, 2, 4 weeks) using a Ballistometer and dermal torque meter, respectively. The one way repeated ANOVA was used to compare the skin elasticity and the elasticity of deeper skin among three times (0, 2, 4 weeks). Results : The skin elasticity (p<.05) and elasticity of deeper skin (p<.05) were significantly increased at 2 weeks and 4 weeks of intervention compared to that at 0 weeks. For the skin elasticity, there was no significant difference between 2 and 4 weeks of intervention (p>.05). For the elasticity of deeper skin, it increased significantly at 4 weeks compared to 2 weeks of intervention (p<.05). Conclusion : These findings suggest that applying multiple SONO® ultrasound to the facial skin of healthy women for 4 weeks, can increase the skin elasticity and elasticity of deeper skin by supporting epidermal hydration and dermal collagen production.

Resistance Activity of Kyung-Ok-Ko on Thermal Stress in C. elegans (경옥고(瓊玉膏)의 열 스트레스에 의한 피부노화 억제 활성)

  • Won-Seok Jung;Sung-Young Cho;Hyun-Woo Cho;Hee-Woon Lee;Young‐IL Jeong;Hee-Taek Kim;Young-Bob Yu
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.37 no.1
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    • pp.17-28
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    • 2024
  • Objectives : This study was conducted to reveal the scientific mechanism of the anti-skin aging activity of Kyung-Ok-Ko(KOK), which is highly useful as a Korean traditional medicine and functional food. Methods : The skin wrinkle and aging inhibitory activity of KOK was confirmed through in vitro experiments of human dermal fibroblast neonatal cell(HDFn) and in vivo of C. elegans, and hairless mouse(SKH-1). Results : The amount of the C-terminus of the collagen precursor in the HDFn cell culture medium treated with KOK using an enzymes-linked immunoassay kit. The group treated with KOK 200㎍/㎖ was a 28.3% increase of collagen precursor compared to the control group. KOK showed inhibitory activity of MMP-1 compared to the control group at a concentration of 200㎍/㎖. In addition, KOK 200㎍/㎖ showed significant inhibitory activity of thermal stress and an oxidative stress compared to the control group in C. elegans. Furthermore, KOK showed a concentration-dependent(100mg/kg and 500mg/kg) anti-wrinkle formation effect in UV-irradiated hairless mouse(SKH-1). Additionally, when KOK was administered to UV-irradiated hairless mice, an increase in procollagen -1 and -3 genes expression was observed, and mmp-1 and mmp-9 genes, which increase collagen decomposition, decreased with the administration of KOK. Conclusions : The skin aging inhibition mechanism of Kyung-Ok-Ko(KOK) is presumed to be achieved through suppressing thermal stress and oxidative stress, suppressing mmp-1 and mmp-9 genes, and increasing procollagen-1 and procollagen-3.

Influence of Age and Fasting on the Anti-hyperglycemic Effect of Onion in Normal and Diabetic rat (정상 및 당뇨 흰쥐에서 주령과 절식에 의한 양파의 혈당조절작용 변화)

  • 문창현;정이숙;김민화;이수환;백은주;박세원
    • Biomolecules & Therapeutics
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    • v.5 no.4
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    • pp.364-368
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    • 1997
  • Onion (Allium cepa Linn) has been reported to have hypoglycemic activity in human and several animal models. In the present study, we performed intraperitoneal glucose tolerance test (IPGTT) in young (1.5mo) and aged (5 mo) rats treated with onion in order to determine whether aging can influence on the anti-hy-perglycemic effect of onion. In addition, we investigated the hypoglycemic effect of onion in streptozotocin- induced diabetic rats treated with aqueous extracts of onion (500 mg/kg, i.p., daily) for 4 weeks. Blood glucose level was determined in fasted and fed rats by using a glucometer (Johnson & Johnson). In glucose tolerance test, blood glucose level was maximally increased 15 min after glucose load (2 g/kg, i.p.), and recovered to the basal level 3 hr after glucose challenge in young and old rats. The maximum blood glucose levels of young and aged rat were 184$\pm$7.49 and 225.2$\pm$ 12.55 mg/dl, respectively. A single i.p. injection of aqueous extract of onion (1 g/kg) 30 min before glucose challenge significantly decreased blood glucose levels at 15, 30, 60, 90 min after glucose load in aged rats, while the administration of onion did not show any significant effect in young rats. In onion-treated diabetic rats, significant hypoglycemic effect (p<0.05) was observed, and the effect was greater in fasted rats than in fed. In conclusion, these results suggest that anti-hyperlycemic effect of onion can be changed by age and fasting.

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