• Food Science and Preservation
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• v.11 no.3
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• pp.364-372
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• 2004

To investigate antioxidative effects of n-hexane fraction of Angelica acutiloba on the ethanol-induced hepatotoxicity of rats, Sprague-Dawley rats weighing 100 $\pm$ 20 g were divided into 5 groups; normal group(NOR), ethanol(10 mL/kg, 35$\%$) treated group(CON), n-hexane fraction of Angelica acutiloba 70 mg/kg treated group(Al), n-hexane fraction of Angelica acutiloba 70 mg/kg and ethanol treated group(A2) and n-hexane fraction of Angelica acutiloba 140 mg/kg and ethanol treated group(A3), respectively. The antioxidative activities of ethanol extract of Angelica acutiloba in vitro were decreased in order of n-hexane > ethylacetate > chlorofonn > n-butanol (>) water fraction. The growth rate and feed efficiency rate decreased by ethanol were gradually increased to the adjacent level of the normal group by administering n-hexane fraction of Angelica acutiloba. It was also observed that the activities of SOD of liver, ALT and AST of serum increased by ethanol were markedly decreased in n-hexane fraction of Angelica acutiloba administered group, and not in activites of XO, catalase, as compared with the control group. The depleted content of GSH by ethanol was increased adjacent to normal level by administering n-hexane fraction of Angelica acutiloba. as a dose-dependent manner. These results suggested that n-hexane fraction of Angelica acutiloba has a possible protective effect on the ethanol-induced hepatotoxicity of rats.

• Korean Journal of Food Science and Technology
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• v.29 no.6
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• pp.1113-1118
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• 1997

Chemical components of domestic Angelica gigas Nakai and Angelica acutiloba Kitagawa were analyzed. Proximate analysis of each species showed crude protein 18.1% and 13.4%, crude lipid 8.9% and 4.3%, crude fiber 8.6% and 9.4%, crude ash 7.4% and 8.2%, and carbohydrate 57.0% and 64.7%, respectively. Contents of potassium which was found to be the most abundant mineral in both species were 2,740.0 mg% and 2,582.8 mg%, and those of sucrose were 0.4 % and 0.3% respectively while neither fructose nor glucose were detected in each species. Major fatty acids in Angelica gigas Nakai and Angelica acutiloba Kitagawa were linoleic acid (60.8% and 59.5%), palmitic acid (17.4% and 15.3%), oleic acid (8.8% and 7.7%) (respectively) but there was no significant difference between two species. Arginine was revealed as the most abundant amino acid in both species with 2,599.8 mg% in Angelica gigas Nakai and 1,543.4 mg% in Angelica acutiloba Kitagawa. Angelica gigas Nakai and Angelica acutiloba Kitagawa also were shown to contained 10.5 mg% and 12.2 mg% $vitamin\;B_1$, 0.1 mg% and 0.04 mg%, $vitamin\;B_2$, 4.3% and 0.8% decursin, and 988.0 mg% and 900.0 mg% tannin, respectively.

• Korean Journal of Medicinal Crop Science
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• v.14 no.4
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• pp.217-220
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• 2006

It is known that the process of variety development and maintenance of original plant is difficult in Angelica gigas and Angelica acutiloba because they are allogamous plants. The contents like this are stand in the way of theirs breeding. This study was conducted to investigate the foraging activity and pollinational efficacy by insects to flowers of A. gigas and A. acutiloba. Foraging activity by pollinators was observed every day from 10:00 to 10:30 during 3 days after September 21. Honey bee and fly were major pollinators. The rate of hymenoptera and diptera to total numbers of insects was the 56.5% and 40.6% in A. gigas, respectively. It was also 46.3% and 51.8% in A. acutiloba, respectively. The other insects were lepidoptera, coleoptera and hemiptera. The numbers of hymenoptera and diptera were more in flowers of A. gigas was 49.2% with bee, 36.0% with fly, 15.3% with human, 0.9% without anything in the nethouse and 76.6% in the open field. That of A. acutiloba was 43.6% with bee, 27.9% with fly, 20.3% with human, 0.6% without anything in the nethouse and 46.9% in the open field. Excepting open field, seed setting rate of with bee in the nethouse was the highest of all the others. However, we concluded that the use of fly was the most effective method for pollination of A. gigas and A. acutiloba considering low cost and convenient handling.

• Korean Journal of Medicinal Crop Science
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• v.13 no.2
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• pp.121-125
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• 2005

An analysis of RAPD-PCR (random amplified polymorphic DNA-polymerase chain reaction) was performed with three Angelica species (A. gigas Nakai, A. sinensis (Olive.) Diels and A. acutiloba Kitag) in an effort to distinguish between members of these three species. Two arbitrary primers (OPC02, OPD11) out of80 primers tested, produced 17 species-specific fragments among the three species. Eight fragments were specific for A. sinensis, four fragments specific for A. gigas, five specific for A. acutiloba. When primers OPC02 and OPD11 were used in the polymerase chain reaction, RAPD-PCR fragments that were specific for each of the three species were generated simultaneously. Primer OPC02 produced eight species-specific fragments: four were specific for A. sinensis, one for A. gigas, and three for A. acutiloba. Primer OPD11 produced nine speciesspecific fragments: four for A. sinensis, three for A. gigas, and two for A. acutiloba. The RAPD-PCR markers that were generated with these two primers should rapidly identify members of the three Angelica species. The consistency of the identifications made with these species-specific RAPD-PCR markers was demonstrated by the observation that each respective marker was generated from three accessions of each species, all with different origins. We also performed the RAPD-PCR analysis with the dried Angelica root samples that randomly collected from marketed and from the OPC02 primer, obtained a A. gigasspecific band and the band were cloned and sequenced.

• Korean Journal of Pharmacognosy
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• v.36 no.2 s.141
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• pp.141-144
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• 2005

Chinese crude drug 'Dang Gui' has been used mainly as a tonifying the blood, promoting blood circulation, relieving pain and moistening the bowels. To clarify the botanical origin of 'Dang Gui' from Korea, the anatomical characteristics of Angelica gigas, Angelica sinensis and Angelica acutiloba were studied. As a result, it was clarified that 'Dang Gui' from Korea was the root of Angelica gigas.

• Korean Journal of Medicinal Crop Science
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• v.22 no.2
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• pp.91-97
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• 2014

The contents of index components in 5 medicinal crops cultivated at different heights in Andong area. The contents of allantoin in Dioscorea batatas Decne and catalpol in Rehmannia glutinosa Liboschitz were not different by cultivation heights (100 ~ 200m). But the contents of index components in Astragalus membranaceus and Angelica acutiloba Kitagawa were higher in samples cultivated at elevated heights. At 700 m of heights, the contents of formononetin and astragaloside I in Astragalus membranaceus were 1.20 and $201.2{\mu}g/g$, respectively. The contents of decursin and nodakenin in Angelica acutiloba Kitagawa were 68.3 and 4.20 mg/g, respectively. Thus Astragalus membranaceus and Angelica acutiloba Kitagawa are recommended to be cultivated in higher altitude.

• Plant Resources
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• v.8 no.1
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• pp.71-74
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• 2005

Activated carbon(AC) can be utilized as a soil conditioner in agricultural crop areas. This study was conducted to investigate the effect of AC on Leaf and Stem Production of Angelica acutiloba as affected by different amounts of AC. The results obtained are summarized as follows. Growth characteristics including plant height and leaf length were the highest when activated carbon added with 10, suggesting that optimum amount of activated carbon was ranged from 10 to $20\%$. Growth and enlargement of the root were improved by $10\%$ AC.

• Natural Product Sciences
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• v.25 no.4
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• pp.285-292
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• 2019

A crude drug "Dang-Gui", belonging to the genus Angelica, has been used as a traditional herbal medicine in Asia. Various studies have investigated the chemical components and pharmacological activities of Dang-Gui worldwide. However, domestic research results published in Korean are undervalued in international academia due to language barriers. Therefore, it is necessary to summarize the domestic research findings systematically for greater accessibility. This review focuses on the results published in four Korean pharmaceutical journals between 1970 and 2018, which detail the botanical, phytochemical, and pharmacological properties of three Angelica species (A. gigas, A. sinensis, and A. acutiloba) used as "Dang-Gui" in Korea, China, and Japan.

• Korean Journal of Medicinal Crop Science
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• v.12 no.1
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• pp.43-46
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• 2004

In genus Angelica, three species have been used and cultivated for medicinal material in orient, A. gigas in Korea, acutiloba in Japan and sinensis in China. A. gigas (Chamdangui) is different from A. acutiloba or A. sinensis in the contents chemical components and their efficacious. In Korea, in particular, A. acutiloba has been cultivated in a small acreage from several decades ago, and recently A. sinensis has been trying to cultivate. A trial of adaptation and cultivation of the three species was performed in different altitudinal regions such as Suwon (50 m of sea level), Jinbu (500 m of sea level) and Taebak (700 m of sea level). A. gigas and acutiloba grew and produced roots successfully at all locations, but A. sinensis could grow only at high altitudinal region, Taebaek. A. sinensis survived 70.3% at Taebaek, but only 45.2% at Jinbu and 3.6% at Suwon. The dry root yield of A. sinensis was as low as 1,600 kg/ha at Taebaek and 1,270 kg/ha at Jinbu comparing farmers' average root yield of A. gigas, 3,000 kg/ha however, no root could be harvested at Suwon. The results, showed it was that A. sinensis could not grow at low altitudinal plane area except high altitude area in Korea. Even though it could grow, the root yield was too low to support the income.

• Journal of Korea Technical Association of The Pulp and Paper Industry
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• v.45 no.3
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• pp.9-19
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• 2013

This research was performed to make functional papers by using the waste of herbal medicine such as Astragalus membranaceus, Angelica acutiloba, and Artemisia capillaris as additives, and to evaluate their physical and optical properties of the manufactured paper. The physical and optical properties were decreased with the increase of the amount of herbal medicine. Of those manufactured papers, the functional paper with Artemisia capillaris showed the dramatic decrease in its physical properties. Adding the herbal medicine waste as additives developed the aesthetic pattern on the surface of the manufactured paper. The paper showing the black pattern on white surface was most favored. Different patterns could be made by changing the size of fibers and the amount of wastes. There was odor emitted from the paper due to the herbal medicine waste, which make the paper to have a potential for the diverse purpose. The herbal medicine waste can be applied to replace weighting agents in the manufacturing process of paper or used for the fuctional additives, resulting in the reduce of the quantity of a pulp consumed. The paper with 10-20% Angelica acutiloba waste were thought to have the most excellent quality on the process point of view.