• 제목/요약/키워드: Analytical validation

검색결과 591건 처리시간 0.024초

Validation of Radioanalytical Techniques for Nuclear Waste Characterisation

  • Warwick, Phillip E.
    • 방사성폐기물학회지
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    • 제17권4호
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    • pp.363-373
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    • 2019
  • Waste characterisation associated with nuclear site decommissioning relies on radiochemical analysis of a diverse range of sample types, requiring extensive validation of analytical techniques using matrix-matched materials. The absence of relevant reference materials has hindered robust method development and validation. The paper discusses how method validation in support of nuclear waste characterisation can be achieved without using reference materials. The key stages in an analytical procedure are evaluated and a multi-stage approach is proposed with the ultimate aim of determining an operational envelope for an analytical procedure.

UV-VIS 분광기기의 성능검증을 위한 밸리데이션 가이드라인의 제정 및 응용 (The Proposed Validation Guidelines and Their Application for Performance Verification of UV-VIS Spectrophotometer)

  • 김경옥;강영구;이원재
    • 약학회지
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    • 제50권3호
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    • pp.154-159
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    • 2006
  • For the increasing demand for the validation of analytical results, one of the important concerns of the analyst is to be assured that the instrumentation is working to qualified conditions. In this study, we have investigated and compared several validation guidelines of the performance verification of UV-VIS spectrophotometer used in pharmacopoeias of major countries and UV-VIS instrument analytical companies, and we proposed the practically useful validation guidelines of UV-VIS spectrophotometer. Based on our proposed validation guidelines of UV-VIS spectrophotometer, several UV-VIS spectrophotometers used in drug manufacturing laboratories were validated for their performances.

Quantitative analysis and validation of naproxen tablets by using transmission raman spectroscopy

  • Jaejin Kim;Janghee Han;Young-Chul Lee;Young-Ah Woo
    • 분석과학
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    • 제37권2호
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    • pp.114-122
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    • 2024
  • A transmission Raman spectroscopy-based quantitative model, which can analyze the content of a drug product containing naproxen sodium as its active pharmaceutical ingredient (API), was developed. Compared with the existing analytical method, i.e., high-performance liquid chromatography (HPLC), Raman spectroscopy exhibits high test efficiency owing to its shorter sample pre-treatment and measurement time. Raman spectroscopy is environmentally friendly since samples can be tested rapidly via a nondestructive method without sample preparation using solvent. Through this analysis method, rapid on-site analysis was possible and it could prevent the production of defective tablets with potency problems. The developed method was applied to the assays of the naproxen sodium of coated tablets that were manufactured in commercial scale and the content of naproxen sodium was accurately predicted by Raman spectroscopy and compared with the reference analytical method such as HPLC. The method validation of the new approach was also performed. Further, the specificity, linearity, accuracy, precision, and robustness tests were conducted, and all the results were within the criteria. The standard error of cross-validation and standard error of prediction values were determined as 0.949 % and 0.724 %, respectively.

대체용매를 이용한 금속가공유 측정방법 타당성에 대한 현장평가 (Field Validation of alternative extraction method for the determination of airborne MWFs)

  • 정지연;백남원
    • 한국산업보건학회지
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    • 제19권2호
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    • pp.96-101
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    • 2009
  • The purpose of this study was to conduct the field validation of alternative method(ETM method) by using non-carcinogenic, and less toxic solvents than NIOSH (National Institute for Occupational Safety and Health) analytical method 5524 for measuring the airborne metalworking fluids in workplaces. We carried out the field validation test by using the exposure chamber, guaranteeing the air sampling homogeneously in a machining environment. The ETM mixed solvent presented the complete solubility of MWFs used in test field. Based on the field test data, the bias of the ETM method from reference method, NIOSH analytical method 5524, was from -7.0% to 5.1%. The overall uncertainty of the ETM nethod was 21.6%, which satisfied the NIOSH criteria for the sampling and analytical criteria.

육두구(Myristica fragrans Houttuyn) 내의 myristicin의 분리 및 HPLC를 이용한 함량분석 방법 밸리데이션 (Isolation and Quantitative Determination Method Validation of myristicin from Myristica fragrans Houttuyn)

  • 김수환;이동호;권수한;임병호;이상훈;민범찬
    • 생약학회지
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    • 제38권1호
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    • pp.19-21
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    • 2007
  • Myristica fragrans has been used for the treatment of stomachache in East Asia. It is very important to determine the amount of myristicin in Myristica fragrans, because excess myristicin causes side effects. In this study, we developed and validated the method for determination contents of myristicin in Myristica fragrans which was purchased from various regions of Korea. The average content of myristicin in Myristica fragrans was 2.10% with the validated HPLC analysis method.

석면분석 정도관리용 표준시료 개발연구 II - Amosite 및 Chrysotile 표준시료 평가 - (Development of Asbestos Quality Contral Samples for Proficiency Analytical Testing II - Evaluation of Amosite and Chrysotile Quality Contral Samples -)

  • 이광용;윤충식;한진구;윤문종;정시정;이종한;이인섭;박두용
    • 한국산업보건학회지
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    • 제19권3호
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    • pp.288-296
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    • 2009
  • We conducted validation for asbestos quality control (QC) samples made by the developed method which was presented in our published paper. The main results of the validation study are as follows. The pooled coefficient variations of analytical results in three different concentrations (low, medium, and high concentration) for amosite and chrysotile were less than 20 %, which met the sample homogenicity criteria of NIOSH. Also we confirmed the homogenicity of asbestos samples by using the relocatable field slide. To evaluate the field applicability of the developed asbestos QC samples, the field validation was performed with four proficient asbestos analysts by using the statistical methods of AIHA asbestos PAT program. All analytical results from four asbestos analysts were located in the acceptable range.

고성능 액체크로마토그래프 기기의 성능검증을 위한 밸리데이션 가이드라인에 대한 연구 (Investigation of Validation Guidelines for Performance Verification of High Performance Liquid Chromatograph)

  • 윤원남;이범규;이원재
    • 약학회지
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    • 제57권5호
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    • pp.362-368
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    • 2013
  • High performance liquid chromatograph (HPLC) is the most frequently used analytical instrument in analytical laboratories for pharmaceutical analysis. In order to provide a high level of assurance for reliable data generated from the HPLC analysis, the performance qualification of the HPLC system is required. For this purpose, the performance of HPLC system should be regularly monitored by examining the key functions of the typical HPLC system (solvent delivery system, injector system, column oven, UV-VIS detector system). We have investigated the validation guidelines of the performance verification of these key modules for HPLC system. And we proposed and evaluated its validation guidelines and the related verification methods for pharmaceutical analysis that could be practically applied in Korea.

SDL 메트릭 집합의 분석적 검증 (Analytical Validation of the SDL Metrics Set)

  • 홍의석;정명희
    • 한국정보처리학회논문지
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    • 제7권4호
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    • pp.1112-1121
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    • 2000
  • Design metrics that quantify the design phase play an important role in reducing system development cost because the problems in early phases of software development seriously affected the quality of the late products. Real-time systems such as telecommunication systems are so large that design quantification is more important in real-time system design. Although many metrics have been proposed, few of them are correctly validated. This paper revises the SDL metrics set proposed in earlier study [9] and perform an analytical validation o the metrics set. Axiomatic approach and dimensional analysis are used for metrics validation and the old metrics are revised ot satisfy the validation criteria.

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Geomechanical and hydrogeological validation of hydro-mechanical two-way sequential coupling in TOUGH2-FLAC3D linking algorithm with insights into the Mandel, Noordbergum, and Rhade effects

  • Lee, Sungho;Park, Jai-Yong;Kihm, Jung-Hwi;Kim, Jun-Mo
    • Geomechanics and Engineering
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    • 제28권5호
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    • pp.437-454
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    • 2022
  • The hydro-mechanical (HM) two-way sequential coupling in the TOUGH2-FLAC3D linking algorithm is validated completely and successfully in both M to H and H to M directions, which are initiated by mechanical surface loading for geomechanical validation and hydrological groundwater pumping for hydrogeological validation, respectively. For such complete and successful validation, a TOUGH2-FLAC3D linked numerical model is developed first by adopting the TOUGH2-FLAC3D linking algorithm, which uses the two-way (fixed-stress split) sequential coupling scheme and the implicit backward time stepping method. Two geomechanical and two hydrogeological validation problems are then simulated using the linked numerical model together with basic validation strategies and prerequisites. The second geomechanical and second hydrogeological validation problems are also associated with the Mandel effect and the Noordbergum and Rhade effects, respectively, which are three phenomenally well-known but numerically challenging HM effects. Finally, sequentially coupled numerical solutions are compared with either analytical solutions (verification) or fully coupled numerical solutions (benchmarking). In all the four validation problems, they show almost perfect to extremely or very good agreement. In addition, the second geomechanical validation problem clearly displays the Mandel effect and suggests a proper or minimum geometrical ratio of the height to the width for the rectangular domain to maximize agreement between the numerical and analytical solutions. In the meantime, the second hydrogeological validation problem clearly displays the Noordbergum and Rhade effects and implies that the HM two-way sequential coupling scheme used in the linked numerical model is as rigorous as the HM two-way full coupling scheme used in a fully coupled numerical model.