• Biomolecules & Therapeutics
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• 제17권1호
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• pp.79-85
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• 2009

Polyphenolic compounds are reported to have various pharmacological activities such as anti-oxidative, anti-cancerous, anti-inflammatory and anti-aging effects. Although numerous papers explore their functional roles in many different cellular actions, not many studies handle their structural features in anti-inflammatory responses. In this study, therefore, we examined structural role of substituted transstilbenes in their NO inhibitory and NF-${\kappa}B$ suppressive activities. Of 10 compounds tested, 4 compounds (cinnamic acid, resveratrol, piceatannol and curcumin) displayed NO inhibitory activities in a dose-dependent manner. Similarly, these compounds blocked LPS-induced cytotoxicity of RAW264.7 cells. All NO inhibitory compounds also inhibited $I{\kappa}B{\alpha}$ phosphorylation, a hallmark for NF-${\kappa}B$ activation. However, these inhibitory compounds exhibited distinct suppressive pattern in tumor necrosis factor (TNF)-${\alpha}$- or phorbol-12-myristate-13-acetate (PMA)-induced NF-${\kappa}B$ and AP-1 activation. According to structure-activity relationship study, polarity and size of ring B seem to be important for diminishing NO production. Therefore, our data suggest that substituted trans-stilbenes can be developed as novel anti-inflammatory drug or further developed as lead compounds for another improvement.

• Natural Product Sciences
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• 제19권1호
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• pp.49-53
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• 2013

Paeonia lactiflora Pall (PL) has been used as a traditional herbal medicine in China, Korea, and Japan for more 1,200 years. PL has reported to have antioxidant activity and protective effect of cells from oxidative stress, although the mechanism has not been verified. FOXO3a is a transcription factor that binds to its target gene's consensus FOXO binding site. FOXO3a protein modulates the various biological functions including cell cycle control, apoptosis, DNA repair, and ROS detoxification. Therefore, FOXO3a activity is associated with cancer, aging, diabetes, infertility, neurodegeneration, and immune system dysfunction. Here we found that FOXO3a was activated by PL extract. Transcriptional target genes such as MnSOD, p27, and GADD45 were activated by PL extract. Protein levels of MnSOD and catalase were increased, consequently, ROS level was reduced in HEF cells by PL extract. These findings suggest that PL extract has an antioxidant activity through FOXO activation and thereby activation of FOXO target genes, MnSOD and catalase.

• 생약학회지
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• 제46권4호
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• pp.295-302
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• 2015

Cynanchi wilfordii Radix roots have been utilized as traditional medicine for variety of diseases including diabetes mellitus, aging progression and scavenging free radicals, enhancing immunity, reducing high serum cholesterol, and anti-tumor activity. However, the mechanisms underlying this effect remain poorly understood. The principal objective of this study was to determine the effect of cynandione A on osteoclast cells. Thus, we was isolated cynandione A from Cynanchi wilfordii Radix roots and evaluated the effect of cynandione A on receptor activator of nuclear factor-${\kappa}B$ ligand (RANKL)-induced osteoclast differentiation. We found that cynandione A significantly inhibited osteoclast differentiation stimulated-RANKL in RAW 264.7 cells. Cynandione A conspicuously inhibited the mRNA and protein expression of matrix metallopeptidase 9 (MMP-9), tartrate-resistant acid phosphatase (TRAP) in cynandione A treated with RANKL. Taken together, our results demonstrated that Cynanchi Wilfordii Radix may be useful treatment option of bone-related disease such as osteoporosis leads to fracture of bone and rheumatoid arthritis.

• Biomolecules & Therapeutics
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• 제24권1호
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• pp.75-84
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• 2016

This study was designed to investigate the cytoprotective effect of rosmarinic acid (RA) on ultraviolet B (UVB)-induced oxidative stress in HaCaT keratinocytes. RA exerted a significant cytoprotective effect by scavenging intracellular ROS induced by UVB. RA also attenuated UVB-induced oxidative macromolecular damage, including protein carbonyl content, DNA strand breaks, and the level of 8-isoprostane. Furthermore, RA increased the expression and activity of superoxide dismutase, catalase, heme oxygenase-1, and their transcription factor Nrf2, which are decreased by UVB radiation. Collectively, these data indicate that RA can provide substantial cytoprotection against the adverse effects of UVB radiation by modulating cellular antioxidant systems, and has potential to be developed as a medical agent for ROS-induced skin diseases.

• 한국동물위생학회지
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• 제26권4호
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• pp.323-328
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• 2003

A total of 419 slaughtered cattle were used to investigate the serum Ig G titers to the Mannheimia haemolytica Al whole cell and leukotoxin recognized with important virulence factor in bacterial pathogenesis. Data obtained in this study were represented with average absorbance${\pm}$standard deviation. Serum Ig G titers were detected with the ranges from 0.1 to 0.5 at 490nm. Whole cell titers were higher than leukotoxin antibody on the whole. Antibody titers of slaughtered cattle between races, ages have no significant difference but gradual decrease under aging in dairy cow for whole cell (decline mean titer from 0.29 to 0.27 according to age) was undertaken. Holstein bulls shipped from Seoul province had a significantly lower Ig G titers than those from another ones (p<0.05).

• Current Photovoltaic Research
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• 제5권3호
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• pp.83-88
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• 2017

The growth of intermetallic compounds is an important factor in the reliability of solar cells. Especially, the temperature change in the soldering process greatly affects the thickness of the intermetallic compound layer. In this study, we investigated the intermetallic compound growth by Sn-diffusion in solder joints of solar cells. The thickness of the intermetallic compound layer was analyzed by IR lamp power and hot plate temperature control, and the correlation between the intermetallic compound layer and the adhesive strength was confirmed by a $90^{\circ}$ peel test. In order to investigate the growth of the intermetallic compound layer during isothermal aging, the growth of the intermetallic compound layer was analyzed at $85^{\circ}C$ and 85% for 500 h. In addition, the activation energy of Sn was calculated. The diffusion coefficient of the intermetallic compound layer was simulated and compared with experimental results to predict the long-term reliability.

• 패션비즈니스
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• 제16권1호
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• pp.121-136
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• 2012

The purpose of this study was to classify pursuit of clothing benefits and analyze the relationship between pursuit of clothing benefits, lifestyle, fast fashion attitude, and cosmetics behavior of college students. Questionnaires were administered to 338 college students living in Deagu and Busan province. Data were analyzed by using frequency, factor analysis, cluster analysis, correlation analysis, $X^2$-test, ANOVA, and Scheffe-test. The findings are as follows. Pursuit of Clothing benefits typologies of college students were classified into three groups such as self-expression, pursuit of economic, and pursuit of social oriented body. In the relationship of the pursuit of clothing benefits was related to the sub-variables of lifestyle, fast fashion, and cosmetics behavior. Pursuit of Clothing benefits groups showed different the sub-variables of lifestyle, fast fashion attitude, and cosmetics behavior factors. Pursuit of Clothing benefits groups showed connected with college students and ages.

• 한국구조물진단유지관리공학회 논문집
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• 제18권1호
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• pp.128-137
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• 2014

내화뿜칠재는 주로 철골구조물 위에 시공하여 내화구조기준을 만족하기 위한 것이다. 국내에서는 원자력발전소를 비롯하여 철골구조물에 내화뿜칠재를 시공하여 왔지만, 재료특성 중 중요한 요건인 부착강도기준이 제정되어있지 않았다. 다만, 원자력발전소는 원전의 기준에 따라 부착강도 기준이 있었다. 본 논문에서는 변전소에 시공되는 내화뿜칠재의 부착강도 기준을 정하고자 하였다. 기준설정 방법은 현재 사용되는 제품으로 실험체를 제작하고, 변전소 환경에 따라 열화시키며 부착강도를 측정하고 구조물 내구연한 기간 동안 열화시킨 후 변전소에서 발생하는 충격하중 실험을 통하여 탈락여부를 평가하여 부착강도기준을 설정하였다. 본 논문에서의 부착강도는 시중에서 사용되는 제품을 기준으로 실험한 것으로 최소한의 값이라고 판단된다.

• 한국의류학회지
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• 제38권5호
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• pp.705-717
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• 2014

The interest and importance of appearance can be expanded by changes in social awareness about appearance, the extension of life expectancy, and the development of science, technology and technology and medicine. Especially, down-aging syndrome through a variety of mediums, amplifies consumer's interest in youth-pursing. This study discusses the relationship of youth-pursuing, appearance concern and appearance management behavior focused on the middle-aged. Data were collected from 300 females aged 40-65 in the areas of Seoul, Daejeon and Chungbuk areas. The data were analyzed by descriptive statistics, factor analysis, regression analysis, using the SPSS-WIN 20.0 program. Youth-pursuing formed social, psychological, and appearance factors. Each of these three dimensions influenced the appearance concern; consequently, appearance had the highest influence. Only appearance influenced appearance management behavior in the regression analysis of youth-pursuing and appearance management behavior. Appearance concern affected significantly appearance in the management behavior of the dimension regression analysis results for the appearance concern and appearance management behavior.

• 디지털융복합연구
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• 제14권2호
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• pp.141-148
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• 2016

농업용 기계는 농촌의 노동인구 감소와 고령화에 따른 노동력 부족에 대응하고 높은 노동 부담과 생산비용을 줄이기 위해 매우 중요한 요소로 작용하고 있다. 최근 이러한 농업용 기계에 첨단 전자기술이 폭넓게 응용되면서 정보통신, 차세대 전지, 반도체, 무선통신, 콘텐츠, 디스플레이 등 첨단 산업과의 융합이 갈수록 증대되고 있는 산업분야로 발전하고 있다. 본 연구에서는 그동안 기계식에 의존해 온 농업용 파종기에 정보통신 기술을 적용하여 신속하고 정교하며, 작업 상태의 모니터링이 가능한 ICT 융합형 파종기를 설계하였다.