• Biomolecules & Therapeutics
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• v.17 no.1
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• pp.79-85
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• 2009

Polyphenolic compounds are reported to have various pharmacological activities such as anti-oxidative, anti-cancerous, anti-inflammatory and anti-aging effects. Although numerous papers explore their functional roles in many different cellular actions, not many studies handle their structural features in anti-inflammatory responses. In this study, therefore, we examined structural role of substituted transstilbenes in their NO inhibitory and NF-${\kappa}B$ suppressive activities. Of 10 compounds tested, 4 compounds (cinnamic acid, resveratrol, piceatannol and curcumin) displayed NO inhibitory activities in a dose-dependent manner. Similarly, these compounds blocked LPS-induced cytotoxicity of RAW264.7 cells. All NO inhibitory compounds also inhibited $I{\kappa}B{\alpha}$ phosphorylation, a hallmark for NF-${\kappa}B$ activation. However, these inhibitory compounds exhibited distinct suppressive pattern in tumor necrosis factor (TNF)-${\alpha}$- or phorbol-12-myristate-13-acetate (PMA)-induced NF-${\kappa}B$ and AP-1 activation. According to structure-activity relationship study, polarity and size of ring B seem to be important for diminishing NO production. Therefore, our data suggest that substituted trans-stilbenes can be developed as novel anti-inflammatory drug or further developed as lead compounds for another improvement.

• Natural Product Sciences
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• v.19 no.1
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• pp.49-53
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• 2013

Paeonia lactiflora Pall (PL) has been used as a traditional herbal medicine in China, Korea, and Japan for more 1,200 years. PL has reported to have antioxidant activity and protective effect of cells from oxidative stress, although the mechanism has not been verified. FOXO3a is a transcription factor that binds to its target gene's consensus FOXO binding site. FOXO3a protein modulates the various biological functions including cell cycle control, apoptosis, DNA repair, and ROS detoxification. Therefore, FOXO3a activity is associated with cancer, aging, diabetes, infertility, neurodegeneration, and immune system dysfunction. Here we found that FOXO3a was activated by PL extract. Transcriptional target genes such as MnSOD, p27, and GADD45 were activated by PL extract. Protein levels of MnSOD and catalase were increased, consequently, ROS level was reduced in HEF cells by PL extract. These findings suggest that PL extract has an antioxidant activity through FOXO activation and thereby activation of FOXO target genes, MnSOD and catalase.

• Korean Journal of Pharmacognosy
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• v.46 no.4
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• pp.295-302
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• 2015

Cynanchi wilfordii Radix roots have been utilized as traditional medicine for variety of diseases including diabetes mellitus, aging progression and scavenging free radicals, enhancing immunity, reducing high serum cholesterol, and anti-tumor activity. However, the mechanisms underlying this effect remain poorly understood. The principal objective of this study was to determine the effect of cynandione A on osteoclast cells. Thus, we was isolated cynandione A from Cynanchi wilfordii Radix roots and evaluated the effect of cynandione A on receptor activator of nuclear factor-${\kappa}B$ ligand (RANKL)-induced osteoclast differentiation. We found that cynandione A significantly inhibited osteoclast differentiation stimulated-RANKL in RAW 264.7 cells. Cynandione A conspicuously inhibited the mRNA and protein expression of matrix metallopeptidase 9 (MMP-9), tartrate-resistant acid phosphatase (TRAP) in cynandione A treated with RANKL. Taken together, our results demonstrated that Cynanchi Wilfordii Radix may be useful treatment option of bone-related disease such as osteoporosis leads to fracture of bone and rheumatoid arthritis.

• Biomolecules & Therapeutics
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• v.24 no.1
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• pp.75-84
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• 2016

This study was designed to investigate the cytoprotective effect of rosmarinic acid (RA) on ultraviolet B (UVB)-induced oxidative stress in HaCaT keratinocytes. RA exerted a significant cytoprotective effect by scavenging intracellular ROS induced by UVB. RA also attenuated UVB-induced oxidative macromolecular damage, including protein carbonyl content, DNA strand breaks, and the level of 8-isoprostane. Furthermore, RA increased the expression and activity of superoxide dismutase, catalase, heme oxygenase-1, and their transcription factor Nrf2, which are decreased by UVB radiation. Collectively, these data indicate that RA can provide substantial cytoprotection against the adverse effects of UVB radiation by modulating cellular antioxidant systems, and has potential to be developed as a medical agent for ROS-induced skin diseases.

• Korean Journal of Veterinary Service
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• v.26 no.4
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• pp.323-328
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• 2003

A total of 419 slaughtered cattle were used to investigate the serum Ig G titers to the Mannheimia haemolytica Al whole cell and leukotoxin recognized with important virulence factor in bacterial pathogenesis. Data obtained in this study were represented with average absorbance${\pm}$standard deviation. Serum Ig G titers were detected with the ranges from 0.1 to 0.5 at 490nm. Whole cell titers were higher than leukotoxin antibody on the whole. Antibody titers of slaughtered cattle between races, ages have no significant difference but gradual decrease under aging in dairy cow for whole cell (decline mean titer from 0.29 to 0.27 according to age) was undertaken. Holstein bulls shipped from Seoul province had a significantly lower Ig G titers than those from another ones (p<0.05).

• Current Photovoltaic Research
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• v.5 no.3
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• pp.83-88
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• 2017

The growth of intermetallic compounds is an important factor in the reliability of solar cells. Especially, the temperature change in the soldering process greatly affects the thickness of the intermetallic compound layer. In this study, we investigated the intermetallic compound growth by Sn-diffusion in solder joints of solar cells. The thickness of the intermetallic compound layer was analyzed by IR lamp power and hot plate temperature control, and the correlation between the intermetallic compound layer and the adhesive strength was confirmed by a $90^{\circ}$ peel test. In order to investigate the growth of the intermetallic compound layer during isothermal aging, the growth of the intermetallic compound layer was analyzed at $85^{\circ}C$ and 85% for 500 h. In addition, the activation energy of Sn was calculated. The diffusion coefficient of the intermetallic compound layer was simulated and compared with experimental results to predict the long-term reliability.

• Journal of Fashion Business
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• v.16 no.1
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• pp.121-136
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• 2012

The purpose of this study was to classify pursuit of clothing benefits and analyze the relationship between pursuit of clothing benefits, lifestyle, fast fashion attitude, and cosmetics behavior of college students. Questionnaires were administered to 338 college students living in Deagu and Busan province. Data were analyzed by using frequency, factor analysis, cluster analysis, correlation analysis, $X^2$-test, ANOVA, and Scheffe-test. The findings are as follows. Pursuit of Clothing benefits typologies of college students were classified into three groups such as self-expression, pursuit of economic, and pursuit of social oriented body. In the relationship of the pursuit of clothing benefits was related to the sub-variables of lifestyle, fast fashion, and cosmetics behavior. Pursuit of Clothing benefits groups showed different the sub-variables of lifestyle, fast fashion attitude, and cosmetics behavior factors. Pursuit of Clothing benefits groups showed connected with college students and ages.

• Journal of the Korea institute for structural maintenance and inspection
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• v.18 no.1
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• pp.128-137
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• 2014

Sprayed fire resistive materials are mainly used at steel structures to satisfy fireproof construction standard. However, the regulations on bond strength have been not considered with the exception of structures in the nuclear power plants, although it is an important factor showing material properties. Therefore, this paper suggested guidelines for bond strength of sprayed fire resistive materials used in the substation, by measuring bond strength according to aging of structures and impact loading considering environment of substations. It is judged that the bond strength suggested in this paper is the minimum value because it was measured from specimens widely used.

• Journal of the Korean Society of Clothing and Textiles
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• v.38 no.5
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• pp.705-717
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• 2014

The interest and importance of appearance can be expanded by changes in social awareness about appearance, the extension of life expectancy, and the development of science, technology and technology and medicine. Especially, down-aging syndrome through a variety of mediums, amplifies consumer's interest in youth-pursing. This study discusses the relationship of youth-pursuing, appearance concern and appearance management behavior focused on the middle-aged. Data were collected from 300 females aged 40-65 in the areas of Seoul, Daejeon and Chungbuk areas. The data were analyzed by descriptive statistics, factor analysis, regression analysis, using the SPSS-WIN 20.0 program. Youth-pursuing formed social, psychological, and appearance factors. Each of these three dimensions influenced the appearance concern; consequently, appearance had the highest influence. Only appearance influenced appearance management behavior in the regression analysis of youth-pursuing and appearance management behavior. Appearance concern affected significantly appearance in the management behavior of the dimension regression analysis results for the appearance concern and appearance management behavior.

• Journal of Digital Convergence
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• v.14 no.2
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• pp.141-148
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• 2016

Agricultural machines can be viewed as a very important factor to reduce the workforce and reduce production costs as well as keep up with now days trend caused Labor shortages and the workforce reduction by aging in rural. The latest agricultural machinery has developed into a major agricultural industry to apply and integrate the telecommunication, next-generation batteries, semiconductors, wireless communications, content and high-tech display industry technology with a wide range of applications. In this study, to apply the information and communication technologies on agricultural planters relied on a mechanical method, we designed a quick and sophisticated ICT convergence planters that enable to monitor.